The function of PCSK9 in doxorubicin-induced cardiotoxicity and its underlying mechanism by Shuai Shi, Zhihui Qin, Chang Liu, Yanru Zhao, Xiaopeng Bai, Chaoyu Sun, Xu Li, Wanting Cong, Xinyue Yuan, Lixiu Sun, Bingchen Liu, Xueqi Li

“…Evolocumab (PCSK9 inhibitors) improved cardiac function, myocardial injury, and fibrosis in DOX-treated mice, indicating a protective effect against DIC. …”
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Femtosecond Laser‐Regulated Microstructures for on‐Demand Functionalization of Magnetic Milli‐Robots by Ruyu Li, Ruokun He, Zhuo‐Chen Ma, Zhiang Zhang, Xiaofu Zhao, Yifei Yao, Shuyue Xu, Xiaosheng Yang, Hesheng Wang, Bing Han

“…However, the challenge of achieving in situ functionalization of these small, flexible robots without compromising their magnetic agility has hindered their widespread deployment. …”
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The interrelationship among exercise intensity, endothelial function, and ghrelin in healthy humans by Kara C. Anderson, Emily E. Grammer, Benjamin Stephenson, Macy E. Stahl, Nathan R. Weeldreyer, Zhenqi Liu, Kaitlin M. Love, Jason D. Allen, Arthur Weltman

“…Abstract Ghrelin circulates in acylated (AG) and deacylated (DAG) isoforms and both may impact endothelial function (EF). Although acute exercise has been shown to modulate ghrelin levels and EF, data on the impact of exercise intensity on these parameters are scarce. …”
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Impact of butyric acid modification on the structural and functional properties of rice starch by Qiaoyan Wu, Yang Yang, Yue Xu, Bing Wang, Xiaofei Liu, Yan Wang, Guang Zhang, Xin Bian, Chunmin Ma, Na Zhang

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Nettle Leaf Water Extracts for Hepatoprotection: Insights into Bioactivity and Mitochondrial Function by Ruta Muceniece, Beatrise Luize Revina, Jorens Kviesis, Aris Jansons, Kirills Kopiks, Kaspars Jekabsons, Kristine Saleniece, Jana Namniece, Zane Grigale-Sorocina, Baiba Jansone

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Chromatin accessibility and transcriptomic profiles of sheep pituitary function associated with fecundity by Shanglai Li, Bingru Zhao, Peiyong Chen, Yu Cai, Hui Xu, Chenbo Yan, Feng Wang, Yanli Zhang

“…Despite this mechanistic insight, the chromatin accessibility landscape of the sheep pituitary and its functional implications for reproductive traits remain largely unexplored. …”
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Signalling pathways and cellular functions of KDEL receptors: implications in cancer biology by Beatrice Dufrusine, Ilaria Cela, Chiara Gramegna Tota, Marta Palumbo, Michele Sallese

“…In conclusion, endomembrane-initiated signalling through KDELR plays a pivotal role in regulating fundamental cellular processes, maintaining physiological functions, and modulating key aspects of cancer biology.…”
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Beyond pollination – The neglected contribution of ground-nesting bees to soil functions by Philippe Tschanz, Matthias Albrecht, Thomas Keller

“…Furthermore, we discuss the large-scale indirect effects on soils through their pollination functions, which shape plant communities and soil functions modulated by plants. …”
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High SERS performance of functionalized carbon dots in the detection of dye contaminants by Yanqiu Yang, Lingru Kong, Yong Ding, Lixin Xia, Shuo Cao, Peng Song

“…Introduction: The long-term overuse of malachite green (MG) has potential carcinogenic, teratogenic, and mutagenic effects. The functional nanocomposite is novel and challenging to construct and implement through surface enhanced Raman scattering (SERS) strategy to reveal the contributions in application. …”
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Peripheral Microcirculation and Endothelial Function in Comas Induced by Acute Cerebrovascular Accident by S. L Kan, Yu. A. Churlyaev, D. G Dantsiger, A. A. Kosovskikh, A. V. Ekimovskikh, P. G. Sitnikov

“…Throughout the study, the patients with coma induced by ACA were found to have microcirculatory disorders consisting in higher microperfusion along with the markedly increased influence of active modulators of vascular tone, as well as endothelial functional structural changes. …”
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Metformin improves Mycobacterium avium infection by strengthening macrophage antimicrobial functions by Sindre Dahl Mediaas, Sindre Dahl Mediaas, Markus Haug, Markus Haug, Claire Louet, Sissel Gyrid Freim Wahl, Sissel Gyrid Freim Wahl, Alexandre Gidon, Trude Helen Flo, Trude Helen Flo

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Impact of CYP3A4 functional variability on ziprasidone metabolism by Qi Zhou, Qi Zhou, Yameng Wu, Zhize Ye, Zheyan Zhang, Kai Zheng, Jianchang Qian, Zhongxiang Xiao, Yang Lu

