Phosphodegrons in Health and Disease: From Cellular Homeostasis to Therapeutic Potential by Tadashi Nakagawa, Makiko Nakagawa

“…Phosphodegrons are critical motifs that play a pivotal role in the regulation of protein stability and function via phosphorylation-dependent signaling pathways. …”
Get full text

Mammalian Ste20-like kinase 1 regulates AMPK to mitigate the progression of non-alcoholic fatty liver disease by Lijuan Wang, Chenglei Zhang, Jie Ma, Jiarui Li, Yuanyuan Wu, Yanru Ren, Jianning Li, Yan Li, Yi Yang

“…Abstract Background Non-alcoholic steatohepatitis (NASH) progression is strongly associated with deteriorating hepatic function, primarily driven by free cholesterol (FC) accumulation-induced lipotoxicity. …”
Get full text

GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolism by Tian Qiu, Tian Qiu, Ou Fu, Ou Fu

“…This review provides an overview of classical loss and gain-of-function studies on GPCRs related to feeding and metabolism, with a focus on emerging cell-type-specific investigations. …”
Get full text

Targeting Methionine Metabolism Reveals AMPK-SAMTOR Signaling as a Therapeutic Vulnerability in Prostate Cancer by Serdar Arisan, Ayyuce Sever, Pinar Obakan-Yerlikaya, Elif Damla Arisan, Pinar Uysal-Onganer

“…Here, we demonstrate that methionine deprivation induces selective vulnerability in AMPK-deficient PC3 PCa cells by disrupting SAMTOR–mTOR signaling and triggering oxidative stress, lipid depletion, and autophagic responses. Through functional and proteomic analyses, we show that SAMTOR directly interacts with p-AMPK and modulates cell fate under methionine-limited conditions. …”
Get full text

Protection of Cochlear Ribbon Synapses and Prevention of Hidden Hearing Loss by Mei Wei, Wei Wang, Yao Liu, Xiang Mao, Tai Sheng Chen, Peng Lin

“…In this review, we describe and summarize the following aspects of ribbon synapses: (1) functional and structural features, (2) potential mechanisms of damage, (3) therapeutic research on protecting the synapses, and (4) the role of synaptic regeneration in auditory neuropathy and the current options for synapse rehabilitation.…”
Get full text

Circulating immune landscape in melanoma patients undergoing anti-PD1 therapy reveals key immune features according to clinical response to treatment by Eleonora Sosa Cuevas, Eleonora Sosa Cuevas, Stéphane Mouret, Guillaume Vayssière, Guillaume Vayssière, Siham Kerboua, Siham Kerboua, Pauline Girard, Pauline Girard, Jean-Paul Molens, Jean-Paul Molens, Marc Manceau, Julie Charles, Philippe Saas, Philippe Saas, Caroline Aspord, Caroline Aspord

“…We assessed the phenotypic and functional features of DC and effector cells’ subsets by multi-parametric flow cytometry and ProcartaPlex® dosages.ResultsWe revealed differences according to response to treatment and modulations of patterns during treatment, highlighting a strong link between the immune landscape and the outcome of anti-PD1 therapy. …”
Get full text

Remapping Body Representation Using Virtual Reality in Chronic Neuropathic Pain: Systematic Review by Maria Grazia Maggio, Mirjam Bonanno, Andrea Calderone, Amelia Rizzo, Nebahat Bulut, Mahmood Bahramizadeh, Alessandra Benenati, Francesco Tomaiuolo, Angelo Quartarone, Daniela Floridia, Rocco Salvatore Calabrò

“…VR could provide innovative and engaging strategies to reduce pain and enhance functional outcomes in populations with neurological conditions. …”
Get full text

Calcium overload via PVT1 reprograms neutrophil fate and constrains gastric cancer progression by Dong Wang, Yunlong Li, Xiaoyu Peng, Lulu Zhang, Ying Zhang, Xue Guan, Xiao Liang, Songbin Fu, Jingcui Yu

“…Mechanistically, multi-omics integration of transcriptomics and 4D-label-free quantitative proteomics identified PVT1-associated pathways driving GC progression. Functional validation through in vitro and in vivo models demonstrated PVT1’s oncogenic role, while transcriptomic profiling further decoded neutrophil activation mechanisms regulated by PVT1. …”
Get full text

Unraveling Diabetic Kidney Disease: The Roles of Mitochondrial Dysfunction and Immunometabolism by Phoom Narongkiatikhun, Ye Ji Choi, Hailey Hampson, Jimmy Gotzamanis, Guanshi Zhang, Daniel H. van Raalte, Ian H. de Boer, Robert G. Nelson, Kalie L. Tommerdahl, Phillip J. McCown, Jenny Kanter, Kumar Sharma, Petter Bjornstad, Pierre Jean Saulnier

“…These insights underscore the modulation of mitochondrial function and immunometabolism as a critical strategy for decelerating DKD progression.…”
Get full text

Integrated Brain Circuits: Neuron-Astrocyte Interaction in Sleep-Related Rhythmogenesis by Michael M. Halassa, Marco Dal Maschio, Riccardo Beltramo, Philip G. Haydon, Fabio Benfenati, Tommaso Fellin

“…In this article, we highlight the role of astrocytes in the modulation of circuit function with particular focus on sleep-related rhythmogenesis. …”
Get full text

Breaking It Down: The Ubiquitin Proteasome System in Neuronal Morphogenesis by Andrew M. Hamilton, Karen Zito

