MICROCIRCULATORY AND TISSUE THEORY: INTEGRAL VISION OF CARCINOGENESIS by A. S. Dzasokhov

“…The current understanding of the  structural and  functional characteristics of  the  microvasculature is described. …”
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Modularity and adaptive architecture – A strategy for managing complex envelope systems by Valentino Manni, Luca Saverio Valzano

“…Illustrating a representative framework of projects and research highlights the role of modularity in adaptive architecture in terms of operational principles, control modes, response mechanisms, functional complexity, and structural complexity. This contribution underscores the centrality of modularity as a strategy to address the multidimensional complexity of technological systems for adaptive envelopes.   …”
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Two classes of bacterial IMPDHs according to their quaternary structures and catalytic properties. by Thomas Alexandre, Bertrand Raynal, Hélène Munier-Lehmann

“…Our work provides new insights into the IMPDH functional regulation and a model for the quaternary structure modulation is proposed.…”
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ɑ1,3-mannosyltransferase promotes the malignant progression of bladder cancer through activating TNF signaling pathway by Mulin Liu, Jingyang Zhang, Siqi Zhu, Wenjun Jiang, Yu Yan, Qin Zheng, Shijun Li

“…The functional impact and mechanism of ALG3 in BCa were investigated through functional assays, RNA sequencing, immunoprecipitation, and lectin pull down assays. …”
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Research of Adding Parking Brake in CRH2 EMUs by SU Chao, GAO Qi

“…The proposed parking brake module perfect function structure is matched well with the brake system in CRH2 EMUs.…”
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Lymphocyte-Infiltrated Periportal Region Detection With Structurally-Refined Deep Portal Segmentation and Heterogeneous Infiltration Features by Hung-Wen Tsai, Chien-Yu Chiou, Wei-Jong Yang, Tsan-An Hsieh, Cheng-Yi Chen, Che-Wei Hsu, Yih-Jyh Lin, Min-En Hsieh, Matthew M. Yeh, Chin-Chun Chen, Meng-Ru Shen, Pau-Choo Chung

“…<italic>Goal</italic>: The early diagnosis and treatment of hepatitis is essential to reduce hepatitis-related liver function deterioration and mortality. One component of the widely-used Ishak grading system for the grading of periportal interface hepatitis is based on the percentage of portal borders infiltrated by lymphocytes. …”
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Thymic peptides in immune reconstitution and clinical outcome after allogeneic hematopoietic cell transplantation by Hannah Kunstek, Janneke Kieviet, Caroline Lindemans, Coco de Koning, Stefan Nierkens

“…These molecules play an essential part in the development and nature of immune responses and may have a role in modulating T-cell expansion and function after HCT. …”
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Pulmonary diseases accurate recognition using adaptive multiscale feature fusion in chest radiography by Mengran Zhou, Lipeng Gao, Kai Bian, Haonan Wang, Ning Wang, Yue Chen, Siyi Liu

“…Abstract Pulmonary disease can severely impair respiratory function and be life-threatening. Accurately recognizing pulmonary diseases in chest X-ray images is challenging due to overlapping body structures and the complex anatomy of the chest. …”
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An Adaptive Control Strategy for a Virtual Synchronous Generator Based on Exponential Inertia and Nonlinear Damping by Huiguang Pian, Keqilao Meng, Hua Li, Yongjiang Liu, Zhi Li, Ligang Jiang

“…To address this issue, an adaptive virtual synchronous generator (VSG) control strategy is proposed, which dynamically adjusts virtual inertia and damping in response to real-time frequency variations. Virtual inertia is modulated by an exponential function according to the frequency variation rate, while damping is regulated via a hyperbolic tangent function, enabling minor support during small disturbances and robust compensation during severe events. …”
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The role of KLF4 in phagocyte activation during infectious diseases by Toni Herta, Toni Herta, Aritra Bhattacharyya, Stefan Hippenstiel, Janine Zahlten

“…Their activation and function are tightly regulated by transcription factors that coordinate immune responses. …”
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From inflammation to immune regulation: The dual nature of dietary lectins in health and disease by Emadeldin H.E. Konozy, Makarim Elfadil M. Osman

“…While some lectins exhibit stability and resistance to digestion, posing threats to gastrointestinal integrity and immune function, others, such as those from butterfly peas and pink bauhinia, show immunomodulatory properties that could bolster immune responses. …”
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Pain, lactate, and anesthetics: intertwined regulators of tumor metabolism and immunity by Qinghai Lan, Aiping Ouyang, Yijian Chen, Youchun Li, Baolin Zhong, Simin Deng

