Bio-inspired multifunctional disruptors of calcium oxalate crystallization by Doyoung Kim, Vraj P. Chauhan, Bryan G. Alamani, Saxton D. Fisher, Zhi Yang, Matthew R. Jones, Tanguy Terlier, Peter G. Vekilov, Jeffrey D. Rimer

“…Abstract Calcium mineralization in biological and geological systems is often regulated by (macro)molecules enriched with anionic functional moieties. Relatively few studies have examined the effects of phosphate-based modifiers that are integral in calcification underlying human bone formation and pathological diseases. …”
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Sera contributing to mycobacterial growth restriction in vitro display enhanced Fc-mediated phagocytosis by Krista E. van Meijgaarden, Patricia S. Grace, Wenjun Wang, Delia Goletti, Fabrizio Palmieri, Manfred Wuhrer, Tom H.M. Ottenhoff, Simone A. Joosten

“…Here, we focus on the functional capacity of antibodies from individuals with TB disease, both before and after TB treatment, individuals with TB infection, and healthy uninfected individuals, using an adapted in vitro mycobacterial growth inhibition assay, measuring Bacillus Calmette-Guérin (BCG) growth inhibition. …”
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Gamma-aminobutyric acid as an element of the mechanisms of cerebro-renal interactions by N.D. Filipets, D.D. Іvanov, О.V. Gerush, О.О. Filipets, О.Н. Kmet, N.M. Fundiur, K.V. Slobodian

“…Given the fact that there is a relationship between GABA levels and the functional and metabolic state of other organs and systems, the aim of the work is to focus on scientific information regarding local GABAergic systems, the location of their components in the nephron and the renal effects of GABA under different conditions. …”
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Isoreticular moiré metal-organic frameworks with quasiperiodicity by Jiyeon Kim, Jaewoong Lee, Changhyeon Cho, Joohan Nam, Byeongju Ji, Hyeonsoo Cho, Hyeon Tae Shin, Dharmalingam Sivanesan, Sarah S. Park, Jihan Kim, Wonyoung Choe

“…This work provides a conceptual framework for incorporating quasiperiodicity into reticular chemistry and expands the structural design space for functional moiré materials.…”
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A Narrative Review of Neuroimaging Studies in Acupuncture for Migraine by Peihong Ma, Xiaohui Dong, Yuzhu Qu, Zhaoxuan He, Tao Yin, Shirui Cheng, Zilei Tian, Yuke Teng, Kunnan Xie, Ruirui Sun, Siyi Yu, Fang Zeng

“…As a result, a total of 28 articles were included. Functional magnetic resonance imaging was the most used neuroimaging technique to explore the cerebral activities of acupuncture for migraine. …”
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GALECTIN-1 AND ITS ROLE IN DEVELOPMENT OF INNATE AND ADAPTIVE IMMUNITY by V. D. Yakushina, O. A. Vasilyeva, N. V. Ryazantseva, V. V. Novitsky, O. E. Savelyeva, T. S. Prokhorenko, E. G. Starikova, A. P. Zima

“…Galectin-1 is considered to play a special role in functional regulation of immune cell activity. Thus protein is a factor of immunocompetent cell cooperation, thus being able to modulate immune reactions. …”
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Organocatalytic enantioselective synthesis of double S-shaped quadruple helicene-like molecules by Shengli Huang, Haojun Wen, Yige Li, Wenling Qin, Pengfei Wang, Yu Lan, Shiqi Jia, Hailong Yan

“…The enantioselective synthesis of (P,P,P,P) and (M,M,M,M) configurational quadruple helical molecules can be achieved by modulating the structure of the catalyst. Density functional theory (DFT) calculations show that the reaction involves the formation of a duplex vinylidene ortho-quinone methide (VQM) intermediate and two successive cycloaddition reactions. …”
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Decoding the regulatory role of ATP synthase inhibitory factor 1 (ATPIF1) in Wallerian degeneration and peripheral nerve regeneration by Yun Qian, Zhiwen Yan, Tianbao Ye, Victor Shahin, Jia Jiang, Cunyi Fan

“…Abstract ATP synthase inhibitory factor 1 (ATPIF1), a key modulator of ATP synthase complex activity, has been implicated in various physiological and pathological processes. …”
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Adipose tissue oxylipin profile changes with subclinical ketosis and depot in postpartum dairy cows by Bridger B. Sparks, Hunter Ford, Tainara C. Michelotti, Clarissa Strieder-Barboza

“…Additionally, PUFA can become oxidized into oxylipins, which modulate inflammation and metabolism. The objective of this work was to identify depot-specific differences on adipose tissue oxylipin profile in dairy cows with and without subclinical ketosis and assess the effects of oxylipins on adipocyte function in vitro. …”
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The gut–kidney axis is regulated by astragaloside IV to inhibit cyclosporine A-induced nephrotoxicity by Cong Han, Ran-ran Gao, Le Zhou, Wei Li

“…Lactobacillus reuteri was highly correlated with renal function and the target genes and metabolites of AS-IV. …”
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DNA dioxygenase TET2 deficiency aggravates sepsis-induced acute lung injury by targeting ITGA10 via the PI3K/AKT signaling pathway by Hongxue Fu, Bin Gao, Xin Zhou, Yingting Hao, Chang Liu, Ailin Lan, Jingyi Tang, Fachun Zhou

