Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin by Gao Y, Qin G, Liang S, Yin J, Wang B, Jiang H, Liu M, Luo F, Li X

“…The cardioprotective effects of allicin treatment were comprehensively assessed using echocardiography, histopathological examinations, intestinal barrier function, and serum inflammatory factors. The potential mechanisms of allicin were elucidated through analysis of metagenomics and serum metabolomics. …”
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SERBP1 interacts with PARP1 and is present in PARylation-dependent protein complexes regulating splicing, cell division, and ribosome biogenesis by Kira Breunig, Xuifen Lei, Mauro Montalbano, Gabriela DA Guardia, Shiva Ostadrahimi, Victoria Alers, Adam Kosti, Jennifer Chiou, Nicole Klein, Corina Vinarov, Lily Wang, Mujia Li, Weidan Song, W Lee Kraus, David S Libich, Stefano Tiziani, Susan T Weintraub, Pedro AF Galante, Luiz O Penalva

“…Based on these results, we propose a feedback regulatory model in which SERBP1 influences PARP1 function and PARylation, while PARylation modulates SERBP1 functions and participation in regulatory complexes.…”
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Epigenetic Mechanisms of Paternal Stress in Offspring Development and Diseases by Xingyun Xu, Zhigang Miao, Miao Sun, Bo Wan

“…The major biological function of the sperm cell is to transmit the paternal genetic and epigenetic information to the embryo as well as the following offspring. …”
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rOS-Instrumentation: An observer of operating system transactions by Fengshan Shen, Mingyuan Jiu

“…Users only need to reference the module name and call the user interface functions provided by the module to utilize its functionality seamlessly. …”
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ZFHX3 is integral to androgen/AR signaling involving protein association with AR in prostate cancer cells by Xing Fu, Zhiqian Zhang, Rui Chen, Jun A, Na An, Xinxin Tian, Jin-Tang Dong

“…Cell proliferation and colony formation assays were used to evaluate ZFHX3’s impact on AR function. Kaplan-Meier analysis assessed the association of AR/ZFHX3 expression with patient survival. …”
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Preliminary analysis of wind and wave retrieval from Chinese 1mC-SAR image by Yu-Hang Zhou, Meng-Yu Hao, Wei-Zeng Shao, Armando Marino, Xin-Gai Song, Xing-Wei Jiang

“…The wave slop spectrum is inverted from co-polarized image by polarimetric technique, in which the term of wind speed is included in the model transfer function (MTF) of tilt modulation. Significant wave height (SWH) retrievals are compared with the simulations by the third-generation numeric wave model, denoted as WAVEWATCH-III (WW3), showing a 0.53 m RMSE with a 0.36 SI. …”
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Decrease of NAD+ Inhibits the Apoptosis of OLP T Cells via Inducing Mitochondrial Fission by Zhang ZY, Wang F, Zhou G

“…Nicotinamide adenine dinucleotide (NAD+) regulates mitochondrial remodeling and function. This study explored the role of NAD+ in modulating mitochondrial fission and apoptosis in T cells under the OLP immune-inflammatory environment.Patients and Methods: T cells and plasma were isolated from peripheral blood. …”
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POSSIBLE WORLDS FOR FICTION. A RECONSTRUCTIVE APPROACH, WITH A PRACTICAL OUTLOOK INTO IAN MCEWAN’S ATONEMENT, ON CHESIL BEACH AND THE CHILD IN TIME by Adriana Diana URIAN

“…The present paper aims at presenting how the possible world framework can function for fictional worlds. It starts from presenting different perspectives on how fictional universes can be understood. …”
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Impact of Terminalia chebula Retz polysaccharide and Rubia cordifolia L. processed Terminalia chebula Retz polysaccharides on cyclophosphamide-induced immunosuppression in Chinese... by Jing Wang, Tiejin Tong, Qiang Wu, Min He

“…Compared to the model group, 0.5 g/kg RTCP restored spleen morphology and function, elevated cytokines (e.g., IL-2, IFN-γ) and immunoglobulins, and upregulated complement components (C3, C5) and acute-phase proteins, enhancing T-cell and B-cell activation (P<0.05). …”
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Modern approaches to cataract surgery with high visual acuity based on wavefront analysis by O.V. Shilovskikh, Е.М. Titarenko, D.I. Ivanov, A.N. Ul’yanov

“…Higher order aberrations were analyzed using Zernike polynomials (3rd to 5th order). The modulation transfer function (MTF) at different spatial frequencies (0–30 c/deg) and the Strehl coefficient in patients in the study groups were also assessed. …”
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Single-cell mitochondrial morphomics reveals cellular heterogeneity and predicts complex I, III, and ATP synthase Inhibition responses by Ratneswary Sutharsan, Maddi Biaut Hontaas, Yan Li, Hao Xiong, Hartwig Preckel, Carolyn M. Sue, Gautam Wali

