Cell biomechanics on muscle atrophy: from intricate mechanisms to therapeutic frontiers by Yilin Wang, Jingyuan Meng, Jiechao Zhang, Lichao Tian, Wenrui Wei, Xiaoye Tang, Qian Zhang, Daofang Ding, Xuepeng Wang, Zicheng Guo, Yong He

“…Although core molecular pathways and cellular changes are well characterized, the role of mechanical cues in modulating these mechanisms remains underexplored.Main Findings Our review reveals five convergent atrophy drivers—mechanical unloading, ECM alterations, mitochondrial dysfunction/oxidative stress, inflammation, and endocrine imbalance—that converge on inhibited mTORC1 signaling, activated FoxO/UPS/autophagy, and impaired satellite‐cell function. …”
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Mechanisms of sorafenib-induced cardiotoxicity: ER stress induces upregulation of ATF3, leading to downregulation of NDUFS1 expression and mitochondrial dysfunction by Ming Yan, Ming Yan, Ming Yan, Cheng Peng, Cheng Peng, Xueyan Lang, Xueyan Lang, Yilan Li, Yilan Li, Yao Zhang, Yao Zhang

“…Silencing ATF3 via siRNA partially restored mitochondrial function, suggesting a negative regulatory effect of ATF3 on NDUFS1 that contributes to sorafenib-induced mitochondrial impairment.ConclusionCollectively, these results uncover a critical signaling cascade—PERK/eIF2α/ATF4/ATF3/NDUFS1—involved in sorafenib-mediated cardiotoxicity and point to ATF3 modulation as a promising target for preventing or reducing cardiac injury caused by this drug.…”
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Deciphering orbital hybridization in heterogeneous catalysis by Xiaoyang Yue, Lei Cheng, Eszter Baráth, Rajenahally V. Jagadeesh, Quanjun Xiang

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CC16 alleviates PM2.5-induced lung epithelial cell injury and airway inflammation in asthmatic mice by inhibiting ferroptosis by Aili Wang, Jianling Liu, Zhangwen Li, Ze Qian, Shuo Yang, Shaohua Luo, Jinle Lin, Jian Wu

“…Furthermore, it enhanced pulmonary function while reducing airway inflammation and mucus secretion and inhibited ferroptosis in PM2.5-induced asthmatic mice. …”
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Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies by Francisco J. Carvajal, Hayley A. Mattison, Waldo Cerpa

“…Here, we will review some of the current evidence of how traumatic brain injury can hasten the onset of several neurological conditions, focusing on the role of NMDAR distribution and the functional consequences in calcium homeostasis associated with synaptic dysfunction and neuronal death present in this group of chronic diseases.…”
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Antimicrobial peptides and proteins against drug-resistant pathogens by Yeji Wang, Minghui Song, Wenqiang Chang

“…These bioactive molecules, whether derived from natural sources, designed synthetically, or predicted using artificial intelligence, can induce lethal effects on pathogens by targeting key microbial structures or functional components, such as cell membranes, cell walls, biofilms, and intracellular components. …”
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Enantio-, atrop-, and diastereoselective macrolactonization to access type III cyclophanes by Jiaming Wang, Kang Lv, Yilu Wen, Tao Liu, Changgui Zhao

“…Thermodynamic experiments reveal that the presence of an all-carbon quaternary carbon center on the ansa chain significantly increases the rotational barriers of the cyclophanes. Moreover, density functional theory calculations suggest that the chiral substituent shrinks the ansa chain by compressing the bond angle, thereby rendering the conformational rotation reaction more challenging.…”
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Non-Hermitian bonding, electronic structure, and mass fluctuation of two-dimensional double-layer transition metal chalcogenide MX2 (M = Mo, W; X = S, Se, Te) by Yaorui Tan, Maolin Bo

“…This study systematically investigates the electronic structure and bonding properties of two-dimensional bilayer transition metal chalcogenides MX2 (M = Mo, W; X = S, Se, Te) using density functional theory calculations. By analyzing band gaps, deformation bond energies, and non-Hermitian bonding characteristics across various MX2 compounds, we comprehensively examine their electronic properties and atomic bonding behavior. …”
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Coordinate responses to alkaline pH stress in budding yeast by Albert Serra-Cardona, David Canadell, Joaquín Ariño

“…Thus, the expression of different genes sharing the same signaling network can be coordinated, allowing functional coupling of their gene products.…”
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Suppressive effects of deep balanced anesthesia on cellular immunity and protein expression: a randomized-controlled pilot study by Xuan Duc Nguyen, Audrey Horn, Dania Fischer, Grietje Beck, Cora C. Spannenberger, Brice Gaudilliere, Jean-Louis Horn, Hermann-Josef Thierse, Thomas Frietsch

