Exploring potential associations between the human microbiota and reservoir of latent HIV by Nel Marín-Sánchez, Roger Paredes, Alessandra Borgognone

“…Further integrative multi-omics assessments and functional studies are crucial to test the outlined hypothesis and to identify potential therapeutic targets ultimately able to achieve an effective cure for HIV.…”
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Targeting Senescence: A Review of Senolytics and Senomorphics in Anti-Aging Interventions by Timur Saliev, Prim B. Singh

“…Cellular senescence is a fundamental mechanism in aging, marked by irreversible growth arrest and diverse functional changes, including, but not limited to, the development of a senescence-associated secretory phenotype (SASP). …”
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Comparative analysis of the LARP1 C-terminal DM15 region through Coelomate evolution. by Elaine Nguyen, Jahree A Sosa, Kevin C Cassidy, Andrea J Berman

“…Among other target transcripts, LARP1 specifically binds TOP (terminal oligopyrimidine) mRNAs encoding all 80 ribosomal proteins in a TOR-dependent manner through its C-terminal region containing the DM15 module. Though the functional implications of the LARP1 interaction with target mRNAs is controversial, it is clear that the TOP-LARP1-TOR axis is critical to cellular health in humans. …”
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Iron responsive elements mRNA regulate Alzheimer’s amyloid precursor protein translation through iron sensing by Mateen A. Khan

“…In this review, I present IREs structural and functional characteristics. For iron metabolism, the mRNAs encoding the proteins are controlled by this family of similar base sequences. …”
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New Insights into Monocyte-Derived Macrophages in Glioblastoma by Xuetong Li, Wei Gao, Xinmiao Long, Minghua Wu

“…Recent technological advances have uncovered substantial heterogeneity among macrophages, including hypoxia-induced, lipid-metabolizing, phagocytic, and interferon-activated subtypes. This functional diversity is shaped by tumor-specific genetic alterations and metabolic reprogramming. …”
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Comparative Analysis of Barriers and Challenges in Adoption of Electronic Health Record System in Government and Private Hospitals of Islamabad by Ghazala Jawwad, Maleha Asim, Amanat Ali, Humaira Fayyaz Khan, Aiman Farogh Anjum, Abdul Qudoos Arain

“…Implementation of single module and multi module was a big challenge for government and private hospital respectively (p value <0.05). …”
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Impact of Azithromycin on the Quorum Sensing-Controlled Proteome of Pseudomonas aeruginosa. by J E Swatton, P W Davenport, E A Maunders, J L Griffin, K S Lilley, M Welch

“…Reinforcing this notion, we further show that AZM is capable of attenuating virulence factor production in another Gram-negative species that secretes copious quantities of exoenzymes (Serratia marcescens), even in the absence of a functional QS system.…”
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Recurrent diffuse tenosynovial giant cell tumour of knee joint with emphasis on treatment trends: a case report by Siddharth Arora, Sandeep Ramawat, Kriti Grover, Shilpi Singh

“…Conclusion: Post operative radiotherapy with advanced External beam radiation therapy techniques IG-IMRT, after surgery produced acceptable functional status and excellent local control with few side effects. …”
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Targeting Hyperuricemia and NLRP3 Inflammasome in Gouty Arthritis: A Preclinical Evaluation of Allopurinol and Disulfiram Combination Therapy by Yahya I. Asiri, Manimekalai Pichaivel, Selva Prasanthi Parameshwaran, Krishnaraju Venkatesan, Saud Alqahtani, Taha Alqahtani, Rehab Ahmed, Hassabelrasoul Elfadil, Mahmoud Elodemi, Shaimaa Genena, Durgaramani Sivadasan, Premalatha Paulsamy

“…Radiographic imaging showed attenuated soft tissue swelling and joint erosion. Renal function markers were also improved in the combination group. …”
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Aquaporins in Acute Brain Injury: Insights from Clinical and Experimental Studies by Stelios Kokkoris, Charikleia S. Vrettou, Nikolaos S. Lotsios, Vasileios Issaris, Chrysi Keskinidou, Kostas A. Papavassiliou, Athanasios G. Papavassiliou, Anastasia Kotanidou, Ioanna Dimopoulou, Alice G. Vassiliou

“…AQP2 is primarily known for its function in the kidneys, but it is also expressed in brain regions related to vasopressin signaling and CSF dynamics. …”
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Mechanism Analysis of UCP2 During the Oxidative Stress Injury of Intestinal Porcine Epithelial Cell Line-J2 by Weide Su, Chuanhui Xu, Hongping Jiang, Wenjing Song, Pingwen Xiong, Jiang Chen, Gaoxiang Ai, Qiongli Song, Zhiheng Zou, Qipeng Wei, Xiaolian Chen

