Cancer-associated fibroblast-derived COL17A1 promotes gemcitabine resistance and tumorigenesis in pancreatic cancer cells by interacting with ACTN4 by Rongyu Shi, Ning Zhang, Han Li, Hu Zhong, Chengcheng Zhong, Wei Du, Xi Yang

“…Functional analyses were conducted using MTT, 5-ethynyl-2ʹ-deoxyuridine, transwell, and sphere formation assays, respectively. …”
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CPT1A/HIF-1α positive feedback loop induced fatty acid oxidation metabolic pathway contributes to the L-ascorbic acid-driven angiogenesis in breast cancer by Xiao Ma, Baojian Zhang, Xuezhe Yin, ShiPeng Yang, Zhenhua Lin, Yang Yang, Xianchun Zhou

“…Methods First, cell functional assays and animal models were employed to elucidate the pro-carcinogenic effects of CPT1A on BC and its role in metabolic alterations. …”
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Cattle welfare assessment based on adaptive fuzzy logic and multimodal data fusion by Lei Tong, Lei Tong, Lei Tong, Jiandong Fang, Jiandong Fang, Jiandong Fang, Xiuling Wang, Xiuling Wang, Xiuling Wang, Yudong Zhao, Yudong Zhao

“…This framework uses a Gaussian membership function to replace the traditional triangular membership function for feature mapping, significantly improving the robustness and accuracy of the evaluation system through a differentiated weight allocation strategy. …”
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Targeted Inhibition of GATA-3 by Pyrrothiogatain: Implications for Adipocyte Biology and Inflammatory Response by Shamma Almuraikhy, Maha Alser, Khaled Naja, Aisha Al-Malki, Nayef A. Mazloum, Mohamed A. Elrayess

“…GATA-3 is a master regulator of preadipocyte differentiation and function. Pharmacological or genetic targeting of GATA-3 will allow us to understand the function of GATA-3 in regulating metabolism, insulin signaling, and inflammation. …”
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Regulation of microtubule nucleation in glioblastoma cells by ARF GTPase-activating proteins GIT1 and GIT2 and protein kinase C by Vadym Sulimenko, Eduarda Dráberová, Vladimíra Sládková, Tetyana Sulimenko, Věra Vosecká, Omar Skalli, Pavel Dráber

“…To further investigate their role in microtubule modulation, we examined the function of GITs in microtubule nucleation and the involvement of protein kinase C (PKC) in this process. …”
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Correlation Between Degree Of Autonomic Nervous System Impairment And Quality Of Life Indices In Older Adults by Flávio Henrique Borin, Michele Lima Gregório, Micael Borin Martins, Moacir Fernandes de Godoy

“…This indicates the importance of a healthy lifestyle for healthy aging, which includes improvement in autonomic function and, consequently, quality of life.…”
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SSDFusion: A Semantic Segmentation Driven Framework for Infrared and Visible Image Fusion by Qishen Lv, Rui Yang, Chengmin Zhang, Shuaihui Liu, Xinyan Fan, Zihao Luo

“…The ablation study further demonstrates that the local global feature fusion module, the adaptive fusion loss function, and the integration of semantic segmentation and image fusion have significant effects on improving the model performance. …”
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Inter-phantom variability in digital mammography: implications for quality control by Gisella Gennaro, Gilberto Contento, Andrea Ballaminut, Francesca Caumo

“…Images were analyzed using automated software to extract 64 IQ metrics, including contrast-to-noise ratio (CNR) as well as modulation transfer function (MTF)-related and other metrics. …”
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Advances in astrocytes in aneurysmal subarachnoid haemorrhage by Jiahui Liu, Kun Sun, Qiushi Chen, Lianshu Ding

“…We also summarise the evidence of therapeutic approaches to modulate astrocyte function after aSAH complications, and provide some new clues for future translational therapies to mitigate injury after aSAH.…”
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Lactate and lactylation in liver diseases: energy metabolism, inflammatory immunity and tumor microenvironment by Shiyi Cheng, Xiaoyu Xiao, Dingye Wang, Xiyuan Wang, Minlan Yang

“…Lactylation is a novel lactate-dependent post-translational modification that plays a role in tumor proliferation, the regulation of immune cell function, and the modulation of gene expression. In this paper, we summarize the roles of lactate and lactylation in energy metabolism, inflammatory immunity, and the tumor microenvironment, while also elucidating recent research advancements regarding lactate and lactylation in the context of hepatic fibrosis, non-alcoholic fatty liver disease, and hepatocellular carcinoma. …”
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An integrated microbiome- and metabolome-genome-wide association study reveals the role of heritable ruminal microbial carbohydrate metabolism in lactation performance in Holstein... by Chenguang Zhang, Huifeng Liu, Xingwei Jiang, Zhihong Zhang, Xinfeng Hou, Yue Wang, Dangdang Wang, Zongjun Li, Yangchun Cao, Shengru Wu, Sharon A. Huws, Junhu Yao

