The transcriptional regulators GATA6 and TET1 regulate the TGF-β pathway in cancer-associated fibroblasts to promote breast cancer progression by Mohammad H. Ghazimoradi, Sadegh Babashah

“…Here, we identified the TET1/SMAD4/GATA6 regulatory axis as a central mechanism governing CAF transformation and function in breast cancer. Through integrative in vitro and in vivo models, we demonstrated that TET1, an epigenetic modulator, demethylates the SMAD4 promoter, enhancing SMAD4 expression. …”
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AMPK in Intestinal Health and Disease: A Multifaceted Therapeutic Target for Metabolic and Inflammatory Disorders by Yibcharoenporn C, Muanprasat C, Moonwiriyakit A, Satitsri S, Pathomthongtaweechai N

“…Chamnan Yibcharoenporn,* Chatchai Muanprasat,* Aekkacha Moonwiriyakit, Saravut Satitsri, Nutthapoom Pathomthongtaweechai Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakan, 10540, Thailand*These authors contributed equally to this workCorrespondence: Nutthapoom Pathomthongtaweechai, Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bang Phli, 111 Moo 14, Bang Pla, Bang Phli, Samut Prakan, 10540, Thailand, Tel +66984800365, Email nutthapoom.pat@mahidol.eduAbstract: The intestines play essential roles in nutrient absorption and immune function and help maintain a protective barrier. Disruptions to its function can result in various diseases, including metabolic disorders, inflammation, and cancer. …”
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Site-specific incorporation of 19F-nuclei at protein C-terminus to probe allosteric conformational transitions of metalloproteins by Xichun Liu, Pengfei Guo, Qiufan Yu, Shu-Qin Gao, Hong Yuan, Xiangshi Tan, Ying-Wu Lin

“…Abstract Allosteric conformational change is an important paradigm in the regulation of protein function, which is typically triggered by the binding of small cofactors, metal ions or protein partners. …”
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Transcorneal electrical stimulation: impact on healthcare and future potential by Takeshi Morimoto

“…Clinically, TES has shown potential in improving visual function in diseases such as RP, optic neuropathies, and ischemic retinal conditions; however long-term benefits remain a challenge. …”
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PTPN2 inhibits TG-induced ERS-initiated TNBC apoptosis through the mitochondrial pathway by Yanhe An, Jinxin Lan, Jiaping Tang, Na Luo

“…This study aims to elucidate the role of PTPN2 in mediating the pro-apoptotic effects of ERS induced by Thapsigargin (TG), and its influence on the fate of TNBC cells, utilizing both loss-of-function and gain-of-function methodologies. Our findings indicate that PTPN2 modulates TG-induced ERS via the IRE1-XBP1 and PERK/EIF2α/ATF-4 signaling pathways. …”
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Optimization Algorithms for Cable Fault Localization and Assessment in Smart Power Systems by Wenxuan Wang, Yali Shi, Minghui Liu

“…Firstly, we use the good self-sustainability of the optical soliton (Soliton) in fiber optic communication to modulate its spectral information into the reflection information of the cable frequency domain, secondly, we define the attenuation operator to compensate for the attenuation of the spectral information and the integral kernel function, and set up the Chebyshev window function to weaken the low-frequency components of the spectrum to be detected. …”
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A Novel Pseudo-Siamese Fusion Network for Enhancing Semantic Segmentation of Building Areas in Synthetic Aperture Radar Images by Mengguang Liao, Longcheng Huang, Shaoning Li

“…Finally, the model was optimized using the combined CE-Dice loss function to achieve superior performance. The experimental results of the SAR images from regions with different geographical characteristics demonstrate that the proposed PSANet outperforms several recent State-of-the-Art methods.…”
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CYBB as a potential therapeutic target through influencing ferroptosis and macrophage in ovarian cancer by Tian Yi Ye, Su Fang Wu, Xiao Yun Wang

“…Abstract Introduction The synergistic function between ferroptosis and tumor-associated macrophages (TAMs) has gained significant attention, but their relationship remains unclear. …”
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Transcriptional corepressor activity of CtBP1 is regulated by ISG15 modification by Yun Hwan Lim, Yoon Jin Park, Jieun Lee, Jung Hwa Kim

“…These findings suggest that the ISG15 modification of CtBP1 modulates the function and activity of CtBP1 and that CtBP1 ISGylation may provide a new insight for CtBP1-mediated cancers.…”
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How does a small molecule bind at a cryptic binding site? by Yibing Shan, Venkatesh P Mysore, Abba E Leffler, Eric T Kim, Shiori Sagawa, David E Shaw

“…Protein-protein interactions (PPIs) are ubiquitous biomolecular processes that are central to virtually all aspects of cellular function. Identifying small molecules that modulate specific disease-related PPIs is a strategy with enormous promise for drug discovery. …”
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Laser weld spot detection based on YOLO-weld by Jianxin Feng, Jiahao Wang, Xinyu Zhao, Zhiguo Liu, Yuanming Ding

