Adrenergic β2 receptor activation stimulates anti-inflammatory properties of dendritic cells in vitro. by Laurens E Nijhuis, Brenda J Olivier, Shobit Dhawan, Francisca W Hilbers, Louis Boon, Monika C Wolkers, Janneke N Samsom, Wouter J de Jonge

“…Hence, adrenergic receptor β2 activation modulates DC function resulting in skewing towards anti-inflammatory T cell phenotypes.…”
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Increasing subsequences, matrix loci and Viennot shadows by Brendon Rhoades

“…As a corollary, the Hilbert series of ${\mathbb {F}}[{\mathbf {x}}_{n \times n}]/I_n$ is the generating function of permutations in ${\mathfrak {S}}_n$ by the length of their longest increasing subsequence. …”
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SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice. by Raffaella Tulino, Agnesska C Benjamin, Nelly Jolinon, Donna L Smith, Eduardo N Chini, Alisia Carnemolla, Gillian P Bates

“…This SIRT1 impairment could not be rescued by the ablation of DBC1, a negative regulator of SIRT1, but was linked to changes in the sub-cellular distribution of AMPK-α1, a positive regulator of SIRT1 function. This work provides insights into the regulation of SIRT1 activity with the potential for the development of novel therapeutic strategies.…”
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Clinical Significance of the 5T;12TG Genotype in Pediatric CFSPID: A Retrospective Study by Ana Morales-Tirado, Enrique Blitz-Castro, Saioa Vicente-Santamaría, Carmen Luna-Paredes, Enrique Salcedo-Lobato, Ana Tabares-González, Celia Gascón-Galindo, Simon Boutry, Adelaida Lamas-Ferreiro

“…Data collected included trends in sweat chloride (SC) values, respiratory and digestive symptoms, lung function by spirometry, microbiological findings in nasopharyngeal aspirates, anthropometric data, and fecal elastase levels. …”
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Development and Application of an Integrated Monitoring and Early Warning Platform for Land Transportation Infrastructure under Special Engineering Conditions by Liujun Zhang, Youqiang Qiu, Hui Yu, Lihua Yin, Faru Zhang, Tong Wu

“…To ensure the safety service performance of land transportation infrastructure under special engineering conditions, centering on the characteristics of structures such as the road high-steep slope, high embankment, special subgrade, railway track, and airport pavement, an integrated monitoring and early warning platform based on health monitoring and safety evaluation was built through the combined design of the safety indicator module, monitoring data module, information processing module, numerical simulation module, inversion prediction analysis module, and safety early warning module. …”
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The modulatory effect of oolong tea polyphenols on intestinal flora and hypothalamus gene expression in a circadian rhythm disturbance mouse model by Ruonan Yan, Chi-Tang Ho, Yanan Liu, Shengnan Zhan, Zufang Wu, Xin Zhang

“…Our results confirmed that OTP can actively improve the intestinal environmental state as well as internal/peripheral circadian rhythm disorders and cognitive impairment, with potential prebiotic functional characteristics to notably contribute to host health.…”
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The effect of ionic radius carbon dot on Ti4+ in lattice parameters of Ba0.2Sr0.8TiO3 thin films by Ripai Ahmad, Setiawan Aep, Laksanawati W.D., Kamaruddin Amrullah, Darmawan Noviyan, Iskandar Johan, Irzaman

“…These results indicate that carbon dot incorporation modulates the structural properties of Ba₀.₂Sr₀.₈TiO₃ films, which could have significant implications for their functional applications.…”
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Cancer-associated fibroblasts in hepatocellular carcinoma: origins, heterogeneity, and therapeutic implications by Xin Shi, Weixiong Zhu, Jianpeng Zhang, Chuanlei Fan, Jing Zhang

“…This review offers a detailed overview of the cellular origins, subtype diversity, and functional differences among CAFs. In addition, it depicts the expression profiles of key markers in various CAF subtypes and clarifies essential signaling pathways and mechanisms of CAFs. …”
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Lipid Antigens: Revealing the Hidden Players in Adaptive Immune Responses by Tamana Eskandari, Yasamin Eivazzadeh, Fatemeh Khaleghinia, Fatemeh Kashi, Valentyn Oksenych, Dariush Haghmorad

“…Recent advances in mass spectrometry, imaging techniques, and lipidomics have revolutionized the identification and characterization of lipid antigens and enhanced our understanding of their structural diversity and functional significance. These advancements have paved the way for lipid-based vaccines and immunotherapies through the application of nanoparticles and synthetic lipid antigens designed to boost immune responses against cancers and infectious diseases. …”
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Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay by Yevgen Levdansky, Justin C. Deme, David J. Turner, Claire T. Piczak, Filip Pekovic, Anna L. Valkov, Sergey G. Tarasov, Susan M. Lea, Eugene Valkov