“…Abstract Background Despite the growing number of studies investigating the connection between host genetics and the rumen microbiota, there remains a dearth of systematic research exploring the composition, function, and metabolic traits of highly heritable rumen microbiota influenced by host genetics. …”
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Effect of Spatial Variations in Floodplain Vegetation on Bed Shear Stress Distribution by REN Chun-ping, YANG Fan, ZHANG Yuan-yuan, WANG Hong-fei

“…This function was introduced to quantitatively characterize the influence of vegetation. …”
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Signal Transduction Pathways Involved in Acupuncture-Mediated Inhibition of Synovitis in Knee Osteoarthritis: A Comprehensive Review by Cao Q, Li Y

“…Acupuncture, a cornerstone of traditional Chinese medicine, has demonstrated clinical efficacy in alleviating pain, attenuating synovial pathology, and restoring joint function in KOA. In this review, we systematically elucidate the molecular mechanisms by which acupuncture suppresses synovial inflammation, focusing on its multimodal modulation of five critical signaling cascades: norepinephrine (NE) signaling, the TLRs/NF‑κB pathway, the MCP1/CCR2 axis, the NLRP3 inflammasome, and the Ras‑Raf‑MEK1/2‑ERK1/2 pathway. …”
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Titanium Ions Promote Exogenous Calcium-Dependent Calcium Influx in Activated Jurkat T Cells: A Possible Mechanism to Explain Its Immunostimulatory Properties by Jing Chen, Qiuying Li, Zhenhua Pang, Ming Gong, Li Tang

“…Calcium signaling has been confirmed to be involved in regulation of lymphocyte immune function. Therefore, we hypothesize that Ti(IV) ions modulated T cell function through the change of intracellular calcium concentrations. …”
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Nitrogen and water additions with or without mowing altered soil microbial community characteristics in a semi-arid steppe by Hao Liu, Feirong Ren, Shiqiang Wan, Shijie Han, Junqiang Zheng

“…Conclusions Overall, N, water addition, and clipping individually and/or interactively, in distinct degrees, altered soil microbial interaction, community structure, and the potential function in a semi-arid steppe. These findings enhance our understanding of soil microbial community assembly and provide a scientific basis for managing temperate grasslands, particularly in the context of global change's impact on ecosystem function and stability.…”
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Evaluating the efficacy of Internet-Based Exercise programme Aimed at Treating knee Osteoarthritis (iBEAT-OA) in the community: a study protocol for a randomised controlled trial by Abhishek Abhishek, Sameer Akram Gohir, Paul Greenhaff, Ana M. Valdes

“…This study aims to explore the benefits of iBEAT-OA (Internet-Based Exercise programme Aimed at Treating knee Osteoarthritis) in modulating pain, function and other health-related outcomes in individuals with knee OA.Methods and analysis A randomised controlled trial was designed to evaluate the efficacy of a web-based exercise programme in a population with knee OA compared with standard community care provided by general practitioners (GPs) in the UK. …”
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Optogenetic approaches for neural tissue regeneration: A review of basic optogenetic principles and target cells for therapy by Davletshin Eldar, Sufianov Albert, Ageeva Tatyana, Sufianova Galina, Rizvanov Albert, Mukhamedshina Yana

“…Evidence has shown that optogenetic modulation can enhance motor axon regeneration, achieve complete sensory reinnervation, and accelerate the recovery of neuromuscular function. …”
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Osteoimmunology: an interdisciplinary approach to studying the relationships between immune and bone cells by V. S. Shirinsky, I. V. Shirinsky

“…In addition, RANK/RANKL/ OPG system modulates maturation and activity of various T and B cell subsets. …”
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Insulin-Enhanced Biological Visual Rehabilitation in Neuroretinal Degeneration Patients Treated with Mesenchymal Cell-Derived Secretome by Paolo Giuseppe Limoli, Celeste Limoli, Marcella Nebbioso

“…<b>Objectives:</b> Insulin plays a crucial role in neuronal survival and oxidative stress modulation, making it a potential therapeutic target. …”
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Targeting Toll-like receptor 4 and microbiota dysregulation: a new frontier in nonalcoholic fatty liver disease management by K.B. Kvit

“…Microbiome-targeted therapy proved effective in reducing TLR4-driven inflammation, improving metabolic and liver function, and normalizing dysbiotic microbial profiles, supporting the use of microbiota-focused interventions in NAFLD management.…”
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