Perturbed gut microbiota and serum metabolites are associated with progressive renal fibrosis by Run-Xi Wang, Hong-Bing Zhou, Hong-Bing Zhou, Jia-Xing Gao, Xing-Hua Li, Wan-Fu Bai, Jia Wang, Ying-Chun Bai, Li-Ya Fan, Hong Chang, Song-Li Shi, Song-Li Shi

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VISUAL ASSESSMENT OF THE MUCOSA OF THE COLON IN IRRITABLE BOWEL SYNDROME IN THE DYNAMICS OF TREATMENT by A. E. Shklyaev, A. S. Pantyukhina, A. A. Sapegin, E. L. Bazhenov

“…Irritable bowel syndrome (IBS) is a common functional disorder of the gastrointestinal tract. The difficulty of its diagnosis related to the lack of specific markers of the disease. …”
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Integration of multi-omics data to unveil the molecular landscape and role of piRNAs in early-onset colorectal cancer by Siyun Zhou, Lili Yu, Jianhui Zhao, Qian Xiao, Jing Sun, Lijuan Wang, Yuan Zhou, Yadong Lu, Malcolm G Dunlop, Evropi Theodoratou, Honghe Zhang, Kefeng Ding, Xue Li

“…Multi-omics profiling revealed PIWIL1/piRNA as a hallmark of EOCRC, with further validation through in vitro functional assays, transcriptomic profiling, and Kaplan-Meier survival analysis. …”
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Shared diagnostic genes and potential mechanism between PCOS and recurrent implantation failure revealed by integrated transcriptomic analysis and machine learning by Wenhui Chen, Wenhui Chen, Wenhui Chen, Qingling Yang, Qingling Yang, Qingling Yang, Linli Hu, Linli Hu, Linli Hu, Mengchen Wang, Mengchen Wang, Mengchen Wang, Ziyao Yang, Ziyao Yang, Ziyao Yang, Xinxin Zeng, Xinxin Zeng, Xinxin Zeng, Yingpu Sun, Yingpu Sun, Yingpu Sun

“…By analyzing differentially expressed genes (DEGs) and module genes using weighted gene co-expression networks (WGCNA), functional enrichment analysis, and three machine learning algorithms, we identified twelve diseases shared genes, and two diagnostic genes, including GLIPR1 and MAMLD1. …”
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Enhancer transcription profiling reveals an enhancer RNA-driven ferroptosis and new therapeutic opportunities in prostate cancer by Sheng Ma, Zixian Wang, Zezhong Xiong, Yue Ge, Meng-Yao Xu, Junbiao Zhang, Yuzheng Peng, Qin Zhang, Jiaxue Sun, Zirui Xi, Hao Peng, Wenjie Xu, Yanan Wang, Le Li, Chunyu Zhang, Zheng Chao, Baojun Wang, Xu Gao, Xu Zhang, Gong-Hong Wei, Zhihua Wang

“…Abstract Enhancer RNAs (eRNAs), a subclass of non-coding RNAs transcribed from enhancer regions, have emerged as critical regulators of gene expression; however, their functional roles in prostate cancer remain largely unexplored. …”
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Dopaminergic system and its relationship with the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-thyroid systems (review) by I. N. Molodovskaya

“…Symptoms of several brain diseases, including schizophrenia, Parkinson’s disease, attention deficit and hyperactivity disorders and depression, are alleviated by the pharmacological modulation of dopamine transmission. However, there is evidence of a functional role of peripheral dopamine. …”
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Identification and characterization of seminal fluid proteins in the Asian tiger mosquito, Aedes albopictus. by Kathryn E Boes, José M C Ribeiro, Alex Wong, Laura C Harrington, Mariana F Wolfner, Laura K Sirot

“…We discuss possible functions of these Sfps in relation to Ae. albopictus reproduction-related biology. …”
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Selectivity and sparseness in randomly connected balanced networks. by Cengiz Pehlevan, Haim Sompolinsky

“…Neurons in sensory cortex show stimulus selectivity and sparse population response, even in cases where no strong functionally specific structure in connectivity can be detected. …”
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PANoptosis as a Two-Edged Sword in Colorectal Cancer: A Pathogenic Mechanism and Therapeutic Opportunity by Györgyi Műzes, Ferenc Sipos

“…The expression and functional status of key molecules within the PANoptosome, such as ZBP1, RIPK1, RIPK3, CASP8, and ASC, may influence tumor viability and immune detection. …”
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The Dynamics of Cell-to-Cell Water Transport and the Involvement of Aquaporins in Response to Apoplast Blockage in the Roots of Intact Maize Plants by Maksim Suslov