“…The addition of ubiquitin tags, either as single moieties or as polyubiquitin chains, has been shown not only to mediate degradation by the proteasome and the lysosome, but also to modulate protein function, localization, and endocytosis. …”
Get full text

Bacterial interactions with platelets: defining key themes by Hammodah R. Alfar, Sidney W. Whiteheart

“…In this review, we highlight eight bacterial strains that have been associated with thrombosis, each possessing unique proteins or toxins capable of activating or modulating platelets. We discuss some common themes in the molecular interactions between these bacterial components and their effects on platelet function. …”
Get full text

Interhemispheric effects of iTBS on the fronto-parietal network: Evidence from dual-site stimulation by Isabell Int-Veen, Beatrix Barth, Ramona Täglich, Betti Schopp, Hans-Christoph Nuerk, Christian Plewnia, Stefanie De Smet, Marie-Anne Vanderhasselt, Andreas J. Fallgatter, Ann-Christine Ehlis, David Rosenbaum

“…This study investigated the neuromodulatory effects of Theta Burst Stimulation (TBS) on resting-state functional connectivity (FC) following psychosocial stress induced by the Trier Social Stress Test (TSST). …”
Get full text

QUOTIENT SEMINEAR-RINGS OF THE ENDOMORPHISM OF SEMINEAR-RINGS by Meryta Febrilian Fatimah, Fitriana Hasnani, Nikken Prima Puspita

“…We show that if  is a seminear-ring, then is also a seminear-ring over addition and composition function. We will apply the congruence relation to get the quotient seminear-ring endomorphism. …”
Get full text

Building a potent TREM2 agonistic, biparatopic, common light chain antibody by Ana da Silva Almeida, Melissa L. Geddie, Anil Bhate, Chao Quan, Joseph W. Arndt, Yang Jiao, Joseph C. Santoro, Liron Noiman, Ramya Vijayakumar, Jorge Sanchez-Salazar, Abhishek Datta, Giovanna Antognetti, Ciputra Adijaya Hartana, Xue Fan Wang, Benjamin A. Smith, Dan Bartlett, Danté Duncan, Chia-Chen Liu, Karel Otero Gutierrez, Thomas O. Cameron, Samir Koirala, Heather A. Cooke

“…Numerous TREM2 activating antibodies have been shown to modulate downstream microglial functions to different degrees, with mixed results in preclinical models and in the clinic. …”
Get full text

The role of the mucin-glycan foraging Ruminococcus gnavus in the communication between the gut and the brain by Erika Coletto, Dimitrios Latousakis, Matthew G. Pontifex, Emmanuelle H. Crost, Laura Vaux, Estella Perez Santamarina, Andrew Goldson, Arlaine Brion, Mohammad K. Hajihosseini, David Vauzour, George M Savva, Nathalie Juge

“…Collectively, these data provide first insights into how R. gnavus metabolites may influence brain regulation and function through modulation of granule cell development and synaptic plasticity in the adult hippocampus. …”
Get full text

Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice by Zhangqiang Ma, Na Hu, Liping Zheng, Yue Xue, Chong Zhou, Wencan Wang, Xiu Cheng, Tao Luo, Jianlin Yu, Liaoliao Hu

“…Abstract Background Tri-ortho-cresyl phosphate (TOCP), a widely used plasticizer, has been shown to impair ovarian function. While tanshinone IIA exhibits ovarian protective effects in aging models, its potential to counteract TOCP-induced ovarian damage and associated signaling mechanisms remains unexplored. …”
Get full text

Iron chelators loaded on myocardiocyte mitochondria-targeted nanozyme system for treating myocardial ischemia-reperfusion injury in mouse models by Ke Zhu, Kun Wang, Rongting Zhang, Ziyang Zhu, Wenyuan Wang, Biao Yang, Jun Zhao, Yunli Shen

“…The D/Ce@mPDA-C/P system significantly reduced oxidative stress, upregulated GPX4 expression, inhibited ferroptosis, and modulated the inflammatory microenvironment. Long-term studies in a MIRI mouse model demonstrated reductions in myocardial fibrosis and improvements in cardiac function, including enhanced fractional shortening and ejection fraction. …”
Get full text

A novel strategy for the protective effect of ginsenoside Rg1 against ovarian reserve decline by the PINK1 pathway by Pengdi Yang, Meiling Fan, Ying Chen, Dan Yang, Lu Zhai, Baoyu Fu, Lili Zhang, Yanping Wang, Rui Ma, Liwei Sun

“…Although ginsenoside Rg1 is known to modulate mitophagy, its effectiveness in mitigating ovarian reserve decline remains unclear.Objective To investigate the role of ginsenoside Rg1 in promoting mitophagy to preserve ovarian reserve.Materials and methods Ovarian reserve function, reproductive capacity, oxidative stress levels, and mitochondrial function were compared between ginsenoside Rg1-treated and untreated naturally aged female Drosophila using behavioral, histological, and molecular biological techniques. …”
Get full text

Ultrasound Renal Denervation Attenuates Early Cardiac Remodeling After Acute Myocardial Infarction in a Swine Model of Hypertensions and Dyslipidemia: A Pilot Study by Thomas E. Sharp III, Amy L. Scarborough, Amelia G. Haydel, J. Stephen Jenkins, Marloe Prince, Aashish Gupta, Florian Rader, Zhen Li, David J. Lefer, Traci T. Goodchild

“…Preservation of the myocardial performance Tei index indicated preserved systolic and diastolic function 2 weeks post AMI. The beneficial effects of uRDN were independent of any reductions in blood pressure. …”
Get full text