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Growth arrest and DNA damage-inducible 45: a new player on inflammatory diseases
Published 2025-02-01“…Growth arrest and DNA damage-inducible 45 (GADD45) proteins are critical stress sensors rapidly induced in response to genotoxic/physiological stress and regulate many cellular functions. Even though the primary function of the proteins is to block the cell cycle, inhibit cell proliferation, promote cell apoptosis, and repair DNA damage to cope with the damage caused by internal and external stress on the body, evidence has shown that GADD45 also has the function to modulate innate and adaptive immunity and plays a broader role in inflammatory and autoimmune diseases. …”
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7642
Balanced CoQ6 biosynthesis is required for lifespan and mitophagy in yeast
Published 2017-02-01“…In yeast its biosynthesis depends on a multiprotein complex in which Coq7 protein has both catalytic and regulatory functions. Coq7 modulates CoQ6 levels through a phosphorylation cycle, where dephosphorylation of three amino acids (Ser/Thr) by the mitochondrial phosphatase Ptc7 increases the levels of CoQ6. …”
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7643
Arthropod autophagy molecules facilitate Anaplasma phagocytophilum infection of Ixodes scapularis tick cells
Published 2025-03-01“…RNAi-mediated knockdown of shp-2 or functional blocking with SHP-2 inhibitor resulted in significantly increased bacterial burden and reduced phospho-mTOR levels in A. phagocytophilum-infected tick cells. …”
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7644
Differential aging of growth plate cartilage underlies differences in bone length and thus helps determine skeletal proportions.
Published 2018-07-01“…Here, we show evidence that these functional, structural, and molecular senescent changes occur earlier in the growth plates of smaller bones (metacarpals, phalanges) than in the growth plates of larger bones (femurs, tibias) and that this differential aging contributes to the disparities in bone length. …”
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7645
Mechanosensitive Piezo channels in mineralized tissues: emerging roles in osteodental adaptation and disease
Published 2025-07-01“…They detect and respond to mechanical forces via mechanosensitive Piezo channels, modulating physiological and pathological processes. …”
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7646
The emerging roles of platelet-derived extracellular vesicles in disease
Published 2025-12-01“…Their role in cellular signal transduction is examined, and their functional properties are compared with other platelet-derived products such as platelet-rich plasma.Results pEVs show potential as both therapeutic agents and diagnostic biomarkers. …”
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7647
Neural Network Underlying Recovery from Disowned Bodily States Induced by the Rubber Hand Illusion
Published 2016-01-01“…We used functional magnetic resonance imaging to investigate how causal influences between brain regions during the rubber hand illusion (RHI) are modulated by tactile and visual stimuli. …”
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7648
Understanding quality of life in Danish women with metastatic breast cancer undergoing multiple treatments
Published 2025-02-01“…QoL, symptoms, and daily life function were measured using the European Organization for Research and Treatment of Cancer (EORTC) core questionnaire (QLQ-C30) and the breast cancer module (BR45). …”
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7650
Insight on the complete process of photoacoustic generation and propagation of cerebrovascular in brain via multi-physics coupling method
Published 2025-01-01“…This visualization study provides theoretical guidance for the research and application of photoacoustic imaging in brain structural and functional imaging.…”
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7651
Design of Stable Controller for Flexible Solar Panel by H∞ Loop-Shaping Method
Published 2020-01-01“…We adopt H∞ loop-shaping design and put forward a directive method for selecting the weighting function. The simulation results indicate that system bandwidth is optimized based on the stable controller. …”
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Hawking-Page and entanglement phase transition in 2d CFT on curved backgrounds
Published 2024-08-01“…By means of conformal mapping we study the equivalent system on flat space governed by the deformed Hamiltonian, which is a spatial integral of the Hamiltonian density modulated by an enveloping function. Focusing on holographic CFTs, we observe Hawking-Page like phase transition for the thermal and the entanglement entropy as we vary the background metric. …”
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7653
Psychological and Biological Aspects of “Without-Body Bereavement”: Reflections at COVID-19 Pandemic Time
Published 2024-01-01“…Furthermore, some biological and neurological processes that modulate and allow for the mourning process will be synthesized.…”
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Molecular Action of Lenalidomide in Lymphocytes and Hematologic Malignancies
Published 2012-01-01“…Although treatment with lenalidomide has translated into a significant extension in overall survival in MM and MDS and has superior safety and efficacy relative to thalidomide, the mechanism of action as it relates to immune modulation remains elusive. Based on preclinical models and clinical trials, lenalidomide, as well as other structural thalidomide derivatives, enhances the proliferative and functional capacity of T-lymphocytes and amplifies costimulatory signaling pathways that activate effector responses and suppress inflammation. …”
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7655
Analytically Explicit Results for the Distribution of the Number of Customers Served during a Busy Period for Special Cases of the M/G/1 Queue
Published 2019-01-01“…This paper presents analytically explicit results for the distribution of the number of customers served during a busy period for special cases of the M/G/1 queues when initiated with m customers. The functional equation for the Laplace transform of the number of customers served during a busy period is widely known, but several researchers state that, in general, it is not easy to invert it except for some simple cases such as M/M/1 and M/D/1 queues. …”
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7656
Exploring the role of unconventional T cells in rheumatoid arthritis
Published 2025-08-01“…NKT, MAIT, and γδ T cells contribute to the amplification of inflammatory responses and joint tissue destruction through diverse mechanisms, exhibiting unique tissue tropism and functional plasticity. Recently, novel therapeutic strategies have been developed to target these subsets, including modulation of antigen presentation pathways, inhibition of pro-inflammatory signaling cascades, and reprogramming of cellular functionalities. …”
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7657
Optimal allocation of STATCOM for multi-objective ORPD problem on thermal wind solar hydro scheduling using driving training based optimization
Published 2025-06-01“…Appropriate probability density functions (PDF) are employed to estimate the uncertain WP, PV source, HP, and load demand. …”
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Mesenchymal stem cells from perinatal tissues promote diabetic wound healing via PI3K/AKT activation
Published 2025-02-01“…The PEGDA/SA/Col-I hydrogel supports MSC viability and function offering a promising scaffold for DFU treatment. …”
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Naringenin and SMER28 target lysosomal reformation and rescue SPG11 and SPG15 hereditary spastic paraplegia phenotypes
Published 2025-08-01“…Our work indicates that lysosomal reformation is a good strategy for herditary spastic parapegia forms with impaired lysosomal function and identifies naringenin as new modulator of this process, offering further hand to planning phase II clinical trials in SPG11-SPG15 patients.…”
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7660
Does the presence of only specific active sites control the switch of selectivity from C1 to C2+ products in CO2RR?
Published 2025-10-01“…By analysing Faradaic selectivity as a function of applied potential across CuO nanoplate samples with different wettability, we observe a transition from 100 % C2+ selectivity to 100 % C1 selectivity, with the potential threshold for this switch dependent on wettability. …”
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