Interference without interferon: interferon-independent induction of interferon-stimulated genes and its role in cellular innate immunity by Shachee Swaraj, Shashank Tripathi

“…ABSTRACT Interferons (IFNs) are multifaceted proteins that play pivotal roles in orchestrating robust antiviral immune responses and modulating the intricate landscape of host immunity. …”
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The immune tolerance role of Bregs in inhibiting human inflammatory diseases, with a focus on diabetes mellitus by Qi Zhang, Qi Zhang, Jinfeng Liao, Zheng Liu, Siyuan Song, Limin Tian, Yi Wang, Yi Wang, Yi Wang

“…In T2DM, chronic inflammation and metabolic stress impair Breg numbers and function, further fueling insulin resistance. While Bregs play a central role in T1DM by directly preventing β-cell destruction, their role in T2DM is more supportive, modulating inflammation in metabolically stressed tissues. …”
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The role of glutamine in supporting gut health and neuropsychiatric factors by Brett J. Deters, Mir Saleem

“…Glutamine supplementation may provide significant adjunctive nutritional support in cases of depression by promoting proper gut health and function.…”
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Bi-directional metabolic reprogramming between cancer cells and T cells reshapes the anti-tumor immune response. by Yajing Qiu, Yihan Xu, Xinyuan Ding, Congcong Zhao, Hongcheng Cheng, Guideng Li

“…While cancer cells reprogram metabolism to support growth and immune evasion, T cells must adapt their metabolic states to maintain effector functions. Tumor-driven metabolic perturbations, such as nutrient depletion and accumulation of immunosuppressive metabolites, profoundly impair T cell function and fate. …”
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Vitamin D exerts endogenous control over TH2 cell fate and immune plasticity by Vrushali D. Fangal, Ayşe Kılıç, Hooman Mirzakhani, Augusto A. Litonjua, Marie B. Demay, Bruce D. Levy, Scott T. Weiss

“…Conversely, Vit-D deficiency reprograms TH2 cell lineage commitment, inducing overexpression of cytolytic molecules and major histocompatibility complex (MHC) class I molecules—traits typically associated with cytotoxicity rather than the canonical helper function. Our findings underscore Vit-D’s role in stabilizing TH2 cell function and fate, offering insights into asthma and autoimmune disorders.…”
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All-Optically Controlled Memristive Device Based on Cu2O/TiO2 Heterostructure Toward Neuromorphic Visual System by Jun Xie, Xuanyu Shan, Ningbo Zou, Ya Lin, Zhongqiang Wang, Ye Tao, Xiaoning Zhao, Haiyang Xu, Yichun Liu

“…Beneficial from the image preprocessing function, the accuracy of handwritten digit classification increases more than 60%. …”
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Concept and Design of Cutting Tools for Osseodensification in Implant Dentistry by Alexander Isaev, Maria Isaeva, Oleg Yanushevich, Natella Krikheli, Olga Kramar, Aleksandr Tsitsiashvili, Sergey Grigoriev, Catherine Sotova, Pavel Peretyagin

“…The purpose of the present research is to identify the key design features of burs for osseodensification and their functional relationship with the qualitative indices of the procedure based on an analytical review of research papers and patent documents. …”
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Bone mechanical loading reduces heart rate and increases heart rate variability in mice by Julian A. Vallejo, Mark Gray, Jackson Klump, Andrew Wacker, Mark Dallas, Mark L. Johnson, Michael J. Wacker

“…Bone also exhibits endocrine functions that modulate a number of tissues including the heart. …”
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Differential brainstem connectivity according to sex and menopausal status in healthy male and female individuals by Lisa A. Kilpatrick, Arpana Church, David Meriwether, Swapna Mahurkar-Joshi, Vince W. Li, Jessica Sohn, Juliana Reist, Jennifer S. Labus, Tien Dong, Jonathan P. Jacobs, Bruce D. Naliboff, Lin Chang, Emeran A. Mayer

“…Abstract Background Brainstem nuclei play a critical role in both ascending monoaminergic modulation of cortical function and arousal, and in descending bulbospinal pain modulation. …”
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Lipocalin-2-mediated ferroptosis as a target for protection against light-induced photoreceptor degeneration by Wenyi Tang, Ruyi Zhai, Jun Ma, Gezhi Xu

“…Lastly, AAV-shRNA-LCN2 administration inhibited light-induced ferroptosis in the retina, and protected the retinal structure and function in vivo. Conclusion LCN2 is a key regulator of light-induced ferroptosis in photoreceptors by modulating the JNK pathway. …”
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Image fusion, based on data from sources of a various spectral range by D. S. Sharak, E. I. Mikhnionok, A. S. Shein, A. V. Khizhniak

