Targeting gut microbiota in osteoporosis: impact of the microbial-based functional food ingredients by Pauline Duffuler, Khushwant S. Bhullar, Jianping Wu

“…Additional reports demonstrate that gut microbiota regulates bone metabolism through the modulation of the gut function (mineral availability and absorption, gut integrity), the immune system, and the endocrine system. …”
Get full text

Sperm Membrane Stability: In-Depth Analysis from Structural Basis to Functional Regulation by Shan-Hui Xue, Bing-Bing Xu, Xiao-Chun Yan, Jia-Xin Zhang, Rui Su

“…This comprehensive review examines the structural and functional mechanisms underlying sperm membrane integrity, including defensive barrier functions, potentiometric ion channel regulation, and motility modulation that collectively optimize sperm survival, motility, and fertilization potential. …”
Get full text

Advanced Modification Strategies of Plant-Sourced Dietary Fibers and Their Applications in Functional Foods by Yansheng Zhao, Ying Shao, Songtao Fan, Juan Bai, Lin Zhu, Ying Zhu, Xiang Xiao

“…In functional food applications, cereal-sourced dietary fibers serve as a versatile functional ingredient in engineered foods including 3D-printed gels and low-glycemic energy bars, addressing specific metabolic disorders and personalized dietary requirements. …”
Get full text

Protein <i>O</i>-Fucosyltransferases: Biological Functions and Molecular Mechanisms in Mammals by Huilin Hao, Benjamin M. Eberand, Mark Larance, Robert S. Haltiwanger

“…<i>O</i>-fucose glycans modulate the function of the proteins they modify and are closely associated with various diseases including cancer. …”
Get full text

Implementation of multi-UAV communication relay function based on mobile telecommunication technology by Wen-Chung Tsai, Nien-Ting Huang

“…The core innovation lies in the introduction of an internal link channel within the Layer-2 MAC, enabling integration of Base Station (BS) and User Equipment (UE) functionalities within a single UAV communication module. …”
Get full text

ABCA1 Deletion Does Not Affect Aqueous Humor Outflow Function in Mice by Bo Qin, Chunchun Hu, Youjia Zhang, Yuhong Chen, Yuan Lei

“…The function of ABCA1 in aqueous humor outflow still requires further research.…”
Get full text

Serum albumin nanoparticles: Ligand functionalization for enhanced targeted therapeutics in precision medicine by Sakshi Shahapurmath, Bhuvaneshwari R. Sharannavar, Rahul Koli

“…Functional moieties such as folic acid, peptides, aptamers, antibodies and their fragments, polymers, chitosan, hyaluronic acid, biotin, transferrin, cholesterol, surfactants, and apolipoproteins have been extensively explored for their role in modulating cellular uptake, drug release kinetics, and site-specific accumulation. …”
Get full text

Silicon Enhances Functional Mitochondrial Transfer to Improve Neurovascularization in Diabetic Bone Regeneration by Yu‐Xuan Ma, Chen Lei, Tao Ye, Qian‐Qian Wan, Kai‐Yan Wang, Yi‐Na Zhu, Ling Li, Xu‐Fang Liu, Long‐Zhang Niu, Franklin R. Tay, Zhao Mu, Kai Jiao, Li‐Na Niu

“…Silicon improves mitochondrial function and modulates mitochondrial fission dynamics in macrophages via the Drp1‐Mff signaling pathway. …”
Get full text

Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes by Oliver Soehnlein, Maik Drechsler, Yvonne Döring, Dirk Lievens, Helene Hartwig, Klaus Kemmerich, Almudena Ortega‐Gómez, Manuela Mandl, Santosh Vijayan, Delia Projahn, Christoph D. Garlichs, Rory R. Koenen, Mihail Hristov, Esther Lutgens, Alma Zernecke, Christian Weber

“…Studies correlating circulating and lesional classical monocytes in gene‐deficient Apoe−/− mice, adoptive transfer of gene‐deficient cells and pharmacological modulation during intravital microscopy of the carotid artery revealed a crucial function of CCR1 and CCR5 but not CCR2 or CX3CR1 in classical monocyte recruitment to atherosclerotic vessels. …”
Get full text

Ancient Grains as Functional Foods: Integrating Traditional Knowledge with Contemporary Nutritional Science by Jude Juventus Aweya, Drupat Sharma, Ravneet Kaur Bajwa, Bliss Earnest, Hajer Krache, Mohammed H. Moghadasian

“…Their health-promoting effects are underpinned by multiple interconnected mechanisms, including the reduction in oxidative stress, modulation of inflammatory pathways, regulation of glucose and lipid metabolism, support for mitochondrial function, and enhancement of gut microbiota composition. …”
Get full text

