Identification of mitophagy-related genes with diagnostic value in acute rejection following kidney transplantation using bioinformatics analysis by Jianan Ma, Dawei Wu, Xinyuan An, Yongrui Zhang, Haijian Wei

“…Functional enrichment analysis uncovered several biological processes and signaling pathways associated with these genes. …”
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Alzheimer’s Disease Pathogenic Mechanisms: Linking Redox Homeostasis and Mitochondria-Associated Metabolic Pathways Through Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) by Agueda Rostagno, Jorge Ghiso

“…This review summarizes mitochondrial functional changes associated with AD with emphasis in the dysregulation of redox homeostasis and the role of nuclear factor erythroid 2-related factor 2 (Nrf2), not only as a central regulator of the antioxidant response but also as a more recently described modulator of cellular metabolic pathways. …”
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Topological Features in Profiling the Antimalarial Activity Landscape of Anilinoquinolines: A Multipronged QSAR Study by Shreekant Deshpande, Mohammad Goodarzi, Seturam B. Katti, Yenamandra S. Prabhakar

“…The antimalarial activity of a series of 4-anilinoquinolines was modeled with topological and other functional descriptors using feature selection approaches CP-MLR and GA. …”
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Mechanistic insights of the anti-ageing dietary plant secondary metabolites vis-à-vis the modern hallmarks of ageing: Implications for developing novel anti-ageing foods by Rohit Sharma, Anamika Sharma

“…In addition, PSM and gut dysbiosis are of particular interest due to their mutual bidirectional interactions and amalgamation that could be useful in developing novel anti-ageing functional foods. Future research on the development of PSM-based anti-ageing therapies is recommended to focus on the integrative assessment of the modern hallmarks of ageing for a more holistic approach.…”
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Chen’s peiyuan tang and premature ovarian failure: unveiling the mechanisms through network pharmacology by Xiao Yang, Yi-Ming Mao, Chong Yao, Chong Yao, Ding-ming Song, Yi-bo He, Wei Shen

“…BackgroundChen’s Peiyuan Tang (CSPYT) is a compound herbal formula that has shown the potential to enhance ovarian function and reduce autophagy in ovarian granulosa cells, which plays a crucial role in follicular development and maturation. …”
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Macula densa cell angiogenic mechanisms and their therapeutic potential in kidney disease by Georgina Gyarmati, Dorinne Desposito, Anne Riquier-Brison, Alejandra Becerra Calderon, Greta Trogen, Audrey Izuhara, Michifumi Yamashita, János Peti-Peterdi, János Peti-Peterdi

“…Treatment of NZM.2328 BAFF transgenic lupus mice with MD factors vs control improved GEnC function, halted the progression of albuminuria, and reduced immune cell homing. …”
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A Novel Ashwagandha (<i>Withania somnifera</i>) Formulation Mitigates Sleep Deprivation-Induced Cognitive Impairment and Oxidative Stress in a Rat Model by Besir Er, Busra Ozmen, Emre Sahin, Cemal Orhan, Nurhan Sahin, Abhijeet A. Morde, Muralidhara Padigaru, Kazim Sahin

“…Moreover, AE treatment enhanced markers of neuronal plasticity and partially improved GABAergic function. These findings suggest that AE formulations, particularly at higher concentrations, exert neuroprotective effects against SD-induced cognitive impairment by modulating oxidative stress, neurotransmitter balance, and neuroplasticity, indicating their potential application in managing stress-related neurological disorders.…”
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Clinical efficacy observation of repetitive magnetic stimulation for treating upper limb spasticity after stroke by Zhifa Wang, Qing Liu, Dongxia Li, Ligang Wei, Erxing Chu, Yangdong Bao, Zhen Liu, Lei Jin, Xiaoxia Chen, Kai Zhao

“…Subgroup analyses revealed no significant differences in FM-UE or MAS outcomes between stroke types, likely due to the limited sample size of intracerebral hemorrhage participants (experimental group: n = 8; control group: n = 16). rTMS effectively alleviates upper limb spasticity and enhances motor function after stroke by modulating cortical and spinal nerve excitability.…”
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Research Progress in Microbial Conversion of Flavonoids by XI Jiayu, SU Yuanjin, DONG Shuqing, SHAO Shijun, LIU Hong, YANG Fude

“…Flavonoids are naturally occurring organic compounds that have a variety of biological activities such as antioxidant and anticancer function, preventing osteoporosis and modulating immunity. …”
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A tale of Rabs and the exocyst complex in ciliary trafficking and biogenesis by Priyanka Upadhyai, Debalina Bose, Neha Quadri

