Quality of life of women with breast cancer undergoing chemotherapy by Edianne Sílvia Lustosa Cesar, Inez Sampaio Nery, Államy Danilo Moura e Silva, Juliana Teixeira Nunes, Ana Fátima Carvalho Fernandes

“…Conclusion: general health presented satisfactory average, which suggests a good quality of life according to the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire-30. However, the Functional and Symptoms domains, as measured by Supplementary Questionnaire Breast Cancer Module, were negatively influenced by old age and larger cycles of chemotherapy.…”
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Quality of life of women with breast cancer undergoing chemotherapy by Edianne Sílvia Lustosa Cesar, Inez Sampaio Nery, Államy Danilo Moura e Silva, Juliana Teixeira Nunes, Ana Fátima Carvalho Fernandes

“…Conclusion: general health presented satisfactory average, which suggests a good quality of life according to the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire-30. However, the Functional and Symptoms domains, as measured by Supplementary Questionnaire Breast Cancer Module, were negatively influenced by old age and larger cycles of chemotherapy.…”
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Enhanced Ischemic Stroke Lesion Segmentation in MRI Using Attention U-Net with Generalized Dice Focal Loss by Beatriz P. Garcia-Salgado, Jose A. Almaraz-Damian, Oscar Cervantes-Chavarria, Volodymyr Ponomaryov, Rogelio Reyes-Reyes, Clara Cruz-Ramos, Sergiy Sadovnychiy

“…This paper proposes a lightweight model based on the U-Net architecture that handles an attention module and the Generalized Dice Focal loss function to enhance the segmentation accuracy in the class imbalance environment, characteristic of stroke lesions in MRI images. …”
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RIS Assisted UAV for Weather-Dependent Satellite Terrestrial Integrated Network With Hybrid FSO/RF Systems by Xin Li, Yongjun Li, Xinkang Song, Long Shao, Hai Li

“…The performance of our proposed scheme is evaluated in terms of outage probability, average bit-error rate (BER) and ergodic capacity in the form of bivariate Fox's H function and bivariate Meijer's G function. …”
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Modified Decision Feedback Equalizers for Nonlinearity Compensation in Coherent PAM4 Transmission System by Zhengxuan Li, Zheng Xin, Siyu Luo, Acai Tan, Bingyao Cao

“…In addition, we incorporate the phase into the error function, proposing the phase-assisted decision feedback equalizer (PA-DFE). …”
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Mapping the hippocampal spatial proteomic signature in male and female mice of an early Alzheimer’s disease model by Ana Contreras, Raquel Jiménez-Herrera, Souhail Djebari, Juan D. Navarro-López, Lydia Jiménez-Díaz

“…Abstract Background Hippocampal dysfunction induced by soluble amyloid-β oligomers (oAβ) is an early neuropathological hallmark of Alzheimer’s disease (AD). oAβ shifts hippocampal synaptic-plasticity induction threshold facilitating long-term depression (LTD) instead of long-term potentiation (LTP, the functional basis of memory), thereby leading to memory deficits in early AD-like amyloidosis mouse models. …”
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Designing Community Houses – Application of the modular approach to an innovative model of facility by Riccardo Pollo, Elisa Biolchini, Valeria Scognamiglio

“… The modular approach is widely used in architecture, and simplifying complex structures to enhance flexibility is one of the many reasons for choosing the module as a design tool, particularly in healthcare construction. …”
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Method for reducing the complexity of clock domain crossing design and its verification in system-on-chips by Dan LIU, Yi FENG, Xiang-lei DANG, Dong TONG, Xu CHENG, Ke-yi WANG

“…Existing methods for clock domain crossing (CDC) design were used directly in a system-on-chip (SoC),which result in high design and verification complexity.To solve this problem,a design method was proposed.It separated CDC design completely from functional design and transmits all the CDC signals in an IP design with the help of an independent and dedicated CDC processing module.It also scaled down the total number of CDC signals to two groups of opposite directions through encapsulating point-to-point communication interface as well as processing CDC signals of the same direction in combination.Experiment results demonstrate that this method is able to sharply reduce the verification complexity of CDC design and also simplify the whole SoC design,without significant adding to transfer delay or area cost of an IP design.…”
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Human Empathy Through the Lens of Social Neuroscience by Jean Decety, Claus Lamm

“…We discuss data from recent behavioral and functional neuroimaging studies with an emphasis on the perception of pain in others, and highlight the role of different neural mechanisms that underpin the experience of empathy, including emotion sharing, perspective taking, and emotion regulation.…”
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Injury-Driven Structural and Molecular Modifications in Nociceptors by Mario García-Domínguez

“…Structural remodeling includes alterations in axonal architecture, dendritic morphology, and synaptic connectivity, collectively impacting nociceptor excitability and functional integration. Simultaneously, molecular adaptations comprise the regulation of ion channels, receptor expression, and intracellular signaling pathways, as well as transcriptional reprogramming that modulates nociceptive signaling. …”
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Method for reducing the complexity of clock domain crossing design and its verification in system-on-chips by Dan LIU, Yi FENG, Xiang-lei DANG, Dong TONG, Xu CHENG, Ke-yi WANG

