Genetic insights into cardiac conduction disorders from genome-wide association studies by Bingxun Li, Hongxuan Xu, Lin Wu

“…Conclusions Our analysis highlight gene regions associated with channel function, cardiac development, sarcomere function and energy modulation as important potential effectors of CCDs susceptibility.…”
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Research on the Optimization of Automobile Plastic Front Frame Structure by Lu Wang, Lingfeng Tang, Peng Wu, Jiaqi CHEN

“…For the lightweighting of the automotive all-plastic front-end frame structure, the initial structural design of the front-end frame was carried out by HyperMesh; based on the compromise planning method and entropy weight method, the compromise planning method with weight coefficients was used to unify the planning of each subobjective to obtain the integrated response function, and the minimization of the integrated response function was the objective. …”
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Human cathelicidin production by the cervix. by Lorraine Frew, Sofia Makieva, Andrew T M McKinlay, Brian J McHugh, Ann Doust, Jane E Norman, Donald J Davidson, Sarah J Stock

“…hCAP18/LL-37 is the sole human cathelicidin; a family of host defence peptides with key roles in innate host defence. hCAP18/LL-37 is expressed primarily by neutrophils and epithelial cells, but its production and function in the lower genital tract is largely uncharacterised. …”
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U-shape-based network for left ventricular segmentation in echocardiograms with contrastive pretraining by Zhengkun Qian, Tao Hu, Jianming Wang, Zizhong Yang

“…Abstract Cardiovascular diseases, characterized by high morbidity, disability, and mortality rates, are a collective term for disorders affecting the heart’s structure or function. In clinical practice, physicians often manually delineate the left ventricular border on echocardiograms to obtain critical physiological parameters such as left ventricular volume and ejection fraction, which are essential for accurate cardiac function assessment. …”
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Mechanosensitive Differentiation of Human iPS Cell-Derived Podocytes by Yize Zhang, Samira Musah

“…Specifically, hydrogels with kidney-like rigidities outperformed traditional tissue culture plates at modulating the molecular-level expression of active mechanosensitive proteins critical for podocyte health and function. …”
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The role of tetrahydrocannabivarin (THCV) in metabolic disorders: A promising cannabinoid for diabetes and weight management by Scott Mendoza

“…Unlike tetrahydrocannabinol (THC), THCV exhibits an antagonistic function on the CB1 receptor and a partial agonist function on the CB2 receptor, thus enabling appetite suppression, enhanced glucose regulation, and increased energy expenditure. …”
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Improvement and Experimental Explore on Coordinated Control of Kinematic Mechanism of FDM 3D Printer by Guozhu Li

“…A modular flow chart is designed for the control system to coordinate and control the parallel and precise operation of multiple nozzles, and the relationship function between the main controller, power driver, and heating module is designed. …”
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Direct Cardiac Mechanisms of the Sodium Glucose Co-Transporter 2 Inhibitor Class by Steven Hopkins M.D., Faiz Baqai M.D., Saivaroon Gajagowni M.D., Gavin Hickey M.D.

“…Emerging evidence suggests that these drugs modulate key pathways such as sodium-hydrogen exchange (NHE) inhibition, improvement of mitochondrial function, and promotion of ketone body utilization in cardiomyocytes. …”
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Role of selenium in the pathophysiology of cardiorenal anaemia syndrome by Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata

“…Selenium critically regulates the function of selenoproteins, in which selenocysteine is present at the active centres. …”
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Metagenomic analysis reveals microbial drivers of heat resistance in dairy cattle by Mingxun Li, Zhiwei Wang, Zheng Ma, Yangyang Wang, Haoran Jia, Lei Zhang, Peng Chen, Yongjiang Mao, Zhangping Yang

“…Metagenomic sequencing of rumen fluid samples revealed distinct microbial compositions and functional profiles between the two groups. HR cows exhibited a more cohesive and functionally stable microbiome, dominated by taxa such as Ruminococcus flavefaciens and Succiniclasticum, which are key players in fiber degradation and short-chain fatty acid production. …”
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Case Report: Diagnostic assessment, developmental trajectory and treatment approaches in a case of a complex neurodevelopmental syndrome associated with non- synonymous variants in... by V. Napoli, V. Napoli, S. Guerrera, F. Demaria, G. Piccolo, G. Piccolo, A. Cianfa, S. Passarini, S. Passarini, M. G. Logrieco, G. Zanni, G. Valeri, S. Vicari, S. Vicari

“…Although Rett-like features are mainly due to MECP2 loss-of-function, MECP2 deficiency disrupts GABAergic signaling, making GABA modulators potential therapeutic targets. …”
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Auto-aggregation in Streptococcus intermedius is driven by the Pel polysaccharide by Deepa Raju, Siobhán A. Turner, Karla Castro, Gregory B. Whitfield, Daphnée Lamarche, Sahil Mahajan, Roland Pfoh, Stephanie H.W. Chuang, François Le Mauff, Maju Joe, Susmita Sarkar, Todd L. Lowary, Donald C. Sheppard, Daniel J. Wozniak, Michael G. Surette, P. Lynne Howell

