The gut-heart axis: a correlation between Paneth cells’ dysfunction, microbiome dysbiosis, and cardiovascular diseases by Aysa Rezabakhsh, Solomon Habtemariam, Rezayat Parvizi, Anne Meddahi-Pellé, Violeta Rodriguez Ruiz, Graciela Pavon-Djavid, Abolfazl Barzgari

“…This review aimed to comprehensively discuss the predominant role of PCs in the gut-heart axis, some effective compounds on PC function and AMP modulation, and finally, a possible correlation between PC dysfunction and CVD pathogenesis, encouraging future research to further elucidate this crosstalk.…”
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Tree semantic segmentation from aerial image time series by Venkatesh Ramesh, Arthur Ouaknine, David Rolnick

“…Our findings highlight the benefit of exploiting the time series modality via our Processor module. Furthermore, leveraging taxonomic information through our hierarchical loss function often, and in key cases significantly, improves semantic segmentation performance.…”
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FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder by Christopher W Fell, Astrid Hagelkruys, Ana Cicvaric, Marion Horrer, Lucy Liu, Joshua Shing Shun Li, Johannes Stadlmann, Anton A Polyansky, Stefan Mereiter, Miguel Angel Tejada, Tomislav Kokotović, Venkat Swaroop Achuta, Angelica Scaramuzza, Kimberly A Twyman, Michelle M Morrow, Jane Juusola, Huifang Yan, Jingmin Wang, Margit Burmeister, Biswa Choudhury, Thomas Levin Andersen, Gerald Wirnsberger, Uffe Holmskov, Norbert Perrimon, Bojan Žagrović, Francisco J Monje, Jesper Bonnet Moeller, Josef M Penninger, Vanja Nagy

“…Further, hippocampal synaptic remodelling in acute slices from Fibcd1 KO mice was deficient but restored upon enzymatically modulating the ECM. Together, we identified FIBCD1 as an endocytic receptor for GAGs in the brain ECM and a novel gene associated with an NDD, revealing a critical role in nervous system structure, function and plasticity.…”
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Hypercholesterolemia and the role of lipid metabolism gene CES1 in immune infiltration promote central nervous system relapse in acute myeloid leukemia by Wanwan Bao, Wanwan Bao, Yansong Tu, Shan Zhang, Shan Zhang, Xiaoyan Jiang, Huijun Chen, Huaijun Tu, Jian Li

“…Moreover, CES1 influenced the proportion of nine types of tumor-infiltrating immune cells (TICs), particularly M2 macrophages, as supported by functional studies involving CES1 knockdown and overexpression in AML cells and AML xenograft tumor models.ConclusionHypercholesterolemia and CES1 can promote CNS relapse in AML patients, particularly through CES1’s potential role in modulating immune infiltration within the TME.…”
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Apple Juice Fermented with <i>Lactiplantibacillus plantarum</i> Improves Its Flavor Profile and Probiotic Potential by Boqian Zhou, Zhuobin Xing, Yiting Wang, Xin Guan, Fuyi Wang, Jiaqi Yin, Zhibo Li, Qiancheng Zhao, Hongman Hou, Xue Sang

“…Collectively, these findings confirm that <i>L. plantarum</i>-fermented FAJ combines favorable sensory properties and safety with promising anti-obesity effects mediated through gut microbiome modulation and metabolic pathway activation. This study provides a critical scientific foundation for designing next-generation functional fermented beverages with targeted health benefits.…”
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Unlocking the Potentials of Exosomes in Achilles Tendinitis by Naveen Jeyaraman, Madhan Jeyaraman, Swaminathan Ramasubramanian, Sangeetha Balaji, Sathish Muthu

“…They promote tenocyte proliferation, enhance extracellular matrix (ECM) synthesis, and improve tendon structure and function. Preclinical studies demonstrate significant benefits of exosome therapy, including reduced inflammation, improved collagen organization, and enhanced biomechanical properties of the tendon. …”
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Design and Strength Simulation of a Modular Auxiliary Inverter by WANG Zhipeng, LI Yan, XU Mingxia

