Comprehensive investigation of matrix metalloproteinases in skin cutaneous melanoma: diagnostic, prognostic, and therapeutic insights by Lingxia Wu, Chenxiaoxiao Liu, Weicai Hu

“…Our findings also revealed associations between MMP expression and immune modulation, drug sensitivity, and functional states of SKCM cells. …”
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Development of a High-Cell-Density Production Process for a Biotherapeutic Yeast, <i>Saccharomyces cerevisiae</i> var. <i>boulardii</i>, for Use as a Human Probiotic by Ghaneshree Moonsamy, Sarisha Singh, Yrielle Roets-Dlamini, Koketso Kenneth Baikgaki, Santosh Omrajah Ramchuran

“…<i>boulardii</i> is a probiotic yeast widely recognized for its ability to enhance gut health and modulate a host’s microbiome. However, there are limited data on its large-scale cultivation in stirred tank bioreactors and subsequent downstream processing into a functional probiotic product. …”
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COMPARISON OF INOTROPIC AND ANTIARRHYTHMIC ACTIVITY OF FLAVONOIDS — QUERCETIN, RUTIN AND (+)-CATECHIN by Sh. S. Khushmatov, R. R. Makhmudov, S. M. Mavlyanov

“…Also the action of the flavonoids might be related to the production of functional activity modulation of Na+ and Са2+-channels in cardiomyocytes.…”
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Low storage temperature maintains the quality, antioxidant activity, and nutraceutical properties of edible flowers and their anti-inflammatory effects on RAW 264.7 cells by Mantana Buanong, Sudarat Khunmuang, Juthamard Promboon, Pathompong Penchaiya, Natnicha Promyos, Apanchanid Thepouyporn

“…Moreover, the inflammatory and anti-inflammatory effects of MeOH extracts (0–5 mg/mL, at the zero time) were also explored in RAW 264.7 cells. Almost all flowers modulated inflammation; A. goyazensis effectively inhibited NO generation and is therefore a candidate functional food.…”
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Integrated Analysis of the Metabolome and Transcriptome During Apple Ripening to Highlight Aroma Determinants in Ningqiu Apples by Jun Ma, Guangzong Li, Yannan Chu, Haiying Yue, Zehua Xu, Jiaqi Wu, Xiaolong Li, Yonghua Jia

“…Furthermore, terpene synthase (<i>TPS7</i>) emerged as a peel-specific regulatory factor, while hydroperoxide lyase (HPL2), alcohol dehydrogenases (<i>ADH2</i> and <i>ADH4</i>), and alcohol acyltransferase (<i>AAT2</i>) were identified as pulp-exclusive modulators of metabolic differentiation. The experimental findings provide foundational insights into the molecular basis of aroma profile variation in Malus domestica “Ningqiu” and establish a functional genomics framework for precision breeding initiatives targeting fruit quality optimization through transcriptional regulatory network manipulation.…”
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基于CPLD和USB2.0的机械传动误差测试系统 by 郑永, 彭东林, 郑方燕, 万文略

“…The FMT system adopts CPLD chip to realize the whole error sampling function, at the same time adding the controllable frequency divider module to control the information process, so it can enhance the flexibleness of system. …”
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Unveiling Salt Tolerance Mechanisms and Hub Genes in Alfalfa (<i>Medicago sativa</i> L.) Through Transcriptomic and WGCNA Analysis by Fengdan Wang, Hanfu Wu, Mei Yang, Wen Xu, Wenjie Zhao, Rui Qiu, Ning Kang, Guowen Cui

“…Among these, 2164 DEGs shared the same expression trend, with GO functions enriched in response to oxidative stress, nucleus, plasma membrane, and others. …”
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Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions by János G Filep

“…Abstract C‐reactive protein (CRP) is a marker of acute inflammation and modulator of host defense against infections. CRP exists in conformationally distinct forms that exhibit opposing biological functions and could amplify tissue damage. …”
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Bone marrow adipocytes: key players in vascular niches, aging, and disease by Yonggang Fan, Mai Elkhalek, Yuheng Zhang, Lu Liu, Qi Tian, Qi Tian, Nareekarn Chueakula, Nareekarn Chueakula, Saravana K. Ramasamy, Rinkoo Dalan, Rinkoo Dalan, Shukry J. Habib, Anjali P. Kusumbe, Anjali P. Kusumbe

“…In this comprehensive review, we integrate recent advances that elucidate the molecular and cellular mechanisms underlying BMA function and their complex interactions with vascular niches. …”
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ST-YOLOv8: Small-Target Ship Detection in SAR Images Targeting Specific Marine Environments by Fei Gao, Yang Tian, Yongliang Wu, Yunxia Zhang

