Wheat endosperm-specific transcription factor TaDOF6 enhances grain development by regulating TaSWEET13h expression and facilitating sugar and gibberellin transport by Run Ding, Tongtong Xiao, ShaSha Li, Jian Qiang, Heng Zhang, Hongmiao Chang, Yueming Yan, Xiaohui Li

“…Seed size is regulated by the coordinated growth of the seed coat, embryo, and endosperm, and is modulated by multiple factors. Plant hormones, sugars, and cell cycle-related processes play key roles in this regulation. …”
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THE CHEMISTRY OF NUTRACEUTICALS: DRIVING HEALTH INNOVATIONS AND SHAPING NEW PARADIGMS

“…The mentioned activities seem to be due to the whole food constituents, however in some cases it was possible to ascribe to specific compounds the salutogenic properties, as reported for beta-glucans or hydroxytyrosol. Also, functional foods may be part of salutogenic and preventive strategies. …”
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Computational analysis of the effect of a binding protein (RbpA) on the dynamics of Mycobacterium tuberculosis RNA polymerase assembly. by Sneha Bheemireddy, Ramanathan Sowdhamini, Narayanaswamy Srinivasan

“…The study elucidates the dynamic behavior within the complex, providing insights into the flexibility and functional dynamics of the RbpA-RNA polymerase interaction. …”
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UNVEILING MULTIPLE MEANINGS OF THE INDONESIAN POEM MENUMBANGKAN POHON BERINGIN AND ITS ENGLISH TRANSLATION by ZULPRIANTO

“…Employing a qualitative approach, both texts were examined through the lens of Systemic Functional Linguistics (SFL) developed by Halliday (1925-2018). …”
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Redox Imbalance in Cystic Fibrosis: The Multifaceted Role of Oxidative Stress by Ilaria Artusi, Michela Rubin, Giorgio Cozza

“…The diverse array of CFTR mutations, categorized into seven distinct classes based on their functional impact on the CFTR protein, presents a significant obstacle to effective therapeutic intervention. …”
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Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells. by Keith E Szulwach, Xuekun Li, Yujing Li, Chun-Xiao Song, Ji Woong Han, SangSung Kim, Sandeep Namburi, Karen Hermetz, Julie J Kim, M Katharine Rudd, Young-Sup Yoon, Bing Ren, Chuan He, Peng Jin

“…In addition, our results provide a detailed epigenomic map of 5-hmC from which to pursue future functional studies on the diverse regulatory roles associated with 5-hmC.…”
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Unveiling FOXO3's metabolic contribution to menopause and Alzheimer's disease by Christopher O'Mahony, Oscar Hidalgo-Lanussa, George E. Barreto

“…This review aims to open a discussion on FOXO3's contribution to the metabolic dysregulation seen in menopause and its impact on the progression of AD. Understanding the functional role of FOXO3 in menopause-associated metabolic changes could lead to targeted therapeutic strategies, offering novel insights for managing for this condition.…”
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A Novel Dopamine Receptor Signaling Unit in Brain: Heterooligomers of D1 And D2 Dopamine Receptors by Susan R. George, Brian F. O'Dowd

“…Thus, the D1-D2 heterooligomer directly links the action of dopamine to rapid calcium signaling and likely has important effects on dopamine-mediated synaptic plasticity and its functional correlates in brain.…”
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Development of 4D printed smart fresnel lenses: dynamic photochromic and UV-blocking capabilities via vat photopolymerization by Bilal Bukhari, Murad Ali, Rashid K. Abu Al-Rub, Haider Butt

“…These findings underscore the potential of 4D printing in developing smart optical devices tailored for applications that demand dynamic light modulation and UV filtering, highlighting a combination of innovative manufacturing techniques and functional optics.…”
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Integrated Analysis of microRNA Targets Reveals New Insights into Transcriptional–Post-Transcriptional Regulatory Cross-Talk by Simona Panni, Roberto Pizzolotto

“…It is becoming increasingly clear that microRNAs are key players in gene regulatory networks, modulating gene expression at post-transcriptional level. …”
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Targeting neuroplasticity: a viewpoint on a future research direction with Parkinson’s disease-related fatigue by Shijie Hao, Jianpeng Zou

“…Further studies have revealed that modulation of functional cortical excitability, induction of neuroplasticity changes, inhibition of oxidative stress, improvement of cardiorespiratory fitness, and enhancement of muscle strength may be potential mechanisms of action of non-pharmacological therapies. …”
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CHAC1 in urological tumors: contextual dualism and therapeutic implications by Deyu Wang, Yongquan Wan, Yunxiang Li, Yuan Ren, Jiakai Ma, Si Ge, Ziqiang Zeng, Zuoping Wang, Lei Zhen

