Adaptive trial for the treatment of depressive symptoms associated with concussion using accelerated intermittent theta burst stimulation (ADEPT): rationale, design and methods by Lindsay M. Oberman, Adriana I. Penafiel, Rachel Dieterich, Cuong T. Phan, Yi-Yu Chou, Dzung L. Pham, Maheen M. Adamson, Maheen M. Adamson, Christopher E. Hines, Zeynab Rezaee, Zhi-De Deng, Hemant Pal, Sarah H. Lisanby, Sarah H. Lisanby, David L. Brody, David L. Brody

“…The mechanism of action of aiTBS is thought to be via the modulation of functional networks. Herein we outline the design of a multisite, double-blind, randomized, sham-controlled trial of aiTBS for the treatment of depressive symptoms in SMs and veterans with a history of concussion. …”
Get full text

Case Report: Effect of transcutaneous auricular vagus nerve stimulation on acute pain after external fixation for bilateral open tibiofibular fractures by Qi Li, Donglin Zhao, Shuyang Zhang, Xinyu Du, Ning Ding, Zheng Xing, Xiaolei Chu, Weiguo Xu

“…This case suggests that taVNS may effectively alleviate acute postoperative pain by modulating autonomic function. Dynamic HRV monitoring provided objective evidence of pain-autonomic nervous system interactions, supporting taVNS as a complementary strategy for postoperative pain management. …”
Get full text

Deep Learning Extraction of Tidal Creeks in the Yellow River Delta Using GF-2 Imagery by Bojie Chen, Qianran Zhang, Na Yang, Xiukun Wang, Xiaobo Zhang, Yilan Chen, Shengli Wang

“…Including dice coefficients in the focal loss function improves the model’s gradient and tackles class imbalance within the dataset. …”
Get full text

Airborne Constant Ground Resolution Imaging Optical System Design by Zhiqiang Yang, Shizhen Gao, Qianxi Chen, Bohan Wu, Qiang Xu, Lei Gong, Lihong Yang

“…The designed optical system achieves near-diffraction-limited modulation transfer function (MTF) performance across the full field of view, with all dispersion spots consistently confined within the Airy disk at every viewing angle. …”
Get full text

Estimation Model of Corn Leaf Area Index Based on Improved CNN by Chengkai Yang, Jingkai Lei, Zhihao Liu, Shufeng Xiong, Lei Xi, Jian Wang, Hongbo Qiao, Lei Shi

“…The model structure was adjusted to enable the integration of growth-stage information, and the loss function was improved to accelerate the convergence speed of the network model. …”
Get full text

SFDA-MEF: An Unsupervised Spacecraft Feature Deformable Alignment Network for Multi-Exposure Image Fusion by Qianwen Xiong, Xiaoyuan Ren, Huanyu Yin, Libing Jiang, Canyu Wang, Zhuang Wang

“…We introduce a deformable convolution in the feature deformable alignment module and construct an alignment loss function to preserve its shape with minimal distortion. …”
Get full text

The role of cannabinoid agonists and antagonists on folliculogenesis and evolutionary events in the mouse ovary by Vida Mirzaie, Touba Eslaminejad, Fatemeh Sheikhbahaei, Shayan Vafaei, Fatemeh Nabipour, Mina Behzadi, Seyyed Noureddin Nematollahi-Mahani

“…This system is crucial in regulating folliculogenesis, fertility, and reproductive function. This study investigated the potential effects of cannabinoid agonists and antagonists on ovarian health and function in female mice.Materials and Methods: 80 NMRI mice were divided into 10 groups. …”
Get full text

Oriented SAR Ship Detection Based on Edge Deformable Convolution and Point Set Representation by Tianyue Guan, Sheng Chang, Yunkai Deng, Fengli Xue, Chunle Wang, Xiaoxue Jia

“…On this basis, a multi-directional ship detection module utilizing radial basis function (RBF) point set representation is developed. …”
Get full text

CircN4bp1 Facilitates Sepsis-Induced Acute Respiratory Distress Syndrome through Mediating Macrophage Polarization via the miR-138-5p/EZH2 Axis by Dongyang Zhao, Chunxue Wang, Xiandong Liu, Na Liu, Shougang Zhuang, Qianqian Zhang, Xiaowei Bao, Shumin Xu, Xiaohui Zhou, Qinshu Meng, Shao Li, Lunxian Tang

“…Therefore, circN4bp1 can function as a miR-138-5p sponge for the modulation of macrophage polarization through regulation the expression of EZH2 and may serve as a potential target and/or prognostic marker for ARDS patients following sepsis.…”
Get full text

直线共轭齿轮泵的基本参数优化设计 by 徐学忠, 宋天麟

“…The design parameter and formulation for calculating dimension in internal gear pump with straight line conjugated curve profile are discussed at first.Then a mathematic model for optimization of the design parameter of this pump,which takes the minimum fluctuation of flow and maximum flow per cubage of the pump as objective function,and contact ratio,pressure angle,profile overlapping and etc as constraint condition.By comparison the optimized design parameter of the two examples with others of this type of pump,the result is satisfactory and the result can be utilized in design same module and same number teeth.it gives a theory foundation for design of the pump.…”
Get full text

Random Vibration Analysis of RV Reducer based on ANSYS Workbench by Songcheng Xie, Rongsong Yang, Qinghua Zhou

