FapR regulates HssRS-mediated heme homeostasis in Bacillus anthracis by Hualiang Pi, Owen S. Burroughs, Sophia M. Carlin, William N. Beavers, Gideon H. Hillebrand, Evan S. Krystofiak, Devin L. Stauff, Eric P. Skaar

“…Furthermore, deletion of fapR affects the loading of HssS onto the cell membrane, compromising its heme sensing function and subsequently reducing endogenous heme biosynthesis. …”
Get full text

Pharmacologic and genetic evidence converge on mechanisms of psychotic illness by Brian Fennessy, Liam Cotter, Nicole W. Simons, Lora E. Liharska, Girish N. Nadkarni, Douglas M. Ruderfer, Alexander W. Charney

“…Only one gene – GRIN2A, encoding the GluN2A subunit of the NMDA glutamate receptor – was implicated in psychotic illness by propsychotics, rare loss-of-function genetic variation, and common genetic variation. …”
Get full text

Icariin-Enhanced Osteoclast-Derived Exosomes Promote Repair of Infected Bone Defects by Regulating Osteoclast and Osteoblast Communication by Zhang Y, Zhang M, Li M, Miao M, Shou D, Tong P

“…ICA-OC-Exo was observed to stimulate osteoblast function by targeting FGF23, reducing DKK1, and subsequently upregulating ALP. …”
Get full text

Preventive effect of the neurodynamic mobilization technique on delayed onset of muscle soreness: a randomized, single-blinded, placebo-controlled study by Ugur Sozlu, Selda Basar, Rabia Semsi, Esedullah Akaras, Aylin Sepici Dincel

“…The NM group exhibited significantly lower muscle soreness scores (F3.160 = 5.436, p = 0.001) and higher PPT values (F3.160 = 12.580, p < 0.001) compared to the placebo NM group at 0, 24, 48, and 72 h. Muscle function scores reached their lowest point at 0 h, with the NM group demonstrating significantly higher function scores than the placebo NM group both before the EIMD protocol and at 0 h (F3.160 = 8.532, p < 0.001). …”
Get full text

Epigenetic modifications in the murine liver upon depletion of transcriptional coregulator host cell factor 1 by Shruti Kaushal, Debashruti Bhattacharya, Saran Kumar, Winship Herr, Jaspreet Kaur Dhanjal, Shilpi Minocha

“…Abstract Background Transcriptional co-regulators fine-tune gene expression by modulating transcription factor activity and chromatin dynamics. …”
Get full text

Multi-scale neural homeostasis mechanisms: Insights into neurodegenerative diseases and therapeutic approaches, including exercise by Ya Wang, Xuhui Chen, Cuntai Zhang, Shangbang Gao

“…By examining neurodegenerative diseases such as amyotrophic lateral sclerosis and Parkinson’s disease as case studies, we demonstrate how multi-scale homeostatic disruptions lead to impaired motor function and disease progression. Additionally, we discuss therapeutic strategies, such as exercise, that target specific scales of homeostatic regulation, emphasizing the potential of multi-dimensional approaches for restoring neural function. …”
Get full text

Evaluation of the immunomodulatory effects of a novel synbiotic made of combined use of probiotic-prebiotic-Chinese traditional herbs by Deshan Ning, Yiru Huang, Yulong Zhou, Hongwei Zhao, Wenlei Nie, Yu Zheng, Xiaojun Huang

“…Conclusion: The study demonstrated that the synbiotic was capable of modulating immune function, as evidenced by an increase in organ index, cellular immunity, and the ability to modulate intestinal flora disorders. …”
Get full text

The role of galectin-1 in the T-lymphocytes homeostasis by V. D. Yakushina, O. A. Vasiliyeva, N. V. Ryazantseva, V. V. Novitsky, O. Ye. Chechina, T. S. Prokhorenko, Ye. G. Starikova

“…So it seems to be interesting to research molecules of T-cell cooperation to develop new more effective therapeutic methods. Important factor modulating T-cell activity is galectin-1 which takes part in multiply process of cell biology — regulation of cell maturation, migration, signal transduction, functional ability and apoptosis.…”
Get full text

Transcutaneous auricular vagal nerve stimulation for consciousness recovery in patients with prolonged disorders of consciousness (TAVREC): study protocol for a multicenter, triple... by Jan D Reinhardt, Jin Liu, Ting Luo, Xiao Lu, Zhen-Yu Liu, Long-yun Zhou, Li-jun Peng, Ya-feng Liu, Shu-wei Wang, Yue Qiu, Si-jing Chen, Ming-ming Feng, Shan-shan Wu, Hui-juan Wu, Jiang-ping Ge

“…Transcutaneous auricular vagal nerve stimulation (taVNS), a safe, non-invasive intervention modulating thalamo-cortical connectivity and brain function, is a possible treatment option of pDoC. …”
Get full text

The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target by Yunpeng Zou, Yunpeng Zou, Jianning Kang, Shaopeng Zhu, Xuechen Ren, Zheng Li, Jiayao Niu, Xuanzhe Qin, Hongbo Li, Lu Xiang, Wei Jiang, Jiangbo Zhong, Ying Zhang, Ying Zhang, Kai Zhao

