Research on Design and Application of Online English Education Platform Based on Web by Yijuan Huang

“…The hardware of the platform is composed of student module, teacher module, administrator module, and database module. …”
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Position transitions of polymer-grafted nanoparticles in diblock-copolymer nanocomposites

“…Self-assembly of block copolymer/nanoparticle blends has promising applications in the design and fabrication of novel functional nanomaterials. Precise control of the spatial positions of nanoparticles within block copolymer-based nanomaterials is crucial to achieve some special physical properties and functions. …”
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Capsid transfer of the retrotransposon Copia controls structural synaptic plasticity in Drosophila. by P Githure M'Angale, Adrienne Lemieux, Yumeng Liu, Shuhao Wang, Max Zinter, Gimena Alegre, Alfred Simkin, Vivian Budnik, Brian A Kelch, Travis Thomson

“…Transposons are parasitic genome elements that can also serve as raw material for the evolution of new cellular functions. However, how retrotransposons are selected and domesticated by host organisms to modulate synaptic plasticity remains largely unknown. …”
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THE ROLE OF NO SYNTHESIS CORRECTION IN PREVENTION OF CARDIOVASCULAR HYPERTENSIVE REMODELING by V. I. Buvaltsev, S. Y. Mashina, D. A. Pokidyshev, B. V. Smirin, L. A. Bayda, V. Y. Malyshev, E. B. Manukina

“…Comparative study of preventive effects of two beta-blocking drugs with different mode of action was performed on SHRSP and WKY rats. Morphological and functional parameters – blood pressure, endothelium-dependent vascular relaxation, plasma level of nitric oxide stable metabolites (nitrite/nitrate), cardiac hyperthrophy and vascular remodeling were monitored during chronic nebivolol and metoprolol injection in parallel groups of rats. …”
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The role of agonistic/antagonistic activity in the development of psychotropic effects of antipsychotics by V. I. Kozlovskiy, D. N. Kosterin, M. Yu. Popov

“…The development of psychotic symptoms is traditionally linked to the increase of the functional activity of endogenous dopaminergic system. …”
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Adenine base editing with engineered virus-like particles rescues the CFTR mutation G542X in patient-derived intestinal organoids by Lucia Nicosia, Iwona Pranke, Roberta V. Latorre, Joss B. Murray, Lisa Lonetti, Kader Cavusoglu-Doran, Elise Dreano, James P. Costello, Michael Carroll, Paola Melotti, Claudio Sorio, Isabelle Sermet-Gaudelus, Martina F. Scallan, Patrick T. Harrison

“…G542X is the second-most common CF-causing variant, and it does not respond to current CFTR modulator drugs. Our study explores the use of adenine base editing to edit G542X to a non-CF-causing variant, G542R, and recover CFTR function. …”
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Two-Dimensional Quaternion Linear Canonical Transform: Properties, Convolution, Correlation, and Uncertainty Principle by Mawardi Bahri, Ryuichi Ashino

“…It is shown that the localization of a quaternion-valued function and the localization of the QLCT are inversely proportional and that only modulated and shifted two-dimensional Gaussian functions minimize the uncertainty.…”
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Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels the molecular feature of tumor-associated neutrophils of head and neck squamous cell carcinoma by Haiyang Cui, Zhikai Li, Yukun Liu, Yuchuan Yang, Linkuan Huangfu, Jinglin Kong, Xiaocong Sun, Shibo Gao, Daoke Yang, Yingjuan Zheng

“…The associations between the TANs signature and clinical characteristics, functional pathways, immune cell infiltration, immune checkpoint expression, and responses to immunotherapy and chemotherapy, were then investigated. …”
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Vascular inflammation in chronic kidney disease: the role of uremic toxins in macrophage activation by Prabhash Kumar Jha, Toshiaki Nakano, Toshiaki Nakano, Lucas Yuji Umesaki Itto, Miguel Cantadori Barbeiro, Adrien Lupieri, Elena Aikawa, Elena Aikawa, Masanori Aikawa, Masanori Aikawa, Masanori Aikawa

“…In this review article, we focus on the signaling through which uremic toxins, particularly indoxyl sulfate—an independent risk factor for cardiovascular complications in CKD patients, modulate macrophage activation and function, and how these changes contribute to vascular inflammation, leading to the increased cardiovascular risk. …”
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A Method for Recognizing Dead Sea Bass Based on Improved YOLOv8n by Lizhen Zhang, Chong Xu, Sai Jiang, Mengxiang Zhu, Di Wu

“…Finally, in order to compensate for the weak generalization and slow convergence of the CIoU loss function in detection tasks, the Inner-CIoU loss function was used to accelerate bounding box regression and further improve the detection performance of the model. …”
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PdYOLO: A Lightweight Algorithm for Detecting Peach Fruits Against a Peach Tree Background by Jiajun Zhang, Jialin Zhang, Kazuki Kobayashi