“…This cluster contains five genes that are homologous to pelDEADAFG in other gram-positive species and four additional genes of unknown function. Characterization of a panel of clinical S. intermedius isolates identified a range of adherent biofilm and aggregation phenotypes , and aggregation in strain C1365 was dependent on each of the pelDEADAFG genes. …”
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LINC01089 governs the miR-1287-5p/HSPA4 axis to negatively regulate osteogenic differentiation of mesenchymal stem cells by Hao Zou, Fei Hu, Xin Wu, Bin Xu, Guifeng Shang, Dong An, Dehao Qin, Xiaolei Zhang, Aofei Yang

“…HSPA4 is a downstream function molecule of the LINC01089/miR-1287-5p pathway; miR-1287-5p negatively modulated HSPA4 levels and attenuated its functional effects. …”
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Movement in the Shadow of Sadness: How Physical Activity Supports the Fight Against Depression by Agata Ossolińska, Patrycja Marta, Filip Huzarski, Gabriela Ferfecka, Klaudia Pawełek, Lucyna Stolarska, Magdalena Rosa-Bończak, Natalia Morawiecka, Olivier Carlton, Weronika Kłosowicz

“… Physical activity plays a critical role in promoting physical and mental health, positively influencing the prevention of non-communicable diseases (NCDs) and enhancing brain function. Research indicates that regular physical exercise, such as aerobic or strength training, aids in the prevention and treatment of mental disorders such as depression, schizophrenia, and Alzheimer’s disease. …”
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Exploring the link between fat-soluble vitamins and aging-associated immune system status: a literature review by Hendrik Schmieder, Christian Leischner, Alban Piotrowsky, Luigi Marongiu, Sascha Venturelli, Markus Burkard

“…This review summarizes the latest findings on the immune modulating functions of fat-soluble vitamins in a physiological and pathophysiological context, provides a graphical comparison of the Recommended Daily Allowances between Deutschland, Austria, Confoederatio Helvetica (D-A-CH; eng. …”
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Not Just PA28γ: What We Know About the Role of PA28αβ in Carcinogenesis by Paolo Cascio

“…Not surprisingly, therefore, alterations in the activity and regulatory mechanisms of the proteasome are common not only in various types of tumors, but often represent a contributing cause of oncogenesis itself. Among proteasome modulators, PA28γ, due to its function in promoting cell growth and proliferation, while inhibiting apoptosis and cell-mediated immune responses, has received great attention in recent years for its well established pro-tumoral activity. …”
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Two Small Peptides from <i>Buthus martensii</i> Hydrolysates Exhibit Antitumor Activity Through Inhibition of TNF-α-Mediated Signal Transduction Pathways by Mengshuang Zhu, Shanshan Zhang, Jiyang Tang, Hairong Hou, Lizhen Wang, Houwen Lin, Xuanming Zhang, Meng Jin

“…Our findings indicated that AK and GK played a pivotal role in offsetting the inflammatory stimuli that caused gastric cancer cell invasion and highlighted the use of <i>B. martensii</i> resources as functional products with health benefits.…”
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Hybrid precoding and power allocation for mmWave NOMA systems based on time delay line arrays by Gangcan SUN, Xinli WU, Wanming HAO, Zhengyu ZHU

“…Specifically,the Dinkelbach method is applied in the outer layer to transform the fractional structure of the objective function in EE optimization into a subtractive structure, and the non-convex objective function is transformed into a convex function by using mathematical tools in the inner layer, and then an iterative algorithm based on alternating optimization (AO) is proposed for power allocation, and finally the solution of the initial problem is obtained by circular iteration in both inner and outer layers. …”
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Post‐Translational Modifications of RNA‐Modifying Proteins in Cellular Dynamics and Disease Progression by Yunfan Lin, Pei Lin, Ye Lu, Jiarong Zheng, Yucheng Zheng, Xiangyu Huang, Xinyuan Zhao, Li Cui

“…Abstract RNA‐modifying proteins, classified as “writers,” “erasers,” and “readers,” dynamically modulate RNA by adding, removing, or interpreting chemical groups, thereby influencing RNA stability, functionality, and interactions. …”
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HSC70-3 in the Gut Regurgitant of Diamondback Moth, <i>Plutella xylostella</i>: A Candidate Effector for Host Plant Adaptation by Qingxuan Qiao, Chanqin Zheng, Huiting Feng, Shihua Huang, Bing Wang, Uroosa Zaheer, Weiyi He

“…However, knockout mutants exhibited no significant developmental defects when reared on an artificial diet, suggesting that <i>hsc70-3</i> primarily functions in modulating plant-induced defense responses rather than directly affecting insect physiology. …”
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