Unveiling the molecular architecture of the mitochondrial respiratory chain of Acanthamoeba castellanii by Christian Q. Scheckhuber, Sutherland K. Maciver, Alvaro de Obeso Fernandez del Valle

“…This review provides a comprehensive overview of the mitochondrial respiratory chain in A. castellanii, focusing on the key alternative components involved in oxidative phosphorylation and their roles in energy metabolism, stress response, and adaptation to various conditions. The functional characterization of the alternative oxidase (AOX), uncoupling protein (UCP), and alternative NAD(P)H dehydrogenases, highlight their roles in reducing oxidative stress, modulating proton gradients, and adapting to changes in temperature and nutrient availability. …”
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Effects of a Novel Bovine Lactoferrin-Derived Peptide on the Intestinal Morphology and Intestinal Flora in Rats by Tianle Huang, Huan Yang, Yang Zhao, Haiyue Cui, Xiaoxi Qi, Liguang Miao

“…In addition, administration of LF-MQL modulates the functional activity of the gut microbiota and regulates their involvement in host-related metabolic pathways, thereby improving gut homeostasis. …”
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Interplay between MAPK signaling pathway and autophagy in skin aging: mechanistic insights and therapeutic implications by Xu Liu, Bo Chen, Xuefeng Liu, Xiaoqing Zhang, Jingdong Wu, Jingdong Wu

“…Skin aging manifests as structural degradation, functional decline, and heightened disease susceptibility. …”
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EBBA-detector: An effective detector for defect detection in solar panel EL images with unbalanced data. by Yixing Zhang, Ziyan Mo, Zhuan Xin, Xianyu Chen, Yuqin Deng, Xuan Dong

“…Additionally, this paper designs a Scaled Dynamic Focal Loss (SDFL) function, which enables the model to pay more attention to minority and hard-to-identify defect samples under imbalanced data distribution. …”
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Apoptotic neutrophils augment the inflammatory response to Mycobacterium tuberculosis infection in human macrophages. by Henrik Andersson, Blanka Andersson, Daniel Eklund, Eyler Ngoh, Alexander Persson, Kristoffer Svensson, Maria Lerm, Robert Blomgran, Olle Stendahl

“…Since anti-inflammatory activity is not compatible with effective immunity to intracellular pathogens, we therefore investigated how uptake of apoptotic neutrophils modulates the function of Mtb-activated human macrophages. …”
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Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism by Kelley C. Larson, Frederick W. Gergits, Abigail J. Renoux, Elizabeth J. Weisman, Borislav Dejanovic, Liyue Huang, Bhaumik Pandya, Donald G. McLaren, Berkley A. Lynch, Richard Fisher, Evan Thackaberry, David Gray, Francois Gaudreault, Christian Mirescu

“…CSF1R-ALSP is caused by heterozygous loss-of-function mutations in the colony stimulating factor 1 receptor (CSF1R) gene, which encodes a receptor required for the differentiation of myeloid cells, as well as for microglial survival and proliferation. …”
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Network pharmacology analyses and corresponding validation of the mechanistic effects of Yangyin Tongnao Granules in ischemic stroke by Jiaying Yu, Qianqian Chen, Xiaotong Dou, Rongjin Zhu, Jiehong Yang, Weifeng Jin, Haitong Wan, Li Yu, Yangyang Zhang

“…The mechanistic basis for its function, however, remains to be established. This study investigates the molecular mechanism of YYTN in treating IS through the HIF-1 signaling pathway. …”
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Modulatory Effects of <i>Urtica dioica</i> on Neurodegenerative Diseases: Unveiling the Latest Findings and Applications Related to Neuroinflammation, Oxidative Stress, and Cogniti... by Ahlem Chira, Stefano Lorenzetti

“…Notably, some phytochemicals are known to modulate crucial pathways for neuronal plasticity, learning, and memory, thereby enhancing cognitive functions. …”
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Selenium enrichment enhances the alleviating effect of Lactobacillus rhamnosus GG on alcoholic liver injury in mice by Ziyi Yang, Jingyu Lian, Yuheng Yang, Jiayi Li, Weiling Guo, Xucong Lv, Li Ni, Youting Chen

“…Oral LGG@Se effectively prevented lipid metabolism disorders and liver oxidative damage in mice caused by excessive alcohol intake. 16S amplicon sequencing showed that LGG@Se intervention increased the abundance of beneficial bacteria and suppressed the growth of harmful bacteria in the intestinal tract of over-drinking mice, and thus effectively modulated the homeostasis of intestinal flora, which were highly correlated with the improvement of liver function. …”
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lncRNA ADAMTS9-AS2/let-7a-5p axis regulates metabolic reprogramming by targeting HK2 in oral submucous fibrosis-associated oral squamous cell carcinoma by Shanghui Zhou, Jingyu Zhan, Jia Wang, Jingang Yang, Dahe Zhang, Zhenming Li, Yue He

