Critical role of Oas1g and STAT1 pathways in neuroinflammation: insights for Alzheimer’s disease therapeutics by Zhixin Xie, Linxi Li, Weizhong Hou, Zhongxi Fan, Lifan Zeng, Limin He, Yunxiang Ji, Jingbai Zhang, Fangran Wang, Zhou Xing, Yezhong Wang, Yongyi Ye

“…Interferon responses and Interferon-stimulated genes (ISGs) significantly function in neuroinflammatory and neurodegenerative diseases involving AD. …”
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An archaeal nucleoid-associated protein binds an essential motif in DNA replication origins by Rajkumar Dhanaraju, Rachel Y. Samson, Xu Feng, Alessandro Costa, Giovanni Gonzalez-Gutierrez, Stephen D. Bell

“…The role of chromatin proteins in origin function in the archaeal domain of life is poorly understood. …”
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mTORC1-selective inhibitors rescue cellular phenotypes in TSC iPSC-derived neurons by Elizabeth D. Buttermore, Elizabeth D. Buttermore, Gayathri Rajaram Srinivasan, Gayathri Rajaram Srinivasan, Hellen Jumo, Hellen Jumo, Amanda C. Swanson, Amanda C. Swanson, Benjamin O’Kelly, Benjamin O’Kelly, Nina R. Makhortova, Nina R. Makhortova, Nina R. Makhortova, Mustafa Sahin, Mustafa Sahin, Mustafa Sahin, Stelios T. Tzannis

“…TSC patients typically present with pathogenic variants in the TSC1 or TSC2 genes, which encode proteins forming a complex that plays an important role in modulating mTOR activity. We previously reported cellular and functional deficits in induced pluripotent stem cell (iPSC)-derived neurons from TSC patients. …”
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The Extended Synaptotagmins of <i>Physcomitrium patens</i> by Alexander Kaier, Maria Ntefidou

“…Extended Synaptotagmins (ESYTs) act at MCSs, functioning as tethers between two membrane compartments. …”
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Bioinformatics analysis of potential pathogenesis and risk genes of neuroinflammation-promoted brain injury in intracerebral hemorrhage by Ilgiz Gareev, Ozal Beylerli, Elmar Musaev, Chunlei Wang, Valentin Pavlov

“…DAVID is used to perform GO function enrichment analysis and KEGG pathway analysis of candidate target genes. …”
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Protein lactylation in kidney diseases by Yelei Xu, Xinming Li, Xinming Li, Zhiguo Mao, Cheng Xue

“…Lactylation influences the metabolic state, inflammatory response, and fibrosis of renal cells by modulating protein function and key gene transcription. …”
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16-channel photonic solver for optimization problems on a silicon chip by Jiayi Ouyang, Shengping Liu, Ziyue Yang, Wei Wang, Xue Feng, Yongzhuo Li, Yidong Huang

“…Due to the parallel and low-latency propagation of lightwaves, the calculation of the cost function can be accelerated. The photonic chip was fabricated on the silicon on insulator (SOI) substrate and integrated 16 high-speed electro-optic modulators, 88 thermo-optic phase shifters, and 16 balanced photodetectors. …”
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The Influence of Regional Anesthesia on the Systemic Stress Response by Tomasz Reysner, Katarzyna Wieczorowska-Tobis, Grzegorz Kowalski, Monika Grochowicka, Monika Pyszczorska, Aleksander Mularski, Malgorzata Reysner

“…<b>Conclusions:</b> RA offers a significant advantage in modulating the systemic stress response to surgery, improving postoperative outcomes by reducing pain, enhancing cardiovascular stability, and preserving immune function. …”
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Curcumin and neuroplasticity: epigenetic mechanisms underlying cognitive enhancement in aging and neurodegenerative disorders by Hao Jiao, Xiuying Wang, Dahui Zhang, Shengxue Zhou, Feng Gao

“…Curcumin, a bioactive polyphenol derived from Curcuma longa, has gained significant attention for its neuroprotective properties, particularly in enhancing cognitive function through epigenetic mechanisms. This review explores the multifaceted role of curcumin in modulating key molecular pathways involved in neuroplasticity, including histone modifications, DNA methylation, and non-coding RNA regulation. …”
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Genomic signatures of SnRKs highlighted conserved evolution within orchids and stress responses through ABA signaling in the Cymbidium ensifolium by Ruiyue Zheng, Kai Zhao, Jiemin Chen, Xuanyi Zhu, Yukun Peng, Mingli Shen, Zhong-Jian Liu, Donghui Peng, Yuzhen Zhou