“…The analysis of existing image fusion devices are carried out, and the function chart of experimental module realizing known fusion video sequences algorithms is presented.…”
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Is Mitochondrial Oxidative Stress the Key Contributor to Diaphragm Atrophy and Dysfunction in Critically Ill Patients? by Hongjie Duan, Hailiang Bai

“…Among these contributors, mitochondrial oxidative stress is strongly implicated to play a key role in the process as it modulates diaphragm protein synthesis and degradation, induces protein oxidation and functional alteration, enhances apoptosis and autophagy, reduces mitochondrial energy supply, and is regulated by inflammatory cytokines via related signaling molecules. …”
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Lipid metabolites enhance secretion acting on SNARE microdomains and altering the extent and kinetics of single release events in bovine adrenal chromaffin cells. by Virginia García-Martínez, José Villanueva, Cristina J Torregrosa-Hetland, Robert Bittman, Ashlee Higdon, Victor M Darley-Usmar, Bazbek Davletov, Luis M Gutiérrez

“…Together these results demonstrate that the kinetics and extent of the exocytotic fusion pore formation can be modulated by specific signalling lipids through related functional mechanisms.…”
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The impact of sulfonylureas on diverse ion channels: an alternative explanation for the antidiabetic actions by Xian-Tao Li, Meng-Ze Yun

“…Accumulated evidence reveals that multiple ion channels, such as Kv and TRP, are also expressed in β-cells in the pancreatic islets of Langerhans, and these channels, particularly Kv2.1, show important functional roles in tuning the electrical activity of β-cells, accordingly participating in the modulation of insulin secretion. …”
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Interbrain neural correlates of self and other integration in joint statistical learning by Zheng Zheng, Jun Wang

“…More importantly, Brain-to-Brain Coupling (BtBC) in the theta band also showed learning and modulation-related trends, with its slope negatively and positively correlating with the slopes of RT and intra-brain functional connectivity, respectively. …”
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Reduced glutathione ameliorates sepsis-induced acute kidney injury in mouse model: involvement of cuproptosis by Lu Wang, Long Jiang, Jingjing Wang, Wen Tang, Zhigao Wang, Rennan Guo, Daquan Zhang

“…Survival rates, bacterial load, inflammatory cytokine levels, oxidative stress markers, kidney function, copper (Cu) levels, and the expression of SLC31A1 were evaluated.Results Reduced GSH treatment significantly improved survival rates and reduced bacterial loads in CLP mice. …”
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Melatonin ameliorates zearalenone-induced ovarian damage in mice through antioxidative effects by Yi Song, Yi Song, Yi Song, Zhong Guo, Zhong Guo, Lei Song, Lei Song, Jianxiu Ma, Jianxiu Ma, Zhifang Zhao, Zhifang Zhao, Yanqing Ma, Xiaoyue Ma, Wenjie Jiang, Wanjing Wang, Chongran Liu, Tongtong Wei, Ling Fu, Zhengli Qi, Jin Zhao, Jin Zhao, Jin Zhao

“…It exerts estrogen-like effects, disrupting hormonal balance and reproductive function, partly through oxidative stress-induced DNA damage. …”
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Gut microbial dysbiosis exacerbates long-term cognitive impairments by promoting intestinal dysfunction and neuroinflammation following neonatal hypoxia-ischemia by Andi Chen, Chengqian Teng, Jianjie Wei, Xuyang Wu, Honghong Zhang, Pinzhong Chen, Dingliang Cai, Haitao Qian, Hui Zhu, Xiaochun Zheng, Xiaohui Chen

“…Additionally, the interventions such as TLR4 inhibitor TLR4-IN-C34 administration, FMT, and oral DEX were demonstrated to modulate intestinal function by inhibiting the LPS/TLR4 signaling pathway, thereby exerting neuroprotective effects. …”
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Sirtuins in kidney homeostasis and disease: where are we now? by Zhongyu Fan, Xuejiao Wei, Xiaoyu Zhu, Yujun Du

“…Sirtuins, identified as (NAD+)- dependent class III histone deacetylases, engage in a spectrum of biological functions, encompassing DNA damage repair, oxidative stress, immune modulation, mitochondrial homeostasis, apoptosis and autophagy. …”
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Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament by Elaine K. Hebda-Bauer, Megan H. Hagenauer, Daniel B. Munro, Daniel B. Munro, Peter Blandino, Fan Meng, Keiko Arakawa, John D. H. Stead, Apurva S. Chitre, A. Bilge Ozel, Pejman Mohammadi, Pejman Mohammadi, Stanley J. Watson, Shelly B. Flagel, Jun Li, Abraham A. Palmer, Abraham A. Palmer, Huda Akil

“…This enabled triangulation of behavior with both genetic and functional genomic data to implicate specific genes and biological pathways. …”
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