Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics by Raymond Laboy, Marjana Ndoci, Shamsh Tabrez Syed, Maximilian Vonolfen, Eugen Ballhysa, Tim Droth, Klara Schilling, Anna Loehrke, Ilian Atanassov, Adam Antebi

“…Similarly, inhibition of the PPP rescues mammalian MondoA nuclear translocation and transcriptional function upon starvation. These studies reveal how metabolic signals and organellar communication regulate a key convergent metabolic transcription factor to promote longevity.…”
Get full text

Tumor suppressor miR-29c regulates radioresistance in lung cancer cells by Elena Arechaga-Ocampo, Cesar Lopez-Camarillo, Nicolas Villegas-Sepulveda, Claudia H Gonzalez-De la Rosa, Isidro X Perez-Añorve, Reynalda Roldan-Perez, Ali Flores-Perez, Omar Peña-Curiel, Oscar Angeles-Zaragoza, Rosalva Rangel Corona, Juan A Gonzalez-Barrios, Raul Bonilla-Moreno, Oscar del Moral-Hernandez, Luis A Herrera, Alejandro Garcia-Carranca

“…Deregulation of microRNAs contributes to the molecular mechanism underlying resistance to radiotherapy in cancer cells. Although the functional roles of microRNAs have been well described in lung cancer, their functional roles in radioresistance are largely unclear. …”
Get full text

Pulsed electromagnetic stimulation promotes neuronal maturation by up-regulating cholesterol biosynthesis by Ping Chen, Jingyi Li, Vsevolod Telezhkin, Yu Gu, Min Tao, Liping Guo, Simin Song, Rihe Dong, Xianyang Luo, Yan Wang, Qian Liu, Weiming Tian, Weihua Meng, Wei Hong, Bing Song

“…PEMF-treated neurons displayed heightened spontaneous calcium signaling and improved functional maturation, including enhanced excitability, action potential kinetics, and voltage-gated ion channel activity. …”
Get full text

Beyond Spin Crossover: Optical and Electronic Horizons of 2,6-Bis(pyrazol-1-yl)pyridine Ligands and Complexes by Yuliia Oleksii, Abdelkrim El-Ghayoury

“…The review highlights fundamental design principles, particularly the role of substituents in tuning the SCO behavior, photophysical properties, and self-assembly into functional nanostructures. Notable advancements include SCO-driven conductivity modulation, reversible luminescent switching, and amphiphilic <b>bpp</b>-based vesicles for multicolor emission. …”
Get full text

Ferroptosis in neurodegenerative diseases: potential mechanisms of exercise intervention by Shaokai Tang, Jianhua Zhang, Jiawei Chen, Zeng Zhou, Qinqin Lin

“…Iron, a vital trace element for normal brain function, has been implicated in the pathogenesis of neurodegenerative diseases via the ferroptosis pathway. …”
Get full text

INTESTINAL MICROBIOTA AND USE OF PROBIOTICS IN PEDIATRIC PRACTICE: NEWS by S. G. Makarova, L. S. Namazova-Baranova

“…The article presents new data on the intestinal microflora's composition and function, as well as on the nature of interaction in the microbiocenosis-host system. …”
Get full text

TNF receptor-associated factors: promising targets of natural products for the treatment of osteoporosis by Xicheng Yang, LiLi Zhao, YinQuan Pang

“…TRAFs mediate pathways associated with bone remodeling, particularly in response to inflammatory stimuli, influencing osteoclast differentiation and function. Dysregulation of TRAF-mediated signaling contributes significantly to osteoporosis, a condition marked by increased bone resorption and fragility. …”
Get full text

Effects of Astragalus–Ginseng Dietary Supplementation on the Growth and Stress Resistance of Yellow Catfish (<i>Pelteobagrus fulvidraco</i>) by Wenkai Lin, Haijing Xu, Xinlan Ma, Zifeng Yin, Aimin Wang, Junqiang Qiu, Mingyou Li

“…Astragalus and ginseng, esteemed as traditional Chinese herbal medicines, have demonstrated the ability to bolster physical health and enhance the immune function of organisms. In this study, the effects of a dietary astragalus–ginseng mixture on the growth performance, intestinal health, and nonspecific immunity of yellow catfish (<i>Pelteobagrus fulvidraco</i>) were evaluated, by measuring growth performance indices, intestinal villus morphology, enzyme activities, and expression levels of immune-related genes. …”
Get full text

Hes5 + astrocytes potentiate primary afferent Aδ and C fiber-mediated excitatory synaptic transmission to spinal lamina I neurons by Itsuki Kagiyama, Sawako Uchiyama, Makoto Tsuda

“…In this study, using electrophysiological and cell type-specific functional manipulation approaches, we found that chemogenetic stimulation of Hes5 + SDH astrocytes enhanced Aδ and C fiber-mediated excitatory postsynaptic currents in lamina I neurons. …”
Get full text

STK32C promotes colon tumor progression through activating c-MYC signaling by Xin Zhang, Mingxin Jin, Yali Chu, Fengjun Liu, Hui Qu, Cheng Chen

“…Analysis of CRC samples and in vitro experiments revealed that STK32C expression is significantly elevated in cancerous tissues and associated with poor prognosis. Functional assays demonstrated that STK32C promotes proliferation, migration, and invasion of CRC cells, likely through phosphorylation of MYC at the S420 site, enhancing MYC stability and signaling activity. …”
Get full text

