For Precision Animal Husbandry: Precise Detection of Specific Body Parts of Sika Deer Based on Improved YOLO11 by Jinfan Wei, Haotian Gong, Lan Luo, Lingyun Ni, Zhipeng Li, Juanjuan Fan, Tianli Hu, Ye Mu, Yu Sun, He Gong

“…Improvements include: designing a lightweight and efficient hybrid backbone network, MobileNetV4HybridSmall; The multi-scale fast pyramid pooling module (SPPFMscale) is proposed. The WIoU v3 loss function is used to replace the default loss function. …”
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Environmental Enrichment as a Possible Adjunct Therapy in Autism Spectrum Disorder: Insights from Animal and Human Studies on the Implications of Glial Cells by Enrique Hernández-Arteaga, Josué Antonio Camacho-Candia, Roxana Pluma-Romo, María Isabel Solís-Meza, Myriam Nayeli Villafuerte-Vega, Francisco Aguilar-Guevara

“…Studies in rodent models of ASD have demonstrated that EE reduces stereotypical behaviors, improves social interactions, and enhances cognitive function, effects that are closely associated with astrocyte and microglia activity. …”
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Gut microbiota: emerging biomarkers and potential therapeutics for premature ovarian failure by Zongyu Liu, Zongyu Liu, Min Wang, Min Wang, Yuanyuan Lei, Yuanyuan Lei, Kaiqi Xu, Kaiqi Xu, Kaiqi Xu, Limei Fan, Limei Fan

“…Studies have shown that GMs play a pivotal role in female reproductive health, participating in the pathogenesis of reproductive endocrine disorders through direct or indirect involvement in sex hormone regulation, stimulation of inflammatory cytokine production, modulation of immune function, metabolic homeostasis, and regulation of neurotransmitter synthesis. …”
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Metabolic reset purification program improves antioxidant balance and gut microbiome in individuals transitioning to a healthier diet by Chinmayee Panda, Ralph Kruse, Kaya Williams, Brea Nance, Maruti Gudavalli, Shirin Pourafshar, Brandon Metzger, Slavko Komarnytsky, Slavko Komarnytsky

“…These findings highlight the potential of whole food-based supplementation to enhance dietary transitions by reducing oxidative stress, supporting kidney function, alleviating psychological stress, and modulating gut microbiota composition.Clinical trial registrationNCT05877365.…”
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Role of Sialic Acids in Central Nervous System Immune Response by Karolina Narejko, Martyna Niemczuk, Agata Urbaniak, Sylwia Koziej, Piotr Jakub Depta, Adrianna Jasiuk, Mateusz Wiekiera

“…Particularly enriched in the Central Nervous System (CNS), polysialic acids are involved in processes such as synaptogenesis, neuroplasticity, and modulation of neurotransmitter activity. This study explores the biosynthesis, recycling, and functional roles of Sia in the CNS, emphasizing their involvement in immune regulation via SIGLEC receptors and complement system modulation. …”
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A Chimeric Peptide Derived from a Bacterial Effector Protein Attenuates TLR-2/4-Mediated Production of Pro-Inflammatory Cytokines and Enhances the Cellular Availability of Gentamic... by Nandi BR, Patra B, Radhakrishnan GK

“…This dual-functional strategy offers a promising novel approach for treating inflammatory diseases and persistent intracellular infections, warranting further investigation toward clinical applications. …”
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Molecular insights into the relationship between sustained CRP elevation and endothelial dysfunction in axial spondyloarthritis by Clementina López-Medina, Nuria Barbarroja, Alejandro Escudero-Contreras, Chary López-Pedrera, Carlos Perez-Sanchez, Pedro Segui, Eduardo Collantes, Jerusalem Calvo, Lourdes Ladehesa-Pineda, Desiree Ruíz-Vilchez, Laura Cuesta-López, Iván Arias-de la Rosa, Jesús Eduardo Martín-Salazar, Antonio Manuel Barranco, Miriam Ruiz-Ponce, María Ángeles Puche Larrubia, Rafaela Ortega, María Carmen Ábalos-Aguilera, Elena Moreno-Caño, Pedro Ortiz-Buitrago

“…Carotid intima-media thickness (CIMT) and microvascular endothelial function (post-ischaemic reactive hyperaemia) were measured. …”
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Increased dopaminergic neurotransmission results in ethanol dependent sedative behaviors in Caenorhabditis elegans. by Pratima Pandey, Anuradha Singh, Harjot Kaur, Anindya Ghosh-Roy, Kavita Babu

“…Here, we identify the posterior dopaminergic sensory neuron as being essential to modulate this behavior. We further demonstrate that in dop-2 mutants, ethanol exposure increases dopamine secretion and functions in a DVA interneuron dependent manner. …”
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Effect of melatonin on gut microbiome and metabolomics in diabetic cognitive impairment by Ming Gao, Ming Gao, Jie Li, Jie Li, Xu Han, Beiyao Zhang, Jinting Chen, Jiadong Lang, Qiangqiang Zhang

“…Recent evidence has demonstrated that the gut microbiome plays a key role in DCI by modulating cognitive function through the gut–brain crosstalk. …”
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A review on probiotics and dietary bioactives: Insights on metabolic well-being, gut microbiota, and inflammatory responses by Alice Njolke Mafe, Great Iruoghene Edo, Osamah S. Majeed, Tayser Sumer Gaaz, Patrick Othuke Akpoghelie, Endurance Fegor Isoje, Ufuoma Augustina Igbuku, Joseph Oghenewogaga Owheruo, Rapheal Ajiri Opiti, Yasal Garba, Arthur Efeoghene Athan Essaghah, Dina S. Ahmed, Huzaifa Umar

