Summary of research advances on the correlation between chronic kidney disease and gastrointestinal microbiome by Chen Li-hua, Zhang Mei-ling, Zhong Hong-bin, Huang Ji-yi

“…The incidence of chronic kidney disease（CKD）in China has remained elevated and it shows an annually rising trend.However,no radical cure is not currently available.Exploring the risk factors of CKD is a research focus of nephrology.It is generally accepted that the change of intestinal flora was correlated with the development of CKD.And micro-ecological balance of gut might impact upon human health.However,owing to an impairment of intestinal function barrier and an alteration of intestinal flora,an accumulation of gut derived toxin gradually induced a continuous deterioration of CKD.This review was intended to describe the relativity between CKD and intestinal flora and explore the possibility of modulating intestinal flora as a new therapeutic target for CKD.…”
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基于虚拟样机技术的机械液控式软启动系统设计与仿真 by 任红霞, 关玉明, 庞思红, 刘金龙

“…In order to relieve the damage to the equipment and the attack to the electricity net, when the heavy-duty transport machine is starting suddenly, we initially designed the structure which is composed by the planetary gear and clutch installed which can turning the freedom from 2 to 1 step by step by controlling the increment of the fluid viscous force between clutch discs, so that the output axis will be loaded flexibly which the help of the tri-dimension flat-form UG, the digital prototyping of the flexible load-applying system is established, and with the help of the kinetic analysis module, the dynamic simulation and the finite element analysis of the soft starting system will be made, which can ensure the exact function of the physical prototyping.…”
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Faster-than-Nyquist transmission based on multi-layer superposition by Shuang-yang LI, Lei PING, Bao-ming BAI, Xiao MA

“…Faster-than-Nyquist (FTN) signaling technique has received much attention recently as an effective way of enhancing the spectral efficiency.In order to reduce the detection complexity for FTN signals,a multi-layer superposition transmission approach was present.In addition,how to calculate upper bounds on the highest information transmission rate was shown and how to choose suitable component codes was suggested.Numerical results show that the system with different code rates and power on each layer outperforms the system with only power variance on each layer,meanwhile results also imply that given the roll-off factor of the pulse shaping function is not zero,the proposed system is superior to the orthogonal system with a higher modulation format.…”
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A Senomorphlytic Three‐Drug Combination Discovered in Salsola collina for Delaying Aging Phenotypes and Extending Healthspan by Jiqun Wang, Wenwen Liu, Yunyuan Huang, Guangwei Wang, Xiaobo Guo, Donglei Shi, Tianyue Sun, Chaojiang Xiao, Chao Zhang, Bei Jiang, Yuan Guo, Jian Li

“…Notably, JM10101 exhibits a more sophisticated senomorphlytic role encompassing both senomorphic and senolytic functions than JM10001 in the modulation of senescent cells, offering a promising strategy for the discovery of combination drugs in the rational development of anti‐aging therapies.…”
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Image Quality Predictor with Highly Efficient Fully Convolutional Neural Network by Cao Yu-Dong, Liao Xin-Lin, Liu Hai-Yan

“…The parameters of the shared layers and the quality module are optimized firstly, and then, the parameters of the weight module are optimized with the designed loss function. …”
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Study affects Pulse Parameters versus cavity length for both Dispersion Regimes in FM mode locked. by Baghdad Science Journal

“…To demonstrate the effect of changing cavity length for FM mode locked on pulse parameters and make comparison for both dispersion regime , a plot for each pulse parameter as Lr function are presented for normal and anomalous dispersion regimes . …”
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The Role of the Gut Microbiota in Heart Failure: Pathophysiological Insights and Future Perspectives by Francisco Epelde

“…Dysbiosis, characterized by alterations in microbial composition and function, has been linked to systemic inflammation, metabolic disturbances, and impaired cardiovascular homeostasis. …”
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Targeting the gut microbiota-bile acid axis: Therapeutic strategies for cholestatic liver disease and metabolic dysfunction-associated steatotic liver disease by Xingtao Zhao, Ruolan Li, Ruiqi Sun, Qiong Pan, Hongyan Lu, Jin Chai

“…Finally, we summarize and discuss mainly nanoparticle-based therapeutic strategies for modulating BA metabolism and the composition and function of the gut microbiota. …”
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Decoding metastatic microenvironments through single-cell omics reveals new insights into niche dynamics and tumor evolution. by Fengshuo Liu, Xiang H-F Zhang

“…Recent advances in single-cell technologies have provided unprecedented insights into metastatic niche formation, evolution and function, including how primary tumors precondition distant organs for metastases and how disseminated tumor cells dynamically interact with host cells to modulate their environments. …”
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The battle between rotavirus and its host for control of the interferon signaling pathway. by Michelle M Arnold, Adrish Sen, Harry B Greenberg, John T Patton

“…Some of the mechanisms viruses use to interfere with antiviral responses in the infected cell include preventing detection of viral components, perturbing the function of transcription factors that initiate antiviral responses, and inhibiting downstream signal transduction. …”
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Stator Electrically-excited Brushless Synchronous Machine and Its Inductance Calculation by JIA Guanglong, CHEN Zhichu, HU Yongfeng, LI Weiye

