Cross‐Cohort Gut Microbiome Signatures of Irritable Bowel Syndrome Presentation and Treatment by Junhui Li, Tarini Shankar Ghosh, Elke Arendt, Fergus Shanahan, Paul W. O'Toole

“…The consistent bacterial species and functional signatures associated with IBS were identified. …”
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Loss of LAPTM4A inhibits M2 polarization of tumor-associated macrophages in glioblastoma, promoting immune activation and enhancing anti-PD1 therapy by Jin Geng, Bing Liang, Zonghao Zhang, Fengping Shan, Xinxin Zhao, Ye Yuan

“…This study investigates the effects of Lysosomal-associated protein transmembrane 4 A (LAPTM4A) deficiency on the polarization of TAMs and its role in modulating anti-tumor immunity. Using C57BL/6 male mice, we established an orthotopic glioma model and employed single-cell RNA sequencing, flow cytometry, in vitro co-culture systems, and in vivo anti-PD-1 therapy experiments to explore the functional role of LAPTM4A. …”
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Analysis of human protein replacement stable cell lines established using snoMEN-PR vector. by Motoharu Ono, Kayo Yamada, Akinori Endo, Fabio Avolio, Angus I Lamond

“…The study of the function of many human proteins is often hampered by technical limitations, such as cytotoxicity and phenotypes that result from overexpression of the protein of interest together with the endogenous version. …”
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Biologic and synthetic skin substitutes: An overview by Halim Ahmad, Khoo Teng, Shah Jumaat

“…The current trend of burn wound care has shifted to more holistic approach of improvement in the long-term form and function of the healed burn wounds and quality of life. …”
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Insulator detection based on SE-YOLOv5s by Qing TIAN, Rong HU, Zuoyong LI, Yuanzheng CAI, Zhaochai YU

“…In a large environment where the power system needs to be inspected, the traditional method of manual inspection has great inconvenience and potential safety risks, and the object detection method of unmanned aerial vehicle has great application prospects in the direction of insulator detection and recognition.SE-YOLOv5s, a lightweight insulator detection network that performs efficient detection for this task was presented.Firstly, backbone of YOLOv5s by fusing the SE attention module was strengthen.Then, the position distribution of insulator object was investigated and predefined templates of a priori box by K-means clustering on prior coordinate vectors were generated.Finally, the network by a multitask loss function was trained combined with confidence and position regression task.Furthermore, Mosaic data augmentation was utilized to supplement additional training samples.Experimental results demonstrate that the proposed SE-YOLOv5s significantly outperforms baseline methods at multiple criterions including accuracy, recall rate, detection rate and mean average precision.In comparison with the baselines, the proposed network has a flexible trade-off between robustness and memory overhead and it is a potential approach to promote the power system development.…”
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Microbial Sensing by the Intestinal Epithelium in the Pathogenesis of Inflammatory Bowel Disease by Michael Scharl, Gerhard Rogler

“…But not only pathways of microbial detection but also intracellular ways of bacterial processing such as autophagosome function are associated with the risk to develop Crohn's disease. …”
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Disulfidptosis as a key regulator of glioblastoma progression and immune cell impairment by Yifu Shu, Jing Li

“…BackgroundGlioblastoma, associated with poor prognosis and impaired immune function, shows potential interactions between newly identified disulfidptosis mechanisms and T cell exhaustion, yet these remain understudied.MethodsKey genes were identified using Lasso regression, followed by multivariate analysis to develop a prognostic model. …”
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CAT TEST IN THOSE SUFFERING FROM CHRONIC OBSTRUCTIVE PULMONARY DISEASE by E. V. Kochetova

“…The studied group included COPD patients with the long history of smoking. The respiratory function was evaluated by the multi-module unit of MasterLab/Jaeger type. …”
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RNA helicases, DDX5 and DDX17, facilitate lytic reactivation of gammaherpesviruses. by Praneet Kaur Sandhu, Blossom Damania