Enhancing Missense Variant Pathogenicity Prediction with MissenseNet: Integrating Structural Insights and ShuffleNet-Based Deep Learning Techniques by Jing Liu, Yingying Chen, Kai Huang, Xiao Guan

“…The classification of missense variant pathogenicity continues to pose significant challenges in human genetics, necessitating precise predictions of functional impacts for effective disease diagnosis and personalized treatment strategies. …”
Get full text

Endogenous Ribonucleases: Therapeutic Targeting of the Transcriptome Through Oligonucleotide-Triggered RNA Inactivation by Daria A. Chiglintseva, Olga A. Patutina, Marina A. Zenkova

“…This field of research has important implications for advancing targeted RNA modulation strategies across various disease contexts.…”
Get full text

Epithelial-mesenchymal transition orchestrates tumor microenvironment: current perceptions and challenges by Yuqi Xie, Xuan Wang, Wenquan Wang, Ning Pu, Liang Liu

“…Recent evidence also indicates that cells undergoing EMT may differentiate into cancer-associated fibroblasts, thereby establishing themselves as functional constituents of the TME. Elucidating the relationship between EMT and the TME offers novel perspectives for therapeutic strategies to enhance cancer treatment efficacy. …”
Get full text

Genomic insights into gestational weight gain uncover tissue-specific mechanisms and pathways by Elizabeth A. Jasper, Jacklyn N. Hellwege, Catherine A. Greene, Todd L. Edwards, Digna R. Velez Edwards

“…We tested for pathway enrichment using the GENE2FUNC module from Functional Mapping and Annotation of Genome-Wide Association Studies. …”
Get full text

The Pharmacological Potential of Algal Polysaccharides in Food Applications and Chronic Disease Management by Xue Wu, Yuxin Guo, Congjie Dai, Chao Zhao

“…By integrating fundamental research with practical applications in functional foods, this synthesis provides critical insights for harnessing algal polysaccharides in precision nutrition and sustainable biomedicine, while identifying key challenges in standardization and environmental safety that warrant future investigation.…”
Get full text

The Impact of Physical Activity on Skin Health and Skin Aging by Paulina Hetnar, Milena Fortuna, Sebastian Kiper, Sławomir Toczek, Magdalena Tomala, Katarzyna Jastrowicz-Chęć, Klaudia Koryszko, Natalia Pokrywka, Dawid Suwała, Marcelina Polak

“…Regular physical activity supports skin health by enhancing circulation, promoting collagen synthesis, reducing oxidative damage, modulating hormones, and improving mitochondrial function. …”
Get full text

Wireless In Situ Catalytic Electron Signaling‐Mediated Transcriptomic Reprogramming for Neuron Regeneration via Adaptable Antennas by Hoi Man Iao, Chih‐Ying Chen, Ya‐Hui Lin, Wan‐Chi Pan, Chun‐Yi Liang, Hsiu‐Ching Liu, Lo‐Jei Ching, Pei‐Yu Weng, Min‐Ren Chiang, Ru‐Siou Hsu, Tsu‐Chin Chou, I‐Chi Lee, Lun‐De Liao, Li‐An Chu, Shih‐Hwa Chiou, Shang‐Hsiu Hu

“…In whole‐brain analyses, effective somatostatin (Sst) production inhibits gamma‐aminobutyric acid (GABA) synthesis in injured areas, thereby improving brain function and behavioral recovery. Furthermore, spatial multiomics combined with single‐cell deconvolution analysis reveals the treatment reprogramming in vivo brain transcriptome of angiogenic markers (Il1a, Lgals3) and GABAergic pathway via modulation of GAD65/67 activity, guiding angiogenesis and neuronal regeneration. …”
Get full text

Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo by Jack Kucinski, Alexi Tallan, Cenny Taslim, Andrew M. Vontell, Katherine M. Silvius, Meng Wang, Matthew V. Cannon, Benjamin Z. Stanton, Genevieve C. Kendall

“…The defining genetic driver, PAX3::FOXO1, encodes a chimeric gain-of-function transcription factor. An incomplete understanding of the in vivo chromatin regulatory mechanisms of PAX3::FOXO1 has hindered therapeutic development. …”
Get full text

PABPC1 promotes cell proliferation and metastasis in pancreatic adenocarcinoma by regulating COL12A1 expression by Weijie Yao, Yanrong Yao, Wen He, Chengsi Zhao, Di Liu, Genwang Wang, Zuozheng Wang

“…The relationship between PABPC1 and COL12A1 expression was assessed by Pearson's correlation analysis. The regulatory function of COL12A1 in PABPC1‐affected BXPC3 cell behavior was studied after COL12A1 was overexpressed. …”
Get full text

Resveratrol-Enhanced Human Neural Stem Cell-Derived Exosomes Mitigate MPP+-Induced Neurotoxicity Through Activation of AMPK and Nrf2 Pathways and Inhibition of the NLRP3 Inflammaso... by Ming-Chang Chiang, Yu-Ping Yang, Christopher J. B. Nicol, Tairui Chiang, Chiahui Yen

“…In conclusion, the results suggest that RES-hNSCs-Exos exhibit potent neuroprotective effects against MPP⁺-induced neurotoxicity by enhancing mitochondrial function, reducing oxidative stress, and inhibiting neuroinflammation. …”
Get full text