“…The structure of each function module was expounded. And structural strength and modal of the converter were analyzed by using the finite element simulation software ANSYS, and the structure was optimized according to the results. …”
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Calcium handling remodeling in dilated cardiomyopathy: From molecular mechanisms to targeted therapies by Yuhan Wang, Tingting Zhou, Jiajing Zhao, Hongjun Zhu, Xiaodong Tan, Jiahao Chen, Zhuojun Zhang, Lijuan Shen, Shu Lu

“…This review aims to systematically analyze how structural and functional remodeling of Ca2+-handling proteins drives DCM progression and to evaluate therapeutic strategies targeting these pathways. …”
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热处理企业信息管理系统的开发与应用 by 王明伟, 周茂军, 于海, 许言平, 田绍洁

“…The management current situation of middle and small heat treatment enterprise is analyzed,based on.NET platform,a set of heat treatment of enterprise information management system is developed.The design of the system requirement and the function of each module are mainly introduced,the intellectualized formulation of heat treatment process is realized.This system development and use is helpful to heat treatment enterprise standard business process,accelerating innovation,reducing costs and improving quality,and has very strong practicability.…”
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Evaluation of Clareon Vivity and PureSee intraocular lenses: optical quality, depth of focus and misalignment effects by Ava Niknahad, Zhiyi Wu, Hyeck-Soo Son, Gerd U Auffarth, Ramin Khoramnia, Grzegorz Łabuz

“…Two EDoF lenses, Clareon Vivity and Tecnis PureSee, were evaluated for optical quality using the OptiSpheric IOL Pro2 according to ISO 11979-2 guidelines and measured using Modulation Transfer Function (MTF) and 1951 USAF resolution test chart at 3.0- and 4.5-mm apertures. …”
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Bardoxolone Methyl: A Comprehensive Review of Its Role as a Nrf2 Activator in Anticancer Therapeutic Applications by Valentina Schiavoni, Tiziana Di Crescenzo, Valentina Membrino, Sonila Alia, Sonia Fantone, Eleonora Salvolini, Arianna Vignini

“…Additionally, bardoxolone methyl modulates mitochondrial function, reduces glycolytic and oxidative phosphorylation capacities, and induces reactive oxygen species (ROS)-mediated stress responses. …”
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Combining dynamin 2 myopathy and neuropathy mutations rescues both phenotypes by Marie Goret, Evelina Edelweiss, Jérémy Jehl, David Reiss, Patricio Aguirre-Pineda, Sylvie Friant, Jocelyn Laporte

“…Here, we present in vitro assays underlining opposing effects of DNM2 mutations, gain-of-function in CNM and loss-of-function in CMT. In vivo, we explored the potential compensatory effects of CNM and CMT mutations by breeding Dnm2 S619L/+ CNM with Dnm2 K562E/+ CMT mouse models. …”
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Molecular basis of ligand-dependent Nurr1-RXRα activation by Xiaoyu Yu, Jinsai Shang, Douglas J Kojetin

“…Small molecule compounds that activate transcription of Nurr1-retinoid X receptor alpha (RXRα) (NR4A2-NR2B1) nuclear receptor heterodimers are implicated in the treatment of neurodegenerative disorders, but function through poorly understood mechanisms. Here, we show that RXRα ligands activate Nurr1-RXRα through a mechanism that involves ligand-binding domain (LBD) heterodimer protein-protein interaction (PPI) inhibition, a paradigm distinct from classical pharmacological mechanisms of ligand-dependent nuclear receptor modulation. …”
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PTSD Increases Risk for Hypertension Development Through PVN Activation and Vascular Dysfunction in Sprague Dawley Rats by Xinqian Chen, Xin Yan, Chunxiu Yu, Qing-hui Chen, Lanrong Bi, Zhiying Shan

