Rearrangement of the liver ubiquitome and NEDDylome in metabolic dysfunction-associated steatotic liver disease by Teresa C. Delgado, Benoît Lectez, Marina Serrano-Maciá, Fernando Lopitz-Otsoa, Leire Uraga-Gracianteparaluceta, Ibon Martínez-Arranz, Jesús M. Arizmendi, Kerman Aloria, Mikel Azkargorta, Félix Elortza, James D. Sutherland, Rosa Barrio, Ugo Mayor, María Luz Martínez-Chantar

“…These PTMs enable rapid adaptation to environmental challenges by modulating protein stability and function. Using transgenic biotinylated ubiquitin and biotinylated NEDD8 mice, we profiled the hepatic ubiquitome and NEDDylome in a diet-induced MASLD model. …”
Get full text

Pancreatic islet β-cell subtypes are derived from biochemically-distinct and nutritionally-regulated islet progenitors by Monica E. Brown, Verda E. Miranda, Simone Nevills, Ruiying Hu, Prasanna K. Dadi, Alan J. Simmons, Yanwen Xu, Yilin Yang, Mahircan Yagan, Sadia Najam, Leesa L. Sampson, Mark A. Magnuson, David A. Jacobson, Ken S. Lau, Emily Hodges, Guoqiang Gu

“…Abstract Endocrine islet β cells comprise heterogenous subtypes with different gene expression and function levels. Here we study when/how this heterogeneity is induced and how long each subtype maintains its characteristic properties. …”
Get full text

Concept for an Electromechanical Connection and Steering Joint for a Small Off-Road Electric Vehicle by Tomáš Gajdošík, Igor Gajdáč, Rudolf Madaj, Matúš Vereš

“…A prototype was built and tested under real-world conditions, assessing functional reliability, ease of integration, and operational performance. …”
Get full text

Three-Phase Phase-Shifting Transformer with Regulation in Neutral Point by Kalinin L.P., Zaitsev D.A., Tirshu M., Golub I.V., Moraru L.

“…In paper the installation functional scheme description, as well main relations which determine currents and voltages character in scheme elements during regulation process are given. …”
Get full text

Non-lethal sonodynamic therapy mitigates hypertensive renal fibrosis through the PI3K/AKT/mTORC1-autophagy pathway by DanDan Liu, Hui Wang, Jialong Li, Siqi Sheng, Shu Wang, Ye Tian

“…Here, we present Non-lethal Sonodynamic Therapy (NL-SDT), in which ultrasound is used to activate locally sonosensitizers, thereby stimulating the production of reactive oxygen species for the purpose of modulating cell function or fate, as a novel methodology to inhibit progression of hypertensive renal fibrosis. …”
Get full text

Vitamin D and susceptibility to infectious diseases: no cure for the common cold by Chris M. Florkowski

“…Vitamin D influences innate immunity through up-regulation of antimicrobial peptides and adaptive immunity through modulation of both T-lymphocyte and B-lymphocyte function. …”
Get full text

Immunomodulatory actions of tonifying polysaccharides: pharmacological effects, mechanisms and therapeutic applications by Jin-Yu Li, Chang Yi, Meng-Qin Zhu, Yan-Feng Yuan, Guang Chen, Ning-Ning Qiu, Lei Shen, Li-Ya Song, Wen-Long Liu, Wen-Long Liu, Wen-Long Liu, Xi-Li Zhang, Xi-Li Zhang

“…Investigations have highlighted the significant impact of polysaccharides derived from Chinese medicinal herbs on the modulation of immune responses, significantly enhancing the functionality of immune organs such as the spleen, thymus, bone marrow, and intestines, stimulating immune cell proliferation and activation of T and B lymphocytes, macrophages, natural killer cells, and dendritic cells, and regulating the secretion and release of immune factors, thereby enhancing overall immune function. …”
Get full text

Estimation of Parameters of Finite Mixture of Rayleigh Distribution by the Expectation-Maximization Algorithm by Noor Mohammed, Fadhaa Ali

“…This paper aims to infer model parameters by the expectation-maximization (EM) algorithm through the maximum likelihood function. The technique is applied to simulated data by following several scenarios. …”
Get full text

Soluble CD52 mediates immune suppression by human seminal fluid by Leonard C. Harrison, Leonard C. Harrison, Natalie L. Stone, Natalie L. Stone, Esther Bandala-Sanchez, Esther Bandala-Sanchez, Nicholas D. Huntington, Nicholas D. Huntington, Robert I. McLachlan, Jai Rautela, Jai Rautela, Moira K. O’Bryan

“…These findings elucidate a critical function of seminal fluid to suppress cellular immunity and facilitate reproduction.…”
Get full text

Updates on Inflammatory Molecular Pathways Mediated by ADAM17 in Autoimmunity by Margherita Sisto, Sabrina Lisi

“…ADAM17 is a member of the disintegrin and metalloproteinase (ADAM) family of transmembrane proteases with immunoregulatory activity in multiple signaling pathways. The functional ADAM17 is involved in the shedding of the ectodomain characterizing many substrates belonging to growth factors, cytokines, receptors, and adhesion molecules. …”
Get full text

Plataforma para la determinación de reactancias de eje directo transitoria y subtransitoria de máquinas síncronas by Emerson Joal Ortiz-Castillo, Luis David Pabón-Fernández, Edison Caicedo-Peñaranda, Jorge Luis Díaz-Rodríguez, Aldo Pardo-García

“…The control diagrams, design and implementation of the work module are shown, in addition to the algorithms and functional tests performed on the prototype.…”
Get full text

