The role of cytokine licensing in shaping the therapeutic potential of wharton’s jelly MSCs: metabolic shift towards immunomodulation at the expense of differentiation by Olena Rogulska, Eliska Vavrinova, Irena Vackova, Jarmila Havelkova, Klara Gotvaldova, Pavel Abaffy, Sarka Kubinova, Michal Sima, Pavel Rossner, Lucie Bacakova, Pavla Jendelova, Katarina Smolkova, Yuriy Petrenko

“…While licensing has demonstrated benefits for immunomodulation, its effects on other key MSC functions, including differentiation and paracrine activity, remain incompletely explored. …”
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ESTIMATION OF THERMAL IMAGER MINIMUM RESOLVABLE TEMPERATURE DIFFERENCE by Ahmed M.L. Al-Mzirawi, V. G. Kolobrodov, V. I. Mykytenko

“…An MRTD calculating algorithm, which is based on a more reliable approximation of the visual system modulation transfer function by Schultz, is considered. …”
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AGW-YOLO-Based UAV Remote Sensing Approach for Monitoring Levee Cracks by HU Weibo, ZHOU Shaoliang, ZHAO Erfeng, ZHAO Xueqiang

“…The incorporation of the Adown module, GMA attention mechanism, and WIoUv3 loss function effectively reduced the model's parameters and computational complexity, while significantly improving the accuracy and robustness of levee crack detection. …”
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基于层片分割算法弧齿锥齿轮及准双面齿轮五轴数控切削仿真 by 李敬财, 徐文丽, 李清, 李琳, 王太勇

“…In order to solve the problems existing in geometric simulation of spiral bevel gear and hypoid gear cutting process,such as slow speed,low precision and lack of independence,slice algorithm is presented.The five axis numerical control simulation system of the forming process of gear’s tooth surface is developed based on the slice algorithm.Basic idea of slice algorithm,structure and function of the system module,and the process of realization of the simulation system is introduced,an example is presented.…”
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Broadband Photonic Microwave Signal Processor With Frequency Up/Down Conversion and Phase Shifting Capability by Tao Li, Erwin Hoi Wing Chan, Xudong Wang, Xinhuan Feng, Bai-Ou Guan, Jianping Yao

“…A new dual-function photonic microwave signal processing structure that has the ability to realize both frequency up/down conversion and RF/IF phase shifting, is presented. …”
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Heparanase, a host gene that potently restricts retrovirus transcription by Brandon Waxman, Kyle Salka, Uddhav Timilsina, Supawadee Umthong, Deepak Shukla, Spyridon Stavrou

“…Apart from its enzymatic function, HPSE has important non-enzymatic functions, which include transcriptional regulation, chromatin modification, and modulation of various signaling pathways. …”
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AM and FM difference limens by A. SĘK, E. OZIMEK

“…This paper reports two basic experiments aimed at determining difference limens (DLs) for amplitude and frequency modulation as a function of the modulation indices (m, β) modulation frequency and sound pressure level of the modulated signals. …”
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Design and Calibration of a Sensory System of an Adaptive Gripper by Cezar Frincu, Ioan Stroe, Sorin Vlase, Ionel Staretu

“…Including the final constructive variants, the variants of the planned force sensor and slip sensors are detailed, highlighting their primary functional and constructive features. The key elements regarding the calibration of the force and slip sensors on each gripper module of the adaptive gripper are then displayed. …”
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Dietary baking soda (NaHCO3) therapy recovered urolithiasis-induced kidney injury in mice by inhibition of oxidative stress, pyroptosis, and inflammation through gut-kidney axis by Shuai Liu, Yuchen Gao, Jun Luo, Yanhua Chen, Heng Cao, Zhuifeng Guo, Hongmin Zhou, Zhongwen Hong, Bowen Chen, Xiao Xu, Jingcheng Zhang, Nengliang Duan, Xiangcheng Zhan, Xudong Yao, Tiancheng Xie, Yunze Dong, Yunfei Xu

“…Biochemical detection, immunohistochemical staining, RT-qPCR, and Western blotting were used to assess kidney function and levels of inflammation and pyroptosis. …”
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A click-based electrocorticographic brain-computer interface enables long-term high-performance switch scan spelling by Daniel N. Candrea, Samyak Shah, Shiyu Luo, Miguel Angrick, Qinwan Rabbani, Christopher Coogan, Griffin W. Milsap, Kevin C. Nathan, Brock A. Wester, William S. Anderson, Kathryn R. Rosenblatt, Alpa Uchil, Lora Clawson, Nicholas J. Maragakis, Mariska J. Vansteensel, Francesco V. Tenore, Nicolas F. Ramsey, Matthew S. Fifer, Nathan E. Crone

“…Conclusions These results demonstrate that a click detector can be trained with a small ECoG dataset while retaining robust performance for extended periods, providing functional text-based communication to BCI users.…”
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Effect of Low-Level Laser Therapy (LLLT) in Pulmonary Inflammation in Asthma Induced by House Dust Mite (HDM): Dosimetry Study by Nicole Cristine Rigonato-Oliveira, Auriléia Aparecida de Brito, Luana Beatriz Vitoretti, Gabriel de Cunha Moraes, Tawany Gonçalves, Karine Zanella Herculano, Cintia Estefano Alves, Adriana Lino-dos-Santos-Franco, Flávio Aimbire, Rodolfo Paula Vieira, Ana Paula Ligeiro de Oliveira

