Transcriptional Regulation and Function of Malic Enzyme 1 in Human Macrophage Activation by Anna Santarsiero, Simona Todisco, Paolo Convertini, Chiara De Leonibus, Vittoria Infantino

“…Notably, ME1 gene silencing decreases nitric oxide as well as reactive oxygen species and prostaglandin E2 inflammatory mediators. Therefore, modulating ME1 provides a potential approach for immunometabolic regulation and in turn macrophage function.…”
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Gut microbiota in regulatory T cell generation and function: mechanisms and health implications by Amit Sharma, Garima Sharma, Sin-Hyeog Im

“…This review explores the sophisticated mechanisms by which the gut microbiota modulates the differentiation, expansion, and functional specialization of Tregs, orchestrating intestinal immune tolerance to support host-microbiota mutualism. …”
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Dimensions of Gut Dysfunction in Irritable Bowel Syndrome: Altered Sensory Function by Fernando Azpiroz

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Function of floral fragrance-related microRNAs and their targets in Hedychium coronarium by Fang Wang, Liang Liu, Rangcai Yu, Xin Li, Yunyi Yu, Xinyue Li, Yuechong Yue, Yanping Fan

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The role of zinc in the premature brain: functions, outcomes and future research perspectives by Myrsini Chamakioti, Luc P. Brion, Pranav Viswanathan, Cheryl S. Lair, Dimitrios Angelis

“…In this review we will summarize the role of Zn in brain functions and outcomes in preterm newborns, gaps in knowledge and areas of future research.…”
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Evaluation of Hypoglycemic Polyphenolic Compounds in Blueberry Extract: Functional Effects and Mechanisms by Yue Qin, Jielong Guo, Yuchen Lin, Yilin You, Weidong Huang, Jicheng Zhan

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Natural Products and Health Care Functions of <i>Inonotus obliquus</i> by Yiming Wang, Jingsheng Gu, Jiaying Wu, Yuxuan Xu, Yiting Liu, Fengxiu Li, Qiao Liu, Kailun Lu, Ting Liang, Jingwen Hao, Ludan Li, Xiaoying Cao, Jihong Jiang

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Metaboloepigenetics: Role in the Regulation of Flow-Mediated Endothelial (Dys)Function and Atherosclerosis by Francisco Santos, Hashum Sum, Denise Cheuk Lee Yan, Alison C. Brewer

“…In this review, we (1) summarize how shear stress (or flow) regulates endothelial (dys)function; (2) explore the epigenetic alterations that occur in the endothelium in response to disturbed flow; (3) review endothelial cell metabolism under different shear stress conditions; and (4) suggest mechanisms which may link this altered metabolism to the regulation of the endothelial epigenome by modulations in metabolite availability. …”
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Mechanism of pentoxifylline mediated down-regulation of killer lineage cell functions by R. S. Parhar, P. Ernst, K. Sheth, M. Einspenner, S. Al-Sedairy

“…Pentoxifylline (PTX) is known to modulate neutrophil functions. In the present study the effects of PTX on lipopolysaccharide (LPS) and cytokine induced T-cell and macrophage (ΦM) activation, and on natural killer (NK) cell and lymphokine activated killer (LAK) cell mediated cytotoxicity were examined. …”
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Chemistry and chemical biology tools contributing to the discovery and functional characterization of strigolactones by Qian Zhou, Changbin Niu, Liang Feng, Meixiu Dong, Xiaoxu Li, Xiaoxu Li, Bo Kong, Bo Kong, Changsheng Li, Changsheng Li

“…Beyond their well-known activity in stimulating parasitic weed germination, strigolactones function in regulating plant architecture, promoting symbiosis with arbuscular mycorrhizal fungi, and modulating responses to various environmental stresses. …”
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The Analysis of Discourse in the Sciences of Language: Theories and Perception of Language Functions in Genres by Qahraman Sulaiman Ahmed