Protein lysine acetylation regulates oral microorganisms by Yuanchao Yang, Yuanchao Yang, Hailun He, Bingshi Liu, Bingshi Liu, Zhuoyue Li, Zhuoyue Li, Jiaman Sun, Jiaman Sun, Zhili Zhao, Yan Yang, Yan Yang

“…Post-translational modifications (PTMs) are integral to the regulation of protein function, stability, and cellular processes. Lysine acetylation, a widespread PTM, has been extensively characterized for its role in eukaryotic cellular functions, particularly in metabolism, gene expression, and disease progression. …”
Get full text

Immunomodulatory Effects Mediated by Serotonin by Rodrigo Arreola, Enrique Becerril-Villanueva, Carlos Cruz-Fuentes, Marco Antonio Velasco-Velázquez, María Eugenia Garcés-Alvarez, Gabriela Hurtado-Alvarado, Saray Quintero-Fabian, Lenin Pavón

“…Thus, pharmacological regulation of the serotonergic system may modulate immune function and provide therapeutic alternatives for these diseases.…”
Get full text

Ginsenoside Rb1 attenuates coronary microvascular inflammatory injury via NDUFS4-SIRT5-DUSP1-mediated mitochondrial quality control in a murine ischemia-reperfusion model by Xiangyi Pu, Jinfeng Liu, Yanli Wang, Xuanke Guan, Qiaomin Wu, Qin Zhang, Ruxiu Liu, Xing Chang

“…Conclusions: Ginsenoside Rb1 regulates the NDUFS4-SIRT5-DUSP1 axis, modulating the mitochondrial quality control network, inhibiting the inflammatory cascade response, and improved myocardial function.…”
Get full text

The Impact of Physical Activity on the Course of Inflammatory Bowel Diseases by Adam Grzebinoga, Julia Szlążek, Michalina Zagalska, Marta Turek, Adam Jan Ząbek, Jakub Paweł Kuźniar, Emilia Gabriela Chrzanowska, Barbara Roguska, Tomasz Tamborski

“…Moderate, regular exercise has been shown to beneficially influence gut microbial diversity, promote the production of anti-inflammatory metabolites, and support mucosal barrier function. Additionally, PA modulates systemic and intestinal immune responses, potentially reducing pro-inflammatory cytokine activity. …”
Get full text

Studies on Mechanical and Dielectric Properties of L-Phenylalanine Benzoic Acid Single Crystal for NLO Applications by S. Suresh, P. Mand, K. Anand

“…The dielectric response of the sample is studied as a function of different frequencies and different temperatures. …”
Get full text

Astrocyte priming enhances microglial Aβ clearance and is compromised by APOE4 by Se-In Lee, Jichang Yu, Hyein Lee, Buyun Kim, Min Jun Jang, Hyeonbin Jo, Na Yeon Kim, Malk Eun Pak, Jae Kwang Kim, Sukhee Cho, Hong-Hee Won, Min Soo Kim, Fan Gao, Younghoon Go, Jinsoo Seo

“…Our findings identify astrocytic immune memory as a modulator of microglial function and Aβ pathology, providing insights into how early protective responses in AD may be disrupted by genetic risk factors.…”
Get full text

Improved Clinical Outcomes With Elexacaftor/Tezacaftor/Ivacaftor in Patients With Cystic Fibrosis and Advanced Lung Disease: Real‐World Evidence From an Italian Single‐Center Study... by Nicola Perrotta, Luigi Angelo Fiorito, Gianfranco Casini, Rossella Gentile, Roberta Vescovo, Alfonso Piciocchi, Roberta Lobello, Carlo Cappelli, Roberto Poscia, Giuseppe Cimino

“…ABSTRACT The combination of Elexacaftor/Tezacaftor/Ivacaftor (ETI) has resulted in a significant improvement in lung function and global clinical parameters, which have not been previously achieved with other CFTR modulators. …”
Get full text

A novel stemness-related lncRNA signature predicts prognosis, immune infiltration and drug sensitivity of clear cell renal cell carcinoma by Jia Liu, Lin Yao, Yong Yang, Jinchao Ma, Ruijian You, Ziyi Yu, Peng Du

“…SRlncRNAs and stemness-related mRNAs (SRmRNAs) in ccRCC were identified through weighted correlation network analysis (WGCNA), which employed sophisticated statistical methodologies to identify interconnected modules of related genes. Enrichment analysis was performed to explore the potential functions of SRmRNAs. …”
Get full text

Building Emotional Awareness and Mental Health (BEAM): study protocol for a hybrid implementation-effectiveness trial of the BEAM app-based program for parents with clinical mental... by Kaeley M. Simpson, Robert J. W. McHardy, J. Grace Zhou, Sydney Levasseur-Puhach, Cynthia M. Côté, Millie Braun, Fiona Clement, Anna L. MacKinnon, Nathan Nickel, Tracie O. Afifi, Gerald F. Giesbrecht, Ryan Giuliano, Laurence Y. Katz, Lauren E. Kelly, Terry P. Klassen, Catherine Lebel, Aislin Mushquash, Kristin Reynolds, Elizabeth Decaire, Wajihah Mughal, Frances Chartrand, Olena Kloss, Jennifer M. Hensel, James M. Bolton, Jo Ann M. Unger, Mandy Archibald, Philip Fisher, Ashley Pharazyn, Lianne Tomfohr-Madsen, Leslie E. Roos

“…Discussion The BEAM program offers a promising solution to address elevated parental mental health symptoms, parenting stress, and related child functioning concerns. The present implementation trial aims to extend the groundwork established by an open pilot trial and RCT of the BEAM program, in a next step of testing BEAM’s readiness for nationwide scaling. …”
Get full text