Potential Roles of Exosomal MicroRNAs as Diagnostic Biomarkers and Therapeutic Application in Alzheimer’s Disease by Jian-jiao Chen, Bin Zhao, Jie Zhao, Shao Li

“…Exciting findings reveal that miRNAs released from exosomes modulate the expression and function of amyloid precursor proteins (APP) and tau proteins. …”
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Partial Discharge (PD) Signal Recognition in Fiber-Optic Acoustic Emission Using a Lightweight Attention Mechanism (ECA) by Yang Feng, Dong Yuhan, Jiang Peng, Liu Guolen

“…Based on the ResNet model, we incorporate an ELU activation function to enhance the model and introduce both CA and ECA attention mechanisms. …”
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A central role for TOR signalling in a yeast model for juvenile CLN3 disease by Michael E. Bond, Rachel Brown, Charalampos Rallis, Jürg Bähler, Sara E. Mole

“…We confirmed that yeast cells modelling CLN3 disease exhibit features consistent with dysfunction in the TORC pathways, and showed that modulating TORC function leads to a comprehensive rescue of defects in this yeast disease model. …”
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The role of osteocalcin in regulating the acute stress response by Ning Kang, Jie Huang, Xiaoguang Han, Xiaoguang Han, Xiaoguang Han, Zhengqian Li, Yi Yuan, Xiangyang Guo, Xiangyang Guo, Ning Yang

“…Beyond its canonical role in bone metabolism, OCN may have many other functions as well. Studies have shown that it may also regulate glucose and lipid metabolism, cognitive function, sexual function, and more. …”
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The contributing role of CCR5 in dementia by Tong Zheng, Meiping Ye, Meiping Ye, Pingyu Zhou, Pingyu Zhou

“…C-C chemokine receptor 5 (CCR5) has been extensively researched for its role in immune responses and function as a co-receptor in HIV infection. Current research indicates that CCR5, which acts as a regulator of synaptic plasticity, is involved in modulating various forms of learning and memory. …”
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Scorpion Peptides: Potential Use for New Drug Development by BenNasr Hmed, Hammami Turky Serria, Zeghal Khaled Mounir

“…Because of their important structural and functional diversity, it is projected that scorpion-derived peptides could be used to develop new specific drugs. …”
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HC-Pro inhibits HEN1 methyltransferase activity, leading to autophagic degradation of AGO1 by Zhao-Jun Pan, Wei-Lun Wei, Phuong-Anh Tran, Ru-Ying Fang, Thanh Ha Pham, John L. Bowman, Chao-Tzu Chung, Bing-Nan Shen, Ju-Ting Yang, Han-Han Chang, Wann-Neng Jane, Chiung-Hsiang Cheng, Chia-Chi Wang, Hsin-Yi Wu, Syuan-Fei Hong, Qian-Wen Shang, Sin-Fen Hu, Pin-Chun Lin, Fu-Hui Wu, Choun-Sea Lin, Yu-Ling Hung, Tang-Long Shen, Shih-Shun Lin

“…Abstract Helper-component proteinase (HC-Pro), encoded by potyviruses, function as viral suppressors of RNA silencing (VSRs). …”
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A pilot randomized controlled double-blind trial of intermittent theta burst stimulation (iTBS) repetitive transcranial magnetic stimulation (rTMS) to improve memory in mild cognit... by Maria I. Lapid, Sandeep R. Pagali, Michael R. Basso, Paul E. Croarkin, Jennifer R. Geske, John Huston, Karimul Islam, Boney Joseph, Walter W. Kennebeck, Daehun Kang, Simon Kung, Allison M. LeMahieu, Brian N. Lundstrom, Ronald C. Petersen, Mikaela M. Sarran, Yunhong Shu, Ilya M. Swanson, Erik K. St. Louis, Melissa K. Wang, Yogatheesan Varatharajah, Neeraj Wagh, Kirk M. Welker, Gregory A. Worrell, Bradley F. Boeve

“…Objectives Our study will test the feasibility of using intermittent theta burst stimulation (iTBS) technique of rTMS in MCI, pilot test the study design, and collect pilot data on the effect of iTBS over three different brain regions on working memory, new learning, and executive function in MCI. Exploratory objectives are to assess the feasibility and usefulness of functional magnetic resonance imaging (fMRI), high-density electroencephalography (HD-EEG), and sleep architecture as potential biomarkers in response to iTBS. …”
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Targeting SETDB1 in cancer and immune regulation: Potential therapeutic strategies in cancer by Bo‐Syong Pan, Cheng‐Yu Lin, Gilbert Aaron Lee, Hui‐Kuan Lin

“…While essential for normal immune cell function, SETDB1 overexpression in cancer cells disrupts immune responses by suppressing tumor immunogenicity and facilitating immune evasion. …”
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Valproate Damaging Effect on Erythrocyte Metabolism as a Decisive Factor in the Development of Encephalopathy by Lyudmila Tikhonova, Eugene Maevsky, Carmina Montoliu, Elena Kosenko

