Valosin-containing protein (VCP), a component of tumor-derived extracellular vesicles, impairs the barrier integrity of brain microvascular endothelial cells by Ramon Handerson Gomes Teles, Nicolas Jones Villarinho, Ana Sayuri Yamagata, Camila Tamy Hiroki, Murilo Camargo de Oliveira, Gisela Ramos Terçarioli, Ruy Gastaldoni Jaeger, Patrick Meybohm, Malgorzata Burek, Vanessa Morais Freitas

“…Thus, this study aimed to investigate sEV-triggered changes in the phosphorylation state of proteins on the surface of brain endothelial cells, as they form the first barrier in contact with circulating tumor cells and EVs, and once identified, to modulate its interactors and effects from this through different functional assays. …”
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Analysis and Calculation of DC-link Ripple for the Inverter in Electric Vehicle by WU Chundong, LI Yun, JIAO Mingliang, ZHU Shiwu

“…Based on the SVPWM modulation mode and its latent modulation wave function, the calculation formulas of ripple current and ripple voltage of DC-link capacitor were deduced and analyzed under different operation conditions.…”
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无铰泵缸体转动规律的参数化研究和实现 by 李玉龙, 刘焜, 王学军, 徐强

“…Based on the special running rule consisted in rotor of non-gemel pump, with integrative expression function and regular curve and optimizing module provided by UGNX software, the real running rule consisted in rotor of non-gemel pump is reappeared, and automatically plotting the rule curves on monitor running and figuring out all extremum by optimizing module at same time are realized, it was all-parameterized and all-automatic and integrative that product design for series was changed into easiness correspondingly. …”
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具有越障功能的输电线路除冰机器人设计 by 张屹, 韩俊, 刘艳, 丁昌鹏, 朱大林

“…By analysing the present de-icing robot design in China,a design scheme of de-icing robot with obstacle negotiation function in consideration of the structure features of the transmission line is proposed.The design scheme consists of the design of mechanical system and the design of the control system.The mechanical system is composed by the walking device,obstacle negotiating device and de-icing device,the control system includes main control module,wireless control module,motor drive module and status information feedback module.Performance tests in both laboratory and field indicate that,the mechanical system design of the de-icing robot is reasonable and the control system is of great stablity and effecitveness.…”
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Effects and mechanisms of phytochemicals on skeletal muscle atrophy in glucolipid metabolic disorders: current evidence and future perspectives by Mengjie Li, Yige Qin, Ruixuan Geng, Jingjing Fang, Seong-Gook Kang, Kunlun Huang, Tao Tong

“…Several studies demonstrated an inverse relationship between dietary phytochemical supplementation and the onset of skeletal muscle atrophy caused by glucolipid metabolic disorders, as evidenced by improved muscle quality and function. Insulin-like growth factor 1/protein kinase B signaling pathway activation, protein ubiquitination inhibition, enhancement of mitochondrial function and inflammatory response, reduction of oxidative stress, and regulation of gut microbiota represent the mechanisms underlying the anti-skeletal muscle atrophy effect of phytochemicals. …”
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Artesunate Mitigates Sepsis-Induced Acute Kidney Injury via Lactate/AMPK/mTOR-Regulated Autophagy Based on Multi-Omics by Chen H, Du P, Guo R, Li X, Zhang L, Duan J, Chen M, Guo J, Li Y, Jiang T

“…Integrative analysis of metabolomics and transcriptomics reveals that ART intervention markedly decreases lactate levels, inhibits excessive AMPK activation, relieves mTOR pathway suppression, and suppresses excessive autophagy, thereby attenuating inflammation and oxidative stress, and mitigating renal cell injury.Conclusion: The findings suggest that ART may mitigate inflammation and oxidative stress while improving renal function in S-AKI by modulating the lactate/AMPK/mTOR pathway and inhibiting excessive autophagy.Keywords: acute kidney injury, artesunate, multi-omics, lactate/AMPK/mTOR pathway, autophagy…”
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Coherence Analysis of Cardiovascular Signals for Detecting Early Diabetic Cardiac Autonomic Neuropathy: Insights into Glycemic Control by Yu-Chen Chen, Wei-Min Liu, Hsin-Ru Liu, Huai-Ren Chang, Po-Wei Chen, An-Bang Liu

