Targeting the hallmarks of aging: mechanisms and therapeutic opportunities by Fumihiro Sanada, Shinichiro Hayashi, Ryuichi Morishita

“…Aging is a complex biological process characterized by a gradual decline in cellular and physiological function, increasing vulnerability to chronic diseases and mortality. …”
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Recognition Algorithm of AE Signal of Rock Fracture Based on Multiscale 1DCNN-BLSTM by Weihua Wang

“…To solve the problem that the recognition accuracy of minority samples decreases, this study replaces ReLU activation function with SELU. The results show that the multiscale 1DCNN-BLSTM model embedded in ECA module has a good antinoise performance, and the recognition accuracy can reach over 90%. …”
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LMD-YOLO: A lightweight algorithm for multi-defect detection of power distribution network insulators based on an improved YOLOv8. by Weiyu Han, Zixuan Cai, Xin Li, Anan Ding, Yuelin Zou, Tianjun Wang

“…The network improves the backbone by introducing SCConv module to improve C2f module, which reduces spatial and channel redundancy, lowering both computational complexity and the number of parameters. …”
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Multimodal fusion image enhancement technique and CFEC-YOLOv7 for underwater target detection algorithm research by Xiaorong Qiu, Yingzhong Shi

“…The local and global information is fused through the CCBC module and the ECLOU loss function to improve the positioning accuracy. …”
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Extracellular Vesicle-Mediated Network in the Pathogenesis of Obesity, Diabetes, Steatotic Liver Disease, and Cardiovascular Disease by Joonyub Lee, Won Gun Choi, Marie Rhee, Seung-Hwan Lee

“…EVs play a critical role in modulating insulin sensitivity, glucose homeostasis, systemic inflammation, and vascular health by transferring functional molecules to target cells. …”
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Gut microbiota from Mori fructus (Morus alba L.) polyphenols and polysaccharides-dosed mice activates the PPARα/PGC-1α signaling pathway to mitigate HFD-induced metabolic syndrome... by Meixia Wan, Qing Li, Yudie Xiao, Dan Zhou, Qianya Lei, Shu Wang

“…Abstract Mori Fructus, rich in polysaccharides and polyphenols, has long been used in East Asia as a functional food and medicinal agent. In traditional Chinese medicine, it is used to treat various ailments like wasting-thirst syndrome and constipation. …”
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USP7 protects TFEB from proteasome-mediated degradation by Swati Keshri, Mariella Vicinanza, Michael Takla, David C. Rubinsztein

“…Specifically, USP7 is identified as the deubiquitinase responsible for removing the K48-linked polyubiquitination signal from TFEB at lysine residues K116, K264, and K274, thereby preventing its proteasomal degradation. Functional assays demonstrate the involvement of USP7 in preserving TFEB-mediated transcriptional responses to nutrient deprivation while also modulating autophagy flux and lysosome biogenesis. …”
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Unraveling oxygen vacancy-driven catalytic selectivity and hot electron generation on heterointerfaces using nanostructured platform by Gyu Rac Lee, Kyoungjae Song, Doosun Hong, Juyoung An, Yujin Roh, Minyoung Kim, Donghun Kim, Yeon Sik Jung, Jeong Young Park

“…Abstract Modulating the physicochemical properties of oxides is crucial to achieve efficient and desirable reactions in heterogeneous catalysis. …”
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Mechanical cues orchestrate monocyte behavior in immune regulation and disease by Yifan Lin, Hardik Makkar, Shuchen Zhang, Bingling Chen, Chaoning Zhan, Kyle Vining

“…Monocytes, key mediators of innate immunity, exhibit remarkable sensitivity to mechanical cues such as extracellular matrix (ECM) stiffness, substrate rigidity, shear stress, compression, and hydrostatic pressure, which shape their activation, differentiation, and functional polarization. Monocytes develop from the bone marrow and populate the vasculature throughout the body. …”
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Early impairment of magnocellular visual pathways mediated by isolated-check visual evoked potentials in primary open-angle glaucoma: a cross-sectional study by Yangfan Yang, Minbin Yu, Zidong Chen, Qiaona Ye, Yanmei Fan, Pingping Liu, Zitian Liu, Kezheng Xu

“…MC visual pathway showed a non-linear response function, while PC visual pathway was a linear response function as contrast increased. …”
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SARS-CoV-2 infection induces adaptive NK cell responses by spike protein-mediated induction of HLA-E expression by Mohammad Zahidul Hasan, Maren Claus, Nadine Krüger, Sarah Reusing, Eline Gall, Christina Bade-Döding, Armin Braun, Carsten Watzl, Markus Uhrberg, Lutz Walter

