The role and prospects of skin microbiota in dermatosis by Yuanyuan Chen, Zhijian Yao, Zhuren Ruan, Gao Wei, Wenjun Zheng, Xianghui Li

“…The composition and distribution of various microorganisms within the skin maintain a dynamic balance, modulating the barrier function and the immune system, thereby constituting the skin microbiota. …”
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Effects of the <i>Agrobacterium rhizogenes rolC</i> Gene Insertion on Secondary Metabolites Profile and In Vitro Biological Activity of <i>Acmella oleracea</i> (L.) R.K. Jansen by Priscilla Paola Bettini, Martina Imbesi, Patrizia Bogani, Valentina Maggini, Filippo Firenzuoli, Fabio Firenzuoli, Domenico Trombetta, Antonella Smeriglio

“…These findings highlight <i>rolC</i>’s role in modulating secondary metabolite synthesis, influencing both the phytochemical composition and functional properties of <i>A. oleracea</i> extracts.…”
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An injectable decellularized extracellular matrix hydrogel with cortical neuron-derived exosomes enhances tissue repair following traumatic spinal cord injury by Gang Wang, Qian Li, Sumei Liu, Mo Li, Baoguo Liu, Tianyao Zhao, Bochao Liu, Zhiguo Chen

“…The Exo-dECM hydrogel also promoted the functional recovery and preservation of urinary tissue in SCI-afflicted rats. …”
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Mesenchymal stromal cells conditioned by peripheral blood mononuclear cells exert enhanced immunomodulation capacities and alleviate a model of Myasthenia Gravis by Alexandra C. Bayer, Natalia Pinzón, Axel You, Cinthia Bergman, Nadine Dragin, Aurélien Corneau, Frédérique Truffault, Danièle Noël, Christophe Martinaud, Rozen Le Panse, Sonia Berrih-Aknin, Jean-Thomas Vilquin

“…Functionally, cMSC induced modulation in PBMC subsets, raising the proportions of lymphocyte populations (CD4 Treg, CD8, B memory), underlining the multimodal effect of conditioning. …”
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Pallidal GABA B receptors: involvement in cortex beta dynamics and thalamic reticular nucleus activity by Nelson Villalobos, Victor Manuel Magdaleno‐Madrigal

“…In this context, two findings are significant: the activity and GABAergic transmission of the GP modulated by GABA B receptors and the presence of the GP-thalamic reticular nucleus (RTn) pathway, the functionality of which is unknown. …”
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Measuring Harmonic Mixer in the Frequency Range from 78.33 to 118.10 GHz by I. A. Zakharov, A. V. Gusinsky, A. V. Saikov, M. M. Kasperovich, D. A. Kondrashov, M. S. Svirid

“…A mathematical model of a measuring harmonic mixer of the millimeter-wave range as a linear device is described. A functional diagram and technical characteristics of a measuring harmonic mixer with a built-in frequency diplexer are given. …”
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Genetic Etiologies for Phenotypic Diversity in Sickle Cell Anemia by Martin H. Steinberg

“…HbF concentration and the presence of a thalassemia are established modulators of the disease, but cannot account for all of its clinical heterogeneity. …”
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Synchronous PWM Regulation of Inverters of Drive Installation with Two Stator Windings of Electrical Motor by Oleschuk V.

“…This goal is achieved by including in the control scheme of the system of functional dependencies linking voltage magnitude on stator windings of motor with the corresponding pole voltages of two inverters controlled by algorithms of synchronous multi-zone pulsewidth modulation (PWM), as well as by including in control scheme of current values of specialized phase shift between control signals of two inverters. …”
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Genetics and clinical implications of SPINK1 in the pancreatitis continuum and pancreatic cancer by Qi-Wen Wang, Wen-Bin Zou, Emmanuelle Masson, Claude Férec, Zhuan Liao, Jian-Min Chen

“…We highlight three variants with well-characterized pathogenic mechanisms: c.-4141G > T, a causative enhancer variant linked to the extensively studied p.Asn34Ser (c.101A > G), which disrupts a PTF1L-binding site within an evolutionarily conserved HNF1A-PTF1L cis-regulatory module; c.194 + 2T > C, a canonical 5′ splice site GT > GC variant that retains 10% of wild-type transcript production; and an Alu insertion in the 3′-untranslated region, which causes complete loss of function by forming extended double-stranded RNA structures with pre-existing Alu elements in deep intronic regions. …”
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Mental and Medical sciences today by David L. Rowland, Ion G. Motofei

“…Many visceral diseases (pancreatitis, liver cirrhosis, etc.) can interfere with brain function and behavior through such modulators (pancreatic/ hepatic encephalopathy), and frequently treatment of the visceral illness can lead to amelioration of accompanying psychological/psychiatric symptoms. …”
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Temperature and WNK-SPAK/OSR1 Kinases Dynamically Regulate Antiviral Human GFP-MxA Biomolecular Condensates in Oral Cancer Cells by Pravin B. Sehgal, Huijuan Yuan, Susan V. DiSenso-Browne