“…Existing methods for clock domain crossing (CDC) design were used directly in a system-on-chip (SoC),which result in high design and verification complexity.To solve this problem,a design method was proposed.It separated CDC design completely from functional design and transmits all the CDC signals in an IP design with the help of an independent and dedicated CDC processing module.It also scaled down the total number of CDC signals to two groups of opposite directions through encapsulating point-to-point communication interface as well as processing CDC signals of the same direction in combination.Experiment results demonstrate that this method is able to sharply reduce the verification complexity of CDC design and also simplify the whole SoC design,without significant adding to transfer delay or area cost of an IP design.…”
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EFFECTS OF MICROGRAVITY AND IONIZING RADIATION OVER HUMAN BODY (A REVIEW) by Raina Ardasheva, Victor Yotov, Valentin Turiiski

“…Data obtained have traced many reliable findings: morphological and functional changes in neuronal tissues (expressed as decreased number of cells and change of their form), vascular system disorders (hemodynamics modulations, pulse rate and blood pressure alteration), and skeletal muscles weakness (change in volume and mass). …”
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Neuropharmacological Assessment of the Hydroethanolic Leaf Extract of Calotropis procera (Ait). R. Br. (Apocynaceae) in Mice by Ernest Obese, Elvis Ofori Ameyaw, Robert Peter Biney, Emmanuel Awintiig Adakudugu, Eric Woode

“…Thus, the potential of the plant to affect neurological functions was evaluated. Methods. Irwin’s test was performed to determine the effect of the oral administration of the extract (30–3000 mg kg−1) on gross behaviour and physiological function. …”
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Aconiti Lateralis Radix Praeparata ameliorates heart failure via PI3K/AKT/Bnip3 pathway by Wenxiu Liu, Xingju Zou, Yang Zheng, Yuan Zhang, Guijuan Cui, Siyu Liu, Chen Sun, Cheng Peng

“…The echocardiography was performed to investigate cardiac function. Histopathological analysis of cardiac tissue was conducted to assess myocardial fibrosis. …”
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A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer’s diseaseResearch in context by Courtney L. Millar, Ike Iloputaife, Kathryn Baldyga, Amani M. Norling, Afroditi Boulougoura, Theodoros Vichos, Tamara Tchkonia, Aaron Deisinger, Tamar Pirtskhalava, James L. Kirkland, Thomas G. Travison, Lewis A. Lipsitz

“…Recruitment rate, adverse events, absolute changes in functional outcomes, and percent changes in biomarkers were calculated. …”
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KAT7-acetylated YBX1 promotes hepatocellular carcinoma proliferation by reprogramming nucleotide metabolism by He Huang, Longfei Ren, Yongqiang Zhou, Pengyu Chen, Haixia Zhao, Shang Li, Haiping Wang, Xun Li

“…Transcriptome sequencing and functional enrichment analysis were employed to elucidate the downstream pathway regulated by KAT7 and YBX1. …”
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PROCR diminishes the efficacy of radiation by impairing T-cell-mediated antitumour immunity by Weipeng Chen, Chuqing Zhang, Zhe Li, Zhimin Xu, Cong Ding, Jiawei Wu, Hanmiao Wei, Zhenji Deng, Tingxiang He, Liufen Long, Yanping Mao, Jun Ma, Xiaoyu Liang

“…Here, we show that tumour cells expressing protein C receptor (PROCR) dampen antitumour immunity by promoting the production of interleukin-6 (IL-6), which inhibits the differentiation of T helper 1 (Th1) cells and suppresses the function of CD8+ T cells. We also demonstrate that radiation therapy enhances PROCR expression by reducing its selective autophagic degradation through the modulation of p62 phosphorylation, a process governed by mTORC1 signalling. …”
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Multiple pathways through which the gut microbiota regulates neuronal mitochondria constitute another possible direction for depression by Hongyi Zhao, Xiongfeng Qiu, Shuyu Wang, Yi Wang, Li Xie, Xiuwen Xia, Weihong Li, Weihong Li

“…Recent studies have revealed that the gut microbiota and neuronal mitochondrial dysfunction play central roles in the pathogenesis of depression: the gut microbiota influences the course of depression through multiple pathways, including immune regulation, HPA axis modulation and neurotransmitter metabolism. Mitochondrial function serves as a key hub that mediates mood disorders through mechanisms such as defective energy metabolism, impaired neuroplasticity and amplified neuroinflammation. …”
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Copper Metabolism and Cuproptosis in Ovarian Cancer by Yuhong Xu, Qiang Wen, Haigang Ding, Jiangjing Shan, Qi Zhang

“…Copper metabolism imbalance promotes OC progression by modulating cancer cell function, contributing to chemotherapy resistance, and influencing responses to anti-angiogenesis, and immunotherapy. …”
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Bojungikki-Tang Augments Pembrolizumab Efficacy in Human PBMC-Injected H460 Tumor-Bearing Mice by Se Won Na, Jin-Mu Yi, Heerim Yeo, Sang-Min Park, Mibae Jeong, Jaemoo Chun, Mi-Kyung Jeong

“…Bojungikki-Tang (BJIKT) is traditionally used to enhance digestive function and immunity. It has gained attention as a supplement to chemotherapy or targeted therapy owing to its immune-boosting properties. …”
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