“…While our previous study demonstrated the utility of multiscale cross-approximate entropy (MS-CXApEn) in detecting early CAN, the present study further investigates the use of frequency-domain coherence analysis between systolic blood pressure (SBP) and R-R intervals (RRI) and evaluates the effects of insulin treatment on autonomic function in diabetic rats. <b>Methods:</b> At the onset of diabetes induced by streptozotocin (STZ), rats were assessed for cardiovascular autonomic function both before and after insulin treatment. …”
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Piezo1 deletion mitigates diabetic cardiomyopathy by maintaining mitochondrial dynamics via ERK/Drp1 pathway by Weipin Niu, Xin Liu, Bo Deng, Tianying Hong, Cuifen Wang, Yameng Yan, Jiali Liu, Yuehua Jiang, Jing Li

“…Piezo1 knockout or treatment with inhibitor improved mitochondrial function. Conclusions This study provides the first evidence that Piezo1 is elevated in DCM through the modulation of mitochondrial dynamics, which is reversed by Piezo1 deficiency. …”
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The delaying effect of toripalimab on disease progression in patients with advanced hepatocellular carcinoma and changes in serum tumor markers by Zhuo Yin, Yaomin Xiao, Jiangxue Gu, Pei Hu, Jiandu Jing, Xia Wang, Yao Liu, Shirong Yan

“…Conclusion TACE combined with toripalimab demonstrates superior disease control in advanced HCC, marked by enhanced ORR, prolonged survival, reduced tumor biomarkers, improved liver function, and favorable immune modulation. The regimen exhibits acceptable safety, supporting its potential as a therapeutic option. …”
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Enhancing ovarian cancer prognosis with an artificial intelligence-derived model: Multi-omics integration and therapeutic implications by You Wu, Kunyu Wang, Yan Song, Bin Li

“…The AIDPI model was developed and refined using univariate Cox regression analysis and an ensemble of machine learning algorithms. Functional analysis, immunoprofiling, and the role of the MFAP4 gene were investigated to elucidate the biological mechanisms underlying the model. …”
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Active Neurodynamic Technique at Home in Patients with Knee Osteoarthritis: An Open Single Arm Clinical Trial by Beatriz Serrano-García, Carmen Belén Martínez-Cepa, Francisco Forriol, Juan Carlos Zuil-Escobar

“…<i>Background and Objectives</i>: Knee osteoarthritis (KO) stands as the third leading cause of disability among the elderly, causing pain, reduced quality of life, and decreased functionality. The objective of this study is to assess the effects of an active neurodynamic technique programme at home on pain, quality of life, and function among individuals with KO. …”
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Neutrophil Spatiotemporal Regulatory Networks: Dual Roles in Tumor Growth Regulation and Metastasis by Pengcheng Li, Feimu Fan, Bixiang Zhang, Chaoyi Yuan, Huifang Liang

“…In tumor progression, neutrophils adopt context-dependent phenotypes and execute diverse functions, including polarization into anti-tumor (N1) or pro-tumor (N2) subsets; secretion of inflammatory and angiogenic mediators; formation of neutrophil extracellular traps (NETs); production of reactive oxygen and nitrogen species (e.g., H₂O₂ and nitric oxide); and modulation of immune cell infiltration and function within the tumor microenvironment. …”
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Longitudinal Modeling and Control of Tailed Flapping-Wings Micro Air Vehicles near Hovering by Tao Jiang, Xiaosong Yang, Hongwei Wang, Wen Gai, Long Cui