“…CHAC1, a glutathione-degrading enzyme, governs context-dependent pathophysiological processes in urological malignancies through modulation of endoplasmic reticulum stress and ferroptotic pathways. …”
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Network analyses–based identification of circular ribonucleic acid–related pathways in intrahepatic cholangiocarcinoma by Anuradha Moirangthem, Xue Wang, Irene K Yan, Tushar Patel

“…Although they can be readily detected, their regulation and functional role in human diseases such as cancer are unknown. …”
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Progress in structure-based drug development targeting chemokine receptors by Jin Wang, Chen Qu, Peng Xiao, Sijin Liu, Jin-Peng Sun, Yu-Qi Ping

“…By specifically recognizing chemokine ligands, CCRs orchestrate immune cell trafficking and tissue positioning, with functional dysregulation implicated in infectious diseases, autoimmune disorders, neurodegenerative pathologies, and cancer. …”
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TLR4 Asp299Gly SNP (rs4986790) Protects from Periodontal Inflammatory Destruction by Altering TLR4 Susceptibility to LPS Stimulation by Franco Cavalla, Claudia C. Biguetti, Ariadne Letra, Renato M. Silva, Alexandre R. Vieira, Franz J. Strauss, Gustavo P. Garlet

“…A total of 1410 individuals from four populations were genotyped, with findings indicating a significant protective effect of the polymorphic allele. Functional assays demonstrated enhanced IL-8 secretion and increased sensitivity to CD14 inhibition in cells expressing the variant receptor. …”
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Induction and amplification of circular dichroism by coupling chiral molecules to achiral plasmonic nanostructured gold films by Xiao-Kang Zhong, Kai-Xiang Liang, Zhen-Long Dou, Qu-Quan Wang, Li Zhou

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Coniferaldehyde reverses 3-nitropropionic acid-induced Huntington’s disease pathologies via PKM2 restoration and JAK2/STAT3 inhibition by Ayooluwa Gabriel Ibiayo, Peeraporn Varinthra, Mukundan Nagarajan, Ingrid Y Liu

“…Molecular docking studies revealed a strong binding affinity between CFA and STAT3, and western blot analysis showed reduced phosphorylation of STAT3, indicating modulation of the JAK2/STAT3 signaling pathway. Conclusion These findings demonstrate that CFA modulates oxidative, PKM2-mediated metabolic, and inflammatory pathways through the JAK2/STAT3 axis, enhancing motor function and neuronal survival in a 3-NP model of HD. …”
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Field-programmable robotic folding sheet by Hyunkyu Park, Yongrok Jeong, Woojong Kim, Jungrak Choi, Junseong Ahn, Jun-Ho Jeong, Inkyu Park, Jung Kim

“…An interconnected set of metallic resistors, incorporated into the thermo-responsive polymer film, performs the dual functionalities of a heater and thermoreceptor, selectively recruited to configure folds through electronic modulation of its electrical power distribution. …”
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Case Report: Extracorporeal photopheresis for BK virus nephropathy as a novel treatment for high-risk rejection kidney transplant recipient by Marilena Gregorini, Marilena Gregorini, Claudia Del Fante, Tefik Islami, Maria Antonietta Grignano, Nicoletta Serpieri, Cesare Perotti, Gianluca Viarengo, Alessia Locurcio, Giuseppe Lanotte, Alessandro Tragni, Emma Diletta Stea, Chiara Martinelli, Alessandro Marchi, Valentina Portalupi, Andreana De Mauri, Elisabetta Margiotta, Eleonora Francesca Pattonieri, Grazia Soccio, Teresa Rampino, Teresa Rampino

“…Over the next two years, the patient showed stable renal function (eGFR 30–40 mL/min), no recurrence of BKV viremia, and a gradual reduction in DSAs titers. …”
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RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway by Luo Rongjin, Liang Huaizhen, Zhang Weifeng, Li Gaocai, Zhao Kangcheng, Hua Wenbin, Song Yu, Yang Cao

“…In the present study, we demonstrated that RETREG1-mediated ER-phagy is induced by glucose deprivation (GD) treatment, along with ER stress activation and cell function decline. Importantly, ER-phagy was shown to be crucial for cell survival under GD conditions. …”
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