Third-degree nasal tip burn in a preterm infant treated with amniotic membrane (Case report) by Paula Andrea Pérez Franco, Sebastian Murcia Espino, María Paula Ruiz Díaz, Juan David Rodríguez Parra

“…Introduction: Non-fatal burns are a global health issue with a considerable impact on morbidity as well as aesthetic and functional sequelae. Facial burns in neonates are rare and often occur in hospital settings due to medical devices. …”
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GRK5 as a Novel Therapeutic Target for Immune Evasion in Testicular Cancer: Insights from Multi-Omics Analysis and Immunotherapeutic Validation by Congcong Xu, Qifeng Zhong, Nengfeng Yu, Xuqiang Zhang, Kefan Yang, Hao Liu, Ming Cai, Yichun Zheng

“…Cellular functional assays revealed that GRK5 knockdown significantly attenuated the malignant phenotype of testicular cancer cells, as evidenced by reduced proliferative capacity and invasive potential. …”
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Epigenetic regulation of TNNT1 in gastrointestinal cancers prognostic implications and clinical significance by Jin Xie, Xin-Yang Qu, Rui-Min Wu, Jie Liu, Fan Cheng, Yu Zhang, Xu-Sheng Liu

“…The impact of TNNT1 expression on patient prognosis was evaluated through Cox regression analyses. Furthermore, functional enrichment analysis was conducted to explore the biological pathways involved, alongside promoter methylation and mutation analyses, to elucidate its regulatory mechanisms. …”
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Wearable inertial sensors and pressure MAT detect risk factors associated with ACL graft failure that are not possible with traditional return to sport assessments by Michael J Dan, William R Walsh, Kimberly Kai Lun, Luke Dan, Jimmy Efird, Matthew Pelletier, David Broe

“…Patients performed biometric and functional tests (thigh circumference and triple hop) and the ViMove knee module (consisting of single and double leg squats, hops and box drops) for lower limb alignment assessment, concurrently with force plate.Results Elite athletes had less varus/valgus (VV) movement during ViMove exercises compared with the ACLR cohort, who in turn had less VV malalignment than controls. …”
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基于数据直接传递的摆线轮参数化设计 by 林昌华, 杨岩

“…Based on direct data transfer,a new modeling method in UG is presented.The fast modeling of cycloid-gear whose 2D profile data generated in AutoLISP is achieved by this method.Using the file function of spline curve in UG modeling module,the data calculated by AutoLISP is loaded in UG.The 2D profile of cycloid-gear is directly obtained,and then,the 3D model is constructed by extruded body and other functions.The problem of data transferred in different software is successfully solved by this method.…”
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Gene expression regulation and polyadenylation in ulcerative colitis via long-chain RNA sequencing by Zhe Zhang, Dan Li, Shihang Zheng, Changqing Zheng, Hao Xu, Xueqing Wang

“…Various bioinformatics analyses were performed, including differential expression gene (DEG) analysis, functional enrichment analysis, APA site analysis, and prediction miRNAs and RNA binding proteins (RBPs) targets, to explore the molecular mechanism underlying UC. …”
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Myogenic IGFBP5 levels in rhabdomyosarcoma are nourished by mesenchymal stromal cells and regulate growth arrest and apoptosis by Yue Zhang, Karim Katkhada, Liu Zhen Meng, Binbin Zhao, Shanlin Tong, Wiem Chaabane, Aditi Kallai, Nicholas P. Tobin, Arne Östman, Alessandro Mega, Monika Ehnman

“…Conclusions This study uses functional modeling and omics approaches to identify IGFBP5 as a candidate mediator of anti-tumor growth mechanisms originating from tumor-neighboring mesenchymal stromal cells. …”
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16S rRNA Sequencing and Metabolomics to Analyze Correlation Between Fecal Flora and Metabolites of Squabs and Parent Pigeons by Xiaobin Li, Shengchen Zheng, Haiying Li, Jiajia Liu, Fan Yang, Xiaoyu Zhao, Yafei Liang

“…These metabolites were primarily concentrated in five functional categories and enriched in 33 pathways, 2 of which showed significant differences. …”
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Temporal Transcriptome Analysis Reveals Core Pathways and Orphan Gene <i>EARLY FLOWERING 1</i> Regulating Floral Transition in Chinese Cabbage by Hong Lang, Yuting Zhang, Shouhe Zhao, Kexin Li, Xiaonan Li, Mingliang Jiang

“…Functional validation through <i>EF1</i> overexpression (EF1OE) in <i>Arabidopsis</i> consistently promoted early flowering. …”
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Comprehensive Analysis of Multi-Omics Data on RNA Polymerase as an Adverse Factor in Head and Neck Squamous Cell Carcinoma by Gu YJ, Zhang J, Liu YJ, Zhang Q, Geng QF

“…In vitro and in vivo experiments were conducted to validate the functional role of the YY1-POLR2C axis in cancer proliferation and immune modulation.Results: POLRs were found to be aberrantly expressed in cancers and associated with genomic alterations. …”
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The Impact of Hydrogen Sulfide Regulatory Gene Alterations on Head and neck squamous cell carcinoma prognosis and tumor microenvironment by Mohamed Rizwan Ghouse, Santhakumar Egambaram, Arunkumar Ramachandran, Rajesh Parsanathan

