Microenvironment-responsive nanomedicines: a promising direction for tissue regeneration by Yuan Xiong, Bo-Bin Mi, Mohammad-Ali Shahbazi, Tian Xia, Jun Xiao

“…Subsequently, we explore the design and functional properties of immunomodulatory nanosystems. …”
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SIM2, associated with clinicopathologic features, promotes the malignant biological behaviors of endometrial carcinoma cells by Hua Nie, Yu Chen

“…This study aimed to identify key regulators involved in EC progression and investigate the biological functions of SIM bHLH transcription factor 2 (SIM2) in EC. …”
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Hypoxic mesenchymal stem cell-derived exosomal circDennd2a regulates granulosa cell glycolysis by interacting with LDHA by Wenxin Li, Minjun Lu, Junyu Shang, Jiamin Zhou, Li Lin, Yueqin Liu, Dan Zhao, Xiaolan Zhu

“…Hypoxia-induced exosomal circRNAs regulate glycolysis, but their biological functions and molecular mechanisms in POI are largely unexplored. …”
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Pharmacological Inhibition of Astrocytic Transglutaminase 2 Facilitates the Expression of a Neurosupportive Astrocyte Reactive Phenotype in Association with Increased Histone Acety... by Thomas Delgado, Jacen Emerson, Matthew Hong, Jeffrey W. Keillor, Gail V. W. Johnson

“…Our proteomic data additionally unveiled pronounced changes in lipid and antioxidant metabolism in astrocytes with TG2 deletion or inhibition, which likely contribute to the enhanced neurosupportive function of these astrocytes.…”
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YOLO-WWBi: An Optimized YOLO11 Algorithm for PCB Defect Detection by Yi Zhao, Zhidi Jiang

“…The manufacturing quality of printed circuit boards (PCBs) significantly influences the functionality and life expectancy of electronic devices. …”
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Integrating sensor networks to facilitate efficient energy management for smart grids by Arpita Nath Baruah, Malatesh S. Akkur, Jyoti Seth, Jaymeel Shah

“…The proposed solution optimizes air conditioner energy usage in Pakistan by analyzing exterior temperature conditions, building dynamics, and data from smart devices. It uses functional interfaces, robust algorithms, and continuous tracking for assessment. …”
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Sensory and motor contents are prioritized dynamically in working memory. by Irene Echeverria-Altuna, Sage E P Boettcher, Freek van Ede, Anna C Nobre

“…Also uncharted is the degree of co-dependence of sensory and motor modulation, which gets at the nature of both working-memory representations and internal attention functions. …”
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Digital platforms for state support of the Olympiad process by Anna V. Diachkova, Dmitry E. Kornev

“…Methodology: systematization and analysis, a comparison method to identify the strengths and weaknesses of digital platforms. Results. Key functional requirements for the architecture of solutions for supporting the Olympiad process are formulated: 1) a module for accounting and analytics of achievements with recording, systematization and visualization of results; 2) developed calendar and event functionality; 3) two-way data exchange; 4) multifunctional communication; 5) a personalized recommendation module based on big data analysis, identifying weak topics and offering an optimal strategy for participation in scientific Olympiads, built on the basis of artificial intelligence and machine learning technologies. …”
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Fiber Nonlinearity Equalizer Based on Support Vector Classification for Coherent Optical OFDM by Tu Nguyen, Sofien Mhatli, Elias Giacoumidis, Ludo Van Compernolle, Marc Wuilpart, Patrice Megret

“…For a 40-Gb/s 16 quadrature amplitude modulated (16QAM) CO-OFDM system at 400 km of transmission, SVM-NLE reduces the fiber-induced nonlinearity penalty by about 1 dB in comparison to the benchmark artificial-neural-network (ANN)-based and inverse-Volterra-series-transfer-function-based NLEs.…”
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Genome-wide association study −Driven drug repositioning for the treatment of insomnia by Rahmat Dani Satria, Wirawan Adikusuma, Usi Sukorini, Devy Eka Avitasari, Indra Sari Kusuma Harahap, Mohammad Hendra Setia Lesmana, Lalu Muhammad Irham, Nur Imma Fatimah Harahap, Pranindya Rinastiti, Donytra Arby Wardhana, Richardus Wisnandito Prabasaktya, Chiou-Feng Lin, Aprilia Paramitasari, Andrian Fajar Kusumadewi

“…Notably, NRXN1 emerged as a highly promising target due to its strong functional annotation score and its known interaction with Duloxetine hydrochloride and nicotine polacrilex. …”
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Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing by Wei Duan, Yue Gao, Ruru Xu, Sheng Huang, Xueqian Xia, Jingwen Zhao, Longhuan Zeng, Qiaolin Wei, Jia-Wei Shen, Jianmin Wu, Yongke Zheng

“…Although nanozymes have made progress in inflammation modulation and antibacterial management, they often lack the ability in pro-angiogenesis, which greatly limits their functional application in the synergistic treatment of burn infected wounds. …”
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Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System by Bruno Rodrigues, Aline Alves Santana, Aline Boveto Santamarina, Lila Missae Oyama, Érico Chagas Caperuto, Cláudio Teodoro de Souza, Catarina de Andrade Barboza, Leandro Yanase Rocha, Diego Figueroa, Cristiano Mostarda, Maria Cláudia Irigoyen, Fábio Santos Lira

