Transcriptome analysis of insecticide resistance mechanisms in field populations of the bean flower thrips, Megalurothrips usitatus (Bagnall) by Hongyi Cao, Jiangjiang Yuan, Yanran Wan, Yingxi Tang, Xiaobin Zheng, Jing Wang, Kanghua Qian, Jiuming Feng, Sirui Chen, Youjun Zhang, Qingjun Wu

“…RNA sequencing (RNA-seq) and weighted gene co-expression network analysis (WGCNA) techniques validated key gene functions. Results showed that the XW population was resistant to five insecticides, with resistance ratios ranging from 7.17 to 42.90 compared to the reference population. …”
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20 years of the Montreal Cystic Fibrosis Related Diabetes Screening Cohort: key insights by Laure Alexandre-Heymann, Valérie Boudreau, Dylan Lim, Danna Cepeda, Heather Girouard, Annick Lavoie, François Tremblay, Rémi Rabasa-Lhoret, Adèle Coriati

“…Results Findings from the MCFC contributed to a better understanding of cystic fibrosis-related diabetes pathophysiology (in particular, the joint roles of reduced insulin secretion and added insulin resistance) and its relationship with lung function. Over the years, we observed a shift towards overweight and obesity among cystic fibrosis patients, along with improved lung function. …”
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Potential Role of CREM in Diabetes‐Associated Testicular Dysfunction: Current Evidence and Future Perspectives by Olabimpe Caroline Badejogbin, Oyedayo Phillips Akano, Oluwafisayo Elizabeth Boluwatife Julius, Mary Olaoluwa Agunloye, Makinde Vincent Olubiyi, Ojichukwuka Ebere Chijioke‐Agu, Matthew Agene Obekpa, Adesina Paul Arikawe, Kehinde Samuel Olaniyi

“…Testiculopathy disrupts spermatogenesis and the sperm microenvironment, with the cyclic adenosine monophosphate (cAMP) response element modulator (CREM) playing a pivotal role in testicular function. …”
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Chronic stress in adulthood results in microvascular dysfunction and subsequent depressive-like behavior by Xiaochen Zhang, Yaru Wang, Song Xue, Li Gong, Jinglan Yan, Yuanjia Zheng, Xiaoyun Yang, Yujing Fan, Kuizhang Han, Yongjun Chen, Lin Yao

“…In conclusion, this study unveils the pivotal role of microvascular dysfunction in the onset of depression induced by chronic stress in adulthood and proposes that modulating microvascular function may serve as a potential intervention in the treatment of depression.…”
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Therapeutic Potential of Kelp Fucoidan in Rebiosis of Gut Microflora and Immune Homeostasis in Cyclophosphamide-Induced Immunosuppressed Mice by Yaqing Liu, Ruining Kang, Yanfei Zhao, Heng Zhang, Qingfeng Rong, Shaoxuan Yu, Yaoguang Chang, Zhengpeng Wei, Lanlan Zhu

“…This research demonstrates that kelp fucoidan enhances immune function in immunosuppressed mice by modulating gut microbiota balance and promoting short-chain fatty acid production.…”
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EDT-Net: A Lightweight Tunnel Water Leakage Detection Network Based on LiDAR Point Clouds Intensity Images by Zhenyu Liu, Xianjun Gao, Yuanwei Yang, Lei Xu, Shaoning Wang, Ningsheng Chen, Zhiwei Wang, Yuan Kou

“…Moreover, we developed a dynamic threshold adaptive loss function that automatically adjusts the loss function based on leakage detection performance to enhance the model's ability to detect challenging targets. …”
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Disruption of Lrpprc affects B cell development and proliferation in a mouse model of Leigh Syndrome French Canadian type by Adrien Fois, Sonia Deschênes, Capucine Bourel, Claudine Beauchamp, Félix Lombard-Vadnais, Matthieu Ruiz, Guy Charron, Lise Coderre, LSFC Consortium, John D. Rioux, Sylvie Lesage

“…Mitochondrial respiration modulates cellular metabolic activity, which impacts many cell processes, including the differentiation and function of immune cells. …”
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On Control Synthesis of Hydraulic Servomechanisms in Flight Controls Applications by Ioan Ursu, Daniela Enciu, Adrian Toader

“…This function is odd, and it is therefore located in quadrants 1 and 3. …”
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GABA, Glx, and GSH in the cerebellum: their role in motor performance and learning across age groups by Shanti Van Malderen, Shanti Van Malderen, Shanti Van Malderen, Melina Hehl, Melina Hehl, Melina Hehl, Melina Hehl, Stefanie Verstraelen, Robbe Breugelmans, Georg Oeltzschner, Stephan P. Swinnen, Stephan P. Swinnen, Koen Cuypers, Koen Cuypers, Koen Cuypers

“…IntroductionThe cerebellum is essential for motor control and learning, relying on structural and functional integrity. Age-related atrophy leads to Purkinje cell loss, but subtle neurochemical changes in GABA, Glx (glutamate + glutamine), and glutathione (GSH) may precede degeneration and contribute to motor decline.Methods25 younger (YA) and 25 older adults (OA) were included in this study. …”
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Genetic polymorphism of immunogenic signaling system by V. N. Tzygan, A. M. Ivanov, T. A. Kamilova, E. A. Коjuhova, N. N. Мurashkin, N. V. Tsygan