“…Results: Our data showed that VPA-induced G6PD inhibition leads to profound oxidative stress, increased MetHb formation and decreased 2,3-DPG and ATP levels in erythrocytes that underlie the loss of their oxygen transport function, thus being a cause of a brain energy crisis that precedes encephalopathy. …”
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Synergistic Effects of Natural Products and Mesenchymal Stem Cells in Osteoarthritis Treatment: A Narrative Review by Hamoud H. Alfaqeh, Ruszymah Binti Hj Idrus, Aminuddin Bin Saim, Abid Nordin

“…Osteoarthritis (OA) is a debilitating joint disorder characterized by cartilage degradation, inflammation, and loss of joint function. While mesenchymal stem cells (MSCs) hold promise for OA therapy due to their regenerative and immunomodulatory properties, challenges such as poor survival, suboptimal differentiation, and an inflammatory microenvironment limit their clinical efficacy. …”
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Cardiocutaneous syndrome is caused by aggregation of iASPP mutants by Rebecca Lotz, Christian Osterburg, Birgit Schäfer, Xin Lu, Volker Dötsch

“…It consists of the three members ASPP1, ASPP2 and iASPP which are best known for modulating the apoptotic function of p53, thereby directing cell fate decision. …”
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Quality of Life and Volume Reduction in Women with Secondary Lymphoedema Related to Breast Cancer by Marcus Lanza, Anke Bergmann, Maria Giseli da Costa Leite Ferreira, Suzana Sales de Aguiar, Ricardo de Almeida Dias, Karen de Souza Abrahão, Ester M. Paltrinieri, Ruy G. Martínez Allende, Mauro Figueiredo Carvalho de Andrade

“…At baseline, in measuring quality of life for the EORTC QLQ-C30 questionnaire subscale of functionality, the worst scores for emotional function (55 points) and better social function (89 points) were observed. …”
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ABER Performance of LDPC-Coded OFDM Free-Space Optical Communication System Over Exponentiated Weibull Fading Channels With Pointing Errors by Xiaoxia Liu, Ping Wang, Tao Liu, Yutao Li, Lixin Guo, Hongxin Tian

“…On the basis of the probability density function and cumulative distribution function of the composite channel gain, the analytical expressions of average bit error rate (ABER) of this FSO-OFDM system with on&#x2013;off keying, <italic>K</italic>-ary quadrature amplitude modulation (QAM) and phase shift keying (PSK) modulation schemes are derived by using generalized Gauss&#x2013;Lagurre quadrature rule, respectively. …”
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Interactions Between the Transcription Factor BOL/DRNL/ESR2 and the Jasmonate Pathway by Beatriz E. Ruiz-Cortés, Yolanda Durán-Medina, C. Cecilia Ramos-Tamayo, Herenia Guerrero-Largo, Ma. Isabel Cristina Elizarraraz-Anaya, Omar Fabián Hernández-Zepeda, Enrique Ramírez-Chávez, Michiel Lammers, Ruud A. de Maagd, Jorge Molina-Torres, Stefan de Folter, Nayelli Marsch-Martínez

“…BOL/DRNL/ESR2, an AP2/ERF transcription factor, regulates early organ development in Arabidopsis (<i>Arabidopsis thaliana</i>). Its loss of function causes flower organ defects, while its overexpression induces green callus formation in roots without the addition of hormones. …”
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Research on the Classification of Sun-Dried Wild Ginseng Based on an Improved ResNeXt50 Model by Dongming Li, Zhenkun Zhao, Yingying Yin, Chunxi Zhao

“…Next, the ELU activation function replaces the original ReLU activation function. …”
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Optimum design of the hybrid (diffractive/refractive) multifocal intraocular lenses implanted within human eye by Ali H. Al-Hamdani, Hayfa G. Rashid, Hussein Talb Hashim

“…The image characteristics, point spread function (PSF), modulation transfer function (MTF), blur spot size and longitudinal chromatic aberration (LCA), were used as an image criterion in this study. …”
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The Cellular and Mitochondrial Consequences of Mevalonate Pathway Inhibition by Nitrogen-Containing Bisphosphonates: A Narrative Review by Adrianna Budzinska, Wieslawa Jarmuszkiewicz

“…The aim of this review is to synthesize the current knowledge on the cellular and molecular effects of N-BPs outside the skeletal system, with particular emphasis on their impact on mitochondrial function and energy metabolism. At the cellular level, N-BPs may reduce viability, modulate inflammatory responses, trigger apoptosis, disrupt cytoskeletal organization, and influence signaling and energy metabolism. …”
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Glucose Metabolism of Human Prostate Cancer Mouse Xenografts by Hossein Jadvar, Xiankui Li, Antranik Shahinian, Ryan Park, Michel Tohme, Jacek Pinski, Peter S. Conti

“…The growth pattern of the CWR-22 tumor was best approximated by an exponential function (tumor size in mm 3 = 14.913 e 0.108 × days , R 2 = .96, n = 5). …”
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SGLT2 Inhibitors and GLP-1 Receptor Agonists in Diabetic Kidney Disease: Evolving Evidence and Clinical Application by Jae Hyun Bae

“…Although indirect comparisons suggest that SGLT2 inhibitors may offer greater protection against kidney function decline, direct head-to-head trials are lacking. …”
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