PGC-1α-Dependent Mitochondrial Adaptation Is Necessary to Sustain IL-2-Induced Activities in Human NK Cells by Dante Miranda, Claudia Jara, Jorge Ibañez, Viviana Ahumada, Claudio Acuña-Castillo, Adrian Martin, Alexandra Córdova, Margarita Montoya

“…Among various cytokines modulating NK cell function, interleukin-2 (IL-2) can induce a more potent cytotoxic activity defined as lymphokine activated killer activity (LAK). …”
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Intelligent analysis of the quality of educational content on statistics of student performance in the learning management system "Scorina" by A. G. Savenko

“…A mathematical model of educational process of learning management system "Scorina", and approach to assessing the knowledge of students are presented.The implementation of functional diagram and the algorithm of the module for the intelligent analysis of the quality of educational content of learning management system "Scorina" is proposed. …”
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Drug discovery and mechanism prediction with explainable graph neural networks by Conghao Wang, Gaurav Asok Kumar, Jagath C. Rajapakse

“…We demonstrate that XGDP not only enhances the prediction accuracy compared to pioneering works but is also capable of capturing the salient functional groups of drugs and interactions with significant genes of cancer cells.…”
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Recent progress in miRNA biogenesis and decay by Xavier Bofill-De Ros, Ulf Andersson Vang Ørom

“…MicroRNAs are processed through a series of steps starting from transcription and primary processing in the nucleus to precursor processing and mature function in the cytoplasm. It is also in the cytoplasm where levels of mature microRNAs can be modulated through decay mechanisms. …”
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Recent advances in the management of brachial plexus injuries by Prem Singh Bhandari, Sanjay Maurya

“…With currently available microsurgical techniques, functional gains are rewarding in upper plexus injuries. …”
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Probiotic Potential of Fermented Foods and Their Effects on Immune System by İlkin Yücel Şengün, Damla Güney

“…In recent years, probiotics have been used in foods in order to produce functional foods that have the potential to improve gastrointestinal health. …”
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PD-1 is expressed in cytotoxic granules of NK cells and rapidly mobilized to the cell membrane following recognition of tumor cells by Cecilia Pesini, Sandra Hidalgo, Maykel A. Arias, Llipsy Santiago, Carlota Calvo, Maitane Ocariz-Díez, Dolores Isla, Pilar M. Lanuza, M José Agustín, Eva M Galvez, Ariel Ramírez-Labrada, Julián Pardo

“…The contribution of the T cell-related inhibitory checkpoint PD-1 to the regulation of NK cell activity is still not clear with contradictory results concerning its expression and role in the modulation of NK cell cytotoxicity. We provide novel key findings on the mechanism involved in the regulation of PD-1 expression on NK cell membrane and its functional consequences for the elimination of cancer cells. …”
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Different Brain Connectivity between Responders and Nonresponders to Dual-Mode Noninvasive Brain Stimulation over Bilateral Primary Motor Cortices in Stroke Patients by Jungsoo Lee, Ahee Lee, Heegoo Kim, Mina Shin, Sang Moon Yun, Youngjin Jung, Won Hyuk Chang, Yun-Hee Kim

“…Participants were classified into responders and nonresponders based on the functional improvement of the affected upper extremity after applying NBS. …”
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The neutrophil protein CD177 is a novel PDPN receptor that regulates human cancer-associated fibroblast physiology. by Jillian L Astarita, Shilpa Keerthivasan, Bushra Husain, Yasin Şenbabaoğlu, Erik Verschueren, Sarah Gierke, Victoria C Pham, Sean M Peterson, Cecile Chalouni, Andrew A Pierce, Jennie R Lill, Lino C Gonzalez, Nadia Martinez-Martin, Shannon J Turley

“…In sum, starting from the unbiased elucidation of the PDPN co-receptome, our work provides insights into PDPN functions and reveals the PDPN/CD177 axis as a possible modulator of fibroblast physiology in the tumor microenvironment.…”
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Exercise and the organ-brain axis: Regulation of neurological disorders by emerging exerkines by Yan Dai, Xiaoke Dou, Bingqing Nie, Yan Sun, Pu Chen, Cuiying Fu, Xinyi Zhang, Yangqi Chu, Qianhao Gao, Yangyang Ge, Yun Lin

“…This concept posits that during brain disorders, functional alterations in peripheral organs such as skeletal muscle, heart, liver, adipose tissue, and spleen can disrupt metabolic and immune homeostasis, thereby bidirectionally modulating brain function via signaling molecules and metabolites. …”
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Random Undersampled Digital Elevation Model Super-Resolution Based on Terrain Feature-Aware Deep Learning Network by Ziqiang Huo, Meng Xi, Jingyi He, Zhengjian Li, Jiabao Wen