“…PLEK was further validated by qRT-PCR and Western blot in OS samples, and its function assessed via siRNA knockdown in macrophages within TME co-cultured with OS cells. …”
Get full text

Optimization of fractional composition of the excipient in the elastomeric covering for asphalt highways by E. M. Nurullaev, A. S. Ermilov

“…The coefficient of dynamic viscosity of polymeric suspension or the initial module of a viscoelasticity of the join solidification low-molecular rubbers with the final functional groups, filled by many fractional dioxide of silicon are considered as criteria of optimization. …”
Get full text

Genome-Wide Characterization of the <i>SnRK</i> Gene Family in <i>Taxus</i> and Homologous Validation of <i>TaSnRK1.2</i> as a Central Regulator in Stress-Responsive Transcriptiona... by Pengjun Lu, Jianqiu Ji, Fangjuan Fan, Tao Liu, Zhenting Shi, Wentao Li, Chongbo Sun

“…This study establishes the <i>Taxus SnRK</i> family and identifies <i>TaSnRK1.2</i> as a hub integrating stress signals (e.g., MeJA) to modulate downstream TF networks, while the novel protoplast system enables future functional studies in this medicinal plant.…”
Get full text

Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy by Sarala Raj Murthi, Andreas Petry, Bachuki Shashikadze, Jan B. Stöckl, Manuel Schmid, Gianluca Santamaria, Karin Klingel, Damir Kračun, Xinpei Chen, Sabine Bauer, Joachim P. Schmitt, Florian Flenkenthaler, Josh Gorham, Christopher N. Toepfer, David Potěšil, Pavel Hruška, Zbyněk Zdráhal, Zsuzsanna Mayer, Mathieu Klop, Luisa Lehmann, Yishi Qin, Laura Papanakli, Nadine Spielmann, Alessandra Moretti, Thomas Fröhlich, Peter Ewert, Stefan Holdenrieder, Jonathan G. Seidman, Christine E. Seidman, Agnes Görlach, Cordula M. Wolf

Get full text

Research on Power Quality Control Device with Super Capacitor and Active Power Filter and Its Control by LONG Lilan, AN Youbin, ZHANG Min, WU Mingshui

“…In order to increase the utilization rate of power quality control devices in micro-grid, a combined device based on super capacitor and active power filter was proposed by using the main circuit topological similarity and functional complementarity between super capacitor energy storage system and active power filter. …”
Get full text

Secretion of the pancreas: from the Pavlov’s elements to the present time by G. F. Korotko

“…The original concept of the functional nonequipotentionality of the gland and modular principle of the organization of its exocrine secretion, acute adaptation of enzyme secretion to nutritional structure of duodenal chyme are described.…”
Get full text

Medical embryology and regenerative medicine: research and applications in clinical practice by Julia Soczyńska, Julia Soczyńska, Wiktor Gawełczyk, Wiktor Gawełczyk, Patrycja Obrycka, Patrycja Obrycka, Mateusz Żołyniak, Mateusz Żołyniak, Adrian Muzyka, Adrian Muzyka, Krzysztof Majcherczyk, Krzysztof Majcherczyk, Julia Papierkowska, Julia Papierkowska, Sławomir Woźniak

“…Detailed research on the influence of microenvironmental factors on the future function of stem cells, including artificial modulation of external signals that mimic in vivo conditions -such as chemical gradients or specific pathways like Notch and Hedgehog -has enabled effective regulation of cellular behavior. …”
Get full text

3D printing-biomimetic local stiff niche enhances glycolysis to boost PDAC cell stem-like phenotype via N6-methyladenosine-suppressed YAP1 mRNA decay by Di Wu, Xiaoqi Guan, Tao Yang, Jiashuai Yan, Biwen Zhu, Junchao Zhou, Yibing Guo, Yuhua Lu

“…However, the stiffness heterogeneity of TME within PDAC functions on tumor cell stem-like phenotypes remains unclear. …”
Get full text

CD109, a master regulator of inflammatory responses by Adel Batal, Adel Batal, Setareh Garousi, Setareh Garousi, Kenneth W. Finnson, Kenneth W. Finnson, Anie Philip, Anie Philip

“…CD109 exerts its effects by modulating processes such as cytokine secretion, immune cell recruitment, macrophage polarization, T helper cell function and cancer cell phenotype and function. …”
Get full text

The LTB4-BLT1 axis attenuates influenza-induced lung inflammation by suppressing NLRP3 activation by Cheng Wei, Yitian Xu, Ying Zheng, Lizhe Hong, Chen Lyu, Haibo Li, Bin Cao

“…Abstract The mortality associated with influenza A virus (IAV) infection typically results from excessive immune responses, leading to immunopathological lung damage and compromised pulmonary function. Various immunomodulators are seen beneficial when used in conjunction with direct anti-infection treatment. …”
Get full text

Toll-like Receptor Activation Remodels the Polyamine and Tryptophan Metabolism in Porcine Macrophages by Meimei Zhang, Lingfei Du, Yinhao Shen, Peng Bin

“…<b>Background:</b> The early nutritional metabolism of piglets is intimately associated with the regulation of immune function, and amino acids play a crucial role in modulating the fate and function of porcine immune cells, especially macrophages. …”
Get full text