“…Kaplan–Meier survival analysis assessed prognostic relevance. Functional enrichment and protein–protein interaction (PPI) networks were examined using ShinyGO, STRING, and GeneMANIA. …”
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ROLE OF COMBINED THERAPY IN THE TREATMENT OF PATIENTS WITH INFERTILITY AND REPRODUCTIVE FAILURES by E. V. Vartanyan, E. A. Devyatova, K. A. Tsaturova, D. R. Aglyamova

“…In this group, the pregnancy rate was 57.1%.Conclusion. Morphologic and functional improvements of the endometrium increase the pregnancy rate in women with the «uterine factor» of infertility. …”
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Cross‐talk between phosphorylation and lysine acetylation in a genome‐reduced bacterium by Vera van Noort, Jan Seebacher, Samuel Bader, Shabaz Mohammed, Ivana Vonkova, Matthew J Betts, Sebastian Kühner, Runjun Kumar, Tobias Maier, Martina O'Flaherty, Vladimir Rybin, Arne Schmeisky, Eva Yus, Jörg Stülke, Luis Serrano, Robert B Russell, Albert JR Heck, Peer Bork, Anne‐Claude Gavin

“…Abstract Protein post‐translational modifications (PTMs) represent important regulatory states that when combined have been hypothesized to act as molecular codes and to generate a functional diversity beyond genome and transcriptome. …”
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Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer by Ewelina Dondajewska, Paula Allepuz‐Fuster, Chloé Maurizy, Alexandre Hego, Sandra Ormenese, Quentin Lion, Arnaud Blomme, Pierre Close, Arnaud Lavergne, Latifa Karim, Marc Thiry, Ivan Nemazanyy, Roopesh Krishnankutty, Jair Marques Jr, Alex vonKriegsheim, Nathaniel F. Henneman, Ganna Panasyuk, Kateryna Shostak, Alain Chariot

“…Mitochondria rely on the transfer of multiple lipids from the endoplasmic reticulum (ER) to their membranes to be functional. Several mitochondrial‐derived metabolites influence cancer cell proliferation by modulating the epigenome. …”
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Treatment of uterine fibroid: focus on endometrial receptivity. A pilot randomized prospective study by Yulia E. Dobrokhotova, Irina A. Lapina, Valeriia M. Gomzikova, Yury А. Sorokin, Eleonora T. Khatagova, Ayshan R. Allakhverdieva, Mariya A. Olkhovskaya

“…Selective progesterone receptor modulators increase fertility, improve the receptivity and morphological and functional features of the endometrium, and reduce the need for surgeries, which is especially important in patients of reproductive age.…”
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The role of sensory attenuation in symptomatic and healthy individuals: a scoping review by Luca Rossi, Francesco Cerritelli, Francesco Cerritelli, Mick Thacker, Jorge E. Esteves, Jorge E. Esteves

“…BackgroundPersistent physical symptoms (PPS), including functional neurological disorders (FND), chronic pain, and other neurological conditions [e.g., Parkinson’s disease (PD), Huntington’s disease (HD), autism spectrum disorder (ASD), and psychosis], present substantial challenges for healthcare systems due to their complex and multifaceted nature. …”
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Biomechanics of the tumor extracellular matrix and regulatory T cells: regulatory mechanisms and potential therapeutic targets by Wen-Bo Huang, Heng-zhou Lai, Jing Long, Zhuo-ling Dai, Qiong Ma, Chong Xiao, Feng-Ming You

“…Moreover, biomechanical signals derived from the ECM strengthen the oxidative phosphorylation (OXPHOS) metabolic phenotype and immunosuppressive function of Tregs by modulating mitochondrial dynamics. …”
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Unveiling the potential of Lactobacillus johnsonii in digestive diseases: a comprehensive review by Jinjie Zhou, Jinjie Zhou, Jinjie Zhou, Shuang Ma, Shuang Ma, Shuang Ma, Zhuo Huang, Zhuo Huang, Zhuo Huang, Qinyan Yao, Qinyan Yao, Qinyan Yao, Zihan Yu, Zihan Yu, Zihan Yu, Jihua Chen, Jihua Chen, Jihua Chen, Liuqing Yao, Liuqing Yao, Liuqing Yao, Lanping Zhu, Lanping Zhu, Lanping Zhu, Xin Chen, Xin Chen, Xin Chen

“…BackgroundLactobacillus johnsonii (L. johnsonii) is a lactic acid-producing probiotic, possessing the potential to modulate intestinal microbiota balance, which can enhance immune function, and reduce the risk of intestinal infections. …”
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Regulation of partial endothelial-to-mesenchymal transition by circATXN1 in ischemic diseases by Yue Li, Zhe Zheng, Yanze Li, Siyuan Fan, Lingyao Kong, Wanrong Fu, Zhonggen Li, Jianchao Zhang, Shuang Li, Zongtao Liu, Chao Liu, Jinhua Cao, Zhenxuan Hao, Lili Xiao, Youyou Du, Xiaofang Wang, Lu Gao

“…To address this, we performed circular RNA profiling of endothelial cells under ischemic-like conditions and identified a marked upregulation of a circular RNA, named circATXN1. Functional studies revealed that circATXN1 knockdown modulates endothelial phenotype and vascular response after ischemia. …”
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CFR-YOLO: A Novel Cow Face Detection Network Based on YOLOv7 Improvement by Guohong Gao, Yuxin Ma, Jianping Wang, Zhiyu Li, Yan Wang, Haofan Bai

“…To optimize the performance of the model, the activation function of FReLU is used instead of the original SiLU activation function, and the CBS module is replaced by the CBF module. …”
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