Integrated multi-omics analysis and machine learning identify G protein-coupled receptor-related signatures for diagnosis and clinical benefits in soft tissue sarcoma by Duo Wang, Duo Wang, Duo Wang, Jihao Tu, Jihao Tu, Jianfeng Liu, Jianfeng Liu, Yuting Piao, Yuting Piao, Yiming Zhao, Yiming Zhao, Ying Xiong, Ying Xiong, Jianing Wang, Jianing Wang, Xiaotian Zheng, Xiaotian Zheng, Bin Liu, Bin Liu

“…Building up a GPR-TME classifier, low GPR combined with high TME exhibited the most favorable prognosis and immunotherapeutic efficacy, which was further performed for immune infiltration, functional enrichment, somatic mutation, immunotherapy response prediction, and scRNA-seq analyses.ConclusionsOur study constructed a GPRS that can serve as a promising tool for diagnosis and prognosis prediction, targeted prevention, and personalized medicine in STS.…”
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Investigation of Fructus sophorae extract’s therapeutic mechanism in atrophic vaginitis based on network pharmacology and experimental validation by Jiarui Zheng, Jiarui Zheng, Weiming Wang, Wenting Song, Yehao Zhang, Mingjiang Yao, Guangrui Wang, Zishan Huang, Feng Li, Junguo Ren, Li Lin, Xiaodi Fan, Jianxun Liu

“…The putative therapeutic targets of FS against AV were identified through target overlap analysis between drug and disease targets. Functional enrichment analyses of GO terms, KEGG pathways, and disease associations were performed using DAVID database, with results visualized by Cytoscape software. …”
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Multifaceted Aspects of Dysfunctional Myelopoiesis in Cancer and Therapeutic Perspectives with Focus on HCC by Andrea Arleo, Annapaola Montagner, Catia Giovannini, Fabrizia Suzzi, Fabio Piscaglia, Laura Gramantieri

“…While the lymphocytic compartment has attracted major attention due to the role of adaptive immunity in anticancer immune response, in recent years, research has found convincing evidence that confirms the importance of innate immunity and the key function played by emergency myelopoiesis. Due to cancer’s ability to manipulate myelopoiesis to its own advantage, the purpose of this review is to outline myelopoiesis processes within the tumor microenvironment and suggest possible therapeutic lines of research to restore the physiological functioning of the host’s immune system, with a special outlook on hepatocellular carcinoma (HCC).…”
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The multifaceted roles of E3 ubiquitin ligases in osteoarthritis by Zheng Jin, Zhenhua Zhu, Jun Chen, Xiaopeng Jing, Jie Tan, Ji Zeng

“…They identify specific substrates and attach ubiquitin molecules to substrates, thus modulating protein stability, function, and cellular localization. …”
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LRRK2 kinase activity regulates Parkinson’s disease-relevant lipids at the lysosome by Michael T. Maloney, Xiang Wang, Rajarshi Ghosh, Shan V. Andrews, Romeo Maciuca, Shababa T. Masoud, Maayan Agam, Richard M. Caprioli, Giuseppe Astarita, Vitaliy V. Bondar, John Chen, Chi-Lu Chiu, Sonnet S. Davis, Audrey Cheuk-Nga Ho, Hoang N. Nguyen, Nicholas E. Propson, Michelle L. Reyzer, Oliver B. Davis, Matthew C. Deen, Sha Zhu, Gilbert Di Paolo, David J. Vocadlo, Anthony A Estrada, Javier de Vicente, Joseph W. Lewcock, Annie Arguello, Jung H. Suh, Sarah Huntwork-Rodriguez, Anastasia G. Henry

“…LRRK2 inhibition normalizes lysosomal function and reduces GSL levels in preclinical models and CSF from LRRK2-PD patients. …”
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U-Net-based VGG19 model for improved facial expression recognition by Xiaohu ZHAO, Jingyi ZHANG, Mingzhi JIAO, Lixun XIE, Lanfei WANG, Weiqing SUN, Di ZHANG