“… In this research, we aim to examine the different variants of language functions within texts. Specifically, our study focuses on the modalities of texts that encompass a broad spectrum of statements and textual genres. …”
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Functional immunopeptides: advancing prevention and therapeutic strategies against animal diseases by Aldryan Cristianto Pratama, Xudong Yin, Jinwei Xu, Fang He

“…These approaches utilize innovative functional immunopeptides—such as antigenic peptides, antimicrobial, immune modulation, and delivery peptides derived from pathogens or hosts—to target specific immune mechanisms. …”
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Lactate-induced protein lactylation in cancer: functions, biomarkers and immunotherapy strategies by Wenjuan Wang, Hong Wang, Qi Wang, Xiaojing Yu, Liangliang Ouyang

“…Contemporary research reveals that lactate functions not merely as the terminal product of glycolysis but also as a nexus for initiating physiological and pathological responses within the body. …”
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A time for sex: circadian regulation of mammalian sexual and reproductive function by Sydney Aten, Oscar Ramirez-Plascencia, Chiara Blake, Chiara Blake, Gabriel Holder, Gabriel Holder, Emma Fishbein, Emma Fishbein, Adam Vieth, Adam Vieth, Arman Zarghani-Shiraz, Arman Zarghani-Shiraz, Evan Keister, Evan Keister, Shivani Howe, Shivani Howe, Ashley Appo, Ashley Appo, Beatrice Palmer, Carrie E. Mahoney

“…Evidence supporting the importance of proper clock function on fertility comes from several lines of work demonstrating that misalignment of biological rhythms or disrupted function of the body’s master clock, such as occurs from repeated shift work or chronic jet lag, negatively impacts reproduction by interfering with both male and female fertility. …”
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Research progress on biological functions of lncRNAs in major vegetable crops by Nan Li, Yujie Wang, Ran Zheng, Xiaoming Song

“…Accumulating evidence demonstrates that lncRNAs play significant roles in a wide range of biological processes, including regulating plant growth and development as well as modulating biotic and abiotic stress responses. Although the study of lncRNAs has been a hotspot of biological research in recent years, the functional characteristics of plant lncRNAs are still in their initial phase and face great challenges. …”
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Functional analysis of Casein Kinase 1 in a minimal circadian system. by Gerben van Ooijen, Matthew Hindle, Sarah F Martin, Martin Barrios-Llerena, Frédéric Sanchez, François-Yves Bouget, John S O'Neill, Thierry Le Bihan, Andrew J Millar

“…Although very few clock components appear to be shared across higher species, Casein Kinase 1 (CK1) is known to affect timekeeping across metazoans and fungi, but has not previously been implicated in the circadian clock in the plant kingdom. We now show that modulation of CK1 function lengthens circadian rhythms in Ostreococcustauri, a unicellular marine algal species at the base of the green lineage, separated from humans by ~1.5 billion years of evolution. …”
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Novelty, Challenge, and Practice: The Impact of Intensive Language Learning on Attentional Functions. by Thomas H Bak, Madeleine R Long, Mariana Vega-Mendoza, Antonella Sorace

“…Our results suggest that even a short period of intensive language learning can modulate attentional functions and that all age groups can benefit from this effect. …”
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Interleukin-27 and Autoimmune Disorders: A Compressive Review of Immunological Functions by Esmaeil Yazdanpanah, Alireza Pazoki, Sepehr Dadfar, Mohammad Hosein Nemati, Seyed Mohammad Sajad Siadati, Mahdieh Tarahomi, Niloufar Orooji, Dariush Haghmorad, Valentyn Oksenych

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Functional Food Targeting the Regulation of Obesity-Induced Inflammatory Responses and Pathologies by Shizuka Hirai, Nobuyuki Takahashi, Tsuyoshi Goto, Shan Lin, Taku Uemura, Rina Yu, Teruo Kawada

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Calcium nanoparticles target and activate T cells to enhance anti-tumor function by Wei Yang, Zhizi Feng, Xinning Lai, Jianwen Li, Zhengwei Cao, Fangchao Jiang, Fanghui Chen, Shuyue Zhan, Feng Kong, Li Yang, Yong Teng, Wendy T. Watford, Gang Zhou, Jin Xie

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