Nutritional support as a way to adjust the body's immune response: Experimental data and clinical studies. A review by Anna A. Makhova, Tatiana A. Fedorova, Evgenia V. Shikh

“…It is advisable to use a differentiated approach to VMCs to modulate the IS function. Basic nutritional support with vitamins C, D, and zinc is most often sufficient for people without the risks of severe and complicated acute respiratory infections. …”
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Effect of four weeks of repeated sprint training with blood flow restriction on upper limb microcirculation in boxers by Qinglou Xu, Lei Liu, Ruiqiu Mao, Zhongjie Wang

“…Abstract This study evaluates the impact of 4 weeks of 40% arterial occlusion pressure (AOP) blood flow restriction (BFR) combined with repeated sprint training (RST) on the microcirculation function of upper limbs in boxers and investigates the potential mechanisms underlying improvements in microcirculation from the perspective of blood factor changes. …”
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Members of the Cyr61/CTGF/NOV Protein Family: Emerging Players in Hepatic Progenitor Cell Activation and Intrahepatic Cholangiocarcinoma by Qunfeng Wu, Marda Jorgensen, Joanna Song, Junmei Zhou, Chen Liu, Liya Pi

“…The Cyr61/CTGF/NOV (CCN) protein family consists of six members, CCN1/CYR61, CCN2/CTGF, CCN3/NOV, CCN4/WISP1, CCN5/WISP2, and CCN6/WISP3, which function as extracellular signaling modulators to mediate cell-matrix interaction during angiogenesis, wound healing, fibrosis, and tumorigenesis. …”
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Effect of pregabalin administration upon reperfusion in a rat model of hyperglycemic stroke: Mechanistic insights associated with high-mobility group box 1. by Young Song, Ji-Hae Jun, Eun-Jung Shin, Young-Lan Kwak, Jeon-Soo Shin, Jae-Kwang Shim

“…Pregabalin administration upon reperfusion decreased neuronal death and improved neurological function in hyperglycemic stroke rats. Cogent mechanisms would include attenuation of HMGB1/TLR-4-mediated inflammation and favorable modulation of the NOS.…”
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RTL-Net: real-time lightweight Urban traffic object detection algorithm by Zhiqing Cui, Jiahao Yuan, Haibin Xu, Yamei Wei, Zhenglong Ding

“…To enhance real-time performance beyond the benchmark, we implemented lightweight designs for the loss function, backbone, neck, and head components. Firstly, a Powerable-IoU (PIoU) loss function was introduced to make the algorithm more suitable for different scales of targets and reduce false detection. …”
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Insights into diversity, host-range, and temporal stability of Bacteroides and Phocaeicola prophages by Nejc Stopnisek, Stina Hedžet, Tomaž Accetto, Maja Rupnik

“…Abstract Background Phages are critical components of the gut microbiome, influencing bacterial composition and function as predators, parasites, and modulators of bacterial phenotypes. …”
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ASHM-YOLOv9: A Detection Model for Strawberry in Greenhouses at Multiple Stages by Yan Mo, Shaowei Bai, Wei Chen

“…Finally, the CIoU function was replaced by the Minimum Point Distance based IoU (MPDIoU) loss function to effectively solve the problem of low precision in identifying bounding boxes. …”
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The malaria parasite PP1 phosphatase controls the initiation of the egress pathway of asexual blood-stages by regulating the rounding-up of the vacuole. by Marie Seveno, Manon N Loubens, Laurence Berry, Arnault Graindorge, Maryse Lebrun, Catherine Lavazec, Mauld H Lamarque

“…Our results underscore a dual function for PP1 in the egress cascade. First, we provide further evidence that PP1 controls the homeostasis of the second messenger cGMP by modulating the basal activity of guanylyl cyclase alpha and consequently the PKG-dependent downstream Ca2+ signaling. …”
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Pear Fruit Detection Model in Natural Environment Based on Lightweight Transformer Architecture by Zheng Huang, Xiuhua Zhang, Hongsen Wang, Huajie Wei, Yi Zhang, Guihong Zhou

“…Secondly, HiLo, an improved and efficient attention mechanism with high and low-frequency information extraction, was used to make the model lightweight and improve the feature extraction ability of Xinli No. 7 in complex environments. The CCFM module is reconstructed based on the Slim-Neck method, and the loss function of the original model is replaced with the Shape-NWD small target detection mechanism loss function to enhance the feature extraction capability of the network. …”
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The efficacy of transcutaneous vagus nerve stimulation in heart failure management - a systematic review and meta-analysis by Zongmei Sun, Lin Liu, Haijun Peng, RunFeng Zhang