“…Abstract Background Sepsis-induced acute lung injury (ALI) is a clinical condition with high morbidity and mortality, and impaired endothelial function is the main pathological characteristic. As a member of DNA demethylases, ten-eleven translocation protein 2 (TET2) is involved in a variety of biological processes. …”
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Single-Cell Transcriptomics Unveils the Mechanistic Role of FOSL1 in Cutaneous Wound Healing by Jingbi Meng, Ge Zheng, Yinli Luo, Ling Ge, Zhiqing Liu, Wenhua Huang, Meitong Jin, Yanli Kong, Shanhua Xu, Zhehu Jin, Longquan Pi

“…Furthermore, Gene Set Variation Analysis (GSVA) was executed across Hallmark, biological process (BP), molecular function (MF), and cellular component (CC) categories to deepen our understanding of the wound healing process. …”
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Effects of varying longitudinal bending stiffness in running shoes on lower limb biomechanics of elite marathon runners by Hailiang Yang, Hailiang Yang, Yuhui Cai, Kuang Li, Xiangdong Wang, Tao Liu

“…Among the three conditions, MLBS better balanced mechanical efficiency and natural joint function, suggesting it may be a more biomechanically suitable option for elite marathon runners. …”
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Efficacy and safety of puerarin injection as an adjunctive therapy for chronic heart failure: a systematic review and meta-analysis by Hesong Fan, Jingrong Yang, Huaizhe Wang, Shuli Zong, Yiwei Qu, Kefei Wang, Fengyi Zhang, Xiao Li

“…The combination therapy demonstrated both a significantly increased total effectiveness rate (RR = 1.26, 95% CI [1.21, 1.31], P < 0.01) and improved hemodynamic parameters, along with favorable modulation of oxidative stress markers evidenced by elevated superoxide dismutase, glutathione peroxidase, and catalase levels concomitant with reduced lipid peroxidation and malondialdehyde concentrations.ConclusionThis meta-analysis suggests that adjunctive puerarin injection with conventional therapy may provide comprehensive benefits for chronic heart failure management, including improved clinical outcomes, enhanced cardiac function, attenuated ventricular remodeling, optimized hemodynamic performance, and reduced oxidative stress, while maintaining a safety profile comparable to conventional therapy. …”
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7-step endoscopic nipple-sparing mastectomy with implant-based breast reconstruction: nipple sensation preservation and low complications by Ze Huang, Zhijie Wu, Xiaoyan Fu, Yonghai Guo, Siyuan Lin, Jieying Chen, Zongyan Li, Zuxiao Chen, Haiyan Li

“…All four sensory types of the nipple—light touch, temperature, pressure, and pain—as well as erectile function, were preserved at favorable rates following the procedure. …”
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Study on the Influence and Mechanism of Resveratrol on Cognitive Impairment in Chronic Kidney Disease Rats Through Regulating Gut Microbiota and the TLR4/NFκB Pathway by Shao B, Nong Y, Lin Y, Meng Y, Zhou Y, Huang M, Huang F, Wang J

“…The CKD+Res group received intragastric Res for 6 weeks. Cognitive function was assessed using the Morris water maze. …”
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Expression of PSMD14 in lung adenocarcinoma and its impact on immune cell infiltration and prognosis: a comprehensive analysis based on RNA and single-cell RNA sequencing by Jing Zhang, Bohao Sun, Jiabin Lai, Weike Kong, Nan Wang, Panyuan Li, Yichen Wu, Zhaochang Jiang

“…Moreover, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that PSMD14 is significantly associated with pathways related to the cell cycle and nicotine dependence, underscoring its vital function in modulating cell proliferation and metabolic activities. …”
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Gui-Pi-Tang Defers Skeletal Muscle and Cardiac Muscle Aging by Promoting Mitochondrial Remodeling by Cai C, Wang M, Yang D, Jing C, Li Y, Xu H, Liu F, Zhao D

“…Mitochondrial morphology, structure, and function were analyzed using transmission electron microscopy, Seahorse assays, and ATP content measurements. …”
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THE INFLAMMASOME DRIVES MICROVASCULAR IMPAIRMENT IN MOUSE MODELS OF INTRAVASCULAR HEMOLYSIS by PL Brito, EMFG Azevedo, LFS Gushiken, FC Leonardo, FF Costa, N Conran

“…Conclusion: These results demonstrate that NLRP3 inflammasome assembly, in response to hemolysis, compromises microvascular function by modulating leukocyte adhesion to the endothelium and impairing blood flow to tissues, which could contribute to clinical complications in hemolytic disorders such as SCD.…”
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Image denoising algorithm based on multi-channel GAN by Hongyan WANG, Xiao YANG, Yanchao JIANG, Zumin WANG

“…Aiming at the issue that the noise generated during image acquisition and transmission would degrade the ability of subsequent image processing, a generative adversarial network (GAN) based multi-channel image denoising algorithm was developed.The noisy color image could be separated into red-green-blue (RGB) three channels via the proposed approach, and then the denoising could be implemented in each channel on the basis of an end-to-end trainable GAN with the same architecture.The generator module of GAN was constructed based on the U-net derivative network and residual blocks such that the high-level feature information could be extracted effectively via referring to the low-level feature information to avoid the loss of the detail information.In the meantime, the discriminator module could be demonstrated on the basis of fully convolutional neural network such that the pixel-level classification could be achieved to improve the discrimination accuracy.Besides, in order to improve the denoising ability and retain the image detail as much as possible, the composite loss function could be depicted by the illustrated denoising network based on the following three loss measures, adversarial loss, visual perception loss, and mean square error (MSE).Finally, the resultant three-channel output information could be fused by exploiting the arithmetic mean method to obtain the final denoised image.Compared with the state-of-the-art algorithms, experimental results show that the proposed algorithm can remove the image noise effectively and restore the original image details considerably.…”
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