The Long-Delayed Response of a Cyclonic Ocean Eddy to the Passage of Typhoons Hinnamnor and Muifa by Jiaqi Wang, Yineng Rong

“…In this study, we use a functional analysis apparatus, namely the multiscale window transform (MWT) and the MWT-based theory of canonical transfer and multiscale energetics analysis, to investigate the dynamics underlying this phenomenon. …”
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The gene signature linked to lactate metabolism predicts the prognosis and correlates with the immune status of head and neck squamous cell carcinoma by Jian Xiao, Wei Li, Guolin Tan, Ru Gao

“…Additionally, eight critical hub genes were identified, revealing significant differences in gene expression between risk score groups. Functional analyses demonstrated that the low-risk group exhibited a more favorable prognosis and enhanced immune characteristics. …”
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Bioinformatic analysis of glycolysis and lactate metabolism genes in head and neck squamous cell carcinoma by Huanyu Jiang, Lijuan Zhou, Haidong Zhang, Zhenkun Yu

“…Analysis of data from the Cancer Genome Atlas and Gene Expression Omnibus identified 16 GALMRGs that were differentially expressed in HNSCC compared to normal tissues. Functional analysis revealed the involvement of lactate and pyruvate metabolism and HIF-1 signaling pathways. …”
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Using genetics, genomics, and transcriptomics to identify therapeutic targets in juvenile idiopathic arthritis by Evan Tarbell, James N. Jarvis

“…More than half of adults who have had JIA continue to have active disease and have developed functional limitations. Medication side effects are common and intrusive. …”
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FEATURES OF IRON METABOLISM IN PATIENTS WITH ANEMIC SYNDROME WITH RHEUMATOID ARTHRITIS by Галина Северьевна Суржикова, Сатеник Аршавиловна Клочкова-Абельянц

“…Anemia in RA occurs as a result of functional iron deficiency, as opposed to true iron deficiency in iron deficiency anemia.…”
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Local translation in primary afferent fibers regulates nociception. by Lydia Jiménez-Díaz, Sandrine M Géranton, Gayle M Passmore, J Lianne Leith, Amy S Fisher, Laura Berliocchi, Anantha K Sivasubramaniam, Anne Sheasby, Bridget M Lumb, Stephen P Hunt

“…There is also increased evidence to suggest that intact adult mammalian axons have a functional requirement for local protein synthesis in vivo. …”
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Psychoneuroimmunoendocrinological and neuroanatomical basis of suicidal behavior: potential therapeutic strategies with a focus on transcranial magnetic stimulation (TMS) by Hesed Virto-Farfan, Gustavo E. Tafet

“…Dysfunctions in these circuits contribute to heightened impulsivity, impaired decision-making, and emotional dysregulation in individuals with suicidal behavior. Structural and functional abnormalities in the DLPFC, coupled with altered neurotransmitter systems and inflammatory markers, have been consistently linked to suicidality. …”
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CTSS in the tumor microenvironment links immune escape and immunotherapy sensitivity in kidney renal clear cell carcinoma by Hanjing Zhou, Jun Ying, Xuchun Xu, Jian Huang

“…Employing advanced machine learning (ML) algorithms, we identified Cathepsin S (CTSS) as the most pivotal tumor suppressor, with elevated CTSS expression consistently predicting improved survival across multiple independent cohorts. Functional analyses revealed significant enrichment of CTSS in immune-regulatory pathways, including B/T cell activation and inflammatory activity. …”
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Genome-wide profiling of GRAS genes in flax (Linum usitatissimum L.) reveals LuGRAS30 as a key regulator of drought stress resistance by Yihang Bao, Chulin Pan

“…GRAS genes are indispensable for modulating plant growth, developmental patterning, and adaptive responses to biotic and abiotic stress conditions. …”
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CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson's disease. by Simon R W Stott, Shaista Hayat, Tom Carnwath, Shaady Garas, Jonathan P Sleeman, Roger A Barker

“…To determine if CD24 may have a functional role in PD, we modelled the dopamine cell loss of PD in Cd24 mutant mice using striatal delivery of the neurotoxin 6-OHDA. …”
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The RFTS domain of Raf2 is required for Cul4 interaction and heterochromatin integrity in fission yeast. by Sharon A White, Alessia Buscaino, Luis Sanchez-Pulido, Chris P Ponting, Matthew W Nowicki, Robin C Allshire

