A fibrin gel-loaded Gouqi-derived nanovesicle (GqDNV) repairs the heart after myocardial infarction by inhibiting p38 MAPK/NF-κB p65 pathway by Huan-Huan Zhou, Xiaolei Zhou, Jianqiu Pei, Shiyin Xu, Biyu Jin, Jiuling Chen, Zixuan Zhang, Mingmeng Tang, Yan Liu, Andreas K. Nüssler, Liegang Liu, Qin Xu, Anxin Wang, Min Xia, Wei Yang

“…The upregulation of the peptide Arg-Thr-Ile-Glu and the downregulation of phosphatidylethanolamine in the hearts of MI mice after GqDNVs-gel intervention may play crucial roles in modulating the associated metabolic pathways. This study is the first to highlight the multifaceted therapeutic effects of GqDNVs-gel, offering a promising strategy for enhancing cardiac function post-MI. …”
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Contagious infection-free medical interaction system with machine vision controlled by remote hand gesture during an operation by Van Doi Truong, Hyun-Kyo Lim, Seongje Kim, Than Trong Khanh Dat, Jonghun Yoon

“…Additionally, a control menu was developed to effectively activate common functions. Results: The proposed hand-pointing system allowed for a large control range of up to 1200 mm in both vertical and horizontal direction. …”
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Energy state guides reward seeking via an extended amygdala to lateral hypothalamus pathway by Kuldeep Shrivastava, Vikshar Athreya, Yi Lu, Jorge Luis-Islas, Ashley Han, Tess F. Kowalski, Mark A. Rossi

“…These findings suggest that hormonal factors modulate the function of the BNST→LHA pathway to align food seeking with current energy needs.…”
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Natural variants suppress mutations in hundreds of essential genes by Leopold Parts, Amandine Batté, Maykel Lopes, Michael W Yuen, Meredith Laver, Bryan‐Joseph San Luis, Jia‐Xing Yue, Carles Pons, Elise Eray, Patrick Aloy, Gianni Liti, Jolanda van Leeuwen

“…For example, loss of gene function may be tolerated in one genetic background, and lethal in another. …”
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Improving cellular fitness of human stem cell-derived islets under hypoxia by Xi Wang, Shlomi Brielle, Jennifer Kenty-Ryu, Nataly Korover, Danny Bavli, Ramona Pop, Douglas A. Melton

“…Elevated EDN3 expression preserves β cell identity and function in hypoxia by modulating genes involved in β cell maturation, glucose sensing and regulation. …”
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Metabolic Alterations Associated With Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: The Modulatory Effects and Improvement Mechanisms of Exercise by Sitong Chen, Gengmin Liang, lokfai Cheang, Qiang Qu, Xinli Li

“…Furthermore, this article discusses how exercise can modulate the aforementioned metabolic pathways to improve metabolic disturbances in the right ventricle and enhance right heart function. …”
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A possible important regulatory role of estrogen in obstructive sleep apnea hypoventilation syndrome by Pinyi Zhou, Hongmei Li, Hongyan Li, Yan Chen, Yunhui Lv

“…Research indicates that sex differences in OSAHS are associated with gonadal function, wherein estrogen exerts a protective effect by modulating pharyngeal muscle tone and mitigating oxidative stress. …”
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Salvianic acid A enhances anti-PD-1 therapy by promoting HEV-mediated stem-like CD8 T cells infiltration in TNBC by Xiaoming Ding, Gai Liang, Yan Luo, Xiaomei Zhou, Qu Zhang, Bo Luo

“…Tumor tissues were analyzed histologically and by flow cytometry to assess immune cell infiltration and function. The expression of immune markers and cytokines was evaluated using immunohistochemistry, Western blot, and quantitative RT-PCR. …”
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Warum sind Enzyme Makromoleküle? by P.L. Luisi

“…It is pointed out that in the process of building polymers from low molecular weight monomers so many structural parameters (copolymerisation, branching, cross-linking, stereoisomerism, grafting, compounding, etc.) can be utilized and regulated, that the physical and chemical properties of the final products can be modulated almost at will. For functional proteins, the two most important of such structural parameters are the copolymerization (from twenty different amino acid residues) and the resultant rigid folding in solution. …”
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Association between fumarate hydratase variant subtypes and the risk of HLRCC-associated renal cell carcinoma: systematic review and meta-analysis by Han Wang, Shamsnur Rehim, Hongjing Wang