“…After 24 hours, we studied inflammatory, functional, and structural parameters. The results showed that LBI was able to modulate the pulmonary inflammation observed by reducing the number of cells in Bronchoalveolar Lavage Fluid (BALF) as well as reducing the percentage of neutrophils, eosinophils and T lymphocytes. …”
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Investigation of neuromodulation of the endbulb of Held synapse in the cochlear nucleus by serotonin and norepinephrine by Maria Groshkova, Maria Groshkova, Maria Groshkova, Maria Groshkova, Maria Groshkova, Theocharis Alvanos, Theocharis Alvanos, Theocharis Alvanos, Yumeng Qi, Fangfang Wang, Carolin Wichmann, Carolin Wichmann, Carolin Wichmann, Carolin Wichmann, Yunfeng Hua, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser

“…Neuromodulators such as monoamines can differentially regulate presynaptic function and neuronal excitability. Variability is found also for the large calyceal synapses of the auditory pathway that display high synaptic vesicle (SV) release probability (Pvr) and large postsynaptic currents in vitro enabling reliable and temporally precise transmission of auditory information. …”
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Potential Role of Exosomes in Mending a Broken Heart: Nanoshuttles Propelling Future Clinical Therapeutics Forward by Julie A. Dougherty, Muhamad Mergaye, Naresh Kumar, Chun-An Chen, Mark G. Angelos, Mahmood Khan

“…In this review, we have summarized studies demonstrating the potential role of exosomes in improving cardiac function, attenuating cardiac fibrosis, stimulating angiogenesis, and modulating miRNA expression. …”
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Hierarchical diagnostic approach for performance problems in cloud computing platforms by MI Hai-bo1, WANG Huai-min1, CAI Hua2, YIN Gang1, ZHOU Qi2, SUN Ting-tao2, ZHOU Yang-fan3

“…A hierarchical diagnosis approach,namely Magnifier,was proposed,which models the execution path graph of a user request as component layer,module layer and function layer,and detects anomalies from higher layer to lower layer separately.Extensive experiments were conducted on the Alibaba cloud computing platform.The results indicate that,under the conditions of large volume of data and high complexity of execution paths,Magnifier can accurately and efficiently locate the prime causes of performance degradation.…”
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Efficacy and safety of dietary polyphenol supplements for COPD: a systematic review and meta-analysis by Dongsheng Wu, Dongsheng Wu, Yuang Dong, Dongyang Zhang, Tongtong Wang, Haipeng Ye, Wei Zhang

“…As bioactive compounds exhibiting dual antioxidant and anti-inflammatory properties, polyphenolic derivatives demonstrate significant therapeutic potential through multimodal mechanisms targeting COPD pathophysiology - particularly in modulating redox homeostasis (GSH/GSSG ratio elevation), attenuating NF-κB-mediated inflammatory cascades, and enhancing respiratory function parameters (FEV1 improvement ≥12% from baseline). …”
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Systematic proteomic and small RNA profiling of extracellular vesicles from cattle infected with a naturally occurring buparvaquone-resistant strain of Theileria annulata and from... by Yijun Chai, Jin Che, Jinming Wang, Guiquan Guan, Hong Yin

“…Furthermore, functional enrichment analyses highlighted key pathways such as ECM-receptor interactions, oxidative phosphorylation, and proton transport, underscoring the role of EVs in host immune modulation. …”
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A Bionic-Based Multi-Objective Optimization for a Compact HVAC System with Integrated Air Conditioning, Purification, and Humidification by He Li, Bozhi Yang, Xinyu Gu, Wen Xu, Xuan Liu

“…Specific methods include the establishment and optimization of mathematical models for air conditioning, air purification, and humidification functions. The air conditioning module employs a nonlinear programming model optimized through the Parrot Optimizer (PO) Algorithm to achieve uniform temperature distribution and minimal energy consumption. …”
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Tumor glyco-immunology, glyco-immune checkpoints and immunotherapy by Heinz Läubli, Salomé S. Pinho, Matthew S. Macauley

“…Here, we summarize how changes in glycosylation in cancer have functional consequences on the immune system. Such changes can be directly targeted with drugs. …”
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Precision thermoelectric semiconductor sensor by S. M. Gadzhieva, T. A. Chelushkina, D. S. Gadzhiev, P. S. Magomedova, I. M. Kurbanov

“…The thermoelectric semiconductor sensor operates in an adaptive temperature measurement mode, allowing you to adjust a functional sensor to measure temperature with the required accuracy depending on the object under study, as well as stabilize the melt or boiling boundary in a container in contact with a digital thermoelectric device.…”
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Connective tissue and the problems of its pathological conditions by V. A. Shkurupy, L. B. Kim, A. V. Kovner, L. A. Cherdantseva

“…Authors’ findings support and illustrate the above conclusions using data on the modulation of functional status of macrophages and fibroblasts as well as data on prevention and correction of fibrotic processes in different experimental pathologic conditions.…”
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