Liposomal Nanoparticle Delivery of Ginkgo Flavone Glycosides Enhances SIRT1 Activation and Improves Diabetic Cardiomyopathy by Gao W, Chen R, Tong H, Wang Y, Liang L, Li Y, Yu H

“…Various evaluations, including body weight, blood glucose levels, and cardiac function, were performed. Network pharmacology, transcriptomic analysis, and molecular docking studies were conducted to elucidate the key role of SIRT1 in inhibiting DCM progression. …”
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lncRNA OIP5-AS1 Suppresses Cell Proliferation and Invasion of Endometrial Cancer by Regulating PTEN/AKT via Sponging miR-200c-3p by Yun Liu, Xiaohui Cai, Yixuan Cai, Yue Chang

“…Moreover, further study revealed that miR-200c-3p could bind to OIP5-AS1, and the loss function of miR-200c-3p could reverse the elevated OIP5-AS1’s inhibitory effect on the progression of EC. …”
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Effects and underlying mechanisms of novel phenothiazine derivative DA414 in rats with intracerebral hemorrhage by MA Yufan, WANG Bingqiao, LIN Sen

“…The size and extent of injury in the ICH area were measured by magnetic resonance imaging (MRI) and histopathological slices. Neurological function was evaluated with a behavioral grading system. …”
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Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts. by Jennie Ong, Wim Timens, Vijay Rajendran, Arjan Algra, Avrum Spira, Marc E Lenburg, Joshua D Campbell, Maarten van den Berge, Dirkje S Postma, Anke van den Berg, Joost Kluiver, Corry-Anke Brandsma

“…As miRNA levels can be influenced by TGF-β, we hypothesized that TGF-β influences miRNA expression in lung fibroblasts, thereby affecting their function.<h4>Materials and methods</h4>We investigated TGF-β1-induced miRNA expression changes in 9 control primary parenchymal lung fibroblasts using miRNA arrays. …”
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Long-term consumption of hydrogen-rich water provides hepatoprotection by improving mitochondrial biology and quality control in chronically stressed mice. by Qi He, Xiang Lan, Mengyuan Ding, Na Zhang

“…It improves mitochondrial biogenesis, function, and ATP production, and attenuates apoptosis by modulating related proteins. …”
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Calculation of Neutron Kinetics Parameters of Pebble-bed HGTR Based on PANGU Code by FU Bin, ZHANG Weijian, WEN Yutong, WEI Chunlin, SHE Ding

“…This method utilizes the adjoint neutron flux as the weighting function, which is determined from the adjoint neutron transport equation. …”
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Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzheimer’s disease by activating the Wnt/β-catenin signaling by Ling Zhu, Tao Zhou, Lei Wu, Xuanang Zhu, Lvan Chen, Mi Zhang, Jing Zhou, Fan Wang

“…M2-Exo reversed the effects induced by Aβ1−42 both in vitro and in vivo, and M2-Exo improved cognitive function in AD mouse. HLY78 also reversed the effects induced by Aβ1−42. …”
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Perioperative acute kidney injury in surgical treatment of renal cancer: pathogenesis, therapy of early and late complications by S. V. Popov, R. G. Guseynov, Ye. V. Pomeshkin, K. V. Sivak, V. V. Perepelitsa, K.  A. Nadein, N. S. Bunenkov, A. S. Ulitina

“…The incidence of these complications increases with an increase in the volume of kidney resection, as a result of which it is important to take into account risk factors, timely diagnosis of the degree of kidney damage and medical measures aimed at restoring kidney function. Currently, the possibility of using various molecules as early markers of kidney damage, which help not only assess the presence of kidney damage, but also localize it, is being studied. …”
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Oral enzyme combination therapy reduces systemic inflammation, urinary CTXII and pain in knee osteoarthritis: a proof-of-mechanism, randomised, crossover, double-blind, placebo-con... by Thomas Pap, Odd Erik Johansen, Yves Henrotin, Valérie Badot, Stefanie Rau, Maximilian von Eynatten, Jean-Emile Dubuc, Siddhartha Lieten, Didier Urbin-Choffray, Karl Brabants

“…Objectives Oral enzyme combination (OEC) therapy with bromelain, trypsin and rutoside reduces pain and improves function in patients with knee osteoarthritis (OA). …”
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The influence of hepatocyte growth factor on the proliferation and differentiation of stem cells by Rafał Bieś, Agnieszka Mikosińska, Jakub Parys, Mateusz Litwin, Patrycja Kałuziak, Marta Jajczak, Maciej Mossakowski, Aleksandra Witek, Martyna Kaźmierczak, Stanisław Jesionek

