ST8Sia2 polysialyltransferase protects against infection by Trypanosoma cruzi. by Bruno Rafael Barboza, Janaina Macedo-da-Silva, Lays Adrianne Mendonça Trajano Silva, Vinícius de Morais Gomes, Deivid Martins Santos, Antônio Moreira Marques-Neto, Simon Ngao Mule, Claudia Blanes Angeli, Juliana Borsoi, Carolina Borsoi Moraes, Cristiane Moutinho-Melo, Martina Mühlenhoff, Walter Colli, Suely Kazue Nagashi Marie, Lygia da Veiga Pereira, Maria Julia Manso Alves, Giuseppe Palmisano

“…Glycosylation is one of the most structurally and functionally diverse co- and post-translational modifications in a cell. …”
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Development of SOCS1 mimetics as novel approach to harmonize inflammation, oxidative stress, and fibrogenesis in metabolic dysfunction-associated steatotic liver disease by Susana Bernal, Ignacio Prieto, María Kavanagh, Isabel Herrero del Real, Sara La Manna, Iolanda Lázaro, Hernán Quiceno, Laura López-Sanz, Belén Picatoste, M. Pilar Valdecantos, Sebastián Mas-Fontao, Aleix Sala-Vila, Ángela M. Valverde, Daniela Marasco, Jesús Egido, Carmen Gómez-Guerrero

“…The dysregulation of Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway and its negative regulators the suppressors of cytokine signaling (SOCS), plays a critical role in liver function and contributes to MASLD progression. Aim: Based on a SOCS1 functional domain, we developed mimetic peptides (linear and cyclic) targeting JAK activity and assessed their hepatoprotective potential in experimental MASLD/MASH. …”
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Neural Mechanisms of Circadian Regulation of Natural and Drug Reward by Lauren M. DePoy, Colleen A. McClung, Ryan W. Logan

“…Circadian rhythms are endogenously generated near 24-hour variations of physiological and behavioral functions. In humans, disruptions to the circadian system are associated with negative health outcomes, including metabolic, immune, and psychiatric diseases, such as addiction. …”
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Insight into the Association between Slitrk Protein and Neurodevelopmental and Neuropsychiatric Conditions by Nidhi Puranik, Minseok Song

“…Slitrks are highly expressed in the developing nervous system of vertebrates, modulating neurite outgrowth and enhancing synaptogenesis; however, the expression and function of Slitrk protein members differ. …”
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Effect of hydrated ions and wettability on ice friction by Chang Dong, Yuan Liu, Tianyi Han, Xue Zhou, Yanan Meng, Yu Tian, Liran Ma

“…Experimental spectra, low-field nuclear magnetic resonance (LF-NMR), density functional theory (DFT) calculations, and molecular dynamics (MD) simulations demonstrated that the addition of ions could break H-bonds. …”
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B7-H3 and Its Role in Antitumor Immunity by Martin Loos, Dennis M. Hedderich, Helmut Friess, Jörg Kleeff

“…B7-H3 is one of the most recently identified members of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T-cell response. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity. …”
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The Metabolites Produced by Lactic Acid Bacteria and Their Role in the Microbiota–Gut–Brain Axis by Yulma Lizbeth Aguirre-Garcia, Neftiti Carolina Cerda-Alvarez, Rosa María Santiago-Santiago, Adriana Rocío Chantre-López, Sarahi Del Carmen Rangel-Ortega, Raúl Rodríguez-Herrera

“…Currently, the impact of these LAB metabolites on human physiology is being actively investigated, especially for modulation of the Microbiota–Gut–Brain axis. Certain compounds derived from LAB have been shown to contribute to neurological, immunological, and metabolic processes, opening new perspectives for the design of functional foods. …”
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Effects of repetitive transcranial magnetic stimulation on inhibitory control in first-episode schizophrenia: behavioral and neural mechanisms by Sihang Yu, Shuai Wang, Hang Sun

“…Future research should explore the long-term effects of this modulation on broader cognitive functions.…”
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CB5712809, a novel Keap1 inhibitor upregulates SQSTM1/p62 mediated Nrf2 activation to induce cell death in colon cancer cells by Ayed A. Dera, Majed Al Fayi

“…The aim is to identify small molecules with high affinity for Keap1 to modulate Keap1, SQSTM1/p62, and Nrf2 functions in colorectal cancer (CRC) cells. …”
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Modeling of Current-Voltage Characteristics of the Photoactivated Device Based on SOI Technology by Doron Abraham, Avraham Chelly, David Elbaz, Shimron Schiff, Michah Nabozny, Zeev Zalevsky