“…Loss of or defects in CLRC components disrupts heterochromatin formation due to loss of H3K9 methylation, thus an intact, fully functional CLRC complex is required for heterochromatin integrity. …”
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Endocannabinoid System and Synaptic Plasticity: Implications for Emotional Responses by María-Paz Viveros, Eva-María Marco, Ricardo Llorente, Meritxell López-Gallardo

“…In this paper, we will focus on the functional relevance of endocannabinoid-mediated plasticity within the framework of emotional responses. …”
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Hidden players in the regulation of secondary metabolism in tea plant: focus on non-coding RNAs by Chengzhe Zhou, Caiyun Tian, Chen Zhu, Zhongxiong Lai, Yuling Lin, Yuqiong Guo

“…Non-coding RNAs (ncRNAs) are functional transcripts with minimal or no protein-coding capacity that comprise a large portion of the plant transcriptome. …”
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Targeted and Biomimetic Nanoparticles for Atherosclerosis Therapy: A Review of Emerging Strategies by Dorota Bartusik-Aebisher, Rafał Podgórski, Iga Serafin, David Aebisher

“…This approach leverages the natural biological functions of the source cells to achieve enhanced immune evasion, prolonged circulation, and precise targeting of atherosclerotic lesions. …”
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Acute Phase Neuronal Activity for the Prognosis of Stroke Recovery by Filippo Zappasodi, Patrizio Pasqualetti, Paolo M. Rossini, Franca Tecchio

“…Strokes causing similar lesions and clinical states can be followed by diverse regains of neurological functions, indicating that the clinical recovery can depend on individual modulating factors. …”
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The role of fructose-1,6-bisphosphatase 1 on regulating the cancer progression and drug resistance by Mengmeng Wang, Xiaoju Huang, Dan Zhang, Yisan Liu, Pian Liu

“…Because of its multifaceted functions, the mechanisms by which FBP1 is involved in tumor development are complex. …”
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Epithelial Cell-Neutrophil Interactions in the Alimentary Tract: A Complex Dialog in Mucosal Surveillance and Inflammation by Sean P. Colgan, Katrina M. Comerford, Donald W. Lawrence

“…The physiologic consequences of such interactions often determine endpoint organ function, and for this reason, much recent interest has developed in identifying mechanisms and novel targets for the treatment of mucosal inflammation. …”
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Belimumab in the treatment of systemic lupus erythematosus: 20 years of basic research, 10 years of clinical practice by E. L. Nasonov, T. V. Popkova, A. M. Lila

“…Currently, strong evidence has been obtained for the fundamental role of pathological activation of B cells in the pathogenesis of immunoinflammatory (autoimmune) rheumatic diseases (IMRD), and drugs that specifically modulate the function or cause depletion of various subpopulations of B cells and plasma cells are considered a promising direction. pharmacotherapy of these diseases. of particular interest is belimumab (BLM), a human monoclonal antibody (mAb) (IgG1λ) to BAFF (B cell-activating factor belonging to the TNF family), which is the first “targeted” biological drug specially developed for the treatment of systemic lupus erythematosus (SLE). …”
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Network Pharmacology and Molecular Docking Analysis of Chrysoeriol for Alzheimer’s Disease by D Hariharasudhan, M Sharmila, M Srihari, Prabhu Puniethaa, Balakrishnan Rengesh, Sabapathi S. Nadana

“…Among the 35 overlapping targets, the Hub genes are highly enriched in the Biological Process, Cellular Component and Molecular Function were analyzed. Further the Molecular Docking analysis revealed that PTGS2, MMP2 and KDR have good binding affinity. …”
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Cancers of the oesophagus and stomach: Additional insight from the oral cavity: Mini review by Kulić Milan, Ilić Bojana, Marinković Jelena

“…Periodontitis and the resulting systemic inflammation are associated with numerous systemic diseases such as cardiovascular disease, diabetes, chronic kidney disease, rheumatoid, arthritis, respiratory diseases, impairment of cognitive function. The exact mechanism of the association between periodontitis and UGI cancers is not known, but may include direct bacterial ingestion, chronic inflammation, and immune modulation. …”
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