“…Oxidative stress poses a significant challenge in livestock production, impairing intestinal function, nutrient absorption, and overall animal performance. …”
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Ginsenoside Ro ameliorates cognitive impairment and neuroinflammation in APP/PS1 mice via the IBA1/GFAP-MAPK signaling pathway by Tianyao Li, Jiaxin Chen, Zhouyuan Xie, Jiansong Fang, Qiqing Wu, Xinyue Cao, Ziying Chen, Yiyun Wang, Qiqi Fan, Qi Wang, Jinman Liu, Jinman Liu

“…This study investigates the therapeutic potential of Ginsenoside Ro and its underlying mechanisms in AD treatment.MethodsIn this study, male APP/PS1 transgenic mice were divided into five groups and treated with Ginsenoside Ro or ginseng for one month. Cognitive function and anxiety were assessed through behavioral tests, including the open field test (OFT) and Morris water maze (MWM). …”
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Probiotics as a therapeutic strategy for metabolic dysfunction-associated steatotic liver disease: A systematic review and meta-analysis by Jing Lu, Xiaoxiao Dong, Ziqi Gao, Huizhen Yan, Dilireba Shataer, Liang Wang, Yanan Qin, Minwei Zhang, Jiayi Wang, Jie Cui, Shengyang Zhou

“…This systematic review and meta-analysis encompassed 12 randomized controlled trials including 657 participants to quantify the effects of probiotic supplementation on liver function indicators, lipid metabolism, and inflammatory markers in MASLD patients. …”
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Single-nucleus RNA sequencing reveals cell types, genes, and regulatory factors influencing melanogenesis in the breast muscle of Xuefeng black-bone chicken by Peng Li, Xu Wei, Qiongtao Zi, Xiangyong Qu, Changqing He, Bing Xiao, Songchang Guo

“…Our findings also suggest that melanocyte function in the breast muscle may be intertwined with intercellular signaling pathways such as PTPRK-WNT5A, NOTCH1-JAG1, IGF1R-IGF1, IDE-GCG, and ROR2-WNT5A. …”
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Weighted Gene Co-Expression Network Analysis Uncovers Critical Genes and Pathways Involved in Soybean Response to Soybean Mosaic Virus by Hanhan Zhu, Ruiqiong Li, Yaoyao Fang, Xue Zhao, Weili Teng, Haiyan Li, Yingpeng Han

“…Further functional enrichment analysis of the 894 genes within the gene clusters showed a significant and repeated enrichment of pathways related to plant–pathogen interaction, linoleic acid metabolism, and plant hormone signaling transduction. …”
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Antidiabetic assessment of mango and soursop leaves bioactive phytochemical formulation on streptozotocin-induced rat model by Churchill Chisom Ogbonna, Samuel Chidi Iwuji, Taofik Oladimeji Azeez, Raymond Maduabuchi Okoronkwo, Tochukwu Nze Ugorji, Christian O. Asadu

“…This is associated with the predominance of ether and tertiary amine, and ester and primary amines functional groups in the extracts formulations of group V and group VII samples respectively, which gave the treatment regimen the ability to reduce surface tension between two immiscible samples thereby stabilizing the extract mixture, serve as free radicals’ scavenger, modulate solubility and provide interactions that trigger responses thus enhancing synergy of the extract’s combination therapy.…”
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A review of the Moses effect and its applications in endourology by Adrià Piñero, Alonso Narváez, José Placer, Enric Miret, Enrique Trilla, Juan Morote

“…However, minimal changes occurred in hemoglobin or hematocrit levels and no significant differences were noted in complications or functional outcomes. Further research is needed to fully evaluate the benefits and limitations of MOSES™ technology in clinical practice.…”
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Transposable elements as genome regulators in normal and malignant haematopoiesis by Dmitry Prokopov, Hale Tunbak, Eve Leddy, Bryce Drylie, Francesco Camera, Özgen Deniz

“…While most TEs have lost the ability to transpose, many retain functional elements that serve as drivers of genome innovation, including the emergence of novel genes and regulatory elements. …”
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Structural Repetition Detector for multi-scale quantitative mapping of molecular complexes through microscopy by Afonso Mendes, Bruno M. Saraiva, Guillaume Jacquemet, João I. Mamede, Christophe Leterrier, Ricardo Henriques

“…Understanding these structures provides insights into their functional roles. While super-resolution microscopy can visualise such patterns, manual detection in large datasets is challenging and biased. …”
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Effect of calcium/sodium addition on rice starch-chickpea protein hydrolysate complexes: Microstructure, rheological properties and digestibility by Cuiping Han, Zhuojia Lv, Yujie Duan, Junfang Zhang, Qingxin Guo

“…These results highlight the innovative application of salt modulation in the RS-CPH system and offer a theoretical foundation for developing functional foods with controlled starch digestibility.…”
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