“…HLA-E expression plays a central role for modulation of NK cell function by interaction with inhibitory NKG2A and stimulatory NKG2C receptors on canonical and adaptive NK cells, respectively. …”
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A High-Fat Diet Induces Oxidative Stress in OPA1^+/− Mouse Cortices: A Critical Double Challenge by Camille Champigny, Marlène Botella, Djamaa Atamena, Sébastien Bullich, Corentin Coustham, Bruno Guiard, Pascale Belenguer, Noélie Davezac

“…Mitochondria, essential for energy production and oxidative metabolism, are adversely affected by a HFD, causing oxidative stress and impaired cellular function. Mutations in the <i>OPA1</i> (OPtic Atrophy 1) gene, crucial for mitochondrial dynamics and functions, are responsible for dominant optic atrophy (DOA), a mitochondrial neurodegenerative disease associated with increased reactive oxygen species (ROS). …”
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Importance of Lactobacilli for Human Health by Piotr B. Heczko, Milena Giemza, Weronika Ponikiewska, Magdalena Strus

“…In this review, we will discuss the acquisition, presence, and functions of lactobacilli in different human microbiota throughout their whole life, including those arising in the amnion and their interactions with mucosal and immune cells. …”
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Natural Products for Improving Soft Tissue Healing: Mechanisms, Innovations, and Clinical Potential by Adina Alberts, Ioana Alexandra Lungescu, Adelina-Gabriela Niculescu, Alexandru Mihai Grumezescu

“…Scar development is a notable clinical and aesthetic issue in soft tissue healing, frequently compromising functionality and quality of life. Conventional treatments demonstrate limited efficacy in avoiding fibrosis and facilitating regenerative repair. …”
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Lactylation modifications in urological diseases: molecular mechanisms and biological implications by Songyuan Yang, Zehua Ye, Sheng Zhao, Fan Cheng

“…This biochemical alteration occurs in histones, where it influences gene transcription, and in non-histone proteins, where it modulates their functional properties. Recent research indicates that lactylation significantly contributes to the development of various urological diseases by affecting key biological processes such as inflammation, angiogenesis, lipid metabolism, and fibrosis. …”
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Protein quality control and regulated proteolysis in the genome‐reduced organism Mycoplasma pneumoniae by Raul Burgos, Marc Weber, Sira Martinez, Maria Lluch‐Senar, Luis Serrano

“…Cellular localization of substrates and epistasis studies supports separate functions for Lon and FtsH. Protein half‐life measurements also suggest a role for Lon‐modulated protein decay. …”
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Engineering Baker’s Yeast for Efficient cAMP Synthesis via Regulation of PKA Activity by Xiaomeng Fu, Kunqiang Hong

“…cAMP (cyclic adenosine-3′,5′-monophosphate) has extensive physiological functions and nutritional value for living organisms, and it regulates cellular metabolism mainly by modulating PKA (protein kinase A) activity. …”
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Restoration of NOX4 signalling reverses endothelial colony-forming cell angiogenic dysfunction associated with experimental and clinical diabetes by Karla M. O’Neill, Kevin S. Edgar, Shun Hay Pun, David C. Campbell, Tinrui Toh, Xin N. Wong, Bianca Botezatu, Jyoti Kandel, Una McCoy, Jennifer Nicell, Catherine McClintock, Kiran J. McLoughlin, Yuxin Wu, Vinuthna Vani Madishetti, Arya Moez, Mohammed Alsaggaf, Eleanor K. Gill, Rawan A. Abudalo, Christina L. O’Neill, Edoardo Pedrini, Jasenka Guduric-Fuchs, Coy Brunssen, Henning Morawietz, Philip D. Dunne, Chris J. Watson, Reinhold J. Medina, David J. Grieve

“…Furthermore, NOX4OE rescued angiogenic function in chronically diabetic CB-ECFCs via modulation of downstream signalling involving both direct and indirect enhancement of pro-angiogenic protein expression (endoglin/SERPINE1/E2F1) linked to reduced p53 phosphorylation. …”
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Structural insight into the distinct regulatory mechanism of the HEPN–MNT toxin-antitoxin system in Legionella pneumophila by Chenglong Jin, Cha-Hee Jeon, Heung Wan Kim, Jin Mo Kang, Yuri Choi, Sung-Min Kang, Hyung Ho Lee, Do-Hee Kim, Byung Woo Han, Bong-Jin Lee

“…Finally, we propose a comprehensive regulatory mechanism of the L. pneumophila HEPN–MNT module based on structural and functional studies. …”
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Roles of lncRNAs in influenza virus infection by Jing Wang, Shan Cen

“…The goal of this review is to stimulate further research on the function of both well-established and newly discovered lncRNAs in IAV infection.…”
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