“…This review synthesizes current understanding of lactate’s production, transport, and functional roles in tumor cells, encompassing the regulation of tumor metabolism, immunity, and progression. …”
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Gut microbiota and autism spectrum disorder: advances in dietary intervention strategies based on the microbiota-gut-brain axis mechanism by Ziji Fang, Yinxiong Zhou, Ke Chen, Juelan Wang, Xiaoli Liu, Ping Jia

“…Building on this foundation, the review further summarizes dietary intervention strategies grounded in the MGBA theory, emphasizing their potential to restore gut microbial composition, modulate immune responses, and enhance metabolic function, thereby offering novel therapeutic perspectives for ASD.…”
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LE-YOLO: A Lightweight and Enhanced Algorithm for Detecting Surface Defects on Particleboard by Chao He, Yongkang Kang, Anning Ding, Wei Jia, Huaqiong Duo

“…To address these challenges, this study proposes the LE-YOLO model, which incorporates a normalized Wasserstein distance into the loss function to enhance the detection capability for minute surface defects. …”
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Microbiome and metabolome reveal beneficial effects of baicalin on broiler growth performance and intestinal health by Xingbo Liu, Yunru Ji, Huiyuan Lv, Zengpeng Lv, Yuming Guo, Wei Nie

“…Overall, 12 mg/kg BA improved intestinal health by modulating intestinal barrier function, antioxidant capacity, immunity, intestinal microbiota, and intestinal mucosal metabolism levels, ultimately enhancing broiler growth performance.…”
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Gut microbiota dysbiosis exacerbates heart failure by the LPS-TLR4/NF-κB signalling axis: mechanistic insights and therapeutic potential of TLR4 inhibition by Chunlei Zhang, Xiaodong Teng, Qiuhang Cao, Yanyan Deng, Mo Yang, Lei Wang, Daorong Rui, Xiu Ling, Cao Wei, Yue Chen, Dasheng Lu, Hongxiang Zhang

“…Conclusion Gut microbiota dysbiosis exacerbates heart failure by activating myocardial inflammation through the LPS-TLR4/NF-κB signalling pathway. By modulating this pathway, TAK-242 improves cardiac function, suggesting its potential as a therapeutic target for heart failure. …”
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Pyruvate kinase M2 activation maintains mitochondrial metabolism by regulating the interaction between HIF-1α and PGC-1α in diabetic kidney disease by Jimin Park, Young Su Joo, Bo Young Nam, Gyuri Kim, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han

“…Conclusion Our study highlights the role of PKM2 activation in restoring impaired mitochondrial metabolism and function by modulating HIF-1α and PGC-1α interactions in DKD.…”
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An evaluation of carbon dots derived from Amaranthus tricolor (L.) leaves for their physicochemical, photoluminescent, and biomedical properties by Sapam Riches Singh, Santosh Mallikarjun Bhavi, Bothe Thokchom, Megha B. Abbigeri, Akshata Choudhari Padti, Akshata Yadawad, B. P. Harini, Chandramohan Govindasamy, Khalid M. Almutairi, Ramesh Babu Yarajarla

“…Abstract This study explores the synthesis, characterization, and bio-functional potential of carbon dots (CDs) derived from Amaranthus tricolor (AT-CDs). …”
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Characterization of Extracellular Vesicles from Infrapatellar Fat Pad Mesenchymal Stem/Stromal Cells Expanded Using Regulatory-Compliant Media and Inflammatory/Hormonal Priming by Marc Philippon, Ramy Labib, Michelle Bellas Romariz Gaudie Ley, Lee D. Kaplan, Armando J. Mendez, Thomas M. Best, Dimitrios Kouroupis

“…A growing body of evidence suggests that the therapeutic effects of MSC are largely mediated by their extracellular vesicles (EVs), which carry bioactive cargo that modulates inflammation and tissue repair. However, optimizing MSC-derived EVs as a cell-free therapeutic approach requires an in-depth understanding of how culture conditions and inflammatory/hormonal priming influence their functional properties. …”
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Chemical composition, physical properties, and immunomodulating study of mare's milk of the Adaev horse breed from Kazakhstan by Gaukhar Kossaliyeva, Kaster Rysbekuly, Karlygash Zhaparkulova, Sabira Kozykan, Juxiu Li, Assiya Serikbayeva, Zhanserik Shynykul, Maira Zhaparkulova, Zura Yessimsiitova

“…These findings suggest that Adaev horse milk supplementation modulates immune responses, improves metabolic and hematological parameters, and mitigates pneumonia-induced tissue damage, highlighting its potential as a functional dietary supplement with immunotherapeutic benefits.…”
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