LINC02888 promotes HGSOC progression and immune evasion via PPIB-mediated stabilization of LAPTM5 mRNA and inhibition of RIG-I-like receptor signaling by BingJie Rui, YanFeng Yang, DanBo Geng, ZiTeng Kuang, TianLi Mu, YuXi Liu, Bo Ren, RunZe He, XiaoWei Zhang, YuCi Zhang, Min Wang

“…Methods We identified overexpression of LINC02888 in HGSOC tissues and cell lines through whole-transcriptome sequencing, qPCR, in situ hybridization, and analyses of TCGA/GTEx datasets. Functional assays including CCK-8, EdU, colony formation, wound healing, Transwell migration/invasion, and flow cytometry were performed after modulating LINC02888 expression. …”
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Integrative multiomics analysis reveals the subtypes and key mechanisms of platinum resistance in gastric cancer: identification of KLF9 as a promising therapeutic target by Pengcheng Zhang, Lexin Wang, Haonan Lin, Yihui Han, Jingfang Zhou, Hang Song, Peng Wang, Huanhuan Tan, Yajuan Fu

“…These functional differences in platinum resistance gene models were further explored in GC. …”
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Shen Shuai II Recipe alleviates renal fibrosis in chronic kidney disease by improving of hypoxia and inhibition of TLR4/MyD88/NF-κB/NLRP3 pathway by Yuan Zhou, Liang Zhou, Meng Wang, Lin Xu, Tingting Li, Chen Wang

“…In vivo, renal function was assessed via serum creatinine, urea nitrogen, and creatinine clearance measurements, alongside histopathological evaluation of renal fibrosis and inflammation. …”
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Is L‐Arginine an Appropriate Alternative for Conventional Anti‐Atherosclerotic Therapy?: A Comprehensive Review by Ali Mortezaei, Mohammad Ghorbani, Bardia Hajikarimloo, Omar Sameer, Toba Kazemi, Ebrahim Salavati, Mohsen Hamidpour, Mohammad Esmail Gheydari

“…Results L‐Arg supplementation has shown promising effects on NO production, improving endothelial function and reducing oxidative stress in preclinical models. …”
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<i>Lactobacillus johnsonii</i> N6.2 Phospholipids Induce T Cell Anergy upon Cognate Dendritic Cell Interactions by Alexandra E. Cuaycal, Monica F. Torrez Lamberti, Graciela L. Lorca, Claudio F. Gonzalez

“…We have previously shown that <i>L. johnsonii</i> N6.2 PLs modulate dendritic cell (DC) function towards a regulatory-like phenotype. …”
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GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis by Joseph A Bisson, Miriam Gordillo, Ritu Kumar, Neranjan de Silva, Ellen Yang, Kelly M Banks, Zhong-Dong Shi, Kihyun Lee, Dapeng Yang, Wendy K Chung, Danwei Huangfu, Todd Evans

“…Here, we used cardiac directed differentiation from human embryonic stem cells (hESCs) as a platform to study GATA6 function during early cardiogenesis. GATA6 loss-of-function hESCs had a profound impairment in cardiac progenitor cell (CPC) specification and cardiomyocyte (CM) generation due to early defects during the mesendoderm and lateral mesoderm patterning stages. …”
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Senescent macrophages in cancer: roles in tumor progression and treatment opportunities by Tianzi Wang, Chang Liu, Xuefeng Hu, Ning Yang, Chen Qiu

“…Senescent macrophages have emerged as dynamic cells within the tumor microenvironment that significantly promote tumor progression through complex cellular and molecular functional alterations. This review explores the multifaceted roles of macrophage senescence in cancer, and establishes links between senescent macrophages and tumor progression from multiple perspectives, on the basis of the first comprehensive analysis of the molecular mechanisms and pathways involved. …”
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Bioavailability Computations for Natural Phenolic Derivatives for Druglikeness Assessment by Amalia Stefaniu, Lucia Camelia Pirvu, Lucia Pintilie, Sorin Constantin Godeanu

“…Structural insights from the point of view of drug-like property assessment are also provided by Density Functional Theory (DFT) predictions on the lowest energy conformers, using the B3LYP/6-311G (d,p) method.…”
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Sirtuins: Emergent Players in Tissue and Organ Regeneration by Ayla Kyler Núñez, Claudia Marcela Arenas-Gómez, Belfran Alcides Carbonell Medina

“…Regeneration is the process that restores structural and functional homeostasis at the cellular, tissue, organ, and appendage levels. …”
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Lack of IFN-γ response of human uterine myometrium-derived MSCs significantly improve multiple IBD parameters compared to bone marrow MSCs: Implications for anti-TNFα-refractory pa... by Li-Tzu Wang, Hsiu-Huan Wang, Shih-Sheng Jiang, Chia-Chih Chang, Pei-Ju Hsu, Ko-Jiunn Liu, Huey-Kang Sytwu, B. Linju Yen, Men-Luh Yen