“…Phase-separated membraneless biomolecular condensates in the cytoplasm and nucleus are now recognized to play a major role in modulating diverse functions in mammalian cells, and contribute to cancer pathogenesis through dysregulated function of condensates of transcription factors such as STAT3 and fusion oncoproteins. …”
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Aerobic Exercise Delays Age-Related Sarcopenia in Mice via Alleviating Imbalance in Mitochondrial Quality Control by Danlin Zhu, Lian Wang, Haoyang Gao, Ze Wang, Ke Li, Xiaotong Ma, Linlin Zhao, Weihua Xiao

“…<b>Results:</b> Results showed that aerobic exercise mitigated age-related declines in muscle mass and function, enhanced markers associated with protein synthesis, reduced oxidative stress, and modulated the expression of genes and proteins implicated in mitochondrial quality control. …”
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Quantitative characteristics of gene regulation by small RNA. by Erel Levine, Zhongge Zhang, Thomas Kuhlman, Terence Hwa

“…The mechanisms by which sRNAs modulate expression of its targets are diverse. In common to most is the possibility that interference with the translation of mRNA targets may also alter the abundance of functional sRNAs. …”
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P03 | THE ROLE OF FILAMIN A IN REGULATING BREAST CANCER CELL BEHAVIOR AND TUMOR MICROENVIRONMENT INTERACTIONS

“…However, due to the cell line-specific effects and conflicting reports in the literature, further research is required to clarify the context-dependent functions of FLNa within diverse tumor microenvironments. …”
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Birch pollen allergen-induced dsDNA release activates cGAS-STING signaling and type 2 immune response in mice by Pauline Chenuet, Manon Mellier, Yasmine Messaoud-Nacer, Elodie Culerier, Quentin Marquant, Louis Fauconnier, Nathalie Rouxel, Aurélie Ledru, Stéphanie Rose, Bernhard Ryffel, Lionel Apetoh, Valérie F.J. Quesniaux, Dieudonnée Togbe

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Enhanced rotator cuff tendon-bone interface regeneration with injectable manganese-based mesoporous silica nanoparticle-loaded dual crosslinked hydrogels by Zihang Chen, Youjie Liu, Tianxiang Liang, Zhaoyuan Du, Liming Deng, Zhiwen Wu, Ye Li, Haobo Zhong, JinJin Ma, Riwang Li, Huajun Wang, Qiu Dong, Tao Yu, Xiaofei Zheng

“…IntroductionDuring the healing process, the functional gradient attachment of the rotator cuff (RC) tendon-bone interface fails to regenerate, which severely impedes load transfer and stress dissipation, thereby increasing the risk of retears. …”
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Osteopontin regulates right ventricular failure through integrin ανβ3/PERK/CHOP-dependent inflammatory and apoptotic pathways by Xiaomei Yang, Xiaomei Yang, Xiaomei Yang, Xuyang Wang, Xuyang Wang, Kai Li, Qiming Deng, Yonghao Hou, Yonghao Hou, Yonghao Hou, Guangmin Xi, Kangping Lu, Kangping Lu, Zihua Liu, Yu Bai, Yu Bai, Yu Bai, Jianbo Wu, Jianbo Wu, Jianbo Wu, Jingui Yu, Peng Zhang

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Effect of PHF-1 hyperphosphorylation on the seeding activity of C-terminal Tau fragments by Léa El Hajjar, Emmanuelle Boll, François-Xavier Cantrelle, Clarisse Bridot, Isabelle Landrieu, Caroline Smet-Nocca

“…Unlike the fibril structure, the PTM signature of tau found in neuronal inclusions, more particularly hyperphosphorylation, is variable between individuals with the same tauopathy, giving rise to diverse strains with different seeding properties that could modulate the aggressiveness of tau pathology. Here, we investigate the conformation, function and seeding activity of two tau fragments and their GSK3β-phosphorylated variants. …”
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PDCNet: A Polarimetric Data-Enhanced Contrastive Learning Network for PolSAR Land Cover Classification by Bo Ren, Chaoyue Hua, Biao Hou, Jian Lv, Chen Yang, Licheng Jiao, Jocelyn Chanussot

“…Thirdly, a loss function is designed to effectively compute the real and complex high-level semantics of the T- and C-matrix's features separately. …”
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Therapeutic Potential of Melatonin: Multifaceted Applications in Muscle Health, Metabolic Disorders and Cardiovascular Disease by Martyna Dydyk, Jakub Wójcik, Ewa Błaszczak, Piotr Malinowski, Urszula Kopczyńska, Cezary Kopczyński, Kinga Gurdak, Martyna Michalska, Aleksander Małachowski, Aleksandra Zając

“…In cardiovascular health, melatonin has shown promise in preventing and managing heart failure by reducing oxidative damage, modulating inflammatory pathways, and supporting endothelial function, which collectively contribute to improved cardiac health and reduced disease progression. …”
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