“…Moreover, distinct functional domains beyond the kinase domain differentiated the subfamilies. …”
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Clearing Amyloid-Beta by Astrocytes: The Role of Rho GTPases Signaling Pathways as Potential Therapeutic Targets by Gyeongah Park, Zhen Jin, Hui Lu, Jianyang Du

“…These key regulators of cytoskeletal dynamics and intracellular signaling pathways function independently through distinct mechanisms but may converge to modulate inflammatory responses. …”
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Neuroprotective role of nitric oxide inhalation and nitrite in a Neonatal Rat Model of Hypoxic-Ischemic Injury. by Peter Jung, Euntaik Ha, Meijuan Zhang, Carolyn Fall, Mindy Hwang, Emily Taylor, Samuel Stetkevich, Aditi Bhanot, Christopher G Wilson, Johnny D Figueroa, Andre Obenaus, Shannon Bragg, Beatriz Tone, Saburi Eliamani, Barbara Holshouser, Arlin B Blood, Taiming Liu

“…We hypothesized that either inhaled NO (iNO) or nitrite would alleviate brain injury in neonatal HII via modulation of mitochondrial function.<h4>Methods</h4>We tested the effects of iNO and nitrite on the Rice-Vannucci model of HII in 7-day-old rats. …”
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Pitch characteristics of real-world infant-directed speech vary with pragmatic context, perceived adult gender, and infant gender. by Emily M Neer, Anvi Brahmbhatt, Catherine R Walsh, Anne S Warlaumont

“…While infant-directed speech tended to have greater mean pitch and pitch modulation than adult-directed speech overall, these patterns were modulated, sometimes in complex ways, by pragmatic function, perceived adult gender, and infant gender. …”
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A Study of Potential Applications of Student Emotion Recognition in Primary and Secondary Classrooms by Yimei Huang, Wei Deng, Taojie Xu

“…Firstly, the study adds the self-made MCC module and the Wise-IoU loss function to make object detection in the YOLOv8 model more accurate and efficient. …”
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Two-Dimensional Coherent Polarization–Direction-of-Arrival Estimation Based on Sequence-Embedding Fusion Transformer by Zihan Wu, Jun Wang, Zhiquan Zhou

“…The module is a combination of a convolutional neural network (CNN) with local information extraction capabilities and a feature dimension transformation function, serving to improve the model’s ability to fuse information about features in the spatial-polarization domain. …”
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Small target detection in UAV view based on improved YOLOv8 algorithm by Xiaoli Zhang, Guocai Zuo

“…The MPDIoU (Minimum Point Distance based IoU) loss function is improved, and the idea of inner-IoU loss function is adopted as a way to improve the model’s learning ability for difficult samples. …”
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Traffic sign detection method based on improved YOLOv8 by Gaihua Wang, Peng Jin, Zhiwei Qi, Xiaohuan Li

“…Finally, the loss function of the original YOLOv8 is replaced with the Wise-IoU loss function, which improves the network’s bounding box regression performance and reduces the negative impact of low-quality samples. …”
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An Algorithm for Extracting Features of Basketball Players' Foul Actions Based on an Attention Mechanism by Peng Wang

“…After fusion, the feature fusion results are input into the classifier with the cross-entropy loss function as the loss function, and the probability value of each possible foul action and the tag target probability are output, complete basketball player foul action feature extraction. …”
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A Fused Multiscale Pictorial Sequence Learning Mechanism Applied to Pavement Detection by Zhang Jiazhen, Wang Xiulai, Zhao Shuxu

“…Using the SVM classifier with the global sequence alignment algorithm as the main kernel function, the data classification module detects anomalies, so that the algorithm can mine valuable feature attributes from multiple angles as much as possible while stably exerting its classification function. …”
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Cloning and expression profile of an ubiquitin-conjugating enzyme-like gene OsCROC-1A in rice (Oryza sativa L.) by WANG Ya, LIU Jianping, XU Mengyun, JI Weijie, TU Jumin, ZHANG Xiaobo

“…It is constitutively expressed in all the tissues examined and is generally modulated by abiotic stress, and OsCROC-1A has functions in both nucleus and cytosol. …”
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