“…Transcriptomic analysis revealed UtMSCs had reduced MHC II pathway activation compared to BMMSCs. Functional validation confirmed UtMSCs compared to BMMSCs expressed lower IFN-γ receptors, prevent MHC II-mediated human unstimulated T cell activation, and modulated stimulated T helper (Th) cells away from effector phenotypes while increasing regulatory T cells (Tregs) and IL-10 levels. …”
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RNA G-quadruplexes control mitochondria-localized mRNA translation and energy metabolism by Leïla Dumas, Sauyeun Shin, Quentin Rigaud, Marie Cargnello, Beatriz Hernández-Suárez, Pauline Herviou, Nathalie Saint-Laurent, Marjorie Leduc, Morgane Le Gall, David Monchaud, Erik Dassi, Anne Cammas, Stefania Millevoi

“…Here, we show that RNA G-quadruplexes (RG4s) regulate mitochondrial function by modulating cytoplasmic mRNA translation of nuclear-encoded mitochondrial proteins. …”
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Protective effects of flavonoid-rich extracts from Hibiscus sabdariffa leaves on streptozotocin-induced testicular damage in rats by Basiru Olaitan Ajiboye, Courage Dele Famusiwa, John Adeolu Falode, Daniel Okwukwe Akojuru, Bamikole Tosin Owolabi, Adedeji A. Adejumo, Babatunji Emmanuel Oyinloye, Olawale Razaq Ajuwon, Oluwatosin Olalekan Ogedengbe, Oluwafemi Adeleke Ojo

“…Results: H. sabdariffa leaf extract was promising for restoring redox balance, normalizing reproductive hormone levels, modulating gene expression, and regulating various biochemical parameters related to testicular function. …”
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CCNY-mediated phosphorylation and TET2-BACH1-driven DNA demethylation activate PRC1 to augment NSCLC progression by Dayu Huang, Xianglin Chu, Chunxiao Wu, Xuan Wang, Mengkun Shi, Xiaofeng Chen, Yubao Lyu, Dapeng Li, Xuyu Gu

“…This study aims to examine the function of PRC1 in non-small cell lung cancer (NSCLC) cells and investigates its regulatory mechanisms. …”
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ROLE OF PREBIOTICS IN CHILDREN’S DIET by A. I. Khavkin, O. N. Komarova

“…Microflora and prebiotics — nutrients which to a great extent maintain the normal function of the immune system play the key role in development and functioning of the immune component of the gastrointestinal tract where almost 2/3 of all immunocompetent cells are concentrated. …”
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Effect of WSSV infection on immunity, intestinal microbial composition and its derived metabolites synthesis in Procambarus clarkii by Xiaochuan Zheng, Jie Yang, Feifan Xu, Qunlan Zhou, Cunxin Sun, Aimin Wang, Jinjuan Wan, Jiajia Li, Bo liu

“…The results suggest that intestinal microorganisms and their specific functional metabolites, acetate and GCDCA, are involved in WSSV infection and immune mobilisation of crayfish. …”
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VTA dopaminergic neurons involved in chronic spared nerve injury pain-induced depressive-like behavior by Ludi Zhang, Menghan Ji, Yufei Sun, Qingwu Wang, Mingyang Jin, Shuling Wang, Hui Sun, Hailin Zhang, Dongyang Huang

“…It has been shown pain and affections have structural and functional circuits to interact with each other, therefore the neuroplastic changes and functional role of VTA dopaminergic neurons within these circuits may serve as potential targets for understanding and therapeutically addressing the development of depressive-like symptoms accompanied by prolonged pain syndromes in humans.…”
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Cannabinoid neuromodulation in the adult early visual cortex. by Ifije E Ohiorhenuan, Ferenc Mechler, Keith P Purpura, Anita M Schmid, Qin Hu, Jonathan D Victor

“…Our findings provide neurophysiologic evidence for a link between cannabinoid-signaling, network dynamics and the function of a canonical cortical circuit.…”
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Postsynaptic adaptations in direct pathway muscarinic M4-receptor signaling follow the temporal and regional pattern of dopaminergic degeneration by Beatriz E. Nielsen, Christopher P. Ford

“…This decrease resulted from reduced postsynaptic M4 receptor function, as ACh release or clearance was unaffected, and could not be rescued by L-DOPA. …”
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Kynu inhibition mitigates bile duct ischemic injury by rewiring tryptophan metabolism to restore tight junction integrity by Guoqing Bao, Siliang Zhang, Zhengchen Ye, Ding Luo, Pinduan Bi, Bin Yang

“…Conclusion Our findings demonstrated that Kynu inhibition alleviates bile duct ischemic injury by reprogramming dysregulated tryptophan metabolism, particularly through XA upregulation. This modulation may restore tight junction function via the GluR2/3/CX50-ZO1 axis, thereby preserving blood-biliary barrier integrity. …”
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Glymphatic inhibition exacerbates tau propagation in an Alzheimer’s disease model by Douglas M. Lopes, Jack A. Wells, Da Ma, Lauren Wallis, Daniel Park, Sophie K. Llewellyn, Zeshan Ahmed, Mark F. Lythgoe, Ian F. Harrison

“…Methods In this study, we investigated the impact of long-term modulation of glymphatic function on tau aggregation and spread by chronically treating a mouse model of tau propagation with a pharmacological inhibitor of AQP4, TGN-020. …”
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