“…This study explored the functional variability of CYP3A4 in ziprasidone metabolism, focusing on drug interactions and genetic polymorphisms.MethodsThe metabolic inhibition and kinetic properties of ziprasidone were evaluated through in vitro experiments utilizing rat liver microsomes (RLM), human liver microsomes (HLM), and CYP3A4 baculosomes. …”
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Anaesthetic impairment of immune function is mediated via GABA(A) receptors. by Daniel W Wheeler, Andrew J Thompson, Federico Corletto, Jill Reckless, Justin C T Loke, Nicolas Lapaque, Andrew J Grant, Pietro Mastroeni, David J Grainger, Claire L Padgett, John A O'Brien, Nigel G A Miller, John Trowsdale, Sarah C R Lummis, David K Menon, John S Beech

“…Whole cell patch clamp electrophysiological studies show that GABA can activate these receptors, resulting in the opening of a chloride-selective channel; activation is inhibited by the GABA(A) receptor antagonists bicuculline and picrotoxin, but not enhanced by the positive modulator diazepam. The anaesthetic drugs propofol and thiopental, which can act via GABA(A) receptors, impaired monocyte function in classic immunological chemotaxis and phagocytosis assays, an effect reversed by bicuculline and picrotoxin.…”
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Functional adaptations of the rhizosphere microbiome for drought-tolerance promotion in common bean by Ana Vitória Reina da Silva, Izadora de Cássia Mesquita Cunha, Thierry Alexandre Pellegrinetti, Eduardo Henrique Marcandalli Boleta, Luis Felipe Guandalin Zagatto, Solange dos Santos Silva Zagatto, Caroline Sayuri Nishisaka, Teresa Maria Lorizolla Mafra, Camila Maistro Patreze, Gordon F. Custer, Francisco Dini-Andreote, Rodrigo Mendes, Siu Mui Tsai, Lucas William Mendes

“…Here, we investigated the rhizosphere microbiomes of drought-tolerant (BAT477, SEA5) and susceptible (IAC Milênio, IAC-Carioca 80SH) common bean cultivars (Phaseolus vulgaris L.) under contrasting water regimes in mesocosm experiments to assess microbiome functional modulation under drought. Analysis of plant growth, physiological responses, nutrient dynamics, and rhizosphere microbial functional diversity revealed that drought-tolerant cultivars exhibited greater water management, minimal growth reductions, and enrichment of beneficial microbial functions, including genes linked to drought tolerance. …”
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Identification and functional analysis of Wall-Associated Kinase genes in Nicotiana tabacum by Ling Li, Linggai Cao, Jintao Li, Zhiqiang Zhang, Zhiqiang Zhang, Jie Liu, Zhongying Ren, Jie Zhang, Rengang Wang, Yangfan Miao, Shizhou Yu, Wei Li, Wei Li

“…DiscussionThis study represents the first genome-wide analysis of the WAK gene family in N. tabacum, laying the groundwork for future functional investigations. …”
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Functional and structural analysis of missense variants in the human PDCD1 Gene by Hanâ Baba, Meryem Bouqdayr, Anass Abbad, Asmae Saih, Benson R. Kidenya, Mohamed A. Sesay, Simpson Addo, Lahcen Wakrim, Anass Kettani

“…Background: Programmed death-1 (PD-1) is an immune checkpoint receptor that regulates T-cell function by modulating and terminating immune responses. …”
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The cognitive cerebellum: linking microstructure to cognitive functions in a healthy population by Nicole Urbini, Carolyn B. McNabb, Derek K. Jones, Craig Hedge, Eirini Messaritaki, Pedro Luque Laguna, Mara Cercignani

“…While studies conducted on people with cerebellar disorders highlight both structural and functional links with cognition, research on cerebellar structure in the healthy population remains sparse. …”
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Unraveling the genetic traits and functional diversity of the pan-genome in Pantoea dispersa by Shiyao He, Qi Ding, Wenting Wu, Yun Zhang, Yan Kang, Yang Meng, Sirui Zhu, Jinyuan Wu

“…This study conducted a pan-genome analysis of three isolates and 57 P. dispersa strains from NCBI to investigate their evolutionary relationships, population structure, and functional characteristics. Results Whole-genome analysis revealed high genomic diversity among 60 strains of P. dispersa, identifying 6,791 orthologous gene clusters (OGs), with core genes accounting for 45.1% and accessory genes accounting for 54.9%. …”
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Interference in melanoma CD248 function reduces vascular mimicry and metastasis by Cheng-Hsiang Kuo, Ya-Fang Wu, Bi-Ing Chang, Chao-Kai Hsu, Chao-Han Lai, Hua-Lin Wu

“…Recombinant CD248 (rCD248) proteins were generated, and whether rCD248 interfered with melanoma CD248 functions was evaluated in vitro. An experimental lung metastasis mouse model was used to investigate the effect of rCD248 treatment in vivo. …”
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Cloning and function verification of epithiospecifier protein gene from Chinese cabbage by SUN Hai-yan, YUAN Gao-feng, WANG Qiao-mei

“…However, the gene of Chinese cabbage (Brassica campestris ssp. chinensis) ESP (BcESP) has not been cloned yet and the function of BcESP in the regulation of glucosinolate hydrolysis and its physiological role in Chinese cabbage remain unclear.To investigate the physiological roles of ESPs in Brassica vegetables, the gene of BcESP was coloned and its function was preliminarily verified.Total RNA was extracted from Chinese cabbage used as the template to amplify 3′ sequence and 5′ sequence of cDNA of BcESP by RT-PCR using degenerate primers, and then the full cDNA of BcESP was obtained. …”
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