“…The natural frequency of RV reducer is solved by ANSYS Workbench， and then the power spectral density （PSD） function is derived according to the probabilistic statistical analysis technology. …”
Get full text

Glucose metabolism and endometrium decidualization by Yunfei Huang, Yunfei Huang, Qinling Zhu, Qinling Zhu, Yun Sun, Yun Sun

“…In this review, we describe the functions and regulation of glucose transporters (GLUTs) involved in glucose uptake, as well as the modulation of key enzymes catalyzing glucose utilization. …”
Get full text

FOXK2 in skeletal muscle development: a new pathogenic gene for congenital myopathy with ptosis by Peixuan Wu, Nan Song, Yang Xiang, Zhe Tao, Bing Mao, Ruochen Guo, Xin Wang, Dan Wu, Zhenzhen Zhang, Xin Chen, Duan Ma, Tianyu Zhang, Bingtao Hao, Jing Ma

“…Preliminary omics analysis suggested FOXK2 directly regulates the expression of mitochondrial function-related genes by modulating chromatin accessibility at its binding sites. …”
Get full text

Targeting mitochondria with natural polyphenols for treating Neurodegenerative Diseases: a comprehensive scoping review from oxidative stress perspective by Yueyue Guan, Lei Li, Rui Yang, Yun Lu, Jun Tang

“…Investigating the mitochondrial targeting capacity of polyphenols, their role in functional regulation, and their ability to modulate oxidative stress, along with exploring novel technologies and strategies for modifying polyphenol compounds and their formulations, holds promise for providing new avenues for the treatment of neurodegenerative diseases.…”
Get full text

Lipid-Metabolism-Related Gene Signature Predicts Prognosis and Immune Microenvironment Alterations in Endometrial Cancer by Zhangxin Wu, Yufei Nie, Deshui Kong, Lixiang Xue, Tianhui He, Kuaile Zhang, Jie Zhang, Chunliang Shang, Hongyan Guo

“…A prognostic risk model was established using univariate Cox analysis, least absolute shrinkage and selection operator (LASSO) regression, and multivariate Cox regression, and its clinical utility was assessed through nomogram construction. Functional enrichment analysis was performed to explore the biological pathways involved. …”
Get full text

<i>Aframomum melegueta</i> Seed Extract’s Effects on Anxiety, Stress, Mood, and Sleep: A Randomized, Double-Blind, Pilot Clinical Trial by Rubén Pérez-Machín, Tanausú Vega-Morales, Carlos Elvira-Aranda, Loreto Lledó-Rico, María José Gomis-Gomis, Laura López-Ríos

“…Additionally, receptor functional assays and enzyme inhibition assays were conducted to test the extract’s functional activity on the non-canonical endocannabinoid receptor (TRPV1) and the cannabinoid fatty-acid amide hydrolase enzyme (FAAH), respectively. …”
Get full text

LIPUS Responsive Dopamine-Modified PVDF Piezoelectric Nanofiber Membrane for Full-Thickness Skin Wound Healing by Zhang Z, Liu L, Wang H, Xie W, Zhai W, Wen L, Zhang B, Liu K, Zhang X, Liu S, Huang L, Li D, Zhou Y

“…The healing process was documented with photographs, and functional skin regeneration was evaluated through histological analysis.Results: The DA/PVDF nanomembranes had an average diameter of 732 ± 232 nm and generated a voltage of 450 mV under LIPUS stimulation, a 1.28-fold increase compared to PVDF membranes alone. …”
Get full text

In vitro characterization of amino acid digestibility and fermentative properties of a specific hydrolyzed yeast, and its in vivo effects on growth performance and fecal microbiota... by Fernando Bravo de Laguna, Caroline S. Achard, Lysiane Dunière, Lysiane Dunière, Elsa Parmentier, Katia Helmja, Bruno Bertaud, Pierre Lebreton, David Saornil, Eric Chevaux, Mathieu Castex, Emmanuelle Apper

“…Weaning is a stressful event that is often accompanied by anorexia, risk of diarrhea, and development of intestinal disorders, making it crucial to provide highly digestible and palatable diets. Novel functional protein sources are being developed to be included in diets fed to weanling pigs. …”
Get full text

Investigation of the Anti-Lung Cancer Mechanisms of <i>Taraxacum officinale</i> Based on Network Pharmacology and Multidimensional Experimental Validation by Jianing Liu, Hailing Yang, Ran Liu, Dongjin Sun, Yongbao Liu, Jing Lu, Jinbiao Liu, Junrui Lu

“…The PPI network highlighted 16 core targets, notably TP53, CASP3 and EGFR. Functional enrichment analysis suggested that dandelion might exert its anticancer effects by modulating the tumor microenvironment through the regulation of these critical targets. …”
Get full text

Comprehensive analysis of glycometabolism-related genes reveals PLOD2 as a prognostic biomarker and therapeutic target in gastric cancer by Wanchun Ye, Xiaolei Zhang, Zhongjie Tang, Yufeng Hu, Yuanliang Zheng, Yuping Yuan

“…Among these, PLOD2 emerged as the most significant gene, exhibiting strong associations with tumor progression and poor survival. Functional analyses revealed that PLOD2 promotes glycolysis and tumor progression through activation of the PI3K/AKT/mTOR pathway. …”
Get full text