“…First, the CIOU regression loss function in YOLOv8s is replaced with the WIoUv2 regression loss function, effectively alleviating the negative impact of uneven distribution of positive and negative samples during model training through a more balanced gradient gain distribution strategy, which significantly improves detection accuracy. …”
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The Cholinergic Amelioration of Sepsis-Induced Baroreflex Dysfunction and Brainstem Inflammation Is Negated by Central Adenosine A3 Receptors by Amany E. El-Naggar, Mai M. Helmy, Sahar M. El-Gowilly, Mahmoud M. El-Mas

“…Considering the importance of central adenosine receptors in baroreceptor function, this study tested whether central adenosine A3 receptors (A3ARs) modulate the cholinergic-baroreflex interaction in sepsis and whether this interaction is modulated by mitogen-activated protein kinases (MAPKs) and related proinflammatory cytokines. …”
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Macrophage Lyn Kinase Is a Sex‐Specific Regulator of Post–Subarachnoid Hemorrhage Neuroinflammation by Rezwanul Islam, Hadi Hasan Choudhary, Feng Zhang, Hritik Mehta, Jun Yoshida, Ajith Thomas, Khalid Hanafy

“…Results Our overall animal and patient data from flow cytometry, immunohistochemistry, western blot, cognitive function tests, and spatial transcriptomic data revealed that Lyn kinase is a sex‐specific regulator in inflammatory cytokine production, red blood cell phagocytosis, neuronal apoptosis, and cognitive function, as well as a negative regulator of TLR4 signaling pathways. …”
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Sodium-Glucose Cotransporter 2 Inhibitors in Diabetic Kidney Disease and beyond by Zein Alabdin Hannouneh, C. Elena Cervantes, Mohamad Hanouneh, Mohamed G. Atta

“…Moreover, SGLT2is reduce albuminuria, improve tubular function, and modulate erythropoiesis. Additionally, they mitigate inflammation and fibrosis by decreasing oxidative stress and downregulating proinflammatory pathways. …”
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Spontaneous blinking and brain health in aging: Large-scale evaluation of blink-related oscillations across the lifespan by Sujoy Ghosh Hajra, Jed A. Meltzer, Prerana Keerthi, Chloe Pappas, Allison B. Sekuler, Cam-CAN Group, Careesa Chang Liu

“…Together, these results suggest that BRO responses are not only present throughout the adult lifespan, but the effects can also capture brain function changes in healthy aging—thus providing a simple yet powerful avenue for evaluating brain health in aging.…”
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PENGUKURAN KUALITAS CITRA DIGITAL COMPUTED RADIOGRAPHY MENGGUNAKAN PROGRAM PENGOLAH CITRA by D. R. Ningtias, S. Suryono, S. Susilo

“…<p>Penelitian yang telah dilakukan adalah pembuatan dan penghitungan kualitas citra digital menggunakan program Modulation Transfer Function (MTF) pada sistem Computed Radiography (CR) untuk kegiatan Quality Control (QC). …”
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Protective effects of shikimic acid against thioacetamide-induced hepatic fibrosis: role of Nrf2/NF-κB signaling pathways by Ashraf Albrakati

“…BackgroundLiver fibrosis is a chronic condition marked by scar tissue accumulation in the liver that impairs function. Shikimic acid (SA) has demonstrated significant antioxidant and anti-inflammatory properties and is a hydroaromatic natural product found in various plant sources, including star anise. …”
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Real-Time Polarimetric Imaging and Enhanced Deep Learning Model for Automated Defect Detection of Specular Additive Manufacturing Surfaces by Dingkang Li, Xing Peng, Hongbing Cao, Yuanpeng Xie, Shiqing Li, Xiang Sun, Xinjie Zhao

“…Secondly, the original CIoU loss function is replaced with the Alpha-IoU loss function to accelerate network convergence and strengthen system robustness. …”
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Mechanisms of the FLASH effect: current insights and advances by Giulia Rosini, Esther Ciarrocchi, Esther Ciarrocchi, Esther Ciarrocchi, Beatrice D’Orsi, Beatrice D’Orsi, Beatrice D’Orsi

“…Additionally, FLASH-RT may modulate the immune response, reducing inflammation and preserving immune cell function. …”
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Optimized expression of oxazolomycins in engineered Streptomyces longshengensis and their activity evaluation by Huiying Sun, Xiang Liu, Junyue Li, Yang Xu, Yue Li, Yuqing Tian, Huarong Tan, Jihui Zhang

“…So a strategy was designed to replace the native promoter regions between oxaG and oxaH with constitutive promoters P neo and P kasO* following functional module evaluation. In the resultant strain (SLOE), the production of oxazolomycin component Toxa5 was increased to 4-fold of that in the wild-type strain. …”
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