“…Non-invasive transcutaneous vagus nerve stimulation (t-VNS) has emerged as a potential therapeutic intervention for improving cardiac function and alleviating clinical symptoms in HF patients by modulating autonomic nervous system equilibrium. …”
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Immune-Boosting and Antiviral Effects of Antioxidants in COVID-19 Pneumonia: A Therapeutic Perspective by Stefano Sanduzzi Zamparelli, Alessandro Sanduzzi Zamparelli, Marialuisa Bocchino

“…Clinical evidence suggests that antioxidant supplementation may improve patient outcomes by decreasing inflammation, supporting immune cell function, and potentially shortening recovery times. …”
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Two-Stage Learning of CPG and Postural Reflex Toward Quadruped Locomotion on Uneven Terrain With Simple Reward by Ryosei Seto, Guanda Li, Kyo Kutsuzawa, Dai Owaki, Mitsuhiro Hayashibe

“…Notably, this improvement is achieved exclusively through piecewise sequential learning with a simplified reward function. The proposed approach expands the applicability of CPG-based locomotion under unstructured environments and contributes to the advancement of bio-inspired control strategies for quadrupedal locomotion. …”
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Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis by Sharon Angela Tanuseputero, Ming-Tsan Lin, Sung-Ling Yeh, Chiu-Li Yeh

“…After Arg treatment, plasma Arg and NO levels increased, kidney function improved, and expressions of renal NLRP3 inflammasome-related proteins were downregulated. …”
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MicroRNA-342 Promotes the Malignant-Like Phenotype of Endometrial Stromal Cells via Regulation of Annexin A2 by Dan Sun, Yiting Wang, Li Wang, Xin Guo

“…Bioinformatics website and dual-luciferase reporter assay revealed that miR-342 negatively modulated ANXA2 expression. Following loss- and gain-of-function approaches, CCK-8, Transwell, and flow cytometry demonstrated that overexpression of miR-342 markedly increased cell proliferation, migration, and invasion but inhibited cell apoptotic ratio of endometrial stromal cells, which was reversed by ANXA2 elevation. …”
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Identification of fatty acid metabolism-related genes in the tumor microenvironment of breast cancer by a development and validation of prognostic index signature by Zhaofeng Ma, Man Zheng, Pulin Liu

“…We aimed to show how FAMGs influence immune function, immune checkpoints, and m6a in BRCA. A co-expression analysis discovered that gene expression is strongly connected to pyroptosis. …”
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SECrackSeg: A High-Accuracy Crack Segmentation Network Based on Proposed UNet with SAM2 S-Adapter and Edge-Aware Attention by Xiyin Chen, Yonghua Shi, Junjie Pang

“…Additionally, a custom loss function incorporating weighted binary cross-entropy and weighted IoU loss is utilized to emphasize challenging pixels. …”
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Acetate ameliorates ovarian mitochondrial dysfunction in letrozole-induced polycystic ovarian syndrome rat model by improving mitofusin-2 by Kehinde S. Olaniyi, Stephanie E. Areloegbe

“…Impaired mitochondrial function and epigenetic alteration have been linked to the development of PCOS. …”
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Enhanced assessment of contractile dynamics in Drosophila hearts by Anthony Cammarato, Shawn Ocorr, Karen Ocorr

“…Importantly, the improved functionality enables the calculation of novel physiological data, suggesting that the fly model system may also be practical for screening drugs and alleles that modulate cardiac repolarization and force production.…”
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Prosaposin: A Multifaceted Protein Orchestrating Biological Processes and Diseases by Xin Li, Liang Guo

“…In neurological disorders, PSAP acts as a neurotrophic factor influencing nerve cell survival and synapse growth, and its dysfunction is associated with a variety of diseases. It modulates immune responses and macrophage functions, affecting inflammation and immune cell activities. …”
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cGAMP-targeting injectable hydrogel system promotes periodontal restoration by alleviating cGAS-STING pathway activation by Xiang Liu, Hua Zhang, Lei Xu, Huayu Ye, Jinghuan Huang, Jing Xiang, Yunying He, Huan Zhou, Lingli Fang, Yunyan Zhang, Xuerong Xiang, Richard D. Cannon, Ping Ji, Qiming Zhai

“…The impaired function of periodontal ligament stem cells (PDLSCs) impedes restoration of periodontal tissues. …”
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