“…To evaluate the association between pathogenic or likely pathogenic FH variant subtypes (Missense vs. Loss-of-Function (LOF)) and the risk of HLRCC-associated RCC, we performed a fixed-effects meta-analysis based on unadjusted odds ratios (ORs). …”
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Regulatory Effects of Zhenxin Formula in Treating Doxorubicin-Induced Heart Failure: Network Pharmacology and Animal Experimental Verification by Wu Q, Wang H, Wang YH, Du J, Li B, Gan XN, Liu CY, Liang J, Liu C, Cao M

“…In vivo, ZXF significantly enhanced cardiac function and mitigated myocardial fibrosis and cardiomyocyte apoptosis. …”
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Valorization of Andean Native Potatoes Through Chuño Processing: Effects of Potato Variety and Freezing Temperature on Physicochemical, Bioactive, Nutritional, and Technological Pr... by Elmer Robert Torres-Gutiérrez, Grimaldo Wilfredo Quispe-Santivañez, Jimmy Pablo Echevarría-Victorio, David Elí Salazar-Espinoza, Joselin Paucarchuco-Soto, Henry Juan Javier-Ninahuaman, Williams Esteward Castillo-Martinez, Rebeca Salvador-Reyes

“…This study aimed to assess how different Andean potato varieties (Chihuanki Negro [C], Puka Huayro Machu [P], and Yana Huayro Machu [Y]) and freezing temperatures (−10 °C, −20 °C, and −30 °C) modulate the physicochemical (pH, acidity, and moisture), bioactive (phenolics and antioxidant activity), nutritional (proximate composition and minerals), and techno-functional (water absorption and swelling power) attributes of chuño. …”
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Production of an Ice Cream Base with Added <i>Lacticaseibacillus rhamnosus</i> GG and Aguamiel Syrup: Probiotic Viability and Antihypertensive Capacity by Edward Hernández-Riveros, Laura Berenice Olvera-Rosales, Judith Jaimez-Ordaz, Emmanuel Pérez-Escalante, Elizabeth Contreras-López, Alma Elizabeth Cruz-Guerrero, Luis Guillermo González-Olivares

“…Given the rising interest in functional foods for health benefits, this study aims to evaluate the antihypertensive activity of an ice cream base incorporating <i>Lacticaseibacillus rhamnosus</i> GG and aguamiel syrup. …”
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The Interaction of Nutrition and Health in Beef Cows by Matt Hersom

“…Therefore, the past and present nutritional status serves as an immune function modulator in cattle that can influence the performance and reproduction of beef cattle. …”
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The Interaction of Nutrition and Health in Beef Cows by Matt Hersom

“…Therefore, the past and present nutritional status serves as an immune function modulator in cattle that can influence the performance and reproduction of beef cattle. …”
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Multi-class segmentation of knee MRI based on hybrid attention by Yuhang Xiang, Xinglin Zhang, Tao Meng, Tao Meng, Tao Chen, Tao Chen

“…Lastly, the loss function is optimized to address the challenges of class imbalance and limited data. …”
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Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction by Chung-Hsi Hsing, Shih-Kai Hung, Yeong-Chang Chen, Tsui-Shan Wei, Ding-Ping Sun, Jhi-Joung Wang, Ching-Hua Yeh

“…Activating the peripheral innate immune system stimulates cytokine secretion in the central nervous system, which modulates cognitive function. Histone deacetylases (HDACs) modulate cytokine synthesis and release. …”
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The effects of rifaximin and lactulose on the gut-liver-brain axis in rats with minimal hepatic encephalopathy. by Xueyan Lin, Zhengchao Zhang, Yi Lin, Shiyun Lu, Rongrong Chen

“…The Morris water maze (MWM) test was used to assess cognitive function in MHE rats following treatment with rifaximin and lactulose. …”
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Integrated network pharmacology reveals the mechanism of action of Xianlinggubao prescription for inflammation in osteoarthritis by Jingyi Hou, Yubo Li, Yu Zhang, Ning Yang, Bin Chen, Guiyun Ma, Naiqiang Zhu

“…Network pharmacology and bioinformatics approaches were employed to construct compound-target and protein–protein interaction (PPI) networks, enabling the identification of pivotal therapeutic targets. Functional enrichment of these targets was performed using the ClusterProfiler package in R. …”
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Root growth and branching are enabled by brassinosteroid-regulated growth anisotropy and carbon allocation by Hitaishi Khandal, Guy Horev, Bas van den Herik, Yoram Soroka, Tamar Lahav, Tamar Avin-Wittenberg, Kirsten ten Tusscher, Sigal Savaldi-Goldstein

“…Our interdisciplinary approach, applied to two plant species and integrating shoot and root hormonal functions, provides a new understanding of how RSA is modulated at various scales.…”
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