“…Following this, a Diverse Class Normalization Loss (DCNLoss)function is designed to emphasize the importance of tail data in the model’s training. …”
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Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia. by Adamantios Mamais, Jillian H Kluss, Luis Bonet-Ponce, Natalie Landeck, Rebekah G Langston, Nathan Smith, Alexandra Beilina, Alice Kaganovich, Manik C Ghosh, Laura Pellegrini, Ravindran Kumaran, Ioannis Papazoglou, George R Heaton, Rina Bandopadhyay, Nunziata Maio, Changyoun Kim, Matthew J LaVoie, David C Gershlick, Mark R Cookson

“…The small GTPase Rab8a is a LRRK2 kinase substrate and is involved in receptor-mediated recycling and endocytic trafficking of transferrin, but the effect of PD-linked LRRK2 mutations on the function of Rab8a is poorly understood. Here, we show that gain-of-function mutations in LRRK2 induce sequestration of endogenous Rab8a to lysosomes in overexpression cell models, while pharmacological inhibition of LRRK2 kinase activity reverses this phenotype. …”
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The Role of Hippocampal NMDA Receptors in Long-Term Emotional Responses following Muscarinic Receptor Activation. by Alexandre A Hoeller, Ana Paula R Costa, Maíra A Bicca, Filipe C Matheus, Gilliard Lach, Francesca Spiga, Stafford L Lightman, Roger Walz, Graham L Collingridge, Zuner A Bortolotto, Thereza C M de Lima

“…Herein, we investigated whether the pilocarpine-induced long-term anxiogenesis modulates the HPA axis function and the putative involvement of NMDA receptors (NMDARs) following mAChRs activation. …”
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Effects of atractylodin and β-Eudesmol on P-glycoprotein and Caco-2 cells permeability by Artitaya Thiengsusuk, Wiriyaporn Sumsakul, Kesara Na–Bangchang

“…However, neither of the compounds were P-gp inhibitors nor modulators of the expression of MDR-1 mRNA, and P-gp function. …”
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Salvia spinosa L. Protects against Diabetes-Induced Nephropathy by Attenuation of Mitochondrial Oxidative Damage in Mice by Milad Jeshan, Fatemeh Yousefbeyk, Hiva Rahmati, Amir Hosein Shoormeij, Mitra Rezazadeh, Ehsan Zamani

“…This study planned to investigate the effects of Salvia spinosa L. on mitochondrial function along with its protection against streptozotocin-induced nephropathy in diabetic mice. …”
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Loss of endocytosis-associated RabGEF1 causes aberrant morphogenesis and altered autophagy in photoreceptors leading to retinal degeneration. by Passley Hargrove-Grimes, Anupam K Mondal, Jessica Gumerson, Jacob Nellissery, Angel M Aponte, Linn Gieser, Haohua Qian, Robert N Fariss, Juan S Bonifacino, Tiansen Li, Anand Swaroop

“…Loss of Rabgef1 in mice (Rabgef1-/-) resulted in defects specifically of photoreceptor morphology and almost complete loss of both rod and cone function as early as eye opening; however, aberrant outer segment formation could only partly account for visual function deficits. …”
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ADSA Foundation Scholar Award: Shakin' off the rust—Oxidative stress and redox status as underlying factors of immune dysfunction in periparturient cows and preweaning calves by Angel Abuelo

“…Antioxidant supplementation can mitigate OS, improve immune function, and reduce disease incidence. However, excessive antioxidant supplementation may lead to adverse effects. …”
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Autism and α7-nicotinic acetylcholine receptors: new pharmacological and herbal interventions by Nourhan A. Khattab, Aya H. El-Kadem, Nada A. Ashour, Nageh Ahmed El-Mahdy, Nagla A. El-Shitany

“…Numerous studies have focused on acetylcholine (ACh), which plays a significant role in modulating neuronal and immunological function via acting on muscarinic and nicotinic receptors. …”
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A Graphite Ore Grade Recognition Method Based on Improved Inception-ResNet-v2 Model by Xueyu Huang, Renjie Pan, Jionghui Wang

“…Key improvements include: 1) To enhance the extraction of global feature information from graphite mine data, a global average pooling branch is incorporated into the Inception-resnet architecture. 2) Incorporating a <inline-formula> <tex-math notation="LaTeX">$1\times 1$ </tex-math></inline-formula> convolutional layer at the tail of the model to control channel dimensions and employing the LeakyReLU activation function to address the limitations of the ReLU activation function. 3) Designing an LDP-Conv structure to replace certain <inline-formula> <tex-math notation="LaTeX">$3\times 3$ </tex-math></inline-formula> convolutions and incorporating a channel attention mechanism to improve feature capture. 4) Optimizing the Stem module to expand the early-stage receptive field and reconstructing the network architecture. …”
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Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans. by Hannah J Smith, Anne Lanjuin, Arpit Sharma, Aditi Prabhakar, Ewelina Nowak, Peter G Stine, Rohan Sehgal, Klement Stojanovski, Benjamin D Towbin, William B Mair

“…Unlike raga-1 loss of function genetic mutations or somatic AID of RAGA-1, neuronal AID of RAGA-1 robustly extends lifespan without impairing body size, developmental rate, brood size, or neuronal function. …”
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