“…We previously identified ADAMTS9-AS2 as a functional tumor suppressor in OSCC-OSF through the regulation of PI3K-AKT signaling. …”
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Altermagnetic ground state in distorted Kagome metal CsCr3Sb5 by Chenchao Xu, Siqi Wu, Guo-Xiang Zhi, Guanghan Cao, Jianhui Dai, Chao Cao, Xiaoqun Wang, Hai-Qing Lin

“…Using first-principles density-functional calculations, we found its ground state to be a 4 × 2 altermagnetic spin-density-wave (SDW) at ambient pressure, with an averaged effective moment of  ~ 1.7μ B /Cr. …”
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Integrin signaling in tumor biology: mechanisms of intercellular crosstalk and emerging targeted therapies by Yifan Li, Shantong Peng, Jiatong Xu, Wenjie Liu, Qi Luo

“…These roles encompass embryonic angiogenesis, tissue repair, and the modulation of tumor cell angiogenesis, progression, invasion, and metastasis. …”
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Electrically Driven Interlayer Excitons in MoSe2/WSe2 Heterostructures by Dohyun Kwak, Kenji Watanabe, Takashi Taniguchi, Thomas Mueller

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Quantifying antibody binding: techniques and therapeutic implications by James Lodge, Lewis Kajtar, Rachel Duxbury, David Hall, Glenn A. Burley, Joanna Cordy, James W.T. Yates, Zahra Rattray

“…The binding kinetics of an antibody for its target antigen represent key determinants of its biological function and success as a novel biotherapeutic. Defining these interactions and kinetics is critical for understanding the pharmacological and pharmacodynamic profiles of antibodies in therapeutic applications, with line of sight to clinical translation. …”
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Dynamic activity changes in transcription factors: Unlocking the mechanisms regulating physiological changes in the brain by Kentaro Abe

“…Quantitative measurement of TF activity during the development, function, and dysfunction of the brain is essential for gaining a deeper understanding of the regulatory mechanisms governing gene expression during these processes. …”
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Enhanced YOLOv8 for Efficient Parcel Identification in Disordered Logistics Environments by Han Yu, Zhang Fengshou, Zhuang Gaoshuai, Qu Yuanhao, He Aohui, Duan Qingyang

“…The proposed algorithm introduces the C2f-OR module to reduce parameters and computation, the Conv-Ghost module for efficient feature extraction, and the HIoU loss function to enhance identification accuracy. …”
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Hierarchical organization of the forebrain cholinergic system in rats by Peter Varsanyi, Kevin Alloway, Candice Chavez, Matthew R. Gielow, Peter Gombkoto, Hideki Kondo, Zoltan Nadasdy, Laszlo Zaborszky

“…These clusters of cholinergic neurons could enable the BFCS to coordinate spatially selective signaling, including the parallel modulation of multiple functionally interconnected yet diverse groups of cortical areas. …”
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Co-encapsulation of norcantharidin prodrugs and lomitapide in nanoparticles to regulate CCL4 expression by inhibiting Wnt/β-catenin pathway for improved anti-tumor immunotherapy by Feng Zhao, Liming Gong, Ping Wang, Dong Chen, Shijie Cao, Feifei Yang, Manqing Tang, Yuanyuan Meng, Yuming Wang, Lin Miao, Yunfei Li, Wei Huang

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Copper sensing transcription factor ArsR2 regulates VjbR to sustain virulence in Brucella abortus by Feijie Zhi, Kemeng Liu, Hao Geng, Mengru Su, Jian Xu, Lei Fu, Ke Ma, Pengcheng Gao, Lvfeng Yuan, YueFeng Chu

“…However, little is known about the function of ArsR family members in Brucella. Here, we identified ArsR2 as a nonclassical member of the family that lacks autoregulatory function, but which nevertheless plays a vital role in maintaining copper homeostasis in B. abortus. …”
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Ergodicity-breaking reveals time optimal decision making in humans. by David Meder, Finn Rabe, Tobias Morville, Kristoffer H Madsen, Magnus T Koudahl, Ray J Dolan, Hartwig R Siebner, Oliver J Hulme

“…We show that utility functions are modulated by gamble dynamics in ways not explained by prevailing decision theories. …”
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