“…The innovation of the SEAttention module lies in replacing the original activation function with the Mish activation function, which can dynamically adjust the weights of different channels to enhance performance. …”
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Neutrophils Display Novel Partners of Cytosolic Proliferating Cell Nuclear Antigen Involved in Interferon Response in COVID-19 Patients by Lucie Pesenti, Rodrigo de Oliveira Formiga, Nicola Tamassia, Elisa Gardiman, François Chable de La Héronnière, Sara Gasperini, Johana Chicher, Lauriane Kuhn, Philippe Hammann, Morgane Le Gall, Giovanni Saraceni-Tasso, Clémence Martin, Anne Hosmalin, Magali Breckler, Roxane Hervé, Patrice Decker, Maha Zohra Ladjemi, Frédéric Pène, Pierre-Régis Burgel, Marco A. Cassatella, Véronique Witko-Sarsat

“…The cytosolic proliferating cell nuclear antigen (PCNA) is a scaffolding protein highly dependent on the microenvironment status and known to interact with numerous proteins that regulate neutrophil functions. This study aimed to examine the cytosolic protein content and PCNA interactome in neutrophils from COVID-19 patients. …”
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The role of PASS and STITCH in the verification of unknown properties of pyruvate and lactate. Literature review and fragments of authors’ own research by N. A. Kolotyeva, F. N. Gilmiyarova, O. A. Gusyakova, E. A. Semashkova

“…The small molecules we studied have a coordinating role in the functioning and modulation of mediator, hormonal, receptor, immune, inflammatory, antibacterial, and antiviral responses and gene expression. …”
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Quantification of Phytochemicals in <em>Cephalotaxus harringtonia</em>: Insights into Plant Tissue-Specific Allocation by Chang-Dae Lee, Jajung Ku, Sullim Lee, Sanghyun Lee

“…While harringtonine and homoharringtonine are synthesized and maintained at elevated levels within buds to fulfill various physiological functions, including modulation of signal transduction pathways and reinforcement of defense mechanisms, the involvement of other constituents and the potential synergistic interactions among compounds cannot be overlooked in mediating the observed radical scavenging activity. …”
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Sleep-related hippocampo-cortical interplay during emotional memory recollection. by Virginie Sterpenich, Geneviève Albouy, Mélanie Boly, Gilles Vandewalle, Annabelle Darsaud, Evelyne Balteau, Thien Thanh Dang-Vu, Martin Desseilles, Arnaud D'Argembeau, Steffen Gais, Géraldine Rauchs, Manuel Schabus, Christian Degueldre, André Luxen, Fabienne Collette, Pierre Maquet

“…This effect is mediated in part by a modulation of the hippocampus by the amygdala. Sleep plays a role in the consolidation of declarative memory. …”
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IMMUNOMODULATORY ACTIVITY OF THE LACTOBACILLUS DELBRUECKII SUBSP. BULGARICUS LB 86 ENZYME LYSATE by L. Lаzarenko, L. Orіabinska, T. Bohdan

“…The aim of the study was to immunomodulatory activity of the enzyme lysate of probiotic culture Lactobacillus delbrueckii subsp. bulgaricus LB86 for the development of a functionally active substance based on it with a deliberate action forapplication in cosmetology and medicine. …”
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A peptide mimetic targeting trans-homophilic NCAM binding sites promotes spatial learning and neural plasticity in the hippocampus. by Igor Kraev, Christian Henneberger, Clara Rossetti, Lisa Conboy, Lene B Kohler, Martina Fantin, Alistair Jennings, Cesar Venero, Victor Popov, Dmitri Rusakov, Michael G Stewart, Elisabeth Bock, Vladimir Berezin, Carmen Sandi

“…Altogether, these findings provide compelling evidence that plannexin is an important facilitator of synaptic functional, structural and molecular plasticity in the hippocampal CA1 region, highlighting the fragment in NCAM's Ig3 module where plannexin binds as a novel target for the development of cognition-enhancing drugs.…”
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Lumpy skin disease virus 001/156 protein is a virulence factor that suppresses interferon production through impairing IRF3 dimerization. by Minmin Zhang, Yujie Shi, Xinyin Lu, Qiwei Zhang, Yubo Zhao, Shaohan Li, Zhiyuan Wen, Jinying Ge, Xijun Wang, Jie Li, Zhigao Bu, Xin Yin