“…This study investigates the impact of single prolonged stress (SPS), a model of post-traumatic stress disorder (PTSD), on cardiovascular responses, hypothalamic paraventricular nucleus (PVN) activity, and vascular function to elucidate the mechanisms linking traumatic stress to hypertension. …”
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Effects of yoga breathing practice on heart rate variability in healthy adolescents: a randomized controlled trial by Maheshkumar Kuppusamy, Dilara Kamaldeen, Ravishankar Pitani, Julius Amaldas, Padmavathi Ramasamy, Poonguzhali Shanmugam, Venugopal Vijayakumar

“…Background: This study was conducted among healthy adolescents to assess the effects of a yoga breathing practice (Bhramari pranayama, Bhr.P) towards cardiac autonomic function using heart rate variability (HRV) parameters. …”
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Reducing severity of inflammatory bowel disease through colonization of Lactiplantibacillus plantarum and its extracellular vesicles release by Yuanyuan Wu, Xinyue Huang, Qianbei Li, Chaoqun Yang, Xixin Huang, Hualongyue Du, Bo Situ, Lei Zheng, Zihao Ou

“…Abstract Inflammatory bowel disease (IBD) is characterized by compromised intestinal barrier function and a lack of effective treatments. Probiotics have shown promise in managing IBD due to their ability to modulate the gut microbiota, enhance intestinal barrier function, and exert anti-inflammatory effects. …”
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Manipulating the symmetry of photon-dressed electronic states by Changhua Bao, Michael Schüler, Teng Xiao, Fei Wang, Haoyuan Zhong, Tianyun Lin, Xuanxi Cai, Tianshuang Sheng, Xiao Tang, Hongyun Zhang, Pu Yu, Zhiyuan Sun, Wenhui Duan, Shuyun Zhou

“…Moreover, a “hot spot” with strong intensity confined near Γ is observed, indicating a momentum-dependent modulation beyond the parity switch. Combining with theoretical calculations, we reveal the light-induced engineering of the wave function of the Floquet-Bloch states as a result of the hybridization between the conduction and valence bands with opposite parities, and show that the “hot spot” is intrinsically dictated by the symmetry properties of black phosphorus. …”
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Automated gait analysis indicates efficacy of T-type calcium channel inhibition for mitigation of disrupted calcium signalling in an SCA5 mouse model by Daumante Suminaite, Nurul Fatihah Talib, Sophie Jane Pettegree, Han Chew Gaelan Tan, Yvonne Louise Odey, Emma Margaret Perkins, Alastair Robert Lyndon, Paul Andrew Skehel, Mandy Jackson

“…These findings highlight the CatWalk XT system as a valuable tool to assess age-dependence of motor function and that modulation of T-type calcium channels has therapeutic potential for SCAs.…”
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Alleviative Effects of Ciprofol on Hepatic Ischemia/Reperfusion Injury Through Inhibiting Macrophage Polarization by Hanjian Chen, Heng Wen, Dongdong Tian, Huina Su, Ru Zhang, Lijia Zhang

“…Hepatic tissue damage and apoptosis were assessed through hematoxylin‐eosin and TUNEL staining. Liver function parameters, including aspartate aminotransferase (AST) and alanine aminotransferase (ALT), as well as pro‐inflammatory cytokine levels, were quantified using commercial assay kits. …”
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Aspirin and Some Other Nonsteroidal Anti-Inflammatory Drugs Inhibit Cystic Fibrosis Transmembrane Conductance Regulator Protein Gene Expression in T-84 Cells by Danielle Tondelier, Franck Brouillard, Joanna Lipecka, Régis Labarthe, Moëz Bali, Marie-Ayliette Costa De Beauregard, Tanja Torossi, Marc Cougnon, Aleksander Edelman, Maryvonne Baudouin-Legros

“…The present study was undertaken to determine whether three nonsteroidal anti-inflammatory drugs (NSAIDs) (aspirin, ibuprofen, and indomethacin) modulate CFTR gene expression in T-84 cells. Treatment with NSAIDs reduced CFTR transcripts, and decreased cAMP-stimulated anion fluxes, an index of CFTR function. …”
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