“…An analytical model of the silicon on insulator photoactivated modulator (SOI-PAM) device is presented in order to describe the concept of this novel device in which the information is electronic while the modulation command is optical. …”
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Decoding population PM2.5 exposure in China: interplay of emissions, meteorology, and inequality (2013–2020) by Sujing Li, Sujing Li, Sujing Li, Sujing Li, Chenxi Wang, Linmeng Ma, Xingxing Wang, Guolei Du, Changhao Wu, Changhao Wu, Changhao Wu, Changhao Wu

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Genome-wide analysis of Nicotiana tabacum IDD genes identifies NtIDD9 as a regulator of leaf angle by Zefeng Li, Zefeng Li, Peijian Cao, Peijian Cao, Huabing Liu, Jianfeng Zhang, Jianfeng Zhang, Zhaopeng Luo, Zhaopeng Luo, Hui Zhang, Hui Zhang, Mingzhu Wu, Mingzhu Wu, Xiaodong Xie, Xiaodong Xie

“…Thus, the study suggested that NtIDD9 played a crucial role in modulation of leaf angle development. Overall, these findings lay foundations for future function and mechanism research on IDDs in tobacco.…”
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Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies by Claire E. L. Smith, Andrew J. Streets, Alice V. R. Lake, Subaashini Natarajan, Sunayna K. Best, Katarzyna Szymanska, Magdalena Karwatka, Thomas Stevenson, Rachel Trowbridge, Gary Grant, Sushma N. Grellscheid, Richard Foster, Ciaran G. Morrison, Georgia Mavria, Jacquelyn Bond, Albert C. M. Ong, Colin A. Johnson

“…Currently, only one drug, Tolvaptan, is licensed to slow the decline of renal function for the ciliopathy polycystic kidney disease. …”
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MYH1 deficiency disrupts outer hair cell electromotility, resulting in hearing loss by Jinsei Jung, Sun Young Joo, Hyehyun Min, Jae Won Roh, Kyung Ah Kim, Ji-Hyun Ma, John Hoon Rim, Jung Ah Kim, Se Jin Kim, Seung Hyun Jang, Young Ik Koh, Hye-Youn Kim, Ho Lee, Byoung Choul Kim, Heon Yung Gee, Jinwoong Bok, Jae Young Choi, Je Kyung Seong

“…In a heterogeneous overexpression system, MYH1 variants, particularly those in the head domain, abolished MYH1 functions, such as by increasing prestin activity and modulating the membrane traction force. …”
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Somatostatin-expressing interneurons induce early NO-driven and late specific astrocyte-mediated vasodilation by Thanh Tan Vo, Won Beom Jung, Tong Jin, Geun Ho Im, Soohyun Lee, Seong-Gi Kim

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Integrative Single-Cell Analysis of Cardiomyopathy Identifies Differences in Cell Stemness and Transcriptional Regulatory Networks among Fibroblast Subpopulations by Wenyang Nie, Zhijie Zhao, Yuhang Liu, Youcao Wang, Jingwen Zhang, Ying Hu, Yang Liu, Yong Wang, Zhen Wang

“…C3 AGT + Fibroblasts exhibit increased sensitivity towards adverse outcomes in cardiomyopathy, such as myocardial fibrosis and impaired cardiac contractile function, compared to other cardiac fibroblast subpopulations. …”
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Effect of Acute Resistance Exercise and Resistance Exercise Training on Central Pulsatile Hemodynamics and Large Artery Stiffness: Part II by Denis J. Wakeham, Gary L. Pierce, Kevin S. Heffernan

“…Key Messages: Habitual RET is fundamentally important for skeletal muscle quality and quantity as well as cardiovascular function. Recent literature suggests that habitual RET has negligible effects on large artery stiffness and central hemodynamic pressure pulsatility, but cross-sectional observations still raise questions about the chronic large artery effects of habitual RET. …”
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Sophisticated Microgrid Communication System Management by Alaa Naji Al Hussein, Maytham Abbas, Emad Jadeen Alshebaney, Mohammed Madhi Janabi

“…Conversation and assurance issues play a crucial function when talking regarding to the wise grid. This particular paper presents opportunities of testing power framework assurance transfers and correspondence standards for smart supply. …”
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Performance Analysis of M2M Sensor Networks by Jingjing Wang, Lingwei Xu, Xinli Dong, Wei Shi, Qiuna Niu

“…Based on the moment generating function (MGF) approach, the exact ASEP expressions are derived for several modulation schemes. …”
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Cadmium Tolerance and Detoxification Mechanisms of <i>Lentinula edodes</i>: Physiology, Subcellular Distribution, and Chemical Forms by Gaigai Chen, Bowen Han, Wene Nan, Xiaobo Dong

“…Antioxidant enzymes played an important role in cadmium detoxification, as well as functional group modulation. Cadmium was predominantly distributed in the cell wall fraction, and NaCl-extractable cadmium was the main chemical form. …”
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