“…However, only a limited number of these proteins have been characterized, with the functions of many-particularly those encoded within the inverted terminal repeat (ITR) regions-remaining largely unknown. …”
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Peptide-modified mesoporous silica nanoparticles for the coordinated regulation of macrophage polarization and pyroptosis in the treatment of implant-related infections by Zhi Li, Yuhang Wang, Xingshi Yuan, Mingyou Xu, Xiaofang Wang, Chang Liu, Chen Zhu, Wei Pei, Jiaxiang Bai, Xifu Shang

“…This excessive pyroptosis impairs the collective immune function of macrophages, enabling pathogens to evade immune system clearance and rendering infection difficult to eradicate. …”
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The Role of Empathy in ADHD Children: Neuropsychological Assessment and Possible Rehabilitation Suggestions—A Narrative Review by Antony Casula, Giulia Belluardo, Carmine Antenucci, Federica Bianca, Francesco Corallo, Francesca Ferraioli, Domenica Gargano, Salvatore Giuffrè, Alice Lia Carmen Giunta, Antonella La Torre, Simona Massimino, Alessio Mirabile, Giuliana Parisi, Cono Daniele Pizzuto, Maria Cristina Spartà, Alessia Tartaglia, Francesco Tomaiuolo, Laura Culicetto

“…Various assessment tools revealed difficulties in understanding beliefs, emotions, and intentions, with executive function deficits playing a crucial role in shaping these social challenges. …”
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Uncovering the molecular mechanisms of Qingdu Zengye Decoction in the treatment of nasopharyngeal carcinoma: an integrative investigation by Qi Quan, Qi Quan, Zeyu Liu, Zeyu Liu, Ran Ding, Yongmiao Lin, Sihe Zhang, Wei Luo, Mengjie Lei, Teng Fan, Teng Fan, Xin Su, Xin Su, Yuanyuan Huang, Yuanyuan Huang, Roujun Peng, Bei Zhang, Bei Zhang

“…Network pharmacology and protein-protein interaction (PPI) analysis was used to identify potential QZD targets. Functional assays (cell proliferation, apoptosis, colony formation) and Western blotting were used to validate key pathways. …”
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Cell migration in dense microenvironments by de Freitas Nader, Guilherme Pedreira, García-Arcos, Juan Manuel

“…The crosstalk between extracellular mechanical inputs and the cell nucleus is a critical component in the modulation of cell function of cells that navigate within packed microenvironments. …”
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Probing the microRNA landscape in cadmium chloride induced renal toxicity through an in silico approach by Arnab Mukherjee, Sai Eashan Vankamamidi, Mukunthan KS

“…In this study, microarray data from HK-2 cells exposed to CdCl₂ was analyzed, revealing increased oxidative stress and disrupted mitochondrial function. The prolonged cadmium exposure disrupted gene expression and induced persistent toxicity. …”
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Exploring the Impact of Olive-Derived Bioactive Components on Gut Microbiota: Implications for Digestive Health by Manuel Garrido-Romero, Marina Díez-Municio, Francisco Javier Moreno

“…Recent advances highlight the crucial role of the gut microbiota in human health and disease, with dietary components emerging as powerful modulators of microbial communities. This review synthesizes current evidence on the effects of olive-derived bioactive compounds, including polyphenols (e.g., hydroxytyrosol, oleuropein or tyrosol), triterpenes and other phytochemicals on gut microbiota composition and function. …”
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Online Fault-Tolerant Onboard Aeroengine Model Tuning Structure by Shuiting Ding, Ye Yuan, Naiyu Xue, Xiaofeng Liu

“…A fault-tolerant OBEM tuning structure is provided to perform the online tuning function when health degradation and sensor fault coexist. …”
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