RNA binding proteins (RBPs) on genetic stability and diseases by Abdullahi Tunde Aborode, Ohilebo Abdulateef Abass, Shaibu Nasiru, Mary Ugunnushe Eigbobo, Sumana Nefishatu, Abdullahi Idowu, Zainab Tiamiyu, Aeshah A. Awaji, Nike Idowu, Babawale Roqeeb Busayo, Qasim Mehmood, Isreal Ayobami Onifade, Sodiq Fakorede, Ashraf Akintayo Akintola

“…Their interactions with RNA molecules govern critical processes such as mRNA splicing, stability, localization, and translation, which are essential for proper cellular function. These proteins interact with RNA molecules and other proteins to form ribonucleoprotein complexes (RNPs), hence controlling the fate of target RNAs. …”
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Targeting Inflammation and Skin Aging via the Gut–Skin Axis: The Role of <i>Lactiplantibacillus plantarum</i> HY7714-Derived Extracellular Vesicles by Hayera Lee, Yun-Ha Lee, Dong-Ki Hong, Sung-Jun Mo, Soomin Jeon, Soo-Dong Park, Jae-Jung Shim, Jeong-Lyoul Lee, Jae-Hwan Lee

“…Inflammation was induced using a gut-on-a-chip, and changes in cell morphology and barrier function were analyzed. Extracellular vesicles (EVs) derived from HY7714-improved intestinal cell structure repaired damage and restored tight junction integrity. …”
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Macrophage migration inhibitory factor mediates joint capsule fibrosis via facilitating phospholipid metabolite PGE2 production in fibroblasts by Yuxin Zhang, Xin Jiao, Yijia Wang, Shilu Liu, Zengguang Wang, Hanwen Chang, Yuntao Li, Xiaokun Yue, Xiaoding Gu, Renjie Xu

“…Joint capsule fibroblast-derived PGE2 in turn selectively modulated fibroblast and macrophage functions to synergistically promote the inflammation and fibrosis process. …”
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Optimization of regular expressions using competitive coevolutionary algorithm based on symbolic regression by Demidova Liliya, Moroshkin Nikita

“…The paper proposes a pseudocode for the regular expression optimization algorithm as an abstract “black box” model, provides hyperparameters of competitive coevolution, as well as a function for assessing the suitability and reliability of individual algorithms within the coevolution. …”
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PD-1 inhibition disrupts collagen homeostasis and aggravates cardiac dysfunction through endothelial-fibroblast crosstalk and EndMT by Zejin Zhang, Zejin Zhang, Zhenzhen Yan, Zhenzhen Yan, Tao Yuan, Tao Yuan, Xiaona Zhao, Xiaona Zhao, Minghui Wang, Minghui Wang, Guoqing Liu, Guoqing Liu, Lijun Gan, Wei Qin, Wei Qin, Wei Qin

“…Inhibiting ROS with N-acetylcysteine (NAC) preserves normal collagen distribution and cardiac function in PD-1 inhibitor-treated mice by reversing TCF12 downregulation and EndMT in ECs.ConclusionOur results suggest that PD-1 inhibitor causes ROS accumulation in cardiac ECs, leading to imbalanced collagen distribution (decrease in interstitial collagen and increase in perivascular collagen) in the heart by modulating TCF12/TGF-β1-mediated EC-CF crosstalk and EndMT. …”
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Correction of gut microbiota disorders in anxiety and depressive disorders by M. D. Ardatskaya

“…Its mechanism of action can be synthetised in three main functions: modulation of gut microbiota, regulation of neurotransmitter pathways and reduction of inflammatory molecules. …”
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Medications for Hypertension Change the Secretome Profile from Marrow Stromal Cells and Peripheral Blood Monocytes by Nikunj Satani, Kaavya Giridhar, Chunyan Cai, Natalia Wewior, Dominique D. Norris, Jaroslaw Aronowski, Sean I. Savitz

“…MSCs are proposed to promote recovery through the release of secretomes that modulate the function of beneficial immune cells. The majority of stroke patients have comorbidities including hypertension, for which they are prescribed antihypertensive medications that might affect the function of MSCs, when they are administered in stroke patients. …”
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L-2-hydroxyglutarate regulates centromere and heterochromatin conformation in the male germline. by Nina Mayorek, Miriam Schlossberg, Yousef Mansour, Nir Pillar, Ilan Stein, Fatima Mushasha, Guy Baziza Paz, Eleonora Medvedev, Zakhariya Manevitch, Julia Menzel, Elina Aizenshtein, Boris Sarvin, Nikita Sarvin, Erwin Goldberg, Bryan A Niedenberger, Christopher B Geyer, Tomer Shlomi, Michael Klutstein, Eli Pikarsky

