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7461
KANDiff: Kolmogorov–Arnold Network and Diffusion Model-Based Network for Hyperspectral and Multispectral Image Fusion
Published 2025-01-01“…It helps the model understand the complex relationships between the modalities by replacing the fixed activation function in the traditional MLP with a learnable activation function. …”
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7462
Dose-dependent therapeutic effects of gum acacia on kidney and metabolic dysfunction in adenine-induced chronic kidney disease in rats: involvement of antioxidant pathways
Published 2025-06-01“…Results AD treatment led to significant reductions in body weight, increased relative kidney weight, and disrupted kidney and liver function markers, including elevated urea, creatinine, ALT, GGT, and glucose levels. …”
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7463
Iron–Immune Crosstalk at the Maternal–Fetal Interface: Emerging Mechanisms in the Pathogenesis of Preeclampsia
Published 2025-07-01“…We outline their origin, distribution, and polarization in pregnancy, and emphasize their aberrant phenotype and function in PE. The bidirectional crosstalk between iron and macrophages is also dissected: iron shapes macrophage polarization and function, while macrophages reciprocally modulate iron homeostasis. …”
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7464
Involvement of hypoxia-inducible factor1-alpha in the protective effect of rivaroxaban against testicular ischemia-reperfusion in rats
Published 2025-07-01“…The higher dose significantly improved hormonal function (486.8% increase in testosterone), reduced oxidative stress (51.8% reduction in MDA), modulated apoptotic markers (68.3% decrease in BAX, 159.1% increase in BCL2), and normalized angiogenic factors (71.8% reduction in HIF-1). …”
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7465
The Effect of Low-Level Laser Therapy on the Expression of 3β-HSD and StAR Genes in the Ovaries of NMRI Mice
Published 2025-08-01“…Low-level laser therapy (LLLT), by modulating cellular activity and increasing the expression of genes involved in steroidogenesis, has the potential to improve ovarian function. …”
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7466
Dynamics of quality of life of head and neck cancer patients after treatment. Clinical significance
Published 2019-01-01“…Changes in general health, emotional function, pain, insomnia, pain in the head and neck, taste and smell disorders, mouth opening, sticky saliva, dry mouth, painkillers and weight gain were found to have some clinical relevance. …”
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7467
A Lightweight Network for UAV Multi-Scale Feature Fusion-Based Object Detection
Published 2025-03-01“…Furthermore, the Focal-EIoU loss function supersedes the traditional CIoU loss function to address challenges related to the regression of small targets. …”
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7468
Acute Hypobaric and Hypoxic Preconditioning Reduces Myocardial Ischemia-Reperfusion Injury in Rats
Published 2021-01-01“…After each exposure, 30 min of myocardial ischemia was followed by 60 min of reperfusion. Cardiac function and infarct size were determined after reperfusion. …”
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7469
Sexual Dysfunction with Antidepressants: A Clinical Review
Published 2023-06-01“…This happens because sex steroids and the various neurotransmitters modulate both sexual function and mood. The mechanism by which psychotropic medications affect the sexual cycle is through the interaction between medications and the various above-mentioned neurotransmitters. …”
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7470
Leucine-Rich Repeat Kinase 1 Signaling Targets Proteins Critical for Endosome/Lysosome Sorting and Trafficking in Osteoclasts
Published 2025-03-01“…Our results indicate that LRRK1 signaling regulates osteoclast function via modulating VPS35 and CFL1 phosphorylation critical for endosome/lysosome trafficking and dynamic cytoskeleton arrangement in osteoclasts.…”
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7471
Regulation of Neuroimmune Microenvironment by PLA/GO/Anti-TNF-α Composite to Enhance Neurological Repair After Spinal Cord Injury
Published 2025-04-01“…In the SCI model, PLA+GO+Ab treatment enhanced motor function recovery, reduced spinal cord damage, and promoted axonal regeneration and oligodendrocyte maturation. …”
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7472
Research on Buckwheat Weed Recognition in Multispectral UAV Images Based on MSU-Net