“…It highlights the various types of probiotics in foods, their effects on immune function, and their role in regulating inflammatory response and metabolic well-being. …”
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History of Micrornas: From Gene Controlling Development of Nematodes to a Promising Tool for Molecular Therapy by Dusan Brany

“…Without this regulation, physiological functioning of cells, and thus also of complex organisms, would not be possible. …”
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Neutrophils in Type 1 Diabetes: Untangling the Intricate Web of Pathways and Hypothesis by Laura Nigi, Erika Pedace, Francesco Dotta, Guido Sebastiani

“…Further research into the diverse functional capabilities of neutrophils is crucial for uncovering novel aspects of their involvement in T1D, potentially revealing new therapeutic targets to modulate disease progression.…”
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Anticancer Potential of Prebiotics: Targeting Estrogen Receptors and PI3K/AKT/mTOR in Breast Cancer by Hussein Sabit, Sama Abouelnour, Bassel M. Hassen, Salma Magdy, Ahmed Yasser, Al-Hassan Soliman Wadan, Shaimaa Abdel-Ghany, Faisal Radwan, Amany I. Alqosaibi, Hala Hafiz, Ohaad F. A. Awlya, Borros Arneth

“…Emerging research highlights the role of prebiotics in modulating gut microbiota, which may influence estrogen metabolism, immune function, and therapeutic responses in BC. …”
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Gut Akkermansia enhances liver protection and facilitates copper removal during D-penicillamine treatment in a Wilson’s disease model by Xi Huang, Yanqi Jin, Tianyuan Wang, Danting Fu, Jindi Ma, Xiaopeng Yu, Yingfeng Lu, Jingyuan Song, Yu Chen, Ren Yan, Yimin Zhang

“…The results of gene function prediction analysis indicated that the altered gut microbial function by DPA and Akk is primarily linked to energy generation/utilization, amino acid, fatty acid, lipid, and nucleic acid metabolisms. …”
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A Computational Analysis Based on Automatic Digitization of Movement Tracks Reveals the Altered Diurnal Behavior of the Western Flower Thrips, <i>Frankliniella occidentalis</i>, Su... by Chunlei Xia, Gahyeon Jin, Falguni Khan, Hye-Won Kim, Yong-Hyeok Jang, Nam Jung, Yonggyun Kim, Tae-Soo Chon

“…A prediction of protein–protein interaction suggested its functional association with clock genes. To test this functional link, RNA interference (RNAi) of the PKG gene expression was performed by feeding a gene-specific double-stranded RNA, which led to significant alteration of the two clock genes (<i>Clock</i> and <i>Period</i>) in their expression levels. …”
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Clonorchis sinensis-driven hepatocarcinogenesis via E2F1-CD24 transcriptional axis: mechanistic and therapeutic implications by Wen-Min Lu, Jin Yan, Zhao-Ji Liu, Yong Wu, Qian-Ru Cui, Ji Feng, Yu Chen, Guang-Zhi Zhu, Tao Peng, Jing Zhou, Guo-Dong Lu

“…Multiplatform bioinformatics validation (GEPIA/UALCAN/TIMER) evaluated CD24’s prognostic significance and immune microenvironment modulation. Functional studies (quantitative polymerase chain reaction (qPCR), Western blotting, CCK-8 assays, flow cytometry) examined CsESPs’ effects on CD24 expression, cell proliferation, and apoptosis. …”
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TCF12 enhances angiogenesis and affects sorafenib response in liver cancer via HIF-1α interaction by Yuanbin Chen, Xiaolong Wang, Jin Chen, Min Dai, Xinyue Zhang, Jie Yin, Xiao He

“…Furthermore, survival analysis demonstrated that patients with elevated TCF12 expression had significantly shorter overall survival. Functional assays indicated that TCF12 knockdown suppressed blood vessel formation and reduced endothelial cell permeability. …”
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Expression of the IL-18-related gene PTX3 correlates with clinicopathological features and prognosis in glioma patients by Delin Wang, Cuimei Liu, Bohao Sun, Xiaodong Zhang, Yejun Zhou, Zhonglin Hu, Duanzheng Cao, Jing Zhang, Jinfang Xu

“…A multigene prognostic signature based on IL-18 signaling-related genes (ISRGs) was constructed using the least absolute shrinkage and selection operator (LASSO) Cox regression method. The functional roles of PTX3 were analyzed through Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Set Enrichment Analysis (GSEA). …”
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Integrating single-cell RNA-Seq and bulk RNA-Seq data to explore the key role of fatty acid metabolism in hepatocellular carcinoma by Hua Dai, Xin Tao, Yuansen Shu, Fanrong Liu, Xiaoping Cheng, Xiushen Li, Bairui Shu, Hongcheng Luo, XuXiang Chen, Zhaorui Cheng

“…Further analytical procedures involved functional enrichment analysis, evaluation of immune infiltration, and examination of the mutation landscape.PTGES3 was identified as a pivotal gene associated with lipid metabolism. …”
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VOPP1 as a Novel Susceptibility Gene in Rheumatoid Arthritis: Insights Into Its Mechanisms From Mendelian Randomization and Experimental Validation by Wu W, Cai H, Nan Y, Tang J, Wang Y

“…Synovial tissue samples were collected from patients undergoing joint surgery at the Affiliated Hospital of Nantong University. Functional validation of the candidate gene vesicular overexpressed in cancer pro-survival protein 1 (VOPP1) was performed in vitro using rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs), and in vivo in a collagen-induced arthritis (CIA) rat model. …”
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