“…Germ cell differentiation in the male testis involves extensive phenotypic, transcriptional, and epigenetic modifications, which are essential for producing functional spermatozoa. Among all organs, the testis exhibits the highest baseline physiological levels of L-2-hydroxyglutarate (L-2HG), yet its role in male germ cell development remains unknown. …”
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Edge-activated graphene nanopores for thermally robust hydrogen membrane separations by Chi Cheng, Lohyun Kim, Aaron H. Persad, Chun Man Chow, Rohit Karnik

“…Combined experiment and modelling trace this behavior to graphene nanopore edge functional groups, whose thermal fluctuations modulate effective pore size. …”
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Midkine (MDK) in cancer and drug resistance: from inflammation to therapy by Berna Yıldırım, Kudret Kulak, Ayhan Bilir

“…This review synthesizes current knowledge on MDK’s expression profiles, molecular mechanisms, and functional roles across pathological conditions. It also discusses MDK’s emerging value as a diagnostic and prognostic biomarker, and highlights recent advances in therapeutic strategies including small molecule inhibitors, RNA-based approaches, and receptor-blocking peptides. …”
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New insights into constitutive neutrophil death by Tong Chen, Qian Ren, Fengxia Ma

“…Furthermore, dead neutrophils retain functional roles via multiple manners. This review provides an overview of current research on the mechanism and modulation of CND. …”
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Knockout of <i>GmCKX3</i> Enhances Soybean Seed Yield via Cytokinin-Mediated Cell Expansion and Lipid Accumulation by Xia Li, Xueyan Qian, Fangfang Zhao, Lu Niu, Yan Zhang, Siping Han, Dongyun Hao, Ziqi Chen

“…Loss of <i>GmCKX3</i> function significantly enhanced the seed size and weight, which was attributed to an increased cell size and fat accumulation in the endosperm. …”
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ПРИМЕНЕНИЕ НИКОРАНДИЛА ПРИ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЯХ И ОПТИМИЗАЦИЯ СХЕМ ЕГО НАЗНАЧЕНИЯ by Ю. Б. Белоусов

“…Next, clinical practice related lo ischemic preconditioning and pharmacological preconditioning with nicorandil as well as other favourable mechanisms of improvement of prognosis, in which it plays a role in improving endothelial function, modulating autonomic nervous system activity and stabilizing plaque are summarized. …”
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Current and Emerging Pharmacotherapy for Fibromyalgia by Roie Tzadok, Jacob N. Ablin

“…Future insights into the fields of cannabinoid and opioid research, as well as an integrative approach towards the incorporation of genetics and functional imaging combined with additional fields of research relevant towards the study of complex CNS disorders, are likely to lead to new developments of novel tailor-made treatments for FMS patients.…”
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Circular RNAs: key regulators of paclitaxel sensitivity and resistance in cancer by Zahra Tajik, Soudeh Ghafouri-Fard

“…Our findings emphasize the urgency of functional studies and standardized profiling methods to harness circRNAs for personalized oncology.…”
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Effects of aging on nitrergic system in human basal nuclei by Bruno Lopes dos Santos

“…Our data demonstrated that: (I) the most posterior regions of the striatum exhibit a higher neuronal density; (II) the limbic cortex-associated areas of the striatum exhibit higher neuronal density than other functional subdivisions; (III) approximately 90% of the neurons in the subthalamic nucleus express NO; (IV) the pedunculopontine nucleus exhibits a massive nitrergic neuronal density; (V) in the globus pallidus, there is a marked presence of NO neurons in the medial medullary lamina; and (VI) nitrergic neurons were not detected in the substantia nigra. …”
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HIV-1 Vpr orchestrates ciTRAN upregulation through TGF-β induction. by Aditi Choudhary, Katyayani Mallick, Rishikesh Dalavi, Ajit Chande

“…SMARCA5 promoter analysis and functional assays further revealed that SAMD2/3 binding motif in the SMARCA5 promoter is crucial for ciTRAN upregulation. …”
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Platelet-Activating Factor-Induced Inflammation in Obesity: A Two-Sided Coin of Protection and Risk by Smaragdi Antonopoulou

“…Finally, it highlights the potential of natural PAF modulators in promoting functional adipose tissue, thermogenesis, and obesity prevention through a healthy lifestyle, including a Mediterranean diet rich in PAF weak agonists/PAF receptor antagonists and regular exercise, which help maintain controlled PAF levels. …”
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Heart crosstalk with other organs and pharmacological strategies for cardioprotection by Zizhuo TU, Yaozu XIANG

“…Various forms of interaction between cardiovascular system diseases and cerebrovascular, liver and intestinal metabolism, kidney and other functional disorders have been widely reported. In this review, we focus on the interactions between the cardiovascular system and other organs in ischemic heart disease and HF, highlight novel therapeutic strategies that modulate cardiometabolic and inflammatory processes.…”
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Designing and Manufacturing Smart Sports-Medical Shoes by Mohammad Malekipooya

“…Objective The foot is the most important organ of interaction between the ground and the human body, and its functional structure is very influential on the correct walking pattern. …”
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