“…The network integrates a deep residual module, a deformable convolution module, and an upsampling module, which are used to extract deep terrain features, extract adaptive terrain features, and improve the resolution of DEM data, respectively. …”
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Gastrodin Mitigates Ketamine-Induced Inhibition of F-Actin Remodeling and Cell Migration by Regulating the Rho Signaling Pathway by Ping-Cheng Shih, I-Shiang Tzeng, Yi-Chyan Chen, Mao-Liang Chen

“…<b>Background/Objects</b>: Rho signaling plays a role in calcium-regulated cytoskeletal reorganization and cell movement, processes linked to neuronal function and cancer metastasis. <i>Gastrodia elata</i>, a traditional herbal medicine, can regulate glutamate-induced calcium influx in PC12 cells and influence cell function by modulating neuronal cytoskeleton remodeling via the monoaminergic system and Rho signaling. …”
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Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'. by Aine Brigette Henley, Ling Yang, Kun-Lin Chuang, Meliz Sahuri-Arisoylu, Li-Hong Wu, S W Annie Bligh, Jimmy David Bell

“…One of their mechanisms of actions is to modulate mitochondrial function through increasing oxidative stress. …”
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Ancestral sequence reconstruction as a tool for structural analysis of modular polyketide synthases by Taichi Chisuga, Shota Takinami, Zengwei Liao, Masayuki Karasawa, Naruhiko Adachi, Masato Kawasaki, Toshio Moriya, Toshiya Senda, Tohru Terada, Fumitaka Kudo, Tadashi Eguchi, Shogo Nakano, Sohei Ito, Akimasa Miyanaga

“…After confirming that KSQAncAT chimeric didomain retains similar enzymatic function to the native KSQAT didomain, we successfully determine a high-resolution crystal structure of the KSQAncAT chimeric didomain and cryo-EM structures of the KSQ–ACP complex. …”
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Conventional and complementary alternative medicine therapies for renal anemia: a literature review by Ching-Ming Lu, Ching-Ming Lu, Yuan-Hsuan Hsu, Yuan-Hsuan Hsu, I-Hsin Lin, Ko-Lin Kuo, Jian-Fu Liao, Hui-Fen Huang, Hui-Fen Huang, Ping-Hsun Lu, Ping-Hsun Lu

“…Inadequate erythropoietin (EPO) production, worsened kidney function, leads to symptoms such as low energy, fatigue, and impaired physical function, significantly affecting patients’ quality of life. …”
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Effect of Mn on the structural, energetic, electronic and elastic properties of ordered L10 FePt Alloy by Lethole Ndanduleni, Sibila Terrence

“…Ab initio calculations based on the density functional theory (DFT) formalism were employed using the CATEP module within the Materials Studio program. …”
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Crystal Structure and Catalytic Mechanism of CouO, a Versatile C-Methyltransferase from Streptomyces rishiriensis. by Tea Pavkov-Keller, Kerstin Steiner, Mario Faber, Martin Tengg, Helmut Schwab, Mandana Gruber-Khadjawi, Karl Gruber

“…Through molecular docking calculations, site-directed mutagenesis and the comparison with homologous enzymes we identified His120 and Arg121 as key functional residues for the enzymatic activity of this group of C-methyltransferases. …”
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Design of public space guide system based on augmented reality technology by Pu Jiao, Limin Ran

“…This demonstrates the advantage of using a scale-invariant feature transformation operator to capture scene space influence and provide a more accurate spatial model reference for augmented reality technology. This enhances the functional design of the guide system.…”
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Cross-modal representation of chewing food in posterior parietal and visual cortex. by Tomohiro Ishii, Noriyuki Narita, Sunao Iwaki, Kazunobu Kamiya, Michiharu Shimosaka, Hidenori Yamaguchi, Takeshi Uchida, Ikuo Kantake, Koh Shibutani

“…This study was conducted to clarify the relationship of chewing food cross-modal perception with cortex activities based on examinations of the posterior parietal cortex (PPC) and visual cortex during chewing in comparison with sham chewing without food, imaginary chewing, and rest using functional near-infrared spectroscopy. Additionally, the effects of a deafferent tongue dorsum on PPC/visual cortex activities during chewing performance were examined. …”
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Evidence for a push-pull interaction between superior colliculi in monocular dynamic vision mode by Rita Gil, Mafalda Valente, Francisca F. Fernandes, Noam Shemesh

“…However, the associated pathway-wide mechanisms remain poorly understood, especially in terms of corticotectal and tectotectal feedback upon encoding the continuity illusion during the dynamic vision mode. Here, we harness functional MRI combined with rat brain lesions to investigate whole-pathway neural interactions in the dynamic vision mode. …”
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