“…The functional studies underline the importance of maintaining structural integrity of the innate immune components of intracellular signaling. …”
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Identification and characterization of CmPP2C31 playing a positive role in the abiotic stress resistance of Chinese chestnut via an integrated strategy by Xuan Wang, Xuan Wang, Wenli Shang, Wenli Shang, Mingyuan Li, Fei Cao, Fei Cao, Dongsheng Wang, Meng Wang, Yi Lu, Haie Zhang, Fei Shen, Jing Liu

“…However, the characteristics and functions of PP2C genes in C. mollissima remain unknown. …”
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Integrator complex subunit 12 knockout overcomes a transcriptional block to HIV latency reversal by Carley N Gray, Manickam Ashokkumar, Derek H Janssens, Jennifer L Kirchherr, Brigitte Allard, Emily Hsieh, Terry L Hafer, Nancie M Archin, Edward P Browne, Michael Emerman

“…We performed a CRISPR screen in conjunction with AZD5582 & I-BET151 and identified a member of the Integrator complex as a target to improve this LRA combination, specifically Integrator complex subunit 12 (INTS12). Integrator functions as a genome-wide attenuator of transcription that acts on elongation through its RNA cleavage and phosphatase modules. …”
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Nucleocytoplasmic Shuttling of Cytoskeletal Proteins: Molecular Mechanism and Biological Significance by Masahiro Kumeta, Shige H. Yoshimura, James Hejna, Kunio Takeyasu

“…The resulting accumulation or depletion of the nuclear populations thereby enhances or attenuates their nuclear functions. We propose that such molecular dynamics constitute a form of cytoskeleton-modulated regulation of nuclear functions which is mediated by the translocation of cytoskeletal components in and out of the nucleus.…”
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Ferrochelatase is a therapeutic target for ocular neovascularization by Halesha D Basavarajappa, Rania S Sulaiman, Xiaoping Qi, Trupti Shetty, Sardar Sheik Pran Babu, Kamakshi L Sishtla, Bit Lee, Judith Quigley, Sameerah Alkhairy, Christian M Briggs, Kamna Gupta, Buyun Tang, Mehdi Shadmand, Maria B Grant, Michael E Boulton, Seung‐Yong Seo, Timothy W Corson

“…FECH depletion modulates endothelial nitric oxide synthase function and VEGF receptor 2 levels. …”
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Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin‐deficient mice by Andrea Farini, Luana Tripodi, Chiara Villa, Francesco Strati, Amanda Facoetti, Guido Baselli, Jacopo Troisi, Annamaria Landolfi, Caterina Lonati, Davide Molinaro, Michelle Wintzinger, Stefano Gatti, Barbara Cassani, Flavio Caprioli, Federica Facciotti, Mattia Quattrocelli, Yvan Torrente

“…Abstract Duchenne muscular dystrophy (DMD) is a progressive severe muscle‐wasting disease caused by mutations in DMD, encoding dystrophin, that leads to loss of muscle function with cardiac/respiratory failure and premature death. …”
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COMMD3 Regulates Copper Metabolism via the ATOX1-ATP7A-LOX Axis to Promote Multiple Myeloma Progression by Yajun Wang, Bo Zhang, Fengjuan Fan, Fei Zhao, Jian Xu, Yuhuan Zheng, Chunyan Sun, Yu Hu

“…Methods: Comprehensive bioinformatics analyses were conducted on bone marrow and extramedullary samples to determine the expression of COMMD3, which was validated through in vitro and in vivo functional assays. The MM cell lines RPMI8226 and MM1S underwent lentiviral transfection for COMMD3 overexpression and knockdown. …”
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STANet: A Novel Spatio-Temporal Aggregation Network for Depression Classification with Small and Unbalanced FMRI Data by Wei Zhang, Weiming Zeng, Hongyu Chen, Jie Liu, Hongjie Yan, Kaile Zhang, Ran Tao, Wai Ting Siok, Nizhuan Wang

“…Traditional methods rely on self-report questionnaires and clinical assessments, lacking objective biomarkers. Combining functional magnetic resonance imaging (fMRI) with artificial intelligence can enhance depression diagnosis using neuroimaging indicators, but depression-specific fMRI datasets are often small and imbalanced, posing challenges for classification models. …”
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Nutritional insights into pulmonary fibrosis: a comprehensive review on the impact of vitamins by Yaqian Qu, Youliang Zhao

“…Beyond their conventional nutritional functions, specific vitamins have recently been found to modulate various biological processes involved in pulmonary fibrosis. …”
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Defining the minimal components of the influenza A virus replication machinery via an in vitro reconstitution system. by Zihan Zhu, Haitian Fan, Ervin Fodor

“…Our highly robust in vitro system enables systematic functional analysis of factors modulating influenza virus vRNP activity and paves the way for imaging key steps of viral transcription and replication.…”
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Myeloid TGF-β signaling shapes liver macrophage heterogeneity and metabolic liver disease pathogenesis by Ziyi Meng, Xiaoxue Qiu, Zhimin Chen, Yu-tung Lee, Linkang Zhou, You Lu, Tongyu Liu, Siming Li, Benjamin Levi, Katherine A. Gallagher, Jiandie D. Lin

“…By elucidating how TGF-β signaling regulates macrophage function, our work paves the way for targeted interventions that modulate immune responses to improve liver health. …”
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