“…Here we demonstrate how gammaherpesviruses hijack the function of two host proteins to promote their lytic replication cycle.…”
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THE APPRAISAL OF ELECTROBIOLOGICAL ACTIVITY OF THE GASTROINTESTINAL TRACT AMONG CHILDREN AND THE SELECTION OF THE DRUG THERAPY by A.P. Ponomareva, S.V. Bel'mer, L.M. Karpina

“…The method of the peripheral electrogastroenteromyography has been used for appraisal of the motor function among 85 children (44 girls, 41 boys) aged between 6 and 15 years old with chronic gastroduodenitis at the stage of recrudescence (I group — 45 children), chronic gastroduodenitis without recrudescence (II group — 20 children), peptic ulcer disease at the stage of recrudescence (III group — 10 children) and chronic duodenal obstruction related in most cases to arteriomesen teric compression (iv group — 10 children). …”
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Metabolic reprogramming in polycystic kidney disease and other renal ciliopathies by Sara Clerici, Alessandra Boletta

“…Alterations in their function cause a plethora of human conditions collectively called the ciliopathies. …”
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Production of oxygen free radicals by Ehrlich ascites tumour cells: effect of lipids by Gopal K. Marathe, Cletus J. M. D'Souza

“…These results suggest that membrane lipids and dietary factors like vitamin A probably function as physiological modulators in regulating the free radical generation.…”
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MicroRNAs as regulators of drug abuse and immunity by Kai Zhang, Xuxiu Jing, Guoqiang Wang

“…We hypothesized that chronic drug abuse leads to aberrant expression of several miRNAs, and then aberrant miRNAs influence the innate and adaptive immunity, especially differentiation and function of T cells and B cells, through down-regulated miRNAs’ target gene expression. …”
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mTOR Deletion Alleviates CD4+ T-Cell Dysfunction in Sepsis through Reducing CTLA4 Accumulation Mediated by Rescuing Autophagy by Xianli Lei, Guoyu Zhao, Yawen Xie, Na Cui

“…Given such a regulatory relationship, targeting mTOR could provide new light to improve immune function in sepsis, and the prospect of using rapamycin in the clinic would be worth exploring further.…”
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Telocytes in inflammatory bowel diseases: contributions to pathology and therapeutic potentials by Ronaldo Paolo Panganiban, Christina McAninch, Marina Chulkina, Irina V. Pinchuk

“…These cells have been identified in various tissues, including the gastrointestinal (GI) tract, where they are suggested to play important roles in maintaining structural integrity, immune modulation, and barrier function. Inflammatory bowel diseases (IBD), which include Crohn’s disease (CD) and ulcerative colitis (UC), are characterized by chronic inflammation and fibrosis. …”
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ASSESSMENT OF COMORBIDITY IN THOSE SUFFERING FROM CHRONIC OBSTRUCTIVE PULMONARY D by E. V. Kochetova

“…SCORE risk charts were used for evaluation of cardiovascular risk. The respiratory function was evaluated by the multi-module unit of MasterLab/Jaeger type. …”
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Oxidative Stress and Heart Failure in Altered Thyroid States by Pallavi Mishra, Luna Samanta

“…It is well established that hyperthyroidism induces a hyperdynamic cardiovascular state, which is associated with a faster heart rate, enhanced left ventricular systolic and diastolic function whereas hypothyroidism is characterized by the opposite changes. …”
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A Locomotive Grading Servicing Scheme Based on LMD System by SHI Hanbo, DENG Guozhi, LUO Hao

“…Firstly,the software function module integrated in LMD system obtains the running mileage of the locomotive through the LMD system, and then judges the level of servicing operation required by the locomotive through the preset logic. …”
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Moringa Oleifera Treatment Prevents Crude Oil Tainted Diet Imposed Toxicity in Rats by Achuba F.I.* , Ubogu L.A. , Ekute B.O.

“…Significant (p<0.05) hepatic derangement occasioned by changes in liver function enzymes and protein profile were observed. …”
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The Significance of Internal Variability for Numerical Experimentation and Analysis by Hans von Storch, Lin Lin

“…The “memory” in the atmosphere and ocean describes the persistence of atmospheric and oceanic conditions, usually quantified by an autocorrelation function. At the system level, this “memory” term, as given by Hasselmann’s stochastic climate model, plays a key role. …”
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