“…We applied known mitochondrial function inhibitors - rotenone, antimycin, and oligomycin to inhibit complexes I, III, and V (ATP synthase) function in human induced pluripotent stem cell-derived cortical neurons, a model commonly used in neurodegenerative disease research. …”
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The effect of vitamin D and vitamin A supplementation on T cell levels of patients with pneumosepsis: A double-blind, randomized clinical trial by Abolfazl Jokar, Alireza Sistani, Ghasem Mosayebi, Atefeh Poyandeh

“…Vitamins A and D are crucial for immune function, acting as regulators and cofactors in immune cell development and function. …”
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Research Progress on Aflatoxin Inhibitors and Their Mechanisms of Action by Shaowen WU, Weijie ZHOU, Siyuan YANG, Shijuan YAN

“…Further analysis reveals that inhibitors function through five major mechanisms: (1) Disrupting cell membrane structural integrity and mitochondrial respiratory chain function in A. flavus, destroying fundamental cellular physiological structures. (2) Regulating the expression of key genes in the aflatoxin biosynthesis gene cluster and inhibiting activities of key enzymes such as polyketide synthase and monooxygenases, directly blocking aflatoxin biosynthetic pathway. (3) Modulating intracellular reactive oxygen species levels and antioxidant enzyme systems to maintain redox balance. (4) Inhibiting fungal development and differentiation processes, including key stages such as sclerotia formation, asexual reproduction, and spore germination. (5) Promoting detoxification of produced aflatoxins through physical adsorption, biodegradation, and chemical transformation. …”
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Handgrip strength and risk of cognitive impairment across different glucose metabolism statuses: insights from the CHARLS study by Shiqi Wang, Liangchen Li, Jia Yu, Xianli Sun, Jianqiao Chen

“…However, whether HGS interacts with glucose metabolism status to influence cognitive function remains unclear. This study explores the relationship between HGS and cognitive impairment risk among middle-aged and older Chinese adults and examines the potential modulation of this association by glucose metabolism status.MethodsData from the China Health and Retirement Longitudinal Study (CHARLS) collected in 2011 and 2018 were analyzed, including 7,301 participants aged ≥ 45 years. …”
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Lightweight deep neural network for contour detection and extraction of wheat spikes in complex field environments by Xin Xu, Haiyang Zhang, Jiangchuan Lu, Ziyi Guo, Juanjuan Zhang, Jibo Yue, Hongbo Qiao, Xinming Ma

“…Ablation studies confirm LDSNet-ELA integration reduces false positives by 27.6%, while the enhanced loss function system improves small-object recall by 19.4%. …”
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Endurance exercise attenuates Gαq-RNAi induced hereditary obesity and skeletal muscle dysfunction via improving skeletal muscle Srl/MRCC-I pathway in Drosophila by Xin-yuan Yin, Deng-tai Wen, Han-yu Li, Zhao-qing Gao, YuZe Gao, WeiJia Hao

“…Thus, the present findings suggest that genetic defects in the Gαq gene in adipose and skeletal muscle tissues induce hereditary obesity and skeletal muscle dysfunction, and that endurance exercise attenuates this hereditary obesity and concomitant skeletal muscle dysfunction in drosophila by improving skeletal muscle fiber contractile proteins, mitochondrial function and function, and antioxidant capacity via mediating the Gαq/Mhc, Gαq/Srl/MRCC-I, and Gαq/SOD pathways.…”
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From signaling pathways to clinical trials: mesenchymal stem cells as multimodal regenerative architects in liver cirrhosis therapy by Vida Bozorgi, Mahnaz Babaahmadi, Mohammad Salehi, Jamshid Vafaeimanesh, Ensiyeh Hajizadeh-Saffar

“…The vesicles contain bioactive cargo, including microRNAs and proteins, that regulate immune function, inhibit cell death, and facilitate liver repair. …”
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Investigating the synergistic antioxidant behavior of catechin and copper ion in tea: The mechanism of coordination-activation effect by Guipeng Jia, Tingting Ouyang, Yanyan Wang, Ximing Huang

“…Additionally, density functional theory calculations indicated that complex formation could reduce the HOMO–LUMO energy gap obviously, thereby contributing to enhanced antioxidant capacity. …”
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Cytokine-, Neurotrophin-, and Motor Rehabilitation-Induced Plasticity in Parkinson’s Disease by Gabriella Policastro, Matteo Brunelli, Michele Tinazzi, Cristiano Chiamulera, Dwaine F. Emerich, Giovanna Paolone

“…Here, we provide an overview of preclinical and clinical research detailing the biological role of proinflammatory molecules in PD and how motor rehabilitation can be used to therapeutically modulate neuroinflammation, restore neural plasticity, and improve motor function in PD.…”
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Adipose Tissue-Derived Therapies for Osteoarthritis: Multifaceted Mechanisms and Clinical Prospects by Hanwen Zhang, Oliver Felthaus, Lukas Prantl

“…Adipose tissue-derived therapies, including both cell-based and cell-free products, have shown promising potential in promoting cartilage repair, modulating inflammation, and improving joint function. …”
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