“…This review provides a comprehensive insight into how membrane trafficking modulators such as Rab and Rab-like proteins, and the exocyst complex control transport to the primary cilia, in turn regulating various aspects of their assembly and function. …”
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Narrative Review: Advancing Dysbiosis Treatment in Onco-Hematology with Microbiome-Based Therapeutic Approach by Salomé Biennier, Mathieu Fontaine, Aurore Duquenoy, Carole Schwintner, Joël Doré, Nathalie Corvaia

“…The mechanisms by which the gut microbiota impacts these conditions are examined, including modulation of immune responses, production of metabolites, and effects on intestinal barrier function. …”
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Dark-field super-oscillatory microscopy with high-pass super-oscillatory filters by Yujie Shen, Wenyan Ou, Ye Zhang

“…The resolution of the corresponding super-oscillatory point-spread function is 0.66 times the diffraction limit, enabling the resolution of transparent objects with 67% transparency at sub-wavelength scales. …”
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Role of mitochondrial dynamics in mouse preimplantation embryonic development and its molecular mechanisms by Xiaoyan Sun, Qingyang Li, Bo Chen

“…These results provide new insights into the molecular mechanisms linking mitochondrial function to early embryonic development and suggest potential strategies for improving assisted reproductive technologies.…”
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Multi-epitope immunocapture of huntingtin reveals striatum-selective molecular signatures by Joshua L Justice, Todd M Greco, Josiah E Hutton, Tavis J Reed, Megan L Mair, Juan Botas, Ileana M Cristea

“…Altogether, we offer insights into tissue- and localization-dependent (m)HTT functions and pathobiology.…”
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The Psu protein of phage satellite P4 inhibits transcription termination factor ρ by forced hyper-oligomerization by Daniela Gjorgjevikj, Naveen Kumar, Bing Wang, Tarek Hilal, Nelly Said, Bernhard Loll, Irina Artsimovitch, Ranjan Sen, Markus C. Wahl

“…Abstract Many bacteriophages modulate host transcription to favor expression of their own genomes. …”
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RUNX1 promotes proliferation of cervical cancer through TGFB2-MAPK pathway by Yongqin Jia, Neng Yang, Shuai Tang, Li Deng, Yanzhou Wang, Xiongwei Cai

“…Here we presented that RUNX1 was upregulated in CC and associated with poor prognosis. Functional studies demonstrated that RUNX1 acts as an oncogene in CC, with overexpression accelerating cell cycle progression and promoting cell proliferation. …”
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Human neuron chimeric mice reveal impairment of DVL-1-mediated neuronal migration by sevoflurane and potential treatment by rTMS by Youyi Zhao, Ya Zhao, Lirong Liang, Andi Chen, Yuqian Li, Ke Liu, Rougang Xie, Honghui Mao, Boyang Ren, Bosong Huang, Changhong Shi, Zhicheng Shao, Shengxi Wu, Yazhou Wang, Hui Zhang

“…Overexpressing DVL-1 enhanced the Ca2+ response, neuronal migration and social function of Sev-pretreated chimeric mice. Furthermore, specific modulation of human neurons by high-frequency transcranial magnetic stimulation not only activated DVL-1/Ca2+ signaling but also improved human neuronal migration and social function in chimeric mice. …”
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Natural product chlorogenic acid achieves pharmacological activity and health protection via regulating gut microbiota: a review by Ke Fu, Shu Dai, Yafang Zhang, Jia Gong, Cheng Wang, Chenhao Yao, Shenglin Zhang, Cheng Peng, Yunxia Li

“…In a word, CA could achieve pharmacological activity as well as health-protective effects by modulating intestinal immune and barrier function, gut microbiota composition, gut microbiota metabolites, and signaling pathways. …”
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Glycogen storage disease type Ib: modern understanding of the pathogenesis of neutropenia and prospects for its treatment with empagliflozin by Andrej N. Surkov, Aleksandr A. Baranov, Lejla S. Namazova-Baranova, Anna L. Arakelyan, Evgenij E. Bessonov, Natal’ya V. Zhurkova

“…A specific sign of GSD Ib is neutropenia with impaired neutrophil function, which creates prerequisites for recurrent infections and the development of inflammatory bowel disease. …”
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Assessing the Skeletal Muscle Pump During Lower Limb Counterpressure: Lags and Causality in Cardiovascular Regulation by Silvin P. Knight, Eoin Duggan, Feng Xue, Roman Romero‐Ortuno

“…The study provides a novel methodological framework for assessing skeletal muscle pump function and its impact on cardiovascular dynamics. …”
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