Metabolic control of ovarian function through the sympathetic nervous system: role of leptin by Camila Astudillo-Guerrero, Alfonso H. Paredes, Jorge Escobar, Daniela Fernandois, Rafael Barra, Gonzalo Cruz

“…Leptin may affect the density or activity of sympathetic nerves, thereby affecting reproductive function. We also speculate that other hormones such as insulin and GLP-1 may activate sympathetic nerves to the ovary. …”
Get full text

Enhancing regeneration and functionality of excitable tissues via integrating bioelectronics and bioengineered constructs by Zijie Meng, Bingsong Gu, Cong Yao, Jiaxin Li, Kun Yu, Yi Ding, Pei He, Nan Jiang, Dichen Li, Jiankang He

“…These interactions enable precise data acquisition and localized modulation of cell and tissue functionalities through intricately designed electronic components according to physiological needs. …”
Get full text

Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions by Ping Jin, Xirui Duan, Zhao Huang, Yuan Dong, Jianmei Zhu, Huiming Guo, Hui Tian, Cheng-Gang Zou, Ke Xie

“…Therefore, understanding the molecular mechanisms underlying nuclear receptor functions is essential for the development of novel therapeutic strategies. …”
Get full text

Fungal Melanin in Plant Pathogens: Complex Biosynthesis Pathways and Diverse Biological Functions by Hui Jia, Ning Liu, Lu Zhang, Pan Li, Yanan Meng, Wei Yuan, Haixiao Li, Dezeng Tantai, Qing Qu, Zhiyan Cao, Jingao Dong

“…The complex biosynthesis pathways and diverse biological functions of fungal melanin highlight its significant theoretical and practical importance for elucidating pathogenic mechanisms and formulating scientific control strategies.…”
Get full text

Increased PRP19 in Hepatocyte Impedes B Cell Function to Promote Hepatocarcinogenesis by Zhiyong Liu, Xiahui Lin, Danying Zhang, Dezhen Guo, Wenqing Tang, Xiangnan Yu, Feng Zhang, Si Zhang, Ruyi Xue, Xizhong Shen, Ling Dong

“…Overall, this study provides valuable insights into the clinical benefits of HCC immunotherapy by targeting PRP19 and modulating tumor‐infiltrating B cell immune function.…”
Get full text

Advances in Nanohybrid Hydrogels for Wound Healing: From Functional Mechanisms to Translational Prospects by Yunfei Mo, Tao Zhou, Weichang Li, Yuqing Niu, Chialin Sheu

“…To address these limitations, nanohybrid hydrogels, composite systems that integrate functional nanomaterials into hydrogel matrices, have emerged as intelligent platforms for advanced wound care. …”
Get full text

The Effect of Transobturator Tape Surgery on Female Sexual Functions: A Systematic Review by Engin Yildirim, Nuriye Buyukkayaci Duman, Umit Gorkem, Ozgur Kan

“…In total, 8 clinical studies employed female sexual function index whereas 8 clinical studies administered Prolapse/Urinary Incontinence Sexual Questionnaire -12. 4 of these studies tried to understand women’s sexual functions through questions determined by the researchers (N/A). 2 of the other studies used the Sexual Impact Questionnaire and a visual analogue scale, 1 study used Nine Questions on Sexual Functioning (NSF-9) and 1 study used International Consultation on Incontinence Questionnaire Vaginal Symptoms Module (ICIQ-VS). …”
Get full text

Transgenerational transmission of the Glossina pallidipes hytrosavirus depends on the presence of a functional symbiome. by Drion G Boucias, Henry M Kariithi, Kostas Bourtzis, Daniela I Schneider, Karen Kelley, Wolfgang J Miller, Andrew G Parker, Adly M M Abd-Alla

Get full text

Structural and Functional Analysis of the Human IQSEC2 S1474Qfs*133 Mutation by Yonat Israel, Aaron Lowenkamp, Michael Shokhen, Shai Netser, Shlomo Wagner, Joseph Zarowin, Shaun Orth, Veronika Borisov, Orit Lache, Nina S. Levy, Andrew P. Levy

“…IQSEC2 is a guanine nucleotide exchange factor that modulates synaptic transmission, the excitatory/inhibitor balance and memory consolidation. …”
Get full text

Review and Validation of Plant Gene Function Research Methods Bypassing Tissue Culture by Huanghuang Jiang, Suya Huang, Jiayi Wang, Deming Sun, Min Wang, Su Lin, Jinhua Liu, Kai Xu, Bei Liu, Haijie Ma

“…Here, we review the advances in plant genetic transformation research, performing analysis of three methods for plant gene function analysis that bypass tissue culture: <i>Agrobacterium rhizogenes</i>-mediated root genetic transformation, developmental regulators (DRs)-mediated genetic transformation, and virus-mediated genome editing. …”
Get full text