“…Additionally, we replace the Complete Intersection over Union (C-IoU) loss function with the Wise Intersection over Union (W-IoU) loss function, which enhances bounding box precision. …”
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Multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk: the SINFONI project by Hugo Hornero-Ramirez, Arianne Morissette, Bruno Marcotte, Armelle Penhoat, Béryle Lecomte, Baptiste Panthu, Jacob Lessard Lord, Florence Thirion, Laurie Van-Den-Berghe, Emilie Blond, Chantal Simon, Cyrielle Caussy, Nathalie Feugier, Joël Doré, Philippe Sanoner, Alexandra Meynier, Yves Desjardins, Geneviève Pilon, André Marette, Patrice D. Cani, Martine Laville, Sophie Vinoy, Marie-Caroline Michalski, Julie-Anne Nazare

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Two-dimensional material-assisted remote epitaxy and van der Waals epitaxy: a review by Liu Zhetong, Liu Bingyao, Chen Zhaolong, Yang Shenyuan, Liu Zhiqiang, Wei Tongbo, Gao Peng, Liu Zhongfan

“…Furthermore, we discuss in detail the improved crystal quality and functional applications, such as flexible devices, wavelength-modulated optoelectronic devices, and thermal management in high-power devices. …”
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Intestinal non-canonical NFκB signaling shapes the local and systemic immune response by Sadeesh K. Ramakrishnan, Huabing Zhang, Xiaoya Ma, Inkyung Jung, Andrew J. Schwartz, Daniel Triner, Samantha N. Devenport, Nupur K. Das, Xiang Xue, Melody Y. Zeng, Yinling Hu, Richard M. Mortensen, Joel K Greenson, Marilia Cascalho, Christiane E. Wobus, Justin A. Colacino, Gabriel Nunez, Liangyou Rui, Yatrik M. Shah

“…Abstract Microfold cells (M-cells) are specialized cells of the intestine that sample luminal microbiota and dietary antigens to educate the immune cells of the intestinal lymphoid follicles. The function of M-cells in systemic inflammatory responses are still unclear. …”
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OSP-1 protects neurons from autophagic cell death induced by acute oxidative stress by Alessandra Donato, Fiona K. Ritchie, Lachlan Lu, Mehershad Wadia, Ramon Martinez-Marmol, Eva Kaulich, Kornraviya Sankorrakul, Hang Lu, Sean Coakley, Elizabeth J. Coulson, Massimo A. Hilliard

“…Finally, we present evidence suggesting that OSP-1 may exert its neuroprotective function by influencing autophagy. Our results point to a potential role of OSP-1 in modulating autophagy, and suggest that overactivation of this cellular process could contribute to neuronal death triggered by oxidative damage.…”
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Thinking- Skins by Jens Böke

“…In the sense of an internet of façade functions, the automated adaptive façade functions ventilation, sun protection as well as heating and cooling are implemented in decentrally organized modules. …”
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User Experiences Among Patients and Health Care Professionals Who Participated in a Randomized Controlled Trial of E-nergEYEze, a Vision-Specific eHealth Intervention to Reduce Fat... by Manon HJ Veldman, Hilde PA van der Aa, Hans Knoop, Christina Bode, Ger HMB van Rens, Ruth MA van Nispen

“…Cognitive and emotional functioning, social roles, and participation are negatively affected in severely fatigued individuals with VI. …”
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Sensitivity of Dendritic Cells to Microenvironment Signals by Juliana Maria Motta, Vivian Mary Rumjanek

“…They do this by integrating stimuli from the environment and changing their functional status as a result of plasticity. The modifications suffered by these cells have consequences in the way the organism may respond. …”
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γ neuromodulations: unraveling biomarkers for neurological and psychiatric disorders by Zhong-Peng Dai, Qiang Wen, Ping Wu, Yan-Ni Zhang, Cai-Lian Fang, Meng-Yuan Dai, Hong-Liang Zhou, Huan Wang, Hao Tang, Si-Qi Zhang, Xiao-Kun Li, Jian-Song Ji, Liu-Xi Chu, Zhou-Guang Wang

“…This review examines clinical applications of γ neuromodulations, including enhancing cognitive function through 40 Hz multisensory stimulation in Alzheimer’s disease, improving motor function in Parkinson’s disease, controlling seizures in epilepsy, and modulating emotional dysfunctions in depression. …”
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Twist Gating of a Graphene Nanoribbon by Shubham Tyagi, Mohammed Ghadiyali, Udo Schwingenschlögl

“…Abstract Employing first‐principles calculations and the non‐equilibrium Green's function method, a hexa‐peri‐hexabenzocoronene nanoflake is investigated on an armchair graphene nanoribbon. …”
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Evobrutinib mitigates neuroinflammation after ischemic stroke by targeting M1 microglial polarization via the TLR4/Myd88/NF-κB pathway by Yixiang Jiang, Ning Wang, Jingyi Liu, Jiayi Li, Lulu Chang, Changxin Yang, Zhengyi Chen, Wei Huang, Jing Wang, Xiujuan Lang, Xijun Liu, Yumei Liu, Bo Sun, Hulun Li

“…Although previous studies have confirmed significant BTK expression in microglia, the potential of Evobrutinib to treat ischemic stroke by modulating microglial function and its underlying mechanisms remain to be elucidated. …”
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