“…Patients on immune modulating drugs or with immune deficits were excluded. …”
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Extracellular vesicles therapy alleviates cisplatin-ınduced testicular tissue toxicity in a rat model. by Halime Tozak Yıldız, Kübra Tuğçe Kalkan, Numan Baydilli, Zeynep Burçin Gönen, Özge Cengiz Mat, Eda Köseoğlu, Gözde Özge Önder, Arzu Yay

“…<h4>Conclusion</h4>EVs protect against cisplatin-induced reproductive toxicity by modulating oxidative stress and autophagy pathways, preserving testicular function and fertility. …”
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Small Polaron-Induced Ultrafast Ferroelectric Restoration in BiFeO_{3} by Wenfan Chen, Tian Wang, Chun-Chieh Yu, Yuancheng Jing, Xiaosong Li, Wei Xiong

“…The time-dependent density functional theory calculation reveals that both ligand-metal charge transfer and local excitation transition occurred upon photo excitation. …”
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Essential Pieces of the Puzzle: The Roles of VEGF and Dopamine in Aging by Melanie B. Thompson, Sanjay P. Tirupattur, Nandini Vishwakarma, Laxmansa C. Katwa

“…Aging is a well-known, complex physiological process characterized by progressive functional decline and increased susceptibility to disease, particularly in the cardiovascular and nervous systems. …”
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Characterization of BAFF and APRIL subfamily receptors in rainbow trout (Oncorhynchus mykiss). Potential role of the BAFF / APRIL axis in the pathogenesis of proliferative kidney d... by Aitor G Granja, Jason W Holland, Jaime Pignatelli, Christopher J Secombes, Carolina Tafalla

“…Finally, to gain further insights on the functional role that these cytokines play during the course of PKD, we have studied their effect on the survival of kidney IgM+ B cells and on immunoglobulin transcription. …”
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Craniofacial Pain: Brainstem Mechanisms by Barry J Sessle

“…Such peripherally induced modulation of brainstem nociceptive neuronal properties reflects the functional plasticity of the central V system, and may be involved in the development of headache and other conditions that manifest craniofacial pain and neuromuscular dysfunction.…”
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Unveiling Cognitive Interference: fNIRS Insights Into Poststroke Aphasia During Stroop Tasks by Chong Lu, Mingzhu Wang, Likan Zhan, Min Lu

“…This study examined blood oxygenation changes during a modified Stroop task with colored Chinese words using functional near-infrared spectroscopy (fNIRS) in patients with poststroke aphasia. …”
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GSDMD is a novel predictive biomarker for immunotherapy response: in the pan-cancer and single cell landscapes by Li Juan Huang, Feng Chen, Lin Chen, Shi Tong Zhan, Ming Min Liu, Jiang Dong Xiang, Qin Yi Zhang, Ye Yang

“…Finally, organoid-based functional assays confirmed that Poly ADP-ribose polymerase inhibitors (PARPi) exert antitumor effects at least in part by enhancing GSDMD-mediated pyroptosis.ResultsGSDMD was found to be aberrantly expressed in multiple tumor types and positively correlated with TMB, MSI, and immune checkpoint expression. …”
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The Interplay Between Melatonin and Nitric Oxide: Mechanisms and Implications in Stroke Pathophysiology by Santos Blanco, María del Mar Muñoz-Gallardo, Raquel Hernández, María Ángeles Peinado

“…These multifaceted actions of melatonin contribute to reduced infarct volume and improved functional outcomes, underscoring its considerable therapeutic potential for ischemic stroke through the favorable modulation of the melatonin–NO axis.…”
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Investigation on Monitoring System for Pantograph and Catenary Based on Condition-Based Recognition of Pantograph by Ning Zhou, Wenjie Yang, Jiurui Liu, Weihua Zhang, Dong Wang

“…For the monitoring system based on the pantograph, the design process, whole architecture, function module, fault diagnosis method, and monitoring scheme have been investigated. …”
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circ-1584 selectively promotes the antitumor activity of the oncolytic virus M1 on pancreatic cancer by Taofang Hao, Yuanyuan Li, Qianyao Ren, Ying Zeng, Leyi Gao, Wenbo Zhu, Jiankai Liang, Yuan Lin, Jun Hu, Guangmei Yan, Shuxin Sun, Jing Cai

“…Through high-throughput circRNA sequencing, we found that circRNA expression varies among these cells. Further gain-of-function and loss-of-function experiments have shown that circ-1584 can selectively enhance the anti-pancreatic cancer effects of the M1 virus in vitro and in vivo. …”
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