“…It is assumed that the apoplastic water flow in plant roots can modulate the cell-to-cell water transport and functional activity of aquaporins.…”
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The Role of Long Non-Coding RNAs in Human Endoderm Differentiation by Annanda Lyra Ribeiro, Bruno Dallagiovanna

“…This review summarizes current findings on the roles of lncRNAs in endoderm differentiation, highlighting the functional mechanisms and regulatory aspects underlying their involvement in cell fate decisions leading to endoderm development. …”
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Angiotensin IV Receptors in the Rat Prefrontal Cortex: Neuronal Expression and NMDA Inhibition by Zsolt Tamás Papp, Polett Ribiczey, Erzsébet Kató, Zsuzsanna E. Tóth, Zoltán V. Varga, Zoltán Giricz, Adrienn Hanuska, Mahmoud Al-Khrasani, Ákos Zsembery, Tibor Zelles, Laszlo G. Harsing, László Köles

“…The prefrontal cortex (PFC), a key region for cognitive function, is heavily implicated in neuropsychiatric disorders, positioning the modulation of its glutamatergic neurotransmission as a promising therapeutic target. …”
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Store-Operated Ca Entry in Fibrosis and Tissue Remodeling by Ahmed Emam Abdelnaby, Mohamed Trebak

“…We highlight the essential functions of myofibroblasts in ECM production, the transformation of fibroblasts, and the participation of immune cells in modulating the fibrotic landscape. …”
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基于DSP的风力发电机齿轮箱故障诊断系统的研究与应用 by 史霞飞, 潘宏侠, 何强

“…Wind turbine gearbox is the most failure frequency component of the wind turbine.For the non-smooth characteristics of the most gearbox vibration signals,a wind turbine gearbox fault diagnosis system is designed,which takes DSP TMS320F28335 as its core processor and can run independently without master computer.The hardware platform of system is built with various peripheral module of TMS320F28335,including the data acquisition of analog,frequency and digital signal acquisition and the communication function of ethernet and CAN bus.The acquired data is processed by EMD algorithm which decompose the vibration signal into IMF components,and then,with the Hilbert transform,and an accurate signal Hilbert marginal spectra is obtained.According to the Hilbert marginal spectra,the potential failure information is got.Tests show that,the system can effectively diagnose the fault of gearbox.…”
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汽车起动齿轮轴的精密塑性成形 by 孟令先, 马建民, 宋学进, 张元国

“…The start gear shaft is the key part of automobile starter,it is involutes small module internal gear with addendum modification;tooth surface of the internal gear is complex shape of five pleats.It is step shaft with H/D>6 in the outline.The shaft can’t be machined and plastic forming also is difficult.Meeting the needs of markets and improving comprehensive function of automobiles,the high efficiency precision forming technology method of single-step chinless-forming for internal gear tooth surface and external gear tooth is put forward based on analysis,study and repeated test.In the same time,a set of high accuracy die with simple novel structure and long service life is designed and manufactured.The advantages of the method have been verified that utilization ratio of material and production efficiency is high.For this reason,the method is profitable reference for producing the same type of complex shape gear.…”
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Soft X-Ray Polarimeter: Potential Instrumentation and Observations by Herman L. Marshall, Norbert S. Schulz

“…The intensity variation with position angle is measured to determine three Stokes parameters: I, Q, and U - all as a function of energy. By laterally grading the multilayer optics and matching the dispersion of the gratings, one may take advantage of high multilayer reflectivities and achieve modulation factors >90% over the entire 0.2 to 0.8 keV band. …”
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Effect of T lymphocyte on hepatic stellate cell activation in liver fibrosis by GONG Xiaoqian, WEI Yehuang, WANG Rongrong, LIU Xudong

“…It is mainly manifested as excessive proliferation and deposition of extracellular matrix in liver tissue, which leads to abnormal changes in liver tissue structure, cirrhosis and liver failure, and affects the normal physiological function of liver. Activated hepatic stellate cells (HSC) are generally considered to be the main cell type that forms liver fibrosis. …”
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Toll-Like Receptors, Tissue Injury, and Tumourigenesis by Savvas Ioannou, Michael Voulgarelis

“…A rapidly expanding area of research regarding the expression and function of TLRs in cancer cells and its association with chemoresistance and tumourigenesis, and TLR-based therapy as potential immunotherapy in cancer treatment is taking place over the last years.…”
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Oestrogene mimetic isoflavones’ pharmacokinetics and pharmacodynamics by Anca Dragomirescu, Dragos, D., Mihaela Andoni

“…It has also estrogen-modulated properties by its binding ability to the beta type estrogen receptor. …”
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The Psychomotor Disorders: Disorders of the Supervisory Mental Processes by P. F. Liddle

“…Each of these three syndromes is associated with a specific pattern of disordered function in multimodal association cortex and related subcortical nuclei. …”
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