Published 2025-07-01“…The neuron death caused by the original ReLU activation function may lead to misidentification, so it was replaced by the Swish function to improve the adaptability to complex inputs. …”
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7473
Translational research from bioinformatics to animal studies: Exploring gene expression and muscle health in COPD through selenium nanoparticles and exercise
Published 2024-06-01“…Recent studies highlight the role of molecular pathways, such as oxidative stress response and mitochondrial function, in COPD. This study explores the role of the PGC-1α gene, a key regulator of mitochondrial biogenesis and energy metabolism, using a rat model and bioinformatics analysis of human lung tissue samples. …”
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7474
An Investigation of Infrared Small Target Detection by Using the SPT–YOLO Technique
Published 2025-01-01“…Finally, the cross-entropy loss function in the original network model is replaced by an adaptive threshold focal loss function, forcing the model to allocate more attention to target features. …”
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7475
Rhein alleviates hepatic steatosis in NAFLD mice by activating the AMPK/ACC/SREBP1 pathway to enhance lipid metabolism
Published 2025-07-01“…Serum lipid profiles, liver function biomarkers, and inflammatory cytokine levels were measured. …”
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7476
MIR22HG Aggravates Oxygen-Glucose Deprivation and Reoxygenation-Induced Cardiomyocyte Injury through the miR-9-3p/SH2B3 Axis
Published 2022-01-01“…Experiments including CCK-8, flow cytometry, TUNEL, HE staining, RT-qPCR, western blotting, and luciferase reporter assays were performed to explore the function and potential mechanism of MIR22HG in MIRI in vitro and in vivo. …”
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7477
Clinical Potential of Misshapen/NIKs-Related Kinase (MINK) 1—A Many-Sided Element of Cell Physiology and Pathology
Published 2024-12-01“…Moreover, MINK1 plays an important role in the nervous system and the cardiovascular system development and function. The modulation of MINK1 activity could influence the course of neurodegenerative diseases, including Alzheimer’s disease. …”
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7478
Detection of underground personnel safety helmet wearing based on improved YOLOv8n
Published 2024-09-01“…The CIoU loss function was replaced with the WIoU loss function to improve the model's localization capability for detection targets. …”
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7479
Coordination of Neutrophil and Apoptosis-Inducing Ligand in Inflammatory Diseases
Published 2025-03-01“…Hanyu Xue,1,* Ran Xie,2,* Zhiwei Wang,3,* Wenqian Fan,4 Yinxiang Wei,5 Lijie Zhang,5 Dan Zhao,5 Zhiming Song6,7 1The First Affiliated Hospital of Henan University, School of Medicine, Henan University, Kaifeng, 475004, People’s Republic of China; 2School of Medical Technology, Shangqiu Medical College, Shangqiu, 476000, People’s Republic of China; 3Department of Oncology, The First Affiliated Hospital of Henan University, Kaifeng, 475000, People’s Republic of China; 4School of Medicine, Henan University, Kaifeng, 475004, People’s Republic of China; 5Joint National Laboratory for Antibody Drug Engineering, the First Affiliated Hospital, Henan University, Kaifeng, 475004, People’s Republic of China; 6Department of Cardiology, the First Affiliated Hospital, Henan University, Kaifeng, 475004, People’s Republic of China; 7Kaifeng Key Laboratory for Modulation and Rehabilitation of Cardiac Function, The First Affiliated Hospital, Henan University, Kaifeng, 475004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dan Zhao, Joint National Laboratory for Antibody Drug Engineering, the First Affiliated Hospital of Henan University, Kaifeng, People’s Republic of China, Email zhaodan2022@henu.edu.cn Zhiming Song, Department of Cardiology, The First Affiliated Hospital, Henan University, Kaifeng, 475004, People’s Republic of China, Email songzhim@vip.henu.edu.cnAbstract: As the most abundant innate immune cells, neutrophils play a key role in host’s anti-infective activity and tissue damage/repair process of sterile inflammation. …”
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7480
Histone deacetylases: the critical enzymes for microglial activation involved in neuropathic pain
Published 2025-03-01“…Furthermore, emerging evidence has shown that the expression and/or activities of different histone deacetylases (HDACs) can modulate microglial function and neuropathic pain. …”
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