“…We explore how HGF/c-Met signaling contributes to stem cell function, tissue repair, and cancer biology, as well as the development of targeted therapies aimed at modulating this pathway. …”
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An Emerging Way for Bacteria to Engage with Host Cells via Protein ADP-riboxanation by Wei Xian, Zhiheng Tang, Qinxin Zhang, Ying Wang, Xiaoyun Liu

“…Post-translational modifications (PTMs) are increasingly recognized as important strategies used by bacterial pathogens to modulate host cellular functions. Protein ADP-riboxanation, a derivative of ADP-ribosylation, has recently emerged as a new biochemical way by which bacterial pathogens interact with host cells. …”
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Design of OpenFOAM mesh generation client software based on C/S architecture by Zhang Zhida, Huai Xiaoyong, Gao Ruochen

“…The client software uses plug-in architecture design, which consists of public module, custom module and mesh generation plugins. …”
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Redefining OSINT Software Architecture With System-Centric Architecture Design: A Framework Shaped by QAW, ADD, and ATAM by Gokhan Yurtalan, Serdar Arslan

“…The architecture is extensively analyzed with metric evaluations and the Architecture Tradeoff Analysis Method (ATAM), confirming critical quality attributes such as performance, reliability, functional suitability, and security. The design decisions taken within this architectural framework are detailed in the article through module view, component and connector view, and allocation view representations. …”
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Mesenchymal stem cell-derived exosomes as a potential therapeutic strategy for ferroptosis by Mohammed Zayed, Enas Elwakeel, Prehan Ezzat, Byung-Hoon Jeong

“…This review summarizes the biological and functional characteristics of MSC-Exos, elucidates their roles in ferroptosis regulation across multiple disease models, and discusses current challenges and future directions for clinical translation.…”
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Wt-1 Expression Linked to Nitric Oxide Availability during Neonatal Obstructive Nephropathy by Luciana Mazzei, Walter Manucha

“…Moreover, recent genetic researches have allowed characterization of many of the complex interactions among the individual components cited, but the realization of new biochemical, molecular, and functional experiments as proposed in our and other research labs allows us to establish a deeper level of commitment among proteins involved and the potential pathogenic consequences of their imbalance.…”
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Ivacaftor–tezacaftor–elexacaftor, tezacaftor–ivacaftor and lumacaftor–ivacaftor for treating cystic fibrosis: a systematic review and economic evaluation by Steven J Edwards, Benjamin G Farrar, Kate Ennis, Nicole Downes, Victoria Wakefield, Isaac Mackenzie, Archie Walters, Tracey Jhita

“…Cystic fibrosis transmembrane conductance regulator gene modulator therapies treat the underlying cause of CF by altering the form or function of the CFTR protein. …”
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Identification and preliminary validation of biomarkers associated with mitochondrial and programmed cell death in pre-eclampsia by Rong Lin, Rong Lin, XiaoYing Weng, XiaoYing Weng, Liang Lin, Liang Lin, XuYang Hu, XuYang Hu, ZhiYan Liu, ZhiYan Liu, Jing Zheng, Jing Zheng, FenFang Shen, FenFang Shen, Rui Li, Rui Li

“…Biomarkers were subjected to localization, functional annotation, regulatory network analysis, and drug prediction. …”
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Sirtuin 3 in diabetic kidney disease: mechanisms and pharmacotherapy by Yinfeng Chen, Ying Wang, Dongrong Yu, Hailing Zhao, Ping Li

“…Sirtuin 3 (SIRT3) is an NAD+-dependent protein deacetylase located in the mitochondria, where it regulates the activity and biological functions of diverse proteins and influences various mitochondrial functions via deacetylation. …”
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Symbol Error Probability of DF Relay Selection over Arbitrary Nakagami-m Fading Channels by George C. Alexandropoulos, Paschalis C. Sofotasios, Khuong Ho-Van, Steven Freear

“…We present a new analytical expression for the moment generating function (MGF) of the end-to-end signal-to-noise ratio of dual-hop decode-and-forward (DF) relaying systems with relay selection when operating over Nakagami-m fading channels. …”
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Analysis of Financial Reports in Companies Using Machine Learning by Piven Artem

“…The process of developing a module intended for automated analysis of financial statements is described in detail, a technical task is created, which is necessary to solve the given task, and the structure and functionality of the developed module in the automated system are described. …”
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