“…Our results show that the natural‐motion mode determines the oscillation divergence characteristics of the tailed FMAV, a mode that can be suppressed with the state feedback controller by real‐time modulation of the tail. The tail can also be used to achieve different flight modes with different control‐signal functions. …”
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Intracellular pH Regulates TRAIL-Induced Apoptosis and Necroptosis in Endothelial Cells by Zhu-Xu Zhang, Ingrid Gan, Alexander Pavlosky, Xuyan Huang, Benjamin Fuhrmann, Anthony M. Jevnikar

“…Thus, the microenvironment can expose parenchymal cells to a reduced extracellular pH which can alter pH-dependent intracellular functions. We have previously shown that while silencing caspase-8 in an in vivo ischemia reperfusion injury (IRI) model results in improved organ function and survival, removal of caspase-8 function in a donor organ can paradoxically result in enhanced receptor-interacting protein kinase 1/3- (RIPK1/3-) regulated necroptosis and accelerated graft loss following transplantation. …”
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Corticobulbar activity in healthy humans and Parkinson’s disease: a study protocol for a novel biomarker of motivational arousal by Francesca Ferraioli, Francesco Tomaiuolo, Alessandra M. Falzone, Angelo Labate, Salvatore M. Cardali, Simona Massimino, Fabrizio Esposito, Antonino Germanò, Luigi Trojano, Carmelo Mario Vicario

“…Findings may contribute to identifying non-invasive biomarkers of motivational functioning in both clinical and normative populations.…”
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Study and Design of the Planetary Reducer Selection System by Zhou Rui, Dong Mingwang, Bao Kaimei

“…The database,calculation module,auxiliary function module and planetary reducer selection system are designed. …”
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Identification of a transcription factor AoMsn2 of the Hog1 signaling pathway contributes to fungal growth, development and pathogenicity in Arthrobotrys oligospora by Qianqian Liu, Kexin Jiang, Shipeng Duan, Na Zhao, Yanmei Shen, Lirong Zhu, Ke-Qin Zhang, Jinkui Yang

“…Additionally, untargeted metabolomic analysis identified an important function of AoMsn2 in the modulation of secondary metabolites. …”
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NEU1-Mediated Extracellular Vesicle Glycosylation in Alzheimer’s Disease: Mechanistic Insights into Intercellular Communication and Therapeutic Targeting by Mohd Adnan, Arif Jamal Siddiqui, Fevzi Bardakci, Malvi Surti, Riadh Badraoui, Mitesh Patel

“…Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is marked by the pathological accumulation of amyloid-β plaques and tau neurofibrillary tangles, both of which disrupt neuronal communication and function. Emerging evidence highlights the role of extracellular vesicles (EVs) as key mediators of intercellular communication, particularly in the propagation of pathological proteins in AD. …”
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Effect of acupuncture at Back-Shu points on gut microbiota in insomnia model rats based on metagenomic sequencing technology by Shangwen Qi, Jiahui Qian, Yubing Li, Yujie Li, Wei Li, Xiyan Gao, Xiyan Gao, Xiyan Gao

“…These changes may act by restoring neurotransmitter balance, strengthening gut barrier integrity, and modulating immune responses. Notably, SCFAs can activate G-protein–coupled receptors to suppress overactivation of the hypothalamic–pituitary–adrenal (HPA) axis, counteracting insomnia-related pathophysiology.ConclusionAcupuncture at Back-Shu points ameliorates PCPA-induced insomnia-like behavior in rats and beneficially remodels gut microbiota structure and metabolic function. …”
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Single-Cell Transcriptomics of Human Tonsils Reveals Nicotine Enhances HIV-1-Induced NLRP3 Inflammasome and Mitochondrial Activation by Nadine Schrode, Trinisia Fortune, Aislinn M. Keane, Jesse F. Mangold, Benjamin Tweel, Kristin G. Beaumont, Talia H. Swartz

“…Single-cell RNA sequencing was used to profile immune cell populations and gene expression linked to inflammasome activation, oxidative stress, and mitochondrial function. Gene set enrichment analysis (GSEA) and synergy assessments were conducted to investigate how nicotine modulates immune responses in the context of HIV. …”
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