“…Based on winding function and superposition method, inductance parameter calculation model of the SEBSM was set up, the inductance parameters of the SEBSM prototype with 8+4 poles were calculated, and the error between the calculated and tested inductances is within ±2.5%, which justified the correctness of the inductance calculation model.…”
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PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation by Zaikuan Zhang, Yajun Xie, Qiying Yi, Jianing Liu, Lin Yang, Runzhi Wang, Jing Cai, Xinyi Li, Xiaosong Feng, Shixiang Yao, Zheng Pan, Magdalena Paolino, Qin Zhou

“…These insights refine our understanding of the mechanisms regulating tight junctions and offer potential therapeutic targets for enhancing epithelial barrier function and treating related diseases.…”
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FGFR4 p.Gly388Arg polymorphism in PBMCs of LAM patients: findings of a pilot study by Sinem Koc-Gunel, Sinem Koc-Gunel, Amy L. Ryan, Melanie Winter, Thomas O. F. Wagner, Thomas O. F. Wagner

“…The FGFR4 p.Gly388Arg gain-of-function polymorphism was identified in four patients, with allelic frequencies ranging from 49 to 99%. …”
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Interplay of hypoxia, immune dysregulation, and metabolic stress in pathophysiology of type 1 diabetes by Rahul Mittal, Rahul Mittal, Joana R. N. Lemos, Joana R. N. Lemos, Prem Chapagain, Prem Chapagain, Khemraj Hirani, Khemraj Hirani

“…Furthermore, we highlight the potential of therapeutic strategies that target hypoxia and its downstream effects to preserve β-cell function and modulate autoimmunity. Collaborative efforts across disciplines will be crucial to translating these insights into clinical innovations that improve outcomes for individuals with T1D.…”
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Sternal interferential current stimulation after sternotomy: A randomized, sham-controlled trial on pain and wound healing by Nils Schulz, Gian Vo, Pascal van Wijnen, Tim Wilhelmi, Michael Coch, Uwe Lange, Philipp Klemm

“…A greater reduction in tumor necrosis factor alpha and interleukin 6 levels was observed. Pulmonary function and quality of life improved in both groups without significant between-group differences. …”
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Impacts of Plu kaow (<i>Houttuynia cordata</i> Thunb.) Ethanolic Extract on Diabetes and Dyslipidemia in STZ Induced Diabetic Rats: Phytochemical Profiling, Cheminformatics Analyse... by Shaikh Shahinur Rahman, Anuwatchakij Klamrak, Napapuch Nopkuesuk, Jaran Nabnueangsap, Piyapon Janpan, Kiattawee Choowongkomon, Jureerut Daduang, Sakda Daduang

“…Based on metabolomic profiling data, the PK was found to contain various putative antidiabetic agents such as kaempferol 7-neohesperidoside, isochlorogenic acid C, rutin, datiscin, and diosmin and they have been proposed to significantly (<i>p</i> < 0.001) reduce blood glucose levels and modulated hyperlipidemia. PK also improved the tested liver, kidney, and heart function biomarkers and reversed damage to normal pancreatic, liver, kidney, and heart cells in histological analysis. …”
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Terahertz radiation affects the dynamics of neurons by decreasing membrane area ratio by Shaoqing Ma, Siyu Li, Huan Wang, Yingwei Li, Chengbiao Lu, Xiaoli Li

“…Terahertz radiation at specific frequencies and energies can mediate cellular morphology or function changes by exciting nonlinear resonance effects in proteins or DNA. …”
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Control of T-cell immunity by fatty acid metabolism by Jaemin Kim, Yoosun Lee, Yeonseok Chung

“…Fatty acids play critical roles in maintaining the cellular functions of T cells and regulating T-cell immunity. …”
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基于PolyMAX法的齿轮箱试验模态分析 by 王佳, 潘宏侠, 杨晓波

“…Based on the method of PolyMAX,a system of modal analysis is built,the model of JZQ-250 gear-box is set up under the LMS modal analysis module.The relating modal datum are obtained by hammering test of single-input multi-output analysis method,then the transfer function is established after the analysis of modal datum.The various modal parameters of the gearbox are obtained by order selection and fitting of the datum which extracted through the method of PolyMAX Modal Parameter Identification.Through the comparison with calculating modal,the validity and reliability are proved.The theoritical basis for the improvement of the gear box structure characteristics and the fault diagnosis of gearbox are provided.The natural frequency is extracted from the modal analysis,the wavelet decomposition of the corresponding frequency band component is removed,and the noise reduction processing on the fault signal is achieved.…”
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Obesity-associated digestive cancers: A review of mechanisms and interventions by Jiachen Zheng, Ming Zhao, Jiahui Li, Guoying Lou, Yanyan Yuan, Shizhong Bu, Yang Xi

“…Evidence that these factors often function interdependently rather than independently in carcinogenesis is presented. …”
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