“…After ET and DT protocols, ventricular function and inflammation, cardiovascular autonomic modulation (spectral analysis), and adipose tissue inflammation and lipolytic pathway were evaluated. …”
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D2HGDH Deficiency Regulates Seizures through GSH/Prdx6/ROS‐Mediated Excitatory Synaptic Activity by Zhijuan Zhang, Hui Zhang, Peng Zhang, Rong Li, Jinyu Zhou, Jiyuan Li, Danmei Hu, Rui Huang, Fenglin Tang, Jie Liu, Demei Xu, Chenlu Zhang, Xin Tian, Yuanlin Ma, Patrick Kwan

“…Furthermore, its potential involvement in the seizure network through synaptic function modulation is investigated. D2HGDH knockdown reduces the glutathione reduced (GSH)/glutathione oxidized (GSSG) ratio and elevates reactive oxygen species (ROS) levels within neurons. …”
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The biological role and molecular mechanism of transfer RNA-derived small RNAs in tumor metastasis by Haotian Dong, Haotian Dong, Chengyuan Ye, Xiaohan Ye, Jianing Yan, Guoliang Ye, Yongfu Shao, Yongfu Shao

“…Transfer RNA-derived small RNAs (tsRNAs), a class of endogenous non-coding RNA molecules, play crucial functional roles in various physiological processes, including the regulation of transcription and reverse transcription, the modulation of translation processes, the modification of epigenetic inheritance, the regulation of the cell cycle, etc. …”
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Genomic insights into mRNA COVID-19 vaccines efficacy: Linking genetic polymorphisms to waning immunity by Min-Jia Hsieh, Ping-Hsing Tsai, Pin-Hsuan Chiang, Zih-Kai Kao, Zi-Qing Zhuang, Ai-Ru Hsieh, Hsiang-Ling Ho, Shih-Hwa Chiou, Kung-Hao Liang, Yu-Chun Chen

“…We hypothesize that specific gene variants may modulate the development of vaccine-initiated immunity, leading to impaired immune function. …”
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Effectiveness of Photobiomodulation Therapy in the Management of Fibromyalgia Syndrome: A Systematic Review by Sebastián Eustaquio Martín Pérez, Joel Rodríguez Niebla, Loanne Giraud Pérez, Raquel Campo León, Alejandro López Mejías, David Morales Tejera, Isidro Miguel Martín Pérez

“…This systematic review evaluated the efficacy of PBMT in managing Fibromyalgia symptoms, including pain, physical function, sleep quality, and overall well-being, while comparing localized and whole-body delivery. …”
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Baicalin alleviates sepsis-associated acute kidney injury through activation of the PPAR-γ/UCP1 signaling pathway by Neng Bao, Ming-Jia Gu, Qiu-Ya Huang, Hai-Jian Sun, Xue-Xue Zhu, Xin Gu, Jin Wang, Xiang Yu, Qing-Bo Lu, Ya-Fen Yu

“…Human kidney-2 cells were used for in vitro validation.Results In this study, baicalin significantly ameliorated LPS-induced acute kidney injury by modulating the PPAR-γ/UCP1 signaling pathway. Both in vivo and in vitro experiments revealed that baicalin attenuates inflammation, oxidative stress, and apoptosis while restoring mitochondrial function. …”
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Th1 Cytokines Inhibit Acinar Morphogenesis and Milk Protein Expression in 3D Mammary Cultures by Lih-Ju Chen, Yi-An Su, Ting-Hui Lin, Wan-Ting Liao, Chun-Chi Wu, Chen-Chu Lin, Chang-Han Chen, Tsai-Ching Hsu, Ya-Wen Yang, Yi-Ju Lee

“…<b>Background</b>: The principal function of mammary glands is to produce milk to nourish the newborn. …”
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Berberine ameliorates septic cardiomyopathy through protecting mitochondria and upregulating Notch1 signaling in cardiomyocytes by Qi Shen, Yufan Yuan, Zelin Li, Ying Ling, Jian Wang, Mingjing Gao, Peng Wang, Mengli Li, Lizhong Lai, Jinlan Jin

“…The objective of this is to elucidate how BBR alleviates SCM.MethodsSeptic cardiomyopathy rat model was established by performing cecal ligation and puncture (CLP), while a cardiomyocyte injury model was provoked in H9C2 cells using lipopolysaccharide (LPS). Cardiac function was assessed through echocardiography, and myocardial histopathology was examined with hematoxylin-eosin (HE) staining. …”
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Integrated bioinformatics analysis identifies CHAD association with osteoporosis and in vitro chondrogenic effects of Wogonin by Keng-Fu Lan, Wei-Hsiang Su, Yongjin Zhong, Yan Wu, Siqi Ye, Dan He, Yancheng Lai, Charles C. N. Wang, Anchun Mo

“…Preliminary in vitro experiments showed that wogonin modulates chondrogenic differentiation, a process related to CHAD’s function, suggesting potential avenues for further investigation into OP therapeutics.…”
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