Machine learning identifies PYGM as a macrophage polarization–linked metabolic biomarker in rectal cancer prognosis by Chengyuan Xu, Chengyuan Xu, Siqi Zhang, Bin Sun, Zicheng Yu, Hailong Liu

“…The prognostic performance of MPGS was evaluated across rectal and multiple other cancer types. Functional analyses, single-cell RNA sequencing, immunohistochemistry of clinical specimens, and in vitro cellular assays were employed to investigate the role of the MPGS hub gene, PYGM, in tumor biology and immune modulation.ResultsThe MPGS exhibited robust prognostic capability and effectively predicted responses to immunotherapy and various chemotherapeutic agents. …”
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Integrating metabolism gene clusters and tumor immune microenvironment in head and neck squamous cell carcinoma by Meina Lian, Xiaoxia Wang, Zixian Huang, Yudong Wang, Zhiquan Huang

“…TNFAIP6 was further evaluated for its functional role through in vitro assays, including proliferation, migration, and invasion analyses. …”
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The pepper MAP4K kinase CaMAP4K3 negatively regulates drought resistance by Chae Woo Lim, Woonhee Baek, Junyoung Cho, Sung Chul Lee

“…While the positioning of MAP4Ks within the canonical MAPK signaling module in plants remains controversial, emerging research continues to shed light on their functional roles. …”
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Loss of TRPV4 is insufficient to promote repair in a spinal cord injury contusion model by Melanie Mertens, Sofie Kessels, Naomi Veeningen, Elle E. M. Scheijen, Femke Mussen, Amber Delbroek, Jana Van Broeckhoven, Yeranddy A. Alpizar, Bert Brône

“…Surprisingly, TRPV4 deficiency in phagocytes did not enhance functional recovery, reduce microgliosis, or diminish scar formation after SCI. …”
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Qing-Xin-Jie-Yu Granule attenuates myocardial infarction-induced inflammatory response by regulating the MK2/TTP pathway by Jianghan Qi, Xiaoyao Gao, Ying Han, Meiling Yang, Chenyi Wei, Ling Zhang, Jianfeng Chu

“…QXJYG may reduce the expression of inflammatory factors in both the heart and serum of myocardial infarction-induced mice and attenuate hypoxia-induced levels of inflammatory factors in cardiomyocytes by decreasing the ratio of p-MK2/MK2 and increasing the protein expression of TTP.Discussion and conclusions QXJYG improved cardiac function and reduced injury, fibrosis, and inflammation after myocardial infarction, likely through modulation of the MK2/TTP signaling pathway.…”
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RE-YOLO: An apple picking detection algorithm fusing receptive-field attention convolution and efficient multi-scale attention. by Jinxue Sui, Li Liu, Zuoxun Wang, Li Yang

“…Finally, the loss function of YOLOv8 is improved using the Wise Intersection over Union (WIOU) function, which not only simplifies the gradient gain assignment mechanism and improves the ability to detect targets of different sizes, but also accelerates the model optimization. …”
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A Recommendation Algorithm Incorporating Adaptive Gating Mechanisms and Knowledge Graph Enhancements by Yi Yu, Teng Lv

“…Finally, a normalized inner product operation is used as an evaluation function to predict the user’s preferences for items. …”
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Design and applications of self-assembled polypeptide matrices in wound healing by Mélanie Côté-Cyr, Mélanie Côté-Cyr, Steve Bourgault, Steve Bourgault

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Seven-Level Soft Charging Switched-Capacitor Multilevel Inverter by Mehmet Memis, Murat Karakilic

“…Moreover, the total cost function (CF) value of 3.26 is among the lowest values, indicating that the system offers an economically advantageous solution. …”
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Early Life Stress and Gut Microbiome Dysbiosis: A Narrative Review by Alejandro Borrego-Ruiz, Juan J. Borrego

“…Results: Early life stress can profoundly impact cognitive function and neurodevelopment, with maternal early-life nutrition playing a significant role in modulating the effects of prenatal and postnatal stress. …”
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Investigating the NF-κB signaling pathway in heart failure: Exploring potential therapeutic approaches by Mohsen Ghiasi

“…It has been found that the NF-κB signaling pathway can affect heart function and HF through the regulation of matrix metalloproteinases and fibrotic mediators. …”
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Inversion of Magnetic Anomaly Based on Cross Attention Transformer by Juntao Lei, Jieru Chi, Shandong Li