“…Additionally, PieF prevents NOT7/8 from associating with their partner deadenylases NOT6/6L, inhibiting the assembly of a functional deadenylase complex. Consequently, PieF robustly blocks mRNA poly(A) tail shortening and degradation with striking potency and selectivity for NOT7/8. …”
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Yin Yang 1 and guanine quadruplexes protect dopaminergic neurons from cellular stress via transmissive dormancy by Kielen R. Zuurbier, Rene Solano Fonseca, Sonja L. B. Arneaud, Jordan M. Wall, Juhee Kim, Lexus Tatge, Gupse Otuzoglu, Sofia Bali, Patrick Metang, Peter M. Douglas

“…When these adaptive pathways are overwhelmed, functional impairment or neurodegeneration follows. …”
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Tunable methacrylated decellularized heart matrix: a versatile scaffold for cardiac tissue engineering by Valinteshley Pierre, Douglas H. Wu, Douglas H. Wu, Chao Liu, Elif Ertugral, Chandrasekhar Kothapalli, Samuel E. Senyo

“…To address this limitation, we functionalized DHM with methacryloyl functional groups (DHMMA) that support UV-induced crosslinking to enhance mechanical properties. …”
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Direct Vector Control With Fuzzy Current Controller for Three-phase Induction Motor by Jos´e L. Azcue-Puma, Alfeu J. Sguarezi Filho, Ernesto Ruppert

“…The rule base for the proposed controller is defined as a function of the stator current error components, and FLCC utilizes trapezoidal and triangular membership functions for the fuzzification of its inputs. …”
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Mechanism of Protective Effect of Mongolia Medicine Nagab-9 on LPS-Induced Acute Lung Injury Based on an Integrated Network Pharmacology and Experimental Verification by Shi Liu, Jiuwang Yu, Zeyu Chen, Lidao Bao

“…ALI-related targets were collected from relevant disease databases, and an intersection of these targets was used to construct a protein-protein interaction (PPI) network to identify core targets. Functional analysis through Gene Ontology (GO) and KEGG pathway enrichment was performed. …”
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U87 Glioblastoma Cell-Derived Extracellular Vesicle Mediated Dysregulation of Angiogenic Mediators in Endothelial Cells: An In Silico and In Vitro Analysis by Swagatama Mukherjee, Prakash P. Pillai

“…Results: We observed that GBM-derived EVs can be key collaborators of promoting angiogenesis by upregulating key pro-angiogenic genes (VEGFA, NRP1, MMP9) and EV biogenesis markers (CD9, CD81, TSG101), facilitating endothelial cell migration and vascular remodelling. Functional assays further confirmed that EVs act as vectors for pro-angiogenic signals, while their inhibition with GW4869 significantly reduced angiogenic activity, highlighting their role in tumour vascularization. …”
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The identification of trans-acting factors that regulate the expression of GDF5 via the osteoarthritis susceptibility SNP rs143383. by Catherine M Syddall, Louise N Reynard, David A Young, John Loughlin

“…Binding was then confirmed in vivo by chromatin immunoprecipitation (ChIP), and the functional effects of candidate proteins investigated by RNA interference (RNAi) and over expression. …”
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Down-regulation of miR-101 in endothelial cells promotes blood vessel formation through reduced repression of EZH2. by Michiel Smits, Shahryar E Mir, R Jonas A Nilsson, Petra M van der Stoop, Johanna M Niers, Victor E Marquez, Jacqueline Cloos, Xandra O Breakefield, Anna M Krichevsky, David P Noske, Bakhos A Tannous, Thomas Würdinger

“…Furthermore, epigenetic changes caused by histone-modifying enzymes were shown to modulate angiogenesis as well. However, a possible interplay between miRNAs and histone-modulating enzymes during angiogenesis has not been described. …”
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DESIGN AND DEVELOPMENT OF THE EKSPERTO APP: AN ON-DEMAND SERVICE PROVIDING APPLICATION by Billy S. Javier, Julieta B. Babas, Leo P. Paliunan, James Karl A. Agpalza

“…The EKSPERTO App features a functional dashboard for service-requesting parties, hiring employers, service providers, and government’s arm for job facilitation. …”
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A major trade-off between growth and defense in Arabidopsis thaliana can vanish in field conditions. by Derek S Lundberg, Sonja Kersten, Ezgi Mehmetoğlu Boz, Pratchaya Pramoj Na Ayutthaya, Wangsheng Zhu, Karin Poersch, Wei Yuan, Sophia Swartz, David Müller, Ilja Bezrukov, HARVEST TEAM, Detlef Weigel

“…Wild Arabidopsis thaliana populations maintain significant functional variation at the ACD6 locus, with some alleles making the protein hyperactive. …”
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Network analyses unraveled the complex interactions in the rumen microbiota associated with methane emission in dairy cattle by Xiaoxing Ye, Goutam Sahana, Mogens Sandø Lund, Bingjie Li, Zexi Cai

“…Key findings revealed that the blue module from network analysis was significantly correlated (0.45) with methane emissions. …”
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