“…Leveraging this mechanism, the Transformer Block can extract features from both magnetic anomaly and magnetic gradient anomaly data, thereby significantly enhancing the accuracy of boundary detection. 2) We propose a learnable Multi-Scale Feature Fusion Module. This module is devised to integrate the multi-scale features from each stage of the encoder, facilitating the decoder to achieve high-precision inversion. 3) We propose a forward constraint loss function. …”
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Tannic Acid and Ethacridine Lactate Attenuate Markers of Stress-Induced Intestinal Barrier Dysfunctions in Murine Small Intestinal Organoids by Louisa Filipe Rosa, Steffen Gonda, Nadine Roese, Stephan C. Bischoff

“…(1) Background: Tannacomp^® is a drug consisting of tannin albuminate, a complex of tannic acid (TA) and ethacridine lactate (Eta) used for treating acute and traveler’s diarrhea. TA is thought to modulate gastrointestinal barrier function, but the underlying mechanisms and whether Eta has similar effects remains unclear. (2) Methods: to investigate the effects of TA and Eta on the intestinal barrier, stress responses were induced in murine intestinal organoids by lipopolysaccharide (LPS) exposure or withdrawal of growth factors from cell culture medium (GF_Red). …”
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KLF5 Regulation of Exosome-Derived miR-152-3p From Bone Marrow Stem Cells Improves Ventricular Arrhythmia After Myocardial Infarction by Chen Wu, Xin-Yue Zou, Yi-Wen Jiang, Da-Wei Lin, Feng Jiang, Yao-Sheng Wang

“…Overall, our findings show that BMSCs transplantation promotes the recovery of cardiac function and reduces the incidence of arrhythmias by inhibiting CFs activation and modulating CFs Kir current remodeling. …”
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Singlet Oxygen-Induced Mitochondrial Reset in Cancer: A Novel Approach for Ovarian Cancer Therapy by Jorgelindo da Veiga Moreira, Laurent Schwartz, Mario Jolicoeur

“…We aimed to examine the role of SO in modulating mitochondrial function, cellular metabolism, and proliferation in ovarian cancer cell lines compared to control cells. …”
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Dietary hormesis: beyond nutrition and energy supply by Yida Wang, Zhao Wang

“…Furthermore, it proposes a biphasic dose-response-based food evaluation system, advocating a paradigm shift toward precision nutrition and hormesis-driven functional food development.…”
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CD9 regulates proliferation, invasion, migration and radioresistance of esophageal squamous cell carcinoma by activating AKT/GSK3β signaling pathway by Liubing Hou, Liubing Hou, Zengyao Hao, Ge Zhang, Jiayuan Li, Yu Wang, Xiaoying Xue, Xiaoying Xue, Huandi Zhou, Huandi Zhou, Huandi Zhou

“…CD9 was overexpressed in Eca109 cells (with low baseline expression) and knocked down in TE13 cells (with high endogenous expression). Functional assays, including proliferation, migration, invasion, and radioresistance tests, were conducted. …”
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Reliability, validity, and acceptability of the simplified Mandarin Chinese EORTC QLQ-OPT30 for uveal melanoma patients by Yonghui Huang, Panpan Cui, Guangyan Dong, Tongfang Fan

“…The module measures various aspects such as ocular irritation, visual impairment, headaches, concerns about disease recurrence, appearance issues, functional problems related to vision impairment, reading difficulties, functional issues in the treated eye, and driving problems. …”
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Impacts of coffee parchment on growth, immunity, and gut microbiota of Nile tilapia (Oreochromis niloticus) in biofloc system by Hien Van Doan, Toungporn Uttarotai, Supreya Wannavijit, Punika Ninyamasiri, Khambou Tayamath, Tran Thi Diem Quynh, Orranee Srinual, Thanongsak Chaiyaso, Pimporn Khamtavee, Wanaporn Tapingkae

“…In conclusion, coffee parchment is a promising functional feed additive that enhances growth, immunity, gene expression, and gut microbiota modulation in Nile tilapia reared in biofloc systems. …”
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Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism by Wesley H Godfrey, Judy J Lee, Shruthi Shanmukha, Kaho Cho, Xiaojing Deng, Chandra Shekar R Ambati, Vasanta Putluri, Abu Hena Mostafa Kamal, Paul M Kim, Nagireddy Putluri, Michael D Kornberg

“…The differentiation and suppressive functions of regulatory CD4 T cells (Tregs) are supported by